CLUSTAL W (1.83) multiple sequence alignment AAR83718 ------------------------------------------------------------ HEM1_BRAJA ------------------------------------------------------------ AF3452 ------------------------------------------------------------ AAD20808 -----------MKAALSCPFLTKIPMNCVRQYAPQVLSYV--DRCPFMSHAVRYASSQQS CAA74915 ---------------MQCPFLNRFTASFIRNYAETLC----------------------- AD20807 --------MHAIMKAMKCPFLTRIPMNHVRQYAPQLLQVA--DQCPIMGHVMKHSTLADQ HEM0_BRARE ----------MSAFLHHCPFLKSSPGPSAR-KVATYLNLA--DRCPIIVRQ--------- HEM0_OPSTA ----------MAAFLHHCPFLKSMPKPALRRRVPALLSLA--DRCPVIVHQ--------- HEM0_MOUSE -------MVAAAMLLRSCPVLSQGPTGLLGKVAKTYQFLFSIGRCPILATQG-------- HEM0_RAT -------MVAAAMLLRSCPVLSKGPTGLLGKVAKTYQFLFGIGRCPILATQG-------- HEM0_HUMAN -------MVTAAMLLQCCPVLARGPTSLLGKVVKTHQFLFGIGRCPILATQG-------- HEM1_HUMAN ----------MESVVRRCPFLSRVPQAFLQKAGKSLLFYA--QNCPKMMEVGAKPAP--- HEM1_RAT ----------METVVRRCPFLSRVPQAFLQKAGKSLLFYA--QNCPKMMEVGAKPAP--- HEM1_CHICK ----------MEAVVRRCPFLARVSQAFLQKAGPSLLFYA--QHCPKMMEAAPPAAA--- HEM1_OPSTA ----------MDVIVRRCPFLARVPQAFFQQSKKSLAVYA--QRCPFMMELASKPMAPSL HEM0_CHICK ----------MAAFLR-CPLLARHP--------PLARAFATGARCPFMGFAH-------- AAO62615 ------------------------------------------------------------ AAX98209 ------------------------------------------------------------ KDN87766 ------------------------------------------------------------ SKA31381 ------------------------------------------------------------ HEM0_RHOSH ------------------------------------------------------------ AAD38391 ------MESLLQQSRAMCPFLKRTSPSSLRTLATATRPSTSSGGGTMSNLQV-------- HEM1_EMENI ------MEALLQQSRAMCPFLKRSSPNTLRSLATATRPSTSPGGGTMTNLQR-------- HEM1_KLULA ------MESVIRSSAKICPFMHSATGSMQSVKALKN-----------ANLPA-------- HEM1_YEAST ---------MQRS---IFARFGNSSAAVSTLNRLST-----------TAAP--------- HEM1_CANAL ------MESITKVSMSVCPFVRSTSTQALRQLSQTS-----------GALAN-------- HEM1_AGABI --MSHHGPRLSTRSQQIVAGYASVAANFDVEKLHREQG---------VNIPT-------- ABD39319 ------------------------------------------------------------ HEM1_RHIME ------------------------------------------------------------ AFU07636 ------------------------------------------------------------ HEM1_PARDE ------------------------------------------------------------ HEM1_RHOCA ------------------------------------------------------------ HEM1_RHOSH ------------------------------------------------------------ CEM21130 -MPGRFLSFATSEIQRLCPFVGRMGDKIKGDWNVFAQMCPVASKIDQPIVIH-------- D87417 ------------------------------------------------------------ ZP_00303686 ------------------------------------------------------------ SGX80493 MRQKKTLKVSIHEIKKYCPFVKNIQLFYSANESKSKDKQNKNNVVLSVMANLCPVGKAIN XP_001350846 MRKKRTLKVSINEIKKYCPFVKNIQFLYNTNE-------KKNNLVLSVMSDLCPVGKAIN . AAR83718 ------------------------------------------------------------ HEM1_BRAJA ------------------------------------------------------------ AF3452 ------------------------------------------------------------ AAD20808 QSKNNLAEAASEDSPASNCPFLAKEKPLAVHEVSPLIKQ--------DMINAFSQAPQEL CAA74915 ------------QSYGSHCPVVGK------------------------------------ AD20807 G----TPESTEKVANVNKCPYISHAKEAG------------------------------- HEM0_BRARE ------ISAKAAQSSEQNGLLPHKEPKRQ---------------------LATTATQVAV HEM0_OPSTA ------VCISRLHILETKLDVSPTQPKRQRLSLLDQKRL-----------FAQTATQVAV HEM0_MOUSE ------PTCSQIHLKATKAGGDSPS-------------------------WAKSHCPFML HEM0_RAT ------PTCSQIHLKATKAGADSPS-------------------------WTKSHCPFML HEM0_HUMAN ------PNCSQIHLKATKAGGDSPS-------------------------WAKGHCPFML HEM1_HUMAN -RALSTAAVHYQQIKETPPASEKDKTAKAKVQQTPDGSQ--QSPDGTQLPSGHPLPATSQ HEM1_RAT -RTVSTSAAQCQQVKETPPANEKEKTAKAAVQQAPDESQMAQTPDGTQLPPGHPSPSTSQ HEM1_CHICK -RGLATSASRGQQVEETPAAQPEAKKAKEVAQQN---------TDGSQPPAGHPPAAAVQ HEM1_OPSTA ARALCSSSSSQQKIEDTMSTGEVLKP-----------------KAEAKLPVGLATPPSNE HEM0_CHICK ------------------------------------------------------------ AAO62615 ------------------------------------------------------------ AAX98209 ------------------------------------------------------------ KDN87766 ------------------------------------------------------------ SKA31381 ------------------------------------------------------------ HEM0_RHOSH ------------------------------------------------------------ AAD38391 ----------------------------------------------------IARRCPVM HEM1_EMENI ----------------------------------------------------IARRCPVM HEM1_KLULA ----------------------------------------------------IAQQCPFM HEM1_YEAST ------------------------------------------------------------ HEM1_CANAL ----------------------------------------------------QARQCPIA HEM1_AGABI ----------------------------------------------------SGASINQC ABD39319 ------------------------------------------------------------ HEM1_RHIME ------------------------------------------------------------ AFU07636 ------------------------------------------------------------ HEM1_PARDE ------------------------------------------------------------ HEM1_RHOCA ------------------------------------------------------------ HEM1_RHOSH ------------------------------------------------------------ CEM21130 ----------------------------------------------------EAAEKANR D87417 ------------------------------------------------------------ ZP_00303686 ------------------------------------------------------------ SGX80493 EKRLIIIDNKS-----------------------------------------KINILKIL XP_001350846 EKHFIIIDNKS-----------------------------------------KINIIKIL . . AAR83718 ------------------------------------------------------------ HEM1_BRAJA ------------------------------------------------------------ AF3452 ------------------------------------------------------------ AAD20808 PATDMKQKISTSVPSSKTVETMATDLDLTTTEQLTDQSVVSATAAANAAATASSPSSSHA CAA74915 ----------TLVSGEKKLSLVAASVTRSHSTGANAHANAGGPATANATAPVSAPASADP AD20807 -PAVHNEVINLTTAAKVSLQASAAAASAPGTTLAMETNLQEAEVSPNMVEEARKTYGRNA HEM0_BRARE SMSQSCPFVSSKIG------LVKASPQVQEDVQ---PNLENQDTSGLISSLFSGLQSH-- HEM0_OPSTA SVSKGCPFVSSQIG------MVRASPEVQEDVQ---ADLKS-----------PVLPTP-- HEM0_MOUSE SELQDR---KSKI-------VQRAAPEVQEDVKTFKTDLLSTMDSTTRSHSFPSFQEP-- HEM0_RAT SELQDR---KSKI-------VQRAAPEVQEDVKTFKTDLLSFMESTTRSQSVPRFQDP-- HEM0_HUMAN SELQDG---KSKI-------VQKAAPEVQEDVKAFKTDLPSSLVSVSLRKPFSGPQEQ-- HEM1_HUMAN GTASKCPFLAAQMNQRGSSVFCKASLELQEDVQEMNAVR--KEVAETSAGPSVVSVKTDG HEM1_RAT SSGSKCPFLAAQLARRAAASSARPVWSFRRTWQEMHAVR--TEVAQSPVLPSLVNAKRDG HEM1_CHICK SSATKCPFLAAQMNHKSSNVFCKASLELQEDVKEMQVDRKGKEFAKIPTNSVVRNTEAEG HEM1_OPSTA AVAPKCPFLAAEMGQNNSNVVRQVGVEFQEDVEEIRTVQ--KEVSPAQLEQPSLIGKTMG HEM0_CHICK ----------------------RAAPELQEDVE------------RPQIPAVEVLEEL-- AAO62615 ------------------------------------------------------------ AAX98209 ------------------------------------------------------------ KDN87766 ------------------------------------------------------------ SKA31381 ------------------------------------------------------------ HEM0_RHOSH ------------------------------------------------------------ AAD38391 SKALAVQSARMAGTKRFTSCAAGITGLGN---KHCRAPTGKRTLHSTSGNGANVSAEIYK HEM1_EMENI SKALAVQSARMTGTKRFTSSAAGVPGAGAGTPKPTRGSPGKRALHSTGGNGANMSTEFHK HEM1_KLULA GKAMEQRRGYASSASGASAAAAATATASTSA----------------------------- HEM1_YEAST ----HAKNGYATATG--AGAAAATATAS-------------------------------- HEM1_CANAL GNAIRAKEISIRSYSSATKPVRATAATPS------------------------------- HEM1_AGABI PHAAAARAAARMADDLASAARAKKSLDAKG------------------------------ ABD39319 ------------------------------------------------------------ HEM1_RHIME ------------------------------------------------------------ AFU07636 ------------------------------------------------------------ HEM1_PARDE ------------------------------------------------------------ HEM1_RHOCA ------------------------------------------------------------ HEM1_RHOSH ------------------------------------------------------------ CEM21130 AQPQGGGGCPYHHAHANGTTLNGASPAHTSAD---------------------------- D87417 ------------------------------------------------------------ ZP_00303686 ------------------------------------------------------------ SGX80493 RKSNIISRQLVDSLGGRTDTGESIPTGEYNPTGASIPTGEYNTRGASIPRGDAHPCGECL XP_001350846 KQANMQSKVLVQCIKNKNIEKENMSNDDLLKSGK---------------RNNNVLFYDIL AAR83718 ------------------------------------MDYTKFFADALDRLHAERRYRVFA HEM1_BRAJA ------------------------------------MDYSQFFNSALDRLHTERRYRVFA AF3452 ------------------------------------MDYRRFFEEAIDQLHAEKRYRVFA AAD20808 --------------VRANKIGGSANGWGSSQGSSTFFDYEKFFEKEIEKKKEDHSYRVFK CAA74915 --------------GKAS--------------AKETFPYERFFNEQIMKKKRDHSYRVFK AD20807 --------------SPLKDFKG--DHSQGKPDSDEVFDYESFYEKKIQEKKDDNSYRIFK HEM0_BRARE ---------------QSTG--PTHLLQDNFNR--PTFSYDEFFTQKIVEKKKDHTYRIFK HEM0_OPSTA ---------------PQTG--ITQLLKDNMVG--PSFDYDNFFNEKIAEKKRDHTYRVFK HEM0_MOUSE ---------------EQTEGAVPHLIQNNMTGS-QAFGYDQFFRDKIMEKKQDHTYRVFK HEM0_RAT ---------------EQTGGAPPLLIQNNMTGS-QAFGYDQFFRDKIMEKKQDHTYRVFK HEM0_HUMAN ---------------EQISGKVTHLIQNNMPGN-YVFSYDQFFRDKIMEKKQDHTYRVFK HEM1_HUMAN GDPSGLLKNFQDIMQKQRPERVSHLLQDNLPKSVSTFQYDRFFEKKIDEKKNDHTYRVFK HEM1_RAT EGPSPLLKNFQDIMRKQRPERVSHLLQDNLPKVVSTFQYDHFFEKKIDEKKNDHTYRVFK HEM1_CHICK EEQSGLLKKFKDIMLKQRPESVSHLLQDNLPKSVSTFQYDQFFEKKIDEKKKDHTYRVFK HEM1_OPSTA EE--GHQKNLMKSLLKQRPKRVSHLLQDNLPGSFTRFYYDNFFEKKIEEKKSDHTYRVFK HEM0_CHICK --------------LRDGGAALNRTVRDCMDED--AFPYEEQFQAQLGALRRTHTYRVVT AAO62615 -----------------------------------MNKHLDFFAR--EMEEFGARRREFL AAX98209 -----------------------------------MNLHLESYSTGVTAKELAERRREFL KDN87766 -----------------------------------MNQYLELFALHMKEGGSPKAEREFL SKA31381 -----------------------------------MFGYVDFFSEEIAKLKRQGGYRTFL HEM0_RHOSH ------------------------------------MEFSQHFQKLIDDMRLDGRYRTFA AAD38391 NTQRDPAGFSKIKTPANATAAAATSGPRPEAPVAKPFNYNSFYNTELEKKHKDKSYRYFN HEM1_EMENI GAQQIHPGLSN-ATRSHVGASATVSGPTPRAPVAAPFDYDAFYNAELQKKHQDKSYRYFN HEM1_KLULA ------------SNSNSSVEASASADVVDHATKEASFDYQGLFDSDLAKKRMDKSYRFFN HEM1_YEAST ----------------STHAAAAAAAAANHSTQESGFDYEGLIDSELQKKRLDKSYRYFN HEM1_CANAL ----------------TPEATFNVSSSFELGSKETAFDYNGYLGNELEKKRSDKSYRYFN HEM1_AGABI --------------SLAGRPVHHKAATESTKAKHTGFDYEAFYKGELAKKHQDKSYRYFN ABD39319 ------------------------------------MDFEAFFTTELQSLHSEGRYRVFA HEM1_RHIME ------------------------------------MDFESFFKNELDGLHQEGRYRVFA AFU07636 ------------------------------------MNYEAYFRRQLDGLHREGRYRVFA HEM1_PARDE ------------------------------------MDYSAALDQAIGKLHEEGRYRTFI HEM1_RHOCA ------------------------------------MDYNLALDKAIQKLHDEGRYRTFI HEM1_RHOSH ------------------------------------MDYNLALDTALNRLHTEGRYRTFI CEM21130 --------------AMAANGTAPAQASSSDSSSGNQFFYHQAIQESIQKLHQEGRYRVFA D87417 ------------------------------------MDYKAAFRSAVEQIREEGRYRVFA ZP_00303686 ------------------------------------MNYDQVFDSAIERLHSEGRYRVFI SGX80493 CKSWTPTQTHTNTLSVVENKPSGSLTWSSEAYRLFQTECQNDLKELLNKLFLDRRYRVFT XP_001350846 EKNKNDHSFQINDNTIQKNNIIYKYINSLDEYKLFKNNCNNNLKDLLNKLYTDKRYRIFT * . AAR83718 DLERVAGRFPHATWHSPSG----------------------------------------- HEM1_BRAJA DLERMAGRFPHAIWHSPKG----------------------------------------- AF3452 DLERIVGRFPQAIWRNNGT----------------------------------------- AAD20808 KVLRKGNK--FPWAEEYSNIN--------------------------------------- CAA74915 