CLUSTAL W(1.5) multiple sequence alignment CBS_HUMAN/80-376 ILKKIGDTPMVRINKIGKKFGLKCELLAKCEFFNAGGSVKDRISLRMIED CBS_RAT/77-373 ILRKIGNTPMVRINRISKNAGLKCELLAKCEFFNAGGSVKDRISLRMIED AAH44091/76-372 ILQKIGDTPLVRINQIGKRFGLKCELLAKCEFFNAGGSVKDRISLRMVED AAD13393/84-375 ILGNIGNTPLVRLNKIPKQFGIKCDILVKCEFFSAGGSIKDRIALRMVED AAN31486/22-319 IMAAIGQTPMVCINSIGKKAHLQCELLAKCEFFNAGGSVKDRIGKRMVED CBS_DICDI/36-329 ILDNIGGTPLVRVNKVSS--DLECELVAKCEFFNAGGSVKDRIGHRMIVD AAF71541/14-306 ALEAIGNTPCIRLNRVPQKHGIQCEVVAKCEFFNPGGSVKDRIGKQMVLD AAK16397/25-318 VLDAIGSTPCIRLNHVPKKHGVCCDVVAKCEFLNPGGSVKDRIARQMILD AAF50862/49-345 ILEVIGCTPLVKLNNIPASDGIECEMYAKCEFLNPGGSVKDRIGYRMVQD NP_001035353/39-334 ILTAIGQTPLIKLNNIPKSYGIKCEIYAKCEFLNPGGSVKDRIAYRMIQD AAL09565/15-312 ILEHIGKTPLVKLNRIPKILNLKPQVYAKVELFNSGGSIKDRIALRMVEQ EAK93698/14-309 ILELIGNTPLVKLNKIPQSLGIKAKVYAKVELFNAGGSIKDRIAKNMVLE CBS_YEAST/14-319 VIDLVGNTPLIALKKLPKALGIKPQIYAKLELYNPGGSIKDRIAKSMVEE AF422799/18-317 ATDLIGNTPLVRLNKIPQSLGIKAQVFGKLELMNTGGSVKDRIALRMIEE EAA30070/20-319 ATELIGNTPLVRLNRIPQSLGIECEVYGKVELFNAGGSVKDRIALRMIEE EAA78329/18-317 ATELIGNTPLVRLNKIPQSLGIECDVYVKPELFSAGGSVKDRIALRMIEE AAG48621/7-296 MISLVGNTPLVKLNNV--TAGIQATVLAKVEYFNPGGSVKDRIAVRMIEA CAB89449/7-296 MISLVGNTPLVRLNSV--SKGIRATVLAKVEYFNPGGSVKDRIALRMIEA ZP_00059346/7-296 LIELVGNTPLVRLKKV--TAGLAPTVLAKVEYFNPGGSVKDRIALRMVED AAS03341/7-296 ISDLIGGTPLVRLNSV--VPDGAGIVAAKVEYLNPGGSSKDRIAVRMIDA NP_215593/7-296 ISELIGGTPLVRLNSV--VPDGAGTVAAKVEYLNPGGSSKDRIAVKMIEA BAB96806/7-296 VVDLIGNTPLVKLTSV--TGENFGTVAAKVEYLNPGGSSKDRIAVKMIDA AAN24961/60-356 LAELIGNTPLVKLNHIPQAAGVKATIAVKVEYFNPGGSSKDRIAERIIDA CAE81156/8-303 ILETIGNTPIVRLKNV--TKGSKHQFFAKIEYFNPGGSIKDRVAVAMIEE CBS_HUMAN/80-376 AERDGTLKPG-DTIIEPTSGNTGIGLALAAAVRGYRCIIVMPEKMSSEKV CBS_RAT/77-373 AERAGTLKPG-DTIIEPTSGNTGIGLALAAAVKGYRCIIVMPEKMSMEKV AAH44091/76-372 AERDGILKPG-DTIIEPTSGNTGIGLALAAAVKGYRCIIVMPEKMSMEKV AAD13393/84-375 AERAGLLKPG-DTIIEPTSGNTGIGLALVASVKGYRCVITMPDRMSMEKV AAN31486/22-319 AEAAGRIKPG-DTLIEPTSGNTGIGLALASAIKGYRCIITLPEKMSLEKV CBS_DICDI/36-329 AEESGRIKKG-DTLIEPTSGNTGIGLALTAAIKGYKMIITLPEKMSQEKV AAF71541/14-306 