CLUSTAL W(1.5) multiple sequence alignment EAA12069/71-416 --EVIRANIGDCHAMGQPPITFIRQVLGLVSYPPLFN--------DPSIP NP_491690/68-415 FPNVIKANIGDAHAMGQKPITFIRQLLACIVNPEIMKT-------DKSIP AAF48262/133-479 FDQVIRANIGDCHAMGQQPLTFLRQLLALTFETRLLD--------SPDYP ALAT1_HUMAN/87-433 FTEVIRANIGDAHAMGQQPITFLRQVMALCTYPNLLN--------SPSFP ALAT2_MOUSE/87-433 FTEVIRANIGDAHAMGQQPITFLRQVMALCTYPNLLN--------SPSFP NP_597700/87-434 FTEVIRANIGDAQAMGQQPITFLRQVMALCTYPNLLD--------SPSFP ALAT_RAT/59-406 FTEVIRANIGDAQAMGQRPITFFRQVLALCVYPNLLS--------SPDFP XP_128019/60-407 FTEVIRANIGDAQAMGQRPITFFRQVLALCVYPNLLS--------SPDFP ALAT_DOG/58-405 FTEVVRANIGDAQAMGQKPITFLRQVLALCVHPDLLN--------SPDFP AAC62456/45-392 FDEILYCNIGNPQSLGQQPVTFFREVLALCDHPCLLEKEE----TKSLFS ALA2_PANMI/45-392 FDEILYCNIGNPQSLGQQPVTFFREVLALCDHPCLLEKEE----TKSLFS ALA2_HORVU/45-392 FDEILYCNIGNPQSLGQQPVTFFREVLALCDHPDLLQREE----IKTLFS AAF82782/106-453 FDEIIYCNIGNPQSLGQQPITFFREVLALCSYTALLDESA----THGLFS NP_565040/52-399 FDEIIYCNIGNPQSLGQLPIKFFREVLALCDHASLLDESE----THGLFS AET01924/87-434 FDEIIYCNIGNPQSLGQQPITFFREVLALCDYPALLDKSE----TQGLFS BBD74338/49-396 FPEIIYCNLGNPQALGQRPITFFREVISLCDNPALLHRDE----TRMLFS XP_001219089/123-474 FNELVYCNIGNPQALEQKPLTFHRQVMSLIDAPFLLEDNA----VVSRYP T08064/86-432 --EIIFTNVGNPHALGAKPLTFTRQVLALCAAPFLLDHPK----VEDMFP ALAM_YEAST/151-505 FDRIINANIGNPQQLQQKPLTYYRQVLSLLQYPELLNQNEQQLVDSKLFK XP_455940/89-441 FSKIISANIGNPQQLDQKPLTFYREVLSLLQHPELLEEADEALQT--LYK XP_720174/77-428 FSKIINANIGNPQQLEQRPLTWYRQVLSLLQYPDLLKNGDPETVKS-LYP EAA28376/49-400 FSQVISANIGNPQQLDQKPITFFRQVLSLLENPLLLEHED-VLINHLGYK ALAT_SCHPO/68-419 FSEIVYANIGNPQQMGQSPITFVRQVLSLCQYPTLLDHAEEKWFQN-LFP EAA12069/71-416 TDAKQRARAILDGCKGGSVGSYSDSAGIEVIRRHAAEYIQRRDGGIPA-- NP_491690/68-415 SDVIEHANAFLGSCGGKSAGAYSQSTGVEIVRKHVAEYIKRRDGGIPC-- AAF48262/133-479 EDVKKRACAILNGCQGQSVGSYTDSAGLEVVRRQVAQYIEKRDGGIAS-- ALAT1_HUMAN/87-433 EDAKKRARRILQACGGNSLGSYSASQGVNCIREDVAAFITRRDG-VPA-- ALAT2_MOUSE/87-433 EDAKKRARRILQACGGNSLGSYSASQGVNCIREDVAAFITRRDG-VPA-- NP_597700/87-434 