KVNRLAGDGLFPHALEYSERT--------------------------------------- AD20807 KVARLGPS--FPRAVEHTGE---------------------------------------- HEM0_BRARE TVNRFAEVFPFAEDYSIAGRL--------------------------------------- HEM0_OPSTA TVNRNAVVFPFAEDYSVSDRQ--------------------------------------- HEM0_MOUSE TVNRWANAYPFAQHFSEASMA--------------------------------------- HEM0_RAT TVNRWANAYPFAQHFSEASMD--------------------------------------- HEM0_HUMAN TVNRWADAYPFAQHFSEASVA--------------------------------------- HEM1_HUMAN TVNRRAHIFPMADDYSDSLIT--------------------------------------- HEM1_RAT TVNRRAQIFPMADDYTDSLIT--------------------------------------- HEM1_CHICK TVNRKAQIFPMADDYSDSLIT--------------------------------------- HEM1_OPSTA TVNRLANEFPMADDFTGSLED--------------------------------------- HEM0_CHICK AVGRRADAPPLG---TRGTAP--------------------------------------- AAO62615 EIGRRAGRFPSAVARQGQDGT--------------------------------------- AAX98209 EIGRRSGHFPSASARQ--DGV--------------------------------------- KDN87766 EIGRLAGKFPAARSLR--DGD--------------------------------------- SKA31381 EIERQAGRFPSARTSD--LGR--------------------------------------- HEM0_RHOSH ELERIAGEFPTALWHG-PDGQ--------------------------------------- AAD38391 NINRLAQEFPRAHTTSAEE----------------------------------------- HEM1_EMENI NINRLAQEFPRAHTASKDE----------------------------------------- HEM1_KLULA NINRLAKEFPMAHRKLEDD----------------------------------------- HEM1_YEAST NINRLAKEFPLAHRQREAD----------------------------------------- HEM1_CANAL NINRLANEFPKAHRTQEED----------------------------------------- HEM1_AGABI NINRLARKFPVAHTANPRD----------------------------------------- ABD39319 DIERRQGNFPRATRYNANGE---------------------------------------- HEM1_RHIME DLARHRGSFPKATRYTADG----------------------------------------- AFU07636 DLERHAGSFPRATHHRPEG----------------------------------------- HEM1_PARDE DIERRKGAYPTAVWTRPDGTE--------------------------------------- HEM1_RHOCA DIEREKGAFPKAQWNRPDGGK--------------------------------------- HEM1_RHOSH DIERRKGAFPKAMWRKPDGSE--------------------------------------- CEM21130 TLQRNCGRFPHAAFFK-DGKR--------------------------------------- D87417 DLKRQRGQFPRATWTRQDGSE--------------------------------------- ZP_00303686 DILRNKGAYPNARCFAGHNGP--------------------------------------- SGX80493 ILNKCRKYYPNVSIENDKLFLPIFFKFFQNFGYKQCVGSSACRIGVDYDAVANGFRSATP XP_001350846 ILNKYRINYPNVYIENNKLMLPSFYEFYQKYGYKPCIGNIRYQLSASFEDNNKNICSFSH : : AAR83718 ---------------------ERDVVIWCSNDYLGMGQHPKVVGAMVETATRLGTGAGGT HEM1_BRAJA ---------------------KRDVVIWCSNDYLGMGQHPKVVGAMVETATRVGTGAGGT AF3452 ---------------------AREITVWCSNDYLGMGHHPDVIKAMCDTAGSAGSGAGGT AAD20808 ---------------------KKDITVWCSNDYVGMSWHPLVTNSVQEALHKYGAGAGGT CAA74915 ---------------------EKPITVWCSNDYLGMSAHPGVKRAVQDALNRHGSGAGGT AD20807 ---------------------KKNITVWCSNDYLGMSWNPKVQEAVVEALYSHGAGAGGT HEM0_BRARE ---------------------GSQVSVWCSNDYLGMSRHPRVVKAIGDALKKHGAGAGGT HEM0_OPSTA ---------------------GSQVSVWCSNDYLGMSRHPRVLEAIREVLERHGAGAGGT HEM0_MOUSE ---------------------SKDVSVWCSNDYLGISRHPRVLQAIEETLKNHGAGAGGT HEM0_RAT ---------------------SKDVSVWCSNDYLGISRHPRVLQAIEETLKNHGAGAGGT HEM0_HUMAN ---------------------SKDVSVWCSNDYLGMSRHPQVLQATQETLQRHGAGAGGT HEM1_HUMAN ---------------------KKQVSVWCSNDYLGMSRHPRVCGAVMDTLKQHGAGAGGT HEM1_RAT ---------------------NNQVSVWSSNDYLGMSRHPRVCGAVIETVKQHGAGAGGT HEM1_CHICK ---------------------KKEVSVWCSNDYLGMSRHPRVCGAVMDTLKQHGAGAGGT HEM1_OPSTA ---------------------KREVSVWCSNDYLGMSRHPRVAQAIMETLRKHGSGAGGT HEM0_CHICK ---------------------HTSVELWCSSDYLGLSRHPAVLRAARAALDAHGLGAGGT AAO62615 ---------------------DVEISVWCSNDYLGMGQNPFVLEAVKNAVDAFGAGSGGS AAX98209 ---------------------DSQISVWCSNDYLGMGQNPQVIEAMKKTIDTHGVGSGGS