CLUSTAL W(1.5) multiple sequence alignment 1PWEA/4-290 QESLHVKTPLRDSMALS-KVAGTSVFLKMDSSQPSGSFKIRGIGHLCKMK NP_663540/4-290 QESLHVKTPLRDSMALS-KLAGTSVFLKMDSSQPSGSFKIRGIGHLCKMK SDHL_HUMAN/4-290 GEPLHVKTPIRDSMALS-KMAGTSVYLKMDSAQPSGSFKIRGIGHFCKRW NP_001091171/4-290 NKCLHLNTPLRDSVPLS-KMAGMTVYLKLDNAQPTGSFKIRGIGHLCKTW CAF91636/4-284 QQSLHVATPLRQSLPLT-KEAGTSVYLKLDSSQPTGSFKIRGIGHLCKTW AAH60346/6-292 QAPFHIVTPLKESRALS-KLAGTEVLMKLENVQPAGSFKIRGIGHYCQKL XP_692090/4-288 QNGFHVVTPLLESTGMS-KLVGSTVYLKMESSQPAGSFKIRGIGYMCQNV NP_001092465/11-296 GEPFHIVTPLLESWALS-QVAGMPVFLKYENVQPAGSFKIRGIGHFCQEV SDSL_HUMAN/11-296 QEPFHVVTPLLESWALS-QVAGMPVFLKCENVQPSGSFKIRGIGHFCQEM XP_001378476/10-295 -EHLHMVTPLLESWTLS-QVAGTTVYLKLENIQPTGSFKIRGIGHFCQEV XP_415319/10-294 --PFHIVSPLLESLPLS-RAAGTQVYMKLENVQPTGSFKIRGVGHLCQEA XP_798802/5-292 GPELHIKTPLLESIPMT-KVAGCPVYIKCDNMQPTASFKIRGIGNRCKKA AAU05774/13-301 KEKLYMETPVMYSFPLS-KHAGFKVYLKLDNLQPSGSFKIRGISNMIQKG ALX72404/15-320 LQSLHVATPLLHAPNLT-KELECNVFLKMENIQPSGSVKMRGIGAFCYQA CEG69314/14-299 LQTLHVPTPLMHSTKLS-VKLDCNIYFKMENIQPSGSVKMRGIGNFCYKA ORZ27577/8-296 -QPLHNPTPLLHSTVLS-RKTQTNIWLKLENLQPSGSFKIRGLGHMCQKA CAP92996/11-336 ---PWIETPLIESATLS-KAAGCRIFLKLESLQPSGSFKSRGIGNLILTS XP_001212195/9-324 ---PWIETPIIESATLS-RAAGCRVFLKLELLQPSGSFKSRGIGNFIRTA XP_775525/12-305 NTVPWIKTPLVRSAALS-KLAGCEILLKLENIQPSGSFKSRGIGNLVLQS EAA55293/11-311 ----WVETPCLYSPQVS-RAAGCNIYLKLDNLQPSGSFKSRGIGNMMQRA XP_387338/11-302 ----WIKTPCIISTQLS-RLTGCNVYLKLENLQPSGSFKTRSISSLMTQA EAK97061/1-297 MKEPSITTTFVEVTDKLPTKPPCRVFFKNEYEQPSGSFKLRGMGHLVGQS EAL00695/13-315 LSQPYIQTSLTEVTNILPTKPPCRIFFKNELEQPSGSFKLRGIGHLVHKS SDHL_YEAST/2-304 EMTHYEKTPLIRQVFNN-GKTNSWFYVKHEILQPGGSFKSRGIGHLIRKS STDH_YEAST/1-302 MSIVYNKTPLLRQFFP--GKASAQFFLKYECLQPSGSFKSRGIGNLIMKS XP_503774/1-292 MRPGYIETPLLKNDIFS-HQVGCNVYLKMENLQPSGSFKSRGMTQVISDA 1PWEA/4-290 AKQG-------CKHFVCSSAGNAGMATAYAARRLGLPATIVVPSTTPALT NP_663540/4-290 AKQG-------CRHFVCSSAGNAGMATAYAARRLGIPATIVVPNTTPALT SDHL_HUMAN/4-290 AKQG-------CAHFVCSSAGNAGMAAAYAARQLGVPATIVVPGTTPALT NP_001091171/4-290 AERG-------CKHFVCSSGGNAGLAAAYSARMLSIPATILVPNTTPAFT CAF91636/4-284 AERG-------CERLVCCSGGNAGMAAAYSARQLGVPATIVVPSVTPVMT