EDAKKRARRILQACGGNSLGSYSASQGVNCIREDVAAYITRRDGGVPA-- ALAT_RAT/59-406 EDAKRRAERILQACGGHSLGAYSISSGIQPIREDVAQYIERRDGGIPA-- XP_128019/60-407 EDAKRRAERILQACGGHSLGAYSISSGIQPIREDVAQYIERRDGGIPA-- ALAT_DOG/58-405 EDAKRKAERILQACGGHSLGAYSVSSGIQLIREDVAEYIERRDGGIPS-- AAC62456/45-392 ADAISRAKQILATIPGRATGAYSHSQGIKGLRDAIAAGIMSRDGFPA--- ALA2_PANMI/45-392 ADAISRAKQILSTIPGRATGAYSHSQGIKGLRDAIAAGIASRDGFPA--- ALA2_HORVU/45-392 ADSISRAKQILAMIPGRATGAYSHSQGIKGLRDAIASGIASRDGFPA--- AAF82782/106-453 SDSIERAWKILDQIPGRATGAYSHSQGIKGLRDAIADGIEARDGFPA--- NP_565040/52-399 TDSIDRAWRILDHIPGRATGAYSHSQGIKGLRDVIAAGIEARDGFPA--- AET01924/87-434 ADSIERAWQIVDQIPGRATGAYSHSQGIQGLRDTIAAGIEERDGFPC--- BBD74338/49-396 PCAINRARKIIESMPGRNTGAYTNSQGIRSLREAVASGIAARDGFPS--- XP_001219089/123-474 SDAVSRARLYLGHIGQR-TGAYTDSAGYAFVRDIVAQYVNERDAYVKPLQ T08064/86-432 ADAIARAKKILASFKGG-VGAYTDSRGNPLVREEVARFIEKRDGVPS--- ALAM_YEAST/151-505 LDAIKRAKSLME-DIGGSVGAYSSSQGVEGIRKSVAEFITKRDEGEISY- XP_455940/89-441 TDSIKRAKRLLS-EVGGSVGAYSQSQGVQGIRETVADFITKRDDGEISY- XP_720174/77-428 EDVIERAQSILK-HIG-SIGAYSHSQGASYFRQSIAEFITNRDGGYVSH- EAA28376/49-400 TDVIERAKWFLK-NVG-SVGAYSASNGAPAIRQHIAEFLERRD-GFPAN- ALAT_SCHPO/68-419 TDVVQRSKMLLK-ESG-SLGAYSASQGIPLVRRHVADFIRARD-GFDCE- EAA12069/71-416 DWQNIILSAGASGGIKVLMALLRCPIDGKKPGVMIPIPQYPLYSATIAEF NP_491690/68-415 NSEDVCLSGGASESIRNVLKLFINHNNAKKVGVMIPIPQYPLYSATIEEF AAF48262/133-479 NWQDIYLTGGASPGIKSILSMINAEVGCKAPGVMVPIPQYPLYSATISEY ALAT1_HUMAN/87-433 DPDNIYLTTGASDGISTILKLLVSGGGKSRTGVMIPIPQYPLYSAVISEL ALAT2_MOUSE/87-433 DPDNIYLTTGASDGISTILKLLVSGGGKSRTGVMIPIPQYPLYSAVISEL NP_597700/87-434 DPDNIYLTTGASDGISTILKILVSGGGKSRTGVMIPIPQYPLYSAVISEL ALAT_RAT/59-406 DPNNIFLSTGASDAIVTMLKLLVSGEGRARTGVLIPIPQYPLYSAALAEL XP_128019/60-407 DPNNIFLSTGASDAIVTMLKLLVAGEGRARTGVLIPIPQYPLYSAALAEL ALAT_DOG/58-405 DPNNIYLSTGASDAIVTVLKLLVAGEGPTRTGVLIPIPQYPLYSAALAEL AAC62456/45-392 NADDIFITDGASPGVHMMMQLLIRN---EKDGILCPIPQYPLYSASIALH ALA2_PANMI/45-392 NADDIFVTDGASPGVHMMMQLLIRN---EKDGILCPIPQYPLYSASIALH