KDN87766 ---------------------AAEISVWCSNDYLGMGQHPLVLAATREALDEYGAGAGGS SKA31381 ---------------------ERHISVWCSNDYLGMGQHPAVLTAMKQAIDEAGAGSGGS HEM0_RHOSH ---------------------ARRVTVWCSNDYLGMGQNAEVLAAMHRSIDLSGAGTGGT AAD38391 -----------------------RVTVWCSNDYLGMGRNPEVLATMHKTLDTYGAGAGGT HEM1_EMENI -----------------------KVTVWCSNDYLGMGRNPEVLATMHKTLDTYGAGAGGT HEM1_KLULA -----------------------KVTVWCSNDYLALSKNQEVIEVMKKTLDKYGAGAGGT HEM1_YEAST -----------------------KVTVWCSNDYLALSKHPEVLDAMHKTIDKYGCGAGGT HEM1_CANAL -----------------------KVTVWCSNDYLGMGKNENTLKEMKRVLDKYGSGAGGT HEM1_AGABI -----------------------EVEVWCSNDYLGMGNNPVVLETMHRTLDKYGHGAGGT ABD39319 ---------------------RKDVTVWCSNDYLGMGQNPKVIEAMKAAIDHCGAGAGGT HEM1_RHIME ---------------------AQEVTVWCSNDYLGMGQCPIVTEAMKNAIDECGAGAGGT AFU07636 ---------------------AGDVTVWCSNDYLGMGQHPAVLTAMHEALDSCGAGAGGT HEM1_PARDE ---------------------T-RITVWCGNDYLGMGQHPVVLAAMHEALDATGAGSGGT HEM1_RHOCA ---------------------Q-DITVWCGNDYLGMGQHPVVLAAMHEALEAVGAGSGGT HEM1_RHOSH ---------------------K-EITVWCGNDYLGMGQHPVVLGAMHEALDSTGAGSGGT CEM21130 ---------------------D-EVKIWCSNDYLGMGQHKKVLEASHAALDAAGTGAGGT D87417 ---------------------H-EVVVWCSNDYLGQGQNPVVLEAMKAAVDEHGSGSGGT ZP_00303686 ---------------------K-PITVWCSNDYLAMGQHPKVIAAMEEALHNVGAGSGGT SGX80493 RKETTHGWKSSNVLSSVIRTTNDKTVVWCSNDYLCLSNNQQVIDVGIETLKKIGNSSGGT XP_001350846 KNKENYLFNFWNLH--IDNVSNEKTVVWCSNDYLCLSNNEKIIEVGIETLKKIGNSSGGT :*...**: . * .:**: AAR83718 RNIAGTHHPLVMLERELADLHGKEAALLFTSGYVSNQTGISTLAKLIPNCLILSDALNHN HEM1_BRAJA RNIAGTHHPLVQLEAELADLHGKEAALLFTSGYVSNQTGIATIAKLIPNCLILSDELNHN AF3452 RNISGNNHPLVELESELADLHGKEAGLVFTSGFVSNEASISTIARLLPNCLILSDELNHA AAD20808 RNISGNSPLHESLEKELASLHQKEAALLFTSCYVANDTTLCTLGKHLPGVQIFSDAGNHA CAA74915 RNISGNSLHHERLESKLAELHQKEAALLFTSCFVANDSTLFTLAKLLPGCEIFSDAGNHA AD20807 RNISGNSPYHEALEKEIADLHQKEGALLFTSCYVANDSTLATLAKMLPGCQVFSDSGNHA HEM0_BRARE RNISGTSNYHVALENELARLHQKDGALVFSSCFVANDSTLFTLAKMLPGCEIYSDMGNHA HEM0_OPSTA RNISGTSKYHVTLEKELAHLHQKDAALVFSSCFVANDSTLFTLAKMLPGCHIYSDAGNHA HEM0_MOUSE RNISGTSKFHVELEQELAELHQKDSALLFSSCFVANDSTLFTLAKLLPGCEIYSDAGNHA HEM0_RAT RNISGTSKFHVELEQELAELHHKDSALLFSSCFVANDSTLFTLAKLLPGCEIYSDAGNHA HEM0_HUMAN RNISGTSKFHVELEQELAELHQKDSALLFSSCFVANDSTLFTLAKILPGCEIYSDAGNHA HEM1_HUMAN RNISGTSKFHVDLERELADLHGKDAALLFSSCFVANDSTLFTLAKMMPGCEIYSDSGNHA HEM1_RAT RNISGTSKFHVELEQELADLHGKDAALLFSSCFVANDSTLFTLAKMMPGCEIYSDSGNHA HEM1_CHICK RNISGTSKFHVDLEKELADLHGKDAALLFSSCFVANDSTLFTLAKMLPGCEIYSDSGNHA HEM1_OPSTA RNISGTSKFHVELEQELADLHRKDAALLFTSCFVANDSTLFTLAKMLPGCEIYSDAGNHA HEM0_CHICK RNIGGTSPLHGALERALALLHRQPRAALFSSCFAANDTALDTLARILPGCQVYSDAGNHA AAO62615 RNIGGTNHYHVLLENELAALHGKEEALIFPSGFTANDGALTVLAGRAPGTLVFSDELNHA AAX98209 RNIGGTNHYHVLLEAELADLHGKEAALLFTSGYTANDGSLSVLAGTPKDTIVFSDEKNHA KDN87766 RNIGGTNHYHVLLERELADLHGKEDALLFTSGYTANDGALTVLAGRPKDCVVFSDEMNHA SKA31381 RNISGNNRYHVELERELADLHGMESALVFPSGYAANDAALTVLAGRLPKCVVFSDELNHA HEM0_RHOSH RNISGTNRQHVALEAELADLHGKESALIFTSGWISNLAALGTLGKILPECAIFSDALNHN AAD38391 RNISGHNQHAVSLENTLAKLHGKEAALVFSSCFVANDATLATLGSKLPDCVILSDSLNHA HEM1_EMENI RNISGHNQHAVSLENTLAKLHGKEAALVFSSCFVANDATLATLGSKMPDCVILSDSLNHA HEM1_KLULA RNIAGHNKHALQLEAELATLHKKEGALVFSSCFVANDAVISLLGQKIKDLVIFSDELNHA HEM1_YEAST RNIAGHNIPTLNLEAELATLHKKEGALVFSSCYVANDAVLSLLGQKMKDLVIFSDELNHA HEM1_CANAL RNIAGHNSHAIKLESELAALHKHDAALVFSSCFVANDAVLSLLGQKIKDLVIFSDELNHA HEM1_AGABI RNIAGNGAMHLGLERELR-LHRKEAALVFSSCYVANDATLSTLGTKLPGCVIFSDTMNHA ABD39319 RNISGTNHHHVLLEQELADLHGKESALIFTSGYVSNWATLGTLGQKIPGLIIFSDALNHA HEM1_RHIME RNISGTNHYHVLLERELADLHGKESALLFTSGYVSNWAALGTLCSKIPGVIVFSDAGNHA AFU07636 RNIAGTNHYHVLLEQELAALHGKESALLFTSGYVSNWASLSTLASRMPGCVILSDELNHA HEM1_PARDE RNISGTTVYHKRLEAELADLHGKEAALVFSSVYIANDATLSTLRKLFPGLIIYSDELNHA HEM1_RHOCA RNISGTTAYHRRLEAEIADLHGKEAALVFSSAYIANDATLSTLRLLFPGLIIYSDSLNHA HEM1_RHOSH RNISGTTLYHKRLEAELADLHGKEAALVFSSAYIANDATLSTLPQLIPGLVIVSDKLNHA CEM21130 RNISGTMSYHVDLEKELADWHHKESALLFTSGYVANEAALSTLGQLFPGLIIFSDEKNHA D87417 RNISGTNHDHVLLEQELADLHGKEAGLLFTSGYVSNEATLSVVQKILPGLIIFSDELNHA ZP_00303686 RNIGGNTHYHIELEHELADLHGKDGALLFTSGYVSNDATLSTLAKILPGCVIFSDELNHA SGX80493 RNISGSLLNHSHLEYILAKWFNKESALLFTSGYIANVGALETLGKLLN-LVFVSDQMNHA XP_001350846 RNISGSLLNHTHLEYIIAKWYNKESSLLFTSGYIANVGALETLGKLLN-LIYISDEMNHA ***.