AEKNGTLKPG-SVIVEATSGNTGIGLSMAAAIRGYRMVIRMPKKMSHEKE AAK16397/25-318 AEASGRLRPN-QTIIEATSGNTGIGLSLVAAVKKYPMIITMPKKMSHEKE AAF50862/49-345 AEEQGLLKPG-YTIIEPTSGNTGIGLAMACAVKGYKCIIVMPEKMSNEKV NP_001035353/39-334 AEDKGLLKPG-CTIIEPTSGNTGIGLAMAAAVRGYKCIIVMPEKMSDEKI AAL09565/15-312 AEKEGRIKPG-YTLIEPTSGNTGIGLALVGAVKGYRTIITLPEKMSNEKV EAK93698/14-309 AEKQGKIKPG-YTLIEPTSGNTGIGLALVGAVRGYRTIITLPEKMSNEKV CBS_YEAST/14-319 AEASGRIHPSRSTLIEPTSGNTGIGLALIGAIKGYRTIITLPEKMSNEKV AF422799/18-317 AEKEGRIKPG-DTLIEPTSGNTGIGLALVGAVKGYKTIITLPEKMSAEKV EAA30070/20-319 AEKEGRIKPG-DTLIEPTSGNTGIGLALVGAIKGYKTIITLPEKMSAEKV EAA78329/18-317 AEKSGRIKPG-DTLIEPTSGNTGIGLALVGAIKGYKTIITLPEKMSAEKV AAG48621/7-296 AEQSGELKPG-GTIVEPTSGNTGVGLAIVAQQKGYKCIFVCPDKVSLDKI CAB89449/7-296 AEKSGELQPG-GTIVEPTSGNTGVGLAIVAQQKGYKCIFVCPDKVSTDKI ZP_00059346/7-296 AERRGLLKPG-GTIVEPTSGNTGVGLAIVAAEKGYRCVFVCPDKVGADKL AAS03341/7-296 AEASGALKPG-GTIVEPTSGNTGVGLALVAQQRGYKCVFVCPDKVGEDKR NP_215593/7-296 AEASGQLKPG-GTIVEPTSGNTGVGLALVAQRRGYKCVFVCPDKVSEDKR BAB96806/7-296 AEASGELKPG-GTIVEPTSGNTGIGLALVAQKRGYKCVFVCPDKVSEDKR AAN24961/60-356 AEQSGQLKPG-GVIVEPTSGNTGVGLALVAQQRGYRTIFTLPDKVSESKR CAE81156/8-303 AEKRGDLKAG-GTIVEATSGNTGVGLALAAAVKGYKCIFVMPEKMSEEKR CBS_HUMAN/80-376 DVLRALGAEIVRTPTNARFDSPESHVGVAWRLKNEIPNSHILDQYRNASN CBS_RAT/77-373 DVLRALGAEIVRTPTNARFDSPESHVGVAWRLKNEIPNSHILDQYRNASN AAH44091/76-372 DVLRALGAEIVRTPTSARFDSPESHVGVAWRLKNEIPNSHILDQYRNASN AAD13393/84-375 DVLKALGAEVVHTPSSAPFDSPESQVGMAWCLKNKIPNSHILDQYRNASN AAN31486/22-319 NVLKALGAEIIRTPTEAAWDSPESHIGIARRLQAELPNAHILDQYANPSN CBS_DICDI/36-329 DVLKALGGEIIRTPTEAAFDAPESHIGVAKKLNSEIPNSHILDQYGNPSN AAF71541/14-306 TTLQARGAEVIRTETSLPNDHPESLIGVATPLRDEK-GYVLLDQYR-PQQ AAK16397/25-318 VTLQALGAEVIRTETALPWDHPDSLIGMARRLEKEK-GYVLLDQYRNPSN AAF50862/49-345 SALRTLGAKIIRTPTEAAYDSPEGLIYVAQQLQRETPNSIVLDQYRNAGN NP_001035353/39-334 STLYALGAKIIRTPTEASWHSPEAHISVAQKLQKEIPNSIILDQYTNPGN AAL09565/15-312 AVLKALGAEIIRTPTEAAWDSPESHIGVARRLEKEIPNAVILDQYGNVNN EAK93698/14-309 SVLKALGAEIIRTPTEAAWDSPESHIGVAKKLEKEIPNSIILDQYGNPAN CBS_YEAST/14-319 SVLKALGAEIIRTPTAAAWDSPESHIGVAKKLEKEIPGAVILDQYNNMMN