ALA2_HORVU/45-392 NADDIFLTDGASPGVHLMMQLLIRN---EKDGILVPIPQYPLYSASIALH AAF82782/106-453 DPNDIFMTDGASPGVHMMMQLLITS---EKDGILCPIPQYPLYSASIALH NP_565040/52-399 DPNDIFLTDGASPAVHMMMQLLLSS---EKDGILSPIPQYPLYSASIALH AET01924/87-434 NANDIFLTDGASPAVHMMMQLLIRS---EKDGILCPIPQYPLYSASITLH BBD74338/49-396 RPEDIFLTDGASSAINLSMQILIRS---QEDGILCPLPEYPLYSASIILH XP_001219089/123-474 EASSIVLTDGASTGVRIILQTLVGD---EKDAVMIPIPQYPLYTAQIALL T08064/86-432 NPDHIFLTDGASVAVRLCLNAMIRH---DRDSVLVPIPQYPLYSASIRLY ALAM_YEAST/151-505 -PEDIFLTAGASAAVNYLLSIFCRG---PETGVLIPIPQYPLYTATLALN XP_455940/89-441 -PEDIYLTAGASAAVSYILSILCKG---PNTGVLIPIPQYPLYTASLALN XP_720174/77-428 -ANNIFLTSGASTAVSYLLQILSVN---ENSGFLIPIPQYPLYTATIALN EAA28376/49-400 -WQDIYLSAGASSGVNTLLHIICAD---EKSGILVPIPQYPLYTASLSIL ALAT_SCHPO/68-419 -PSDIYLTSGASHAARLIMTLIIAR---PTDGVMVPAPQYPLYGAQIDLM EAA12069/71-416 DMEQIGYYLDEANKWGLDIAELERSLKEARKTS--APRILVVINPGNPTG NP_491690/68-415 GLGQVGYYLSESSNWSMDEAELERSFNDHCKEY--DIRVLCIINPGNPTG AAF48262/133-479 GMTKVDYYLEEETGWSLDRKELQRSYDEAKKVC--NPRALVVINPGNPTG ALAT1_HUMAN/87-433 DAVQVNYYLDEENCWALNVDELRRALRQAKDHC--DPKVLCIINPGNPTG ALAT2_MOUSE/87-433 DAVQVNYYLDEENCWALNVDELRRALRQAKDHC--DPKVLCIINPGNPTG NP_597700/87-434 DAIQVNYYLDEENCWALNVNELRRAVQEAKDHC--DPKVLCIINPGNPTG ALAT_RAT/59-406 DAVQVDYYLDEERAWALDIAELRRALCQARDRC--CPRVLCVINPGNPTG XP_128019/60-407 DAVQVDYYLDEERAWALDIAELRRALCQARDRC--CPRVLCVINPGNPTG ALAT_DOG/58-405 NAVQVDYYLDEERTWALDVAELRRALCQARAHC--RPRALCVINPGNPTG AAC62456/45-392 GGTLVPYYLNEKNGWGLEISDFKTRLEDVRSKG-IDVRALVVINPGNPTG ALA2_PANMI/45-392 GGTLVPYYLDEKTGWGLEISDLKKQLEDARSKG-IDVRALVVINPGNPTG ALA2_HORVU/45-392 GGALVPYYLNESTGWGLETSDVKKQLEDARSRG-INVRALVVINPGNPTG AAF82782/106-453 GGTLVPYYLDEASGWGLEISELKKQLEDARSKG-ITVRALAVINPGNPTG NP_565040/52-399 GGSLVPYYLDEATGWGLEISDLKKQLEEARSKG-ISVRALVVINPGNPTG AET01924/87-434 GGHLVPYYLDEATGWGLEISELKKQLEDAKSKG-ISVRALAVINPGNPTG BBD74338/49-396 GGTMVPYNLSEDGDWGLEIFEVKRCLEEARIAG-LTVRAMVIINPGNPTG XP_001219089/123-474 