AAH60346/6-292 AKKG-------CTRFVCSSGGNAGLAAAYACRGLNLPATIVVPQSTGADI XP_692090/4-288 RKN--------SRGVICSSGGNAGMATAYAARKLNLPATIVLPLSTPELV NP_001092465/11-296 AKKG-------CRHLVCSSGGNAGIAAAYAARKLRIPATIVLPEGTSVKV SDSL_HUMAN/11-296 AKKG-------CRHLVCSSGGNAGIAAAYAARKLGIPATIVLPESTSLQV XP_001378476/10-295 AKKG-------CKHLVCSSGGNAGVAAAYAARKLGIPATIVLPKGANPNL XP_415319/10-294 ARKG-------CQRFVCSSGGNAGMAAAYAARKLGLPATVVVPTSTSPST XP_798802/5-292 LEAG-------YTRIISSSGGNAGYAAAYAARQLGMPATVVIPESTSKFM AAU05774/13-301 IDRGD------SEHVYCASGGNAGMAAAHASKQLGIPCTIVVPQTTPEFV ALX72404/15-320 VQTRGT-----NIQFVCGSGPNTVLAVSYCARQLGVEAIIVVPKATNERI CEG69314/14-299 VETRGT-----DIQLVCGSGVNTVLAVAYCARQLKIKATIVVPKATHSSI ORZ27577/8-296 ALKHGS-----KTRLVSSSGGNAGLAVAYAARQLGIQATIIVPQTCNAFM CAP92996/11-336 LSDPSN--NGRTLHFFSSSAGNAGMAAVIAARDLGCPCTVVVPLSVKPTM XP_001212195/9-324 LLNPTN--NGKNLHFYISSGGNAGLAAVIAANDLGCPCTVVVPHSTKPLM XP_775525/12-305 VNSAPP--D-TPLHFYSSSGGNAGLACVNAASTLGYPSSVIVPLSTKPFM EAA55293/11-311 IALTPR--D--DVHFYCPSGGNAGLACATSAASLGKPATIVVPIKTPAHM XP_387338/11-302 AAAATG-----PVHFYCSSGGNAGLACATSAISLGHKATIVMPTIVSPLM EAK97061/1-297 IDVARK-LGKSNVAVFSSSGGNAGLAAAYASQFFGVSCTVVLPESSKPTV EAL00695/13-315 IENALKNHSNKTIHVFASSGGNAGLAAAYSAQFYKVKCTVVLPIISKPVV SDHL_YEAST/2-304 NQQPLS-EGSGKLAVFSSSGGNAGLAAATACRSMALNCSVVVPKTTKPRM STDH_YEAST/1-302 AIRIQK-DGKRSPQVFASSGGNAGFAAATACQRLSLPCTVVVPTATKKRM XP_503774/1-292 LDSDPQ-ASLDTLHVCSSSGGNAGLAAAVTSRLNGVACTVVVPESTKPRM 1PWEA/4-290 IERLKNEG-ATVEVVGEMLDEAIQLAKALEKNNPG--------WVYISPF NP_663540/4-290 IERLKNEG-ATVEVVGEMLDEAIQVAKALEKNNPG--------WVYISPF SDHL_HUMAN/4-290 IERLKNEG-ATCKVVGELLDEAFELAKALAKNNPG--------WVYIPPF NP_001091171/4-290 IQRMKDEG-ATVCVVGEMLDETIEHGKELVRNNPG--------WVYIPPF CAF91636/4-284 VERLRDEG-AT------ALNESIEYGKQLVANNPG--------WIFISPF AAH60346/6-292 VQKLQDLG-ADVVIIGKVWDDADAHAHQLTETP-G--------SVYISPF XP_692090/4-288 AQKLKDQG-ATVKAVGKVWDDANAEALRLAESE-G--------LTVIHPF NP_001092465/11-296 VKRLQGEG-AEVQLTGKIWEEANLRAQELAKND-G--------WVNLPPF SDSL_HUMAN/11-296 VQRLQGEG-AEVQLTGKVWDEANLRAQELAKRD-G--------WENVPPF XP_001378476/10-295 LRRLERER-AEVQMVGKVWDDANLKAQELVKTY-G--------WVEVHPF XP_415319/10-294 VHRLEELG-ATVEIYGKVWDEANQRALVLAQNK-G--------WASIHPF