* ** : . . :*.* : :* : : ** ** AAR83718 SMIEGIRQSGCERIVWRHNDTAHLEELLR-----AVEPGRPVLIAFESLYSMDGDVAPMA HEM1_BRAJA SMIEGIRQSGCERQVFRHNDLADLEALLK-----AAGANRPKLIACESLYSMDGDVAPLA AF3452 SMIEGVRRSGAEKKIFRHNDVEHLEQLLK-----AADRSRAKLIVFESVYSMDGDIAPIE AAD20808 SMIQGIRNSRAPKHIFNHNDPLHLEELLR-----KADPNIPKIVALETVHSMTGAVCPLE CAA74915 SMIMGIRNSGVPKHIFRHNDVDHLHQLLK-----QTDKSVPKIVAFETVHSMTGAICPLE AD20807 SMIQGIIRSGMPKHVFRHNDPEHLEELIS-----KVDVSIPKIVAFETVHSMTGAICPLQ HEM0_BRARE SMIQGIRNSGAKRFIFRHNDASHLEELLS-----RSDPLTPKIVAFETVHSMDGAICPLE HEM0_OPSTA SMIQGIRNSGAKRFIFRHNDSRHLEELLQ-----QSDPKTPKIVAFETVHSMDGAICPLE HEM0_MOUSE SMIQGIRNSGAAKFVFRHNDPGHLKKLLE-----KSDPKTPKIVAFETVHSMDGAICPLE HEM0_RAT SMIQGIRNSGAVKFVFRHNDPGHLKKLLE-----KSDPKTPKIVAFETVHSMDGAICPLE HEM0_HUMAN SMIQGIRNSGAAKFVFRHNDPDHLKKLLE-----KSNPKIPKIVAFETVHSMDGAICPLE HEM1_HUMAN SMIQGIRNSRVPKYIFRHNDVSHLRELLQ-----RSDPSVPKIVAFETVHSMDGAVCPLE HEM1_RAT SMIQGIRNSRVPKYIFRHNDVNHLRELLQ-----RSDPSVPKIVAFETVHSMDGAVCPLE HEM1_CHICK SMIQGIRNSRVPKHIFRHNDVNHLRELLK-----KSDPSTPKIVAFETVHSMDGAVCPLE HEM1_OPSTA SMIQGIRNSGAKKFIFRHNDVAHLRELLE-----KGDPTKPKIVAFETVHSMDGAVCPLE HEM0_CHICK SMIQGIRRRGVPKFIFRHNDPHHLEQLLG-----RSPPGVPKIVAFESLHSMDGSIAPLE AAO62615 SIIDGLRHSGAEKRIFRHNDMAHLEELLA-----AADPERPKLIVLESVYSMSGDIAPLA AAX98209 SIIDGLRHSGAQKHIFRHNDVAHLAELLA-----AAPADRPKLIVLESVYSMSGDIAPLA KDN87766 SIIDGLRHSGAQKHIFRHNDTAHLEELLS-----AADPDRPKMIVAESVYSMAGDVAPLA SKA31381 SMIAGIRHSKAEKHVFRHNDVDHLEELLA-----GTDPALPKLIALESIYSMESDVAPLA HEM0_RHOSH SMIEGIRRSGAERFIFHHNDPVHLDRLLS-----SVDPARPKIVAFESVYSMDGDIAPIA AAD38391 SMIQGIRHSGAKKMVFKHNDLVDLEAKLA-----ALPLHVPKIIAFESVYSMCGSIAPIE HEM1_EMENI SMIQGIRHSGRKKMVFKHNDLVDLETKLA-----SLPLHVPKIIAFESVYSMCGSIAPIE HEM1_KLULA SMIVGIKHASTKKHIFKHNNLDQLEELLA-----MYPKSTPKLIAFESVYSMSGSVADID HEM1_YEAST SMIVGIKHANVKKHIFKHNDLNELEQLLQ-----SYPKSVPKLIAFESVYSMAGSVADIE HEM1_CANAL SMIQGIRNSRARKHIFKHNNLADLESKLA-----QYPKSTPKLIAFESVYSMCGSIAPIE HEM1_AGABI SMIQGMRHSTPKRVIFKHNDLEDLETKLQ-----QYPKETPKIIAFESVYSMCGSIGPVK ABD39319 SMIEGIRYGRCERVIWKHNDLEDLEAKLK-----AADPNAPKLIAFESVYSMDGDIAPIK HEM1_RHIME SMIEGIRHSKCERVIFKHNSVADLEAKLA-----AADPRAPKIIAFESVYSMDGDIAPIR AFU07636 SMIEGIRHSRSETRIFAHNDPRDLERKLA-----DLDPHAPKLVAFESVYSMDGDIAPIA HEM1_PARDE SMIEGIKRSTAPKRIFRHNDVGHLRELLA-----ADDPEAPKLIAFESIYSMDGDFAPIK HEM1_RHOCA SMIEGIKRNAGPKRIFRHNDVAHLRELIA-----ADDPAAPKLIAFESVYSMDGDFGPIK HEM1_RHOSH SMIEGIRRSGTEKHIFKHNDLDDLRRILT-----SIGKDRPILVAFESVYSMDGDFGRIE CEM21130 SMIAGIRGSKCDKKIFKHNDMAHLEELLK-----AADPAKPKLVAFESVYSMDGSISPIT D87417 SMIAGIRNGGGPRKIFKHNDLAHLEQLLA-----EAPADAPKLIAFESVYSMDGDIADLA ZP_00303686 SMIAGIRNSGAEKRVFRHNDVEHLEQLLA-----ETDPALPKLIAFESVYSMDGDIAPIH SGX80493 SIINGIRESRCEKIIFKHNDMVDLEKVLKSLRTDKEYQNRKIMIVFESIYSMSGNISNIP XP_001350846 SIINGIRESRCEKFIFKHNDMNDLERILYNLRINKQYENRKIMIVFESIYSMSGHISNIE *:* *: :: **. .