GGTPAMYYLRESEGWALNVGELEAVYKDCVANGNATPRVLVVINPGNPTG T08064/86-432 GGTLVGYFLDERRGWGLSVEELQRALQESREEG-KLVRGLVFINPGNPTG ALAM_YEAST/151-505 NSQALPYYLDENSGWSTNPEEIETVVKEAIQNE-IKPTVLVVINPGNPTG XP_455940/89-441 NSRPLPYYLREEQNWSTDPEEIEQVVLDAIQKG-IKPTCLVVINPGNPTG XP_720174/77-428 NAKPIGYYLDESNHWSTNPQEIRELIETNQSQG-INIKALVVINPGNPTG EAA28376/49-400 NATCVPYLLDESKNWGTDINTIKESYQKAKDAG-VDTRAIVIINPGNPTG ALAT_SCHPO/68-419 SGSMVSYSLSEENNWDIDFDQFKKSFDEASKKG-INVRLCVVINPGNPTG EAA12069/71-416 QVLSRSNIEDIIKFAQRERLVLFADEVYQDNVYESGSQFHSFKKVMMEMG NP_491690/68-415 QALSRENIETIIKFAQKKNLFLMADEVYQDNVYAQGSQFHSFKKVLVEMG AAF48262/133-479 QVLTRENIEEIIKFAHDNKVLVLADEVYQDNVYDKNSKFWSFKKVAYEMG ALAT1_HUMAN/87-433 QVQSRKCIEDVIHFAWEEKLFLLADEVYQDNVYSPDCRFHSFKKVLYQMG ALAT2_MOUSE/87-433 QVQSRKCIEDVIHFAWEEKLFLLADEVYQDNVYSPDCRFHSFKKVLYQMG NP_597700/87-434 QVQSRKCIEDVIHFAWEEKLFLLADEVYQDNVYSPDCRFHSFKKVLYEMG ALAT_RAT/59-406 QVQTRECIEAVIRFAFKEGLFLMADEVYQDNVYAEGSQFHSFKKVLMEMG XP_128019/60-407 QVQTRECIEAVIRFAFEEGLFLMADEVYQDNVYAEGSQFHSFKKVLTEMG ALAT_DOG/58-405 QVQARECIEAVIRFAFEERLFLMADEVYQDNVYAEGSQFHSFKKVLTEMG AAC62456/45-392 QVLAEDNQYDIVKFCKNEGLVLLADEVYQENIYVDNKKFNSFKKIVRSMG ALA2_PANMI/45-392 QVLAEDNQCDIVRFCKNEGLVLLADEVYQENIYVDDKKFNSFKKIARSVG ALA2_HORVU/45-392 QVLAEENQYDIVKFCKNEGLVLLADEVYQENIYVDNKKFHSFKKIVRSLG AAF82782/106-453 QVLSEENQRDVVNFCKQEGLVLLADEVYQENVYVPDKKFHSFKKVARSMG NP_565040/52-399 QVLAEENQRDIVNFCKQEGLVLLADEVYQENVYVPDKKFHSFKKVARSLG AET01924/87-434 QVLAEDNQRAIVEFCKQEGLVLLADEVYQENVYVPEKKFHSFKKVSRSMG BBD74338/49-396 QVLSVTNQEEIVEFCRKEGLVILADEVYQDNVYVEDRKFNSFKKVARSLG XP_001219089/123-474 GVLERTVMEEVAKFCCDHGVVLMADEVYQENIYTATKRFESFRKIVLELP T08064/86-432 QCLSKENLQELIKLAYQEKIVLMADEVYQENVYQDERPFVSAKKVMWEMG ALAM_YEAST/151-505 AVLSPESIAQIFEVAAKYGTVVIADEVYQENIFPGT-KFHSMKKILRHLQ XP_455940/89-441 AILSEQSIQKIFEVAAKYGIVVIADEVYQENVFKGS-KFYSMKKVLRNLQ XP_720174/77-428 AILSSQDIIELIDIAAEYGIVLIADEVYQENIFKG--KFVSFKKILSELI EAA28376/49-400 ASLSEEDIRAVLEFARQERLVVLADEVYQTNVFIG--EFISFKRVLRQLQ ALAT_SCHPO/68-419 