XP_798802/5-292 ADKIRGLG-ADVIVHGKVWDYANEHALQLAKEDSS--------AVVIHPF AAU05774/13-301 NERLRNLG-AEVKVHGSVYDEAKKLAVELGSQP-R--------CMLIPAF ALX72404/15-320 CQSIRTDG-SHLILYGENWTAAEVHARKLVRRN----------GIYVPSS CEG69314/14-299 CDSVKLEG-AQLILFGDSWSAADSHARRLVKRN----------CVYVPSS ORZ27577/8-296 IKKIKEEG-AHVEMHGEAWDEADLRAKSVVADDPH--------AVYIPPF CAP92996/11-336 IEKIRAAGASDVIRHGASWFEADAYLRENFIENEDSKLDPLVRNIYVPPF XP_001212195/9-324 INKLHAAGATEVIQHGASWVEADSHLRETFIDHQEGKQT----NIYIPPF XP_775525/12-305 IDKLRTAGATEVIQTGQTWFEADKHLQEEILARDP-------NGIYVPPF EAA55293/11-311 VEKLEALG-AEVLRRGGSIAEADAYLKSQLLINDPN-------GVYVSPF XP_387338/11-302 KSKLLDLG-VEVHQKGKNWAECDKYMREELVANDPS-------AIYVAPF EAK97061/1-297 IEKLKSLG-ADVIIHGKHWGEADNYLTD-FVIKNLD---KTVYPVYCHPF EAL00695/13-315 QEKLKSYG-ARIVLFGNTINEADQHLKN-LMSSIDL---DSIYPVYCHPF SDHL_YEAST/2-304 VKKIQSAG-AKVIIHGDHWGEADEYLRHKLMAQESQ---HGSKTLYVHPF STDH_YEAST/1-302 VDKIRNTG-AQVIVSGAYWKEADTFLKTNVMNKIDS---QVIEPIYVHPF XP_503774/1-292 VEKLRAAG-AEVIVHGKHWSEANDFLQKEEMPRLEK---TGKTPIYCHPF 1PWEA/4-290 DDPLIWEGHTSLVKELKETLSA-----------KPGAIVLSVGGGGLLCG NP_663540/4-290 DDPLIWEGHTSLVKELKETLSA-----------KPGAIVLSVGGGGLLCG SDHL_HUMAN/4-290 DDPLIWEGHASIVKELKETLWE-----------KPGAIALSVGGGGLLCG NP_001091171/4-290 DDPLIWEGHTSLVKEIKASLPS-----------KPGAIALSVGGGGMLCG CAF91636/4-284 DDPLIWEGHTSLVKELEQELRE-----------TPGAIALSVGGGGLLNG AAH60346/6-292 NHPLVWEGHSSLVCELKASLGSQ----------KPGALVVSVGGGGLLAG XP_692090/4-288 NQPLVWKGHSSIVHELKASLPS-----------RPGLIVLSVGGGGLFCG NP_001092465/11-296 DHPLIWEGHVSLVRELKAALGT-----------PPGALVLAVGGGGLLAG SDSL_HUMAN/11-296 DHPLIWKGHASLVQELKAVLRT-----------PPGALVLAVGGGGLLAG XP_001378476/10-295 DHPLIWEGHGSMIHELKDTLGT-----------QPGAIILSVGGGGLLAG XP_415319/10-294 DHPLMWQGHASLVLELKDALDT-----------KPDAIVLAVGGGGLLAG XP_798802/5-292 DHPDIWEGHESIIVEIQDQLHGK----------KPDVVVTCVGGGGLLCG AAU05774/13-301 EHPDIWEGHASLINESSRQMSE-----------RPDLVITCVGGGGLLNG ALX72404/15-320 DHALIWQGHSTIVQELKTQLNDN----------PPAAIICPVGGGGLLNG CEG69314/14-299 DHEDIWQGHSSIIYELKAQLQDN----------IPAAIICPVGGGGLLNG ORZ27577/8-296 DHPDVWQGNSTMITELKAQLGGI----------VPDAIVCSVGGGGMMNG CAP92996/11-336 