AF422799/18-317 SVLKALGATIIRTPTQAAWDAPESHIGVAKRLLKEIPNSHILDQYSNPNN EAA30070/20-319 SVLRALGATIIRTPTQAAWDSPESHIGVARRLLKEIPNSHILDQYTNPNN EAA78329/18-317 SVLRALGATIIRTPTQAAWDAPESHIGVARRLEKELPNAHILDQYSNKDN AAG48621/7-296 NVLRAYGAEVVVCPTAVDPEHPDSYYNVSDRLVRETPGAWKPDQYSNPNN CAB89449/7-296 NVLRAYGAEVVVCPTAVDPEHPDSYYNVSDRLVRETPGAWKPDQYSNPNN ZP_00059346/7-296 AVLRAYGAEVVVCPTTVAPDHPESYYSVSDRLAATIPGAWKPDQYSNPNN AAS03341/7-296 NVLMAYGAEVVVCPTAVPPEHPDSYYSVSDRLVTEIEGAWKPDQYANPEG NP_215593/7-296 NVLIAYGAEVVVCPTAVPPHDPASYYSVSDRLVRDIDGAWKPDQYANPEG BAB96806/7-296 NVLRAYGAEVVVCPTAVAPDNPNSYYSVSDRLTREIPGAWKPNQYSNPGG AAN24961/60-356 AVLRAYGAEVIVTPTDAGPDDPRSYYQVAERLANTIPGGFRPNQYDNPNG CAE81156/8-303 AILRAYGAKVVITP-MVDPEHPLSHYSVSQKIAKETPGAFLTNQYHNPDN CBS_HUMAN/80-376 PLAHYDTTADEILQQCDG-----KLDMLVASVGTGGTITGIARKLKEKCP CBS_RAT/77-373 PLAHYDDTAEEILQQCDG-----KVDMLVASAGTGGTITGIARKLKEKCP AAH44091/76-372 PLAHYDSTAEEILQQCQG-----QLDMLVAGAGTGGTITGLARKLKEKCP AAD13393/84-375 PLAHYDATAEEILEQCDG-----KLDMLVAGIGTGGTLTGVARKLKEKCP AAN31486/22-319 PLAHYDGTAEEILEQCDG-----KVDMVVMGVGTGGTISGIAKKLKEKCP CBS_DICDI/36-329 PLAHYDGTAEELLEQCEG-----KIDMIVCTAGTGGTITGIARKIKERLP AAF71541/14-306 P-DPLRVDRSEIYDQCGG-----KVDMVVVSAGTGGTITGAAKKQKELIP AAK16397/25-318 PKAHYEGTAQEIYDQCGG-----KVDMAVFTTGTGGTMAGVAKRLKELLP AAF50862/49-345 PLAHYDGTAAEILWQLDN-----KVDMIVVSAGTAGTISGIGRKIKEQVP NP_001035353/39-334 PLAHYDQTAIEIWKQCEG-----KIDYLVAGAGTGGTISGIGRKLKELSP AAL09565/15-312 PDAHFYTTGAEIWDQTNG-----KVTHGVAGAGTGGTITGIAKFLKSKNP EAK93698/14-309 PDAHYYGTGYEIWEQTEG-----KITHLVAGAGTGGTITGISKYLKEKNS CBS_YEAST/14-319 PEAHYFGTGREIQRQLEDLNLFDNLRAVVAGAGTGGTISGISKYLKEQND AF422799/18-317 PLAHEHGTAEEIWAQTGG-----KITAVVAGAGTGGTISGLARGLRKHSK EAA30070/20-319 PLAHEFGTAEEIWKQTNG-----KVTAVVAGAGTGGTITGIARGLRKHNK EAA78329/18-317 PNAHEFGTAQEIWEQTGG-----KITALVAGAGTGGTITGIARGLKKHNQ AAG48621/7-296 PRSHYETTGPELWEQTDG-----KITHFVAGVGTGGTISGTGNYLKEASG CAB89449/7-296 PLSHYHSTGPELWEQTEG-----KITHFVAGVGTGGTISGTGRYLKDASD ZP_00059346/7-296 PESHYYSTGPEIWEQTEG-----RITHFVAGIGTGGTITGTGRYLKEVSN AAS03341/7-296 PASHYATTGPEIWADTDG-----KVTHFVAGIGTGGTITGAGRYLKEVSG