ACISENSMEKVLRFAKAKGIVLLADEVYQNNIYQN--KFHSFRRKLGELR EAA12069/71-416 EPYS-----KMELCSFMSCSKGYMGECGIRGGYAEIVNLCPDVRTMLLKC NP_491690/68-415 EPYN-----KMELASFHSVSKGYMGECGMRGGYVEFLNLDPEVYVLFKKM AAF48262/133-479 DPYR-----NLEMVSFLSTSKGYLGECGIRGGYMEVLNLDPKVKAMLTKS ALAT1_HUMAN/87-433 HEYS----SNVELASFHSTSKGYMGECGYRGGYMEVINLHPEIKGQLVKL ALAT2_MOUSE/87-433 HEYS----SNVELASFHSTSKGYMGECGYRGGYMEVINLHPEIKGQLVKL NP_597700/87-434 PEYS----SNVELASFHSTSKGYMGECGYRGGYMEVINLHPEIKGQLVKL ALAT_RAT/59-406 PPYS----TQQELASFHSVSKGYMGECGFRGGYVEVVNMDAEVQKQMGKL XP_128019/60-407 PPYA----TQQELASFHSVSKGYMGECGFRGGYVEVVNMDAEVQKQMAKL ALAT_DOG/58-405 PPYA----THQELASFHSVSKGYMGECGFRGGYVEVVNMDPAVQRQMQKL AAC62456/45-392 -YGE----DDLPLVSLQSVSKGYYGECGKRGGYMEITGFSAPVREQIYKI ALA2_PANMI/45-392 -YGE----DDLPLVSFQSVSKGYYGECGKRGGYMEITGFSAPVREQIYKI ALA2_HORVU/45-392 -YGE----EDLPLVSYQSVSKGYYGECGKRGGYFEITGFSAPVREQIYKI AAF82782/106-453 -YGE----KDLALVSFQSVSKGYYGECGKRGGYMEVTGFTSDVREQIYKM NP_565040/52-399 -YGE----KDISLVSFQSVSKGYYGECGKRGGYMEVTGFTSDVREQIYKM AET01924/87-434 -YGD----NDICLVSFQSVSKGYHGECGKRGGYMEVTGFSPDVREQIYKV BBD74338/49-396 -YDE----NDISIVSFHSVSMGYSGECGRRGGYMEICGFGDDVMGEIRKV XP_001219089/123-474 PPYN----TDTVLVSLHSVSKGIIGECGRRGGYFTLTNAPPELVEQVMKL T08064/86-432 EPYR----SHVELLSFHTVSKGTAGECGLRGGYVEMTNIHPGAIEEVYKC ALAM_YEAST/151-505 REHP-GKFDNVQLASLHSTSKGVSGECGQRGGYMELTGFSHEMRQVILKL XP_455940/89-441 KTYH-GQYDNIQLASLHSTSKGVSGECGQRGGYMELVGFNHDIRQVFLKL XP_720174/77-428 EQDP-QTYKHVQLASLHSTSKGVSGECGQRGGYMELVGFKPEVKDVVFKL EAA28376/49-400 KENPDGKYDCVELASLHSISKGMVGECGHRGGYFELVNFDPEVQAEIYKF ALAT_SCHPO/68-419 EKEPDNHWDQVSLISVNSVSKGQFGECGQRGGYLDVVNIPEPAKDQILKL EAA12069/71-416 ISAQLCPTTAGQAVLDCVVNPPRKGEPSYEQFEKEKASVLESLRERAELV NP_491690/68-415 ISAKLCSTVLGQAVIDAVVNPPKEGDASYALWKQEKDAVLASLKERATLV AAF48262/133-479 ITAALCSTTAGQVAVSALVNPPQPGEPSYDLYKKERDGILAALKERAELV ALAT1_HUMAN/87-433 LSVRLCPPVSGQAAMDIVVNPPEPGEESFEQFSREKEFVLGNLAKKAKLT ALAT2_MOUSE/87-433 LSVRLCPPVSGQAAMDIVVNPPEPGEESFEQFSREKEFVLGNLAKKAKLT