* : ::. *:::** . . : AAR83718 KICDLAEKYGAMTYCDEVHAVGMYGARGAGVAERD----------------------GVM HEM1_BRAJA KICDLAEKYNAMTYVDEVHAVGMYGPRGGGIAERD----------------------GVM AF3452 KIADLADKYNAMTYIDEVHAVGMYGAHGGGITERD----------------------GLA AAD20808 ELCDVAHKYGALTFVDEVHAVGLXGENGAGIGERD----------------------KVL CAA74915 ELLDVAHEHGAITFIDEVHAVGLYGDHGAGVGERD----------------------GVL AD20807 EMCDIAHKYGAITFIDEVHAVGLYGKHGAGIGERD----------------------NLL HEM0_BRARE ELCDVAHKYGALTFVDEVHAVGLYGAHGAGVGERD----------------------NVM HEM0_OPSTA ELCDVAHRHGALTFVDEVHAVGLYGAHGAGVGERD----------------------NVM HEM0_MOUSE ELCDVAHQYGALTFVDEVHAVGLYGARGAGIGERD----------------------GIM HEM0_RAT ELCDVAHQYGALTFVDEVHAVGLYGTRGAGIGERD----------------------GIM HEM0_HUMAN ELCDVSHQYGALTFVDEVHAVGLYGSRGAGIGERD----------------------GIM HEM1_HUMAN ELCDVAHEFGAITFVDEVHAVGLYGARGGGIGDRD----------------------GVM HEM1_RAT ELCDVAHEFGAITFVDEVHAVGLYGASGGGIGDRD----------------------GVM HEM1_CHICK ELCDVAHEHGAITFVDEVHAVGLYGARGGGIGDRD----------------------GVM HEM1_OPSTA EMCDLAHEFGAITFVDEVHAVGLYGPRGGGIGDRD----------------------GIM HEM0_CHICK ELCDVAHAYGALTFVDEVHAVGLYGARGAGIAERD----------------------GVQ AAO62615 ETAALARRHGATTFIDEVHAVGMYGPQGAGIAARE----------------------GIA AAX98209 EIAELARRYDATTYIDEVHAVGMYGPQGAGIAARE----------------------GIA KDN87766 EIARIAREYGAMTFLDEVHAVGMYGPEGAGIAAGL----------------------GIA SKA31381 RVAELAERYGAFTYLDEVHAVGMYGPRGAGKAAEQ----------------------GLA HEM0_RHOSH EICDVAERHGALTYLDEVHAVGLYGPRGGGISDRD----------------------GLA AAD38391 KICDLADKYGAITFLDEVHAVGMYGPHGAGVAEHLDYDIYASQDTVNPRSTKG----TVM HEM1_EMENI AICDLADKYGAITFLDEVHAVGMYGPHGAGVAEHLDYEIYASQDTANPLSTKG----TVM HEM1_KLULA KICDLAEKYGALTFLDEVHAVGLYGPHGAGVAEHCNFDRHRKAGIASPEFR------TVM HEM1_YEAST KICDLADKYGALTFLDEVHAVGLYGPHGAGVAEHCDFESHRASGIATPKTNDKGGAKTVM HEM1_CANAL AICDLAEKYGALTFLDEVHAVGMYGPHGAGVAEHLNFEAHLKSGIERPEIT------TVM HEM1_AGABI EICDLAEQYGAITFLDEVHAVGLYGPRGAGVAEHLDYDAHLAAGS-SPDPIPG----SVM ABD39319 EICDLADRYGAMTYLDEVHAVGMYGPRGGGIAERE----------------------GLM HEM1_RHIME EFCDLADKYGAMTYLDEVHAVGMYGPRGGGIAERE----------------------GLM AFU07636 EICDVADAHNAMTYLDEVHGVGLYGPNGGGIADRE----------------------GIS HEM1_PARDE EICDLADEFNALTYLDEVHAVGMYGPRGGGVAERD----------------------GLS HEM1_RHOCA EICDIADEFGALTYIDEVHAVGMYGPRGAGVAERD----------------------GLM HEM1_RHOSH EICDIADEFGALKYIDEVHAVGMYGPRGGGVAERD----------------------GLM CEM21130 EIADLAKKYNALTYIDEVHAVGMYGPRGAGVTEQV----------------------GEL D87417 GTVALAKKYGAMTYLDEVHAVGMYGPRGGGVAERD----------------------GLM ZP_00303686 AICDLAEKYNALTYIDEVHAVGMYGPRGGGITDRD----------------------EAA SGX80493 RIVQLAKKYNALTYVDEVHAVGLYGKTGSGYSEEL----------------------HLC XP_001350846 YIVQLAKKYNALTYVDEVHAVGLYGNKGSGYLEEL----------------------HLC :: ..* .: ****.**: * *.* AAR83718 HRIDIIEATLAKAFGCLGGYISGKKDVIDAVRSYAPGFIFTTALPPPICAAATAAIRHLK HEM1_BRAJA HRIDILEGTLAKAFGCLGGYIAANGRIIDAVRSYAPGFIFTTALPPAICSAATAAIKHLK AF3452 HRIDIIEGTLAKAFGALGGYITGSRAIIDAVRSYAPGFIFTTSLPPAVAAAATAAIRHLK AAD20808 HKMDMITGTLGKAFGNMGGYMASTTLTIDMIRSYASGFIFTTSLPPTTLAGATTAIRVMK CAA74915 HKMDIISGTLGKAFGNIGGYIAGTHNLVDMIRSYAAGFIFTTSLPPTVLCGALEAVNILA AD20807 HEMDIISGTLGKAFGNIGGYIAGSAALVDMLRSYASGFIFTTSLPPTVLYGARRSIQVLK HEM0_BRARE HKIDIVSGTLGKAFGCVGGYIASTAALVDTVRSFAAGFIFTTSLPPMVLAGALESVRVLK HEM0_OPSTA HKIDIVSGTLGKAFGCVGGYVASSAALVDTVRSFAAGFIFTTSLPPMILAGALESVRVLK HEM0_MOUSE HKLDIISGTLGKAFGCVGGYIASTRDLVDMVRSYAAGFIFTTSLPPMVLSGALESVRLLK HEM0_RAT HKLDIISGTLGKAFGCVGGYIASTRDLVDMVRSYAAGFIFTTSLPPMVLSGALESVRLLK HEM0_HUMAN HKIDIISGTLGKAFGCVGGYIASTRDLVDMVRSYAAGFIFTTSLPPMVLSGALESVRLLK HEM1_HUMAN PKMDIISGTLGKAFGCVGGYIASTSSLIDTVRSYAAGFIFTTSLPPMLLAGALESVRILK HEM1_RAT PKMDIISGTLGKAFGCVGGYIASTSLLIDTVRSYAAGFIFTTSLPPMLLAGALESVRILK HEM1_CHICK HKMDIISGTLGKAFACVGGYISSTSALIDTVRSYAAGFIFTTSLPPMLLAGALESVRTLK HEM1_OPSTA HKMDIISGTLGKAFGCVGGYIASTATLVDTVRSYAAGFIFTTSLPPMLLAGAKQSIQILK HEM0_CHICK HKVDVVSGTLGKALGAVGGYIAGSEALVDAVRSLGPGFIFTTALPPQRGGGALAALQVVG AAO62615 DEFTVVMGTLAKGFGTAGGYIAGPAALIDAVRNFSRGFIFTTSIPPATAAGALAAVQHLR AAX98209 DQFTVVMGTLAKGYGTVGGYIAGPAALVDAVRTLSRAFVFTTSLPPAVAAGALEAVRYLR KDN87766 DEFTVIMGTLAKGFGTTGGYIAGPAELVDAVRGLSRSFIFTTALPPAVVAGALAAVRHLR SKA31381 GRFDVIQGTLAKAFGTAGGYIAGPDSVIDAVRSFASAFIFTTSLPPAVAAGALAAVRHLK HEM0_RHOSH DRVTIIEGTLAKAFGVMGGYVSGPSLLMDVIRSMSDSFIFTTSICPHLAAGALAAVRHVK