DHHDIWRGAGTLIDEIVKQLPRHNGEPDTDRSFPADAIVCSVGGGGLLNG XP_001212195/9-324 DHPDVWAGAATMVSEIAAQVPPRD---SSGCAFPADAIVCSVGGGGLFNG XP_775525/12-305 DHSDIWQGAATMVDEIVQELTHVP-----------DAIVCSVGGGGLMIG EAA55293/11-311 DHPDIWEGASSIVDEITTQMRLQP-----GGPKEADGIVCNVGGGGLLIG XP_387338/11-302 DDPRLWDGAATMVDEIRDQLEDR-----------VDGIVCSVGGGSLVNG EAK97061/1-297 DDPLLWEGHSKIITEIIDQKQLPNF-------DKVKGVICSVGGGGLYNG EAL00695/13-315 NNPLIWNGHSSLVDEVSQQLDSKDR-------KLLKGMVCSFGGGGLYNG SDHL_YEAST/2-304 DNETIWEGHSTIVDEIIEQLKENDIS-----LPRVKALVCSVGGGGLFSG STDH_YEAST/1-302 DNPDIWEGHSSMIDEIVQDLKSQHIS-----VNKVKGIVCSVGGGGLYNG XP_503774/1-292 DAPAVWKGNSTLIDEIIKQGITPDA------------VVCSVGGGGLFNG 1PWEA/4-290 VVQGLRE----------VG--WEDVPIIAMETFGAHSFHAAVKEGKLVTL NP_663540/4-290 VVQGLRE----------VG--WEDVPIIAMETFGAHSFHAAIKEGKLVTL SDHL_HUMAN/4-290 VVQGLQE----------CG--WGDVPVIAMETFGAHSFHAATTAGKLVSL NP_001091171/4-290 VVQGLRE----------EG--WDDVPIIAMETKGAHSLNAALQAGKLVTL CAF91636/4-284 VVEGLRR----------AG--WGDVPIVAMETLGAHSLNAAMEAGELVTL AAH60346/6-292 LAEGLKK----------VG--WSDIPIIAMETKGAHCLNAALEAGKPISL XP_692090/4-288 VIEGLDE----------VG--WGDVPVLCMETKGADCFNVALKAKNLVTL NP_001092465/11-296 VSAGLAE----------VG--WQHVPIIAMETQGAHCFNAAIKAGKLVTL SDSL_HUMAN/11-296 VVAGLLE----------VG--WQHVPIIAMETHGAHCFNAAITAGKLVTL XP_001378476/10-295 VVAGMKE----------VG--WQDVPIIAMETRGADCFNQAIRAGKLVTL XP_415319/10-294 VVAGLQQ----------VG--WLDVPIIAAETWGAHSFHAALKAGHLITL XP_798802/5-292 VVQGLQT----------VG--WGDVPVVAMETFGAESFNAAVKAGKLVTL AAU05774/13-301 IVQGMRD----------VG--WDEVPVLAMETHGANCFNAAIAAGEAVFI ALX72404/15-320 VIMGLQE----------AD--WKDVPVIAVETHGSNAFQASVVAGELVIM CEG69314/14-299 VITGLQE----------VD--WKEVPVIAVETHGSNSFQASVVAGKLVTL ORZ27577/8-296 IILGCQS----------VG--WDKVPLLTVETHGSNSFQQSVLAGELVTL CAP92996/11-336 IIDGLERHLPAYQPRTLPNKEAKKVRVLAAETAGADSLAHSVRKSYLHTL XP_001212195/9-324 IVQGLDEYLRSHEAADKTG----NVQVLAVETQGADSLAHSLRAGRLDSL XP_775525/12-305 VCKGLER-------LDKEK----KAKVVAVETLGAESLHKSVKAGQLITL EAA55293/11-311 IMDGLD--------RIYCGRPQNQPRVLAVETRGAESLDASIRAGELVTL XP_387338/11-302 LMQGIES-------RPWLG---TKPAVLAVETEGADSLNASVLAGEHVTL EAK97061/1-297 IVEG-LENHK-------------EIPVLAIETKQAATFHEAVKEGKVVHL EAL00695/13-315 