NP_597700/87-434 LSVRLCPPVSGQAAMDIVVNPPVAGEESFEQFSREKESVLGNLAKKAKLT ALAT_RAT/59-406 MSVRLCPPVPGQALMDMVVSPPTPSEPSFKQFQAERQEVLAELAAKAKLT XP_128019/60-407 MSVRLCPPVPGQALMGMVVSPPTPSEPSFKQFQAERQEVLAELAAKAKLT ALAT_DOG/58-405 MSVRLCPPVPGQVLLSIVVSPPAPSDPSFVQFQAERQAVLAELAAKAKLT AAC62456/45-392 ASVNLCSNITGQILASLVMNPPKAGDESYASYKAEKDGILESLARRAKAL ALA2_PANMI/45-392 ASVNLCSNITGQILASLVMNPPKVGDESYAAYKAEKDGILQSLARRAKAL ALA2_HORVU/45-392 ASVNLCSNITGQILASLVMNPPKASDESYASYKAEKDGILASLARRAKAL AAF82782/106-453 ASVNLCSNISGQILASLIMSPPKPGDDSYESYIAEKDGILSSLARRAKTL NP_565040/52-399 ASVNLCSNISGQILASLVMSPPKPGDDSYDSYMAERDGILSSMAKRAKTL AET01924/87-434 ASVNLCSNITGQILASLIMSPPKVGDESYESFMAERGAILSSLTTRAKAL BBD74338/49-396 ASVTLCPNTNGQILTSLAMDPPKLGDGCFEAFMAEKEEISTSLAKRAKTL XP_001219089/123-474 CSINLCSNVNGQLMTALMCSPPKPGDASFDHYTAEYSGIFESLKRRADLL T08064/86-432 ASINLSPNTMGQIALSVLVNPPKPGDPSYDQYTKEKASELVSLRRRRHMV ALAM_YEAST/151-505 ASISLCPVVTGQALVDLMVRPPVEGEESFESDQAERNSIHEKLITRAMTL XP_455940/89-441 ASISLCPVVTGQALVDLMVSPPQPGDESYEQDQQEREDIHDALDERASKL XP_720174/77-428 ASINLCSVVSGQALMELMINPPQEGDPSYPLYKSETESIHNDLESRAESL EAA28376/49-400 VSIMLCAPVIGQCLVELMVNPPKPGEPSYELYEKEYRGIYEGMRERANAL ALAT_SCHPO/68-419 ATIDICPPVAGQLLVDMLVNPPKPGDPSYDLFIKEVDEIHEALRLQCRQL EAA12069/71-416 ARTFNSIEGFSCNP NP_491690/68-415 EKAYSSIDGISCNP AAF48262/133-479 HKALNSFEGYKVNP ALAT1_HUMAN/87-433 EDLFNQVPGIQCNP ALAT2_MOUSE/87-433 EDLFNQVPGIQCNP NP_597700/87-434 EDLFNQVPGIHCNP ALAT_RAT/59-406 EQVFNEAPGIRCNP XP_128019/60-407 EQVFNEAPGIRCNP ALAT_DOG/58-405 EQVFNESPGIRCNP AAC62456/45-392 EDAFNKLEGFSCNK ALA2_PANMI/45-392 EDAFNNLEGISCNK ALA2_HORVU/45-392 EHAFNKLEGITCNE AAF82782/106-453 EEALNKLEGVTCNR NP_565040/52-399 EDALNSLEGVTCNR AET01924/87-434 EEALNKLEGVTCNK BBD74338/49-396 VNAFSSLEGMTCNK XP_001219089/123-474 AKELNNIRGFKSQS T08064/86-432 TDGFNALDGVTCNF ALAM_YEAST/151-505 YETFNSLEGIECQK XP_455940/89-441 FETFSRLEGIECRK XP_720174/77-428 YQAFLQMEDIKCNK EAA28376/49-400 HKAFEQMEGVECGA ALAT_SCHPO/68-419 YEGTKRMKRVSCLE