NP_215593/7-296 PASHYVTTGPEIWADTEG-----KVTHFVAGIGTGGTITGAGRYLKEVSG BAB96806/7-296 PESHYETTGPEIWADTDG-----KITHFVAGVGTGGTITGTGRYLKEVSG AAN24961/60-356 PLSHYYTTGPEIWEATDH-----KVTHFVAGIGTGGTISGTGKYLKEASN CAE81156/8-303 PQRHYQTTGPEIWKQMDG-----KVDVVVGGAGTGGTLSGVAKYLKEMNP CBS_HUMAN/80-376 G-CRIIGVDPEGSILAE-PEELNQTEQTT-YEVEGIGYDFIPTVLDRTVV CBS_RAT/77-373 G-CKIIGVDPEGSILAE-PEELNQTEQTA-YEVEGIGYDFIPTVLDRAVV AAH44091/76-372 N-CKIVGVDPDGSILAE-PEELNQTDKTG-YEVEGIGYDFIPTVLDRTVV AAD13393/84-375 ---TIVAVDPEGSLLIH-S---DDHCKSS-YEVEGIGYDFVPTVLDKSLV AAN31486/22-319 S-VIVVGVDPEGSILAL-PDSLNDKNRLQSYKVEGIGYDFIPDVLDRSLV CBS_DICDI/36-329 N-CIVVGVDPHGSILAQ-PESLNNTNKSY--KIEGIGYDFIPNVLERKLV AAF71541/14-306 E-IIVVGVDPIGSVVAD-PEHPCEP-VMYQ-EVEGIGYDFVPAVCERKYV AAK16397/25-318 N-IVIVGVDPYGSILAD-PSVPLDP-KPY--LVEGIGYDFVPDVCERKYV AAF50862/49-345 S-CQIVGVDPYGSILAR-PAELNKTDVQFY-EVEGIGYDFPPTVFDDTVV NP_001035353/39-334 N-IKIIAVDPKGSILD--PSSDSQNEVGFY-EVEGIGYDFIPTVLDRNVI AAL09565/15-312 N-IQIIGADPHGSILAL-PESLN--TSNEQYKVEGIGYDFIPEVLDREIV EAK93698/14-309 K-IHVTGADPKGSILAE-PESLN--NSTEGYLVEGIGYDFIPDVLNRKYV CBS_YEAST/14-319 K-IQIVGADPFGSILAQ-PENLNK-TDITDYKVEGIGYDFVPQVLDRKLI AF422799/18-317 T-VKVIAADPIGSILAL-PESLNDNGVNEPYKVEGIGYDFIPDVLDRELV EAA30070/20-319 D-IKVIAADPVGSILAQ-PESLNDPNATAPYKVEGIGYDFIPDVLDREFV EAA78329/18-317 D-IKVIAADPHGSILAL-PELLNQEHINEGYKVEGIGYDFIPDVLDQHIV AAG48621/7-296 GSVKIIGADPEGSV-----YSGGSG---RPYLVEGVGEDFWPTAYDRNVT CAB89449/7-296 GAVTVIGADPEGSV-----YSGGSG---RPYLVEGVGEDFWPTAYDREVA ZP_00059346/7-296 GRVKVIGADPEGSV-----YSGGTG---RPYLVEGVGEDIWPATYDTKIC AAS03341/7-296 GRVRVIGADPEGSV-----YSGGTG---RPYLVEGVGEDFWPQAYDRTVP NP_215593/7-296 GRVRIVGADPEGSV-----YSGGAG---RPYLVEGVGEDFWPAAYDPSVP BAB96806/7-296 GKVKVIGADPEGSV-----YSGGTG---RPYLVEGVGEDFWPSAYDPSIP AAN24961/60-356 GAVKVIGSDPEGSI-----YSASSRDEVHQYDIEGVGEDFYPKAFDRNIT CAE81156/8-303 N-IKAICADPIGSILYDLYYHKKIVDPPGSYKVEGVGEDMLPDNVHLNIY CBS_HUMAN/80-376 DKWFKSNDEEAFTFARMLIAQEGLLCGGSAGSTVAVAVKAAQE---LQEG CBS_RAT/77-373 DRWFKSNDDDSFAFARMLISQEGLLCGGSSGSAMAVAVKAAQE---LKEG AAH44091/76-372 