IYQGMVKNQI-------------RGDILLIETLQAPTLTQSLEADEVITL SDHL_YEAST/2-304 IIKGLDRNHLAE-----------KIPVVAVETAGCDVLNKSLKKGSPVTL STDH_YEAST/1-302 IIQGLERYGLAD-----------RIPIVGVETNGCHVFNTSLKIGQPVQF XP_503774/1-292 VVEGLKRHKLN-------------CPVIVVETNGADALSRSLQKGEQVTL 1PWEA/4-290 PKITSVAKALGVNTVGAQTLKLFYEH----PIFSEVISDQEAVTAIEKFV NP_663540/4-290 PKITSVAKALGVNTVGAQTLKLFYEH----PIFSEVISDQEAVSALEKFV SDHL_HUMAN/4-290 PKITSVAKALGVKTVGSQALKLFQEH----PIFSEVISDQEAVAAIEKFV NP_001091171/4-290 PEITSVAKTLGAKTVGAQTLKVAQEH----SVFSEVISDQEAVMAIEKFA CAF91636/4-284 PEITSVATTLGLARVSAQTLKLVKEH----AVFSEVVTDQEAVKAVERFV AAH60346/6-292 PDITSVAKCLGAKTVCDRAFECTREH----NVISITVDDREAIRAVEMFL XP_692090/4-288 PDITSQAVCLGAKTACQQAFEYGKRP----TVISEVVTDLQALEAVELFL NP_001092465/11-296 PGITSLAKSLGARTVAARALECTKEF----RIFSEVVEDAEAVSAVQRFL SDSL_HUMAN/11-296 PDITSVAKSLGAKTVAARALECMQVC----KIHSEVVEDTEAVSAVQQLL XP_001378476/10-295 PDITSLAKCLGAKTAAARALECIHEC----QIISVVVDDEDAIQAIERFL XP_415319/10-294 PDITSVAKCLGAKTVSARALQCAQEI----QVISEVVEDAEAVRAVESFL XP_798802/5-292 PDITSVAKSLGSLRVAERCLTLSREH----SILSGVVTDQKAVDACLHLL AAU05774/13-301 PAITSIAKSLGSLIVSPQTLEYYKQARP--RILNEMVSDNQVIDACVRFS ALX72404/15-320 EKNNTIATSLISKAVSSKSLELSLNH----PVVPFAVSDAMAADAVRLFA CEG69314/14-299 PKITTIASSLASETVCAKSLELSLIH----PVVPFAVSDPMAADSVRQFA ORZ27577/8-296 PKITSIATTLGAKTPSAKSLELSLVH----PVVPFAVSDAMAASACWQFL CAP92996/11-336 PAITSQAITLGALCVARQTLKNAQSPPPGVEVTSIVGTDADAAKGVVRLC XP_001212195/9-324 PAITSLATSLGARCVSAQTFKYAQSSPAGINVVSVVGSDAEAARGVVTLA XP_775525/12-305 PGITSLATSLGATTVAAKALEYALQP----QVRSTVVSDKEALEACIRFL EAA55293/11-311 PNITSICSSLGVARVAPRAYEWTKAAAG--QLATTVVDDADAVMGSVKFL XP_387338/11-302 PEMTSIATSLGATRVSEQTWKWSQHPSG--MMKSLVVSDADAAISTVRFA EAK97061/1-297 QKVQTLATSLASPYLSSKALANYIER----PTVLAEIDDLDAVKGVVDVY EAL00695/13-315 KSVNSLATSLACSYTTEQSLKYYKDQSL-VKSQVELIDDIDSLRACVAFE SDHL_YEAST/2-304 EKLTSVATSLASPYIASFAFESFNKYG----CKSVVLSDQDVLATCLRYA STDH_YEAST/1-302 KKITSIATSLGTAVISNQTFEYARKYN----TRSVVIEDKDVIEPCLKYT XP_503774/1-292 PGITSIATSLGAVRVADKTFENAQTYP----TVSAVVSDDDAVSALVEYA 1PWEA/4-290 --------------------DDEKILVEPACGAALAAVYS-GVVCRLQAE NP_663540/4-290 --------------------DDEKILVEPACGAALAAVYS-RVVCRLQDE SDHL_HUMAN/4-290 --------------------DDEKILVEPAWGAALAAVYS-HVIQKLQLE NP_001091171/4-290 --------------------DDEKMLVEPACGAALAAVYS-NVAERLKKE CAF91636/4-284 --------------------DDEKILVEPACGAALAAVYS-GVLKKLQCE AAH60346/6-292 --------------------DDELIFVEPACGAALAAVYS-GHIQRLQQE XP_692090/4-288 --------------------DEERVLVELACGASLAAVYS-GVVNRLQDE NP_001092465/11-296 --------------------DDERTLVEPACGAALAAIYS-GLLGKLQAE SDSL_HUMAN/11-296 --------------------DDERMLVEPACGAALAAIYS-GLLRRLQAE XP_001378476/10-295 --------------------DDERMLVEPACGAALAALYS-GCVGQLQAE XP_415319/10-294 --------------------DDERMLVQPACGAALALLYS-GRLQQLQRD XP_798802/5-292 --------------------DDHRILVEPACGAAVSAVYS-DVLGELRAE AAU05774/13-301 --------------------DDHRFLVEPACGASLAAVYS-NVVKQLQDS ALX72404/15-320 GACVFAACLVVPIMCLSLYLEDFKMLVEASAGAALSLCYT-HLIRDILPS CEG69314/14-299 --------------------EDYKTLVEPACGAALSLCYT-EIVRDILPS ORZ27577/8-296 --------------------DDHRFAVEPSCGTALSIAYTPALLSNIFPN CAP92996/11-336 --------------------DELRLEVELACGISVQVGL-DRLREVMPEL XP_001212195/9-324 --------------------DEQRLQVELACGINVDVVTGEKFKQAVPDL XP_775525/12-305 --------------------DDERILVEPACGATLAMVYSGKLKDVL-KL EAA55293/11-311 --------------------DDARLLVEVACGATISVVYNGQLRQKLGKG XP_387338/11-302 --------------------DDALQLVEVACGAALAIAYRGDLRDVLGKG EAK97061/1-297 --------------------DHFGYMVEPACGASVASVMH---RQDLLNK EAL00695/13-315 --------------------KCFGKVVEPACGAAMAVVYN---KIDLLYK SDHL_YEAST/2-304 --------------------DDYNFIVEPACGASLHLCYH---PEILEDI STDH_YEAST/1-302 --------------------HQFNMVIEPACGAALHLGYN---TKILENA XP_503774/1-292 --------------------ETKQIIVEPACGASLAVLPA---LKDLVDL 1PWEA/4-290 AR NP_663540/4-290 GR SDHL_HUMAN/4-290 GN NP_001091171/4-290 GK CAF91636/4-284 GK AAH60346/6-292 GI XP_692090/4-288 GR NP_001092465/11-296 GH SDSL_HUMAN/11-296 GC XP_001378476/10-295 GR XP_415319/10-294 GH XP_798802/5-292 GK AAU05774/13-301 GK ALX72404/15-320 -- CEG69314/14-299 -- ORZ27577/8-296 -- CAP92996/11-336 TP XP_001212195/9-324 TP XP_775525/12-305 DA EAA55293/11-311 LS XP_387338/11-302 LS EAK97061/1-297 -F EAL00695/13-315 NF SDHL_YEAST/2-304 LE STDH_YEAST/1-302 LG XP_503774/1-292 --