DEWYKSNDEESFFMARALIREEGLLCGGSSGSAMSAAMKAAKE---LGEG AAD13393/84-375 DYFYKVNDKETFNMSRRLIRDEGLLCGGSSGSAMAAAVKVAQH---LKEG AAN31486/22-319 DQWEKTNDQESFIMSRRLIREEGLLCGGSSGSAMAAAVRAASV---LKPG CBS_DICDI/36-329 DQWIKTDDKESFIMARRLIKEEGLLCAGSSGSAMVGALLAAKQ---LKKG AAF71541/14-306 DRWVKTRDQQSFDLARELHRDEGLLVGGSSGAAMAGVLEAAKD---LRAD AAK16397/25-318 DRWVKSADKESFALASEVHREEALLVGGSSGAAMWGVLQAAKD---LRPD AAF50862/49-345 DVWTKIGDSDCFPMSRRLNAEEGLLCGGSSGGAMHAALEHARK---LKKG NP_001035353/39-334 DKWIKTEDNESLNAARMLIRQEGLLCGGSSGAALIAALKIAKD---IPEE AAL09565/15-312 DTWYKTDDKDFFKLARQLISEEGILVGGSSGSALSAAVKIINDA-KLDES EAK93698/14-309 DDWIKTDDAESFKLARRIIREEGILVGGSSGSALQAALQVAKD---LTED CBS_YEAST/14-319 DVWYKTDDKPSFKYARQLISNEGVLVGGSSGSAFTAVVKYCEDHPELTED AF422799/18-317 DKWYKTEDRESFMYARRLIAEEGLLVGGSSGSAMAAMVRAVKDL-NLGED EAA30070/20-319 DKWYKTEDRESFHLARRLIAEEGLLVGGSSGSAMAAMIRAVKDY-NLGKD EAA78329/18-317 DKWYKTDDRESFHLARRLISEEGLLVGGSSGSAMAAMLLAVKEY-GFKKG AAG48621/7-296 DRIVAVSDKDSFQMTRRLAKEEGLLVGGSCGMAVVAALEVAREL-GPDD- CAB89449/7-296 DEIVAVSDKDSFQMTRRLAKEEGLLVGGSCGMAVVAALEVAARL-GEDD- ZP_00059346/7-296 DEIIAVSDKDSFLMTRRLAKEEALLVGGSCGLAVVAALKVAAQA-GPDD- AAS03341/7-296 DEIIAVSDSDSFNMTRRLAREEAMLVGGSCGMAVVAALRVAEQA-GPDA- NP_215593/7-296 DEIIAVSDSDSFDMTRRLAREEAMLVGGSCGMAVVAALKVAEEA-GPDA- BAB96806/7-296 DEIIAVSDADSFEMTRRLAREEGLLVGGSCGMAVVAALEVAKRE-GPDA- AAN24961/60-356 DDIVRVSDAEAFEMTRRLAGEEALLVGGSSGMAVASAIKYALAN-DLDEN CAE81156/8-303 DGFERVSDPEAFTMTRRLVAEEGLLVGPSSALALVGAMKAAEKI-EKPS- CBS_HUMAN/80-376 QRCVVILPD CBS_RAT/77-373 QRCVVILPD AAH44091/76-372 QRCVVILPD AAD13393/84-375 QRCVVILAD AAN31486/22-319 QRCVVVLPD CBS_DICDI/36-329 QRCVVLLAD AAF71541/14-306 QRCVVLMAD AAK16397/25-318 QRCVVVFPD AAF50862/49-345 QRCVVILPD NP_001035353/39-334 KRMVIILPD AAL09565/15-312 AVVVVVCPD EAK93698/14-309 DTVVVVFPD CBS_YEAST/14-319 DVIVAIFPD AF422799/18-317 DVVVVVLPD EAA30070/20-319 DVVVVVLPD EAA78329/18-317 DVVVVVLPD AAG48621/7-296 -VVVVLLPD CAB89449/7-296 -VVVVLLPD ZP_00059346/7-296 -VIVVLLPD AAS03341/7-296 -LVVVLLPD NP_215593/7-296 -LIVVLLPD BAB96806/7-296 -LIVVLLPD AAN24961/60-356 QIVVVLAPD CAE81156/8-303 -NIVVVFPD