AAD38391 DRIDIITGTLGKAYGCVGGYIAGSAAMVDTIRSLAPGFIFTTSLPPATMAGADTAIQYQA HEM1_EMENI DRINIITGTLGKAYGCVGGYIAGSAALVDTIRSLAPGFIFTTSLPPATMAGADTAIRYQA HEM1_KLULA DRVDMITGTLGKSFGTVGGYVAGSLQLIDWVRSYAPGFIFTTTLPPAVMAGAAEAIRYQR HEM1_YEAST DRVDMITGTLGKSFGSVGGYVAASRKLIDWFRSFAPGFIFTTTLPPSVMAGATAAIRYQR HEM1_CANAL SRVDMVTGTLGKAYGVVGGYITGKTNLIDWFRSYAPGFIFTTSLPPAIMAGCSASIRYQR HEM1_AGABI DRIDIITGTLGKSYGAVGGYIAGSEEFVDMIRSYAPGFIFTTSLPPATVAGARASIVYQS ABD39319 DRLTIIEGTLGKAFGVMGGYIAGSTAVCDFIRSFASGFIFTTALPPSLAAGAIASIQHLK HEM1_RHIME HRLTVIEGTLGKAFGVMGGYITGSAALCDFIRSFASGFIFTTALPPALAAGALASIRHLK AFU07636 HRLTIIEGTLAKAFGVVGGYIAGSSAVCDFVRSFASGFIFSTSPPPAVAAGALASIRHLR HEM1_PARDE HRIDIFNGTLAKAFGVFGGYIGFGARMVDAIRSYAPGFIFTTSLPPAVAAGVAASIAFLK HEM1_RHOCA HRIDIFNGTLAKAYGVFGGYIAASAKMVDAVRSYAPGFIFSTSLPPAIAAGAQASIAFLK HEM1_RHOSH DRIDIINGTLGKAYGVFGGYIAASSKMCDAVRSYAPGFIFSTSLPPVVAAGAAASVRHLK CEM21130 DRIDIINGTLGKAVGVFGGYIAGSRTMLDAIRSYAAGFIFTTALPPVVCAGATASIRHLK D87417 GEIDIIEGTLGKAFGVMGGYITGDAEVIDAIRLMASGFIFTTSLPPALTAGALASVRWLK ZP_00303686 HRIDIIEGTLGKAFGVMGGYIAADTRIIDVIRSYAPGFIFTTSLSPVLVAGVLASVRHLK SGX80493 DHIDIINGTLSKAIGSLGGFICANKYYIDVIRSYSPHFIFTTSLTPVNINTSAEAIHIIQ XP_001350846 NHIDIINGTLSKAIGSLGGFICANKYYIDVIRSYSSHFIFTTSLTPVNINTSAEAIHIIQ .. :. .**.*. . **:: * .* . *:*:*: * :: AAR83718 TSTWE--RERHQDRAARLKAVLNTAGLPVMPTDTHIVPVFVGDAERCKKASDLLLEKHGI HEM1_BRAJA TSSWE--RERHQDRAARVKAILNAAGLPVMSSDTHIVPLFIGDAEKCKQASDLLLEEHGI AF3452 SSQAE--RDGQQRQAQRAKDVLSAAGLPVMPSQTHIVPILVGDPELCKKASDRLLEVHGI AAD20808 SDEGKQLRRKHQSNVKYLRDCLLTVGIPAVLCPSHIIPIHVGDPKLSTSICNDLLIKHNI CAA74915 SEEGRQLRHLHQRNVSYLKSLLKREGFPVEETPSHIIPIKIGDPLKSSQISNVLIEQFGH AD20807 GDEGR-IAPRHQANVKYLRDHLTDAGLPVIHAPSHIIPIHVGEPKLCRKLADELMEEHGI HEM0_BRARE SDEGQALRRAHQRNVKHMRQLLLDAGLPVVNCPSHIIPIRVGNAAKNSEVCDILLEKHNI HEM0_OPSTA SPEGQLLRRAHQRNVKYMRQLLMDKGLPVVNCPSHIIPIRVGNAELNTKVCDSLLEKHNI HEM0_MOUSE GEEGQALRRAHQRNVKHMRQLLMDRGFPVIPCPSHIIPIRVGNAALNSKICDLLLSKHSI HEM0_RAT GEEGQALRRAHQRNVKHMRQLLMDRGFPVIPCPSHIIPIRVGNAALNSKICDLLLAKHSI HEM0_HUMAN GEEGQALRRAHQRNVKHMRQLLMDRGLPVIPCPSHIIPIRVGNAALNSKLCDLLLSKHGI HEM1_HUMAN SAEGRVLRRQHQRNVKLMRQMLMDAGLPVVHCPSHIIPVRVADAAKNTEVCDELMSRHNI HEM1_RAT SNEGRALRRQHQRNVKLMRQMLMDAGLPVIHCPSHIIPVRVADAAKNTEICDELMTRHNI HEM1_CHICK SAEGQVLRRQHQRNVKLMRQMLMDAGLPVVHCPSHIIPIRVADAAKNTEICDKLMSQHSI HEM1_OPSTA GEEGCTLRRKHQRNVKLLRQMLMDSGLPVVHCPSHIIPIRVSDAEKNTKVCDLMMSHHNI HEM0_CHICK SAEGAALRRAHQRHAKHLRVLLRDRGLPAL--PSHIVPVR-WDAEANTRLSRALLEEHGL AAO62615 ASEGE--RTRLAANAGLLHRLLKERDIPFVSDQSHIVSVFVGDDGLCRQASALLLERHGI AAX98209 NSDVE--RKVLAENAQLLHRLLDEADIPFISPDSHIVSAFIGDDETCKQASRLLFERHGI KDN87766 GSEEE--RDRLHANARLTHRLLTEHGIPFVSDGSHIVSIFVGDDALAQRISALLLDRHGI SKA31381 RSDHE--RRSLQERAALLQGLLRERAIPVVSEAAHIIPVLVGDSLKCRQVAAELLDRHGF HEM0_RHOSH AHPDE--RRRQAENAVRLKVLLQKAGLPVLDTPSHILPVMVGEAHLCRSISEALLARHAI AAD38391 RHQGD--RVLQQLHTRAVKAAFKELDIPVIPNPSHIIPLLVGDAEVAKKASDKLLEEHGI HEM1_EMENI RHQQD--RILQQLHTRAVKQSFKDLDIPVIPNPSHIVPLLVGDAELAKQASDKLLEEHGI HEM1_KLULA SHLDL--RQDQQRHTTYVKDGLADLGIPVMPNPSHIVPVLVGNPHLAKQASDILMDKHRI HEM1_YEAST CHIDL--RTSQQKHTMYVKKAFHELGIPVIPNPSHIVPVLIGNADLAKQASDILINKHQI HEM1_CANAL ATLKD--RIAQQKNTRLVKNNLNELGIPVIPNPSHIVPVLVGNAADAKRASDLLLNKHDI HEM1_AGABI EYLGD--RQLKQINVREVKRRLAELDIPVVPGSSHIVPVLVGDAALARAASDKLLSEHDI ABD39319 ASPFE--RARHQDRVRKLRGLLDARGIPHMDNPSHIVPVMVGDAAKCKWISDILLDNHGV HEM1_RHIME ESQVE--RFAHQERVRRLRSLLDQRGIPHMVNPSHIVPVIVGDAAKCKWISDLLLDNFGI AFU07636 ASSAE--RERHQDRVARLRARLDQAGVAHMPNPSHIVPVMVGDAALCKQISDELISRYGI HEM1_PARDE TAEGQFVRDQQQLNGRLLKMRLRGAGMPVMDHGSHIVPVHVGNPVHCKALSDMLLADFSI HEM1_RHOCA TAEGQKLRDAQQMHAKVLKMRLKALGMPIIDHGSHIVPVVIGDPVHTKAVSDMLLSDYGV HEM1_RHOSH GD--VELREKHQTQARILKMRLKGLGLPIIDHGSHIVPVHVGDPVHCKMISDMLLEHFGI CEM21130 QS--TVERELQHLKAAQLKHLLRSRKIPVMDNPSHIVPVFVGDPVKCKEASDRLLKEHSL D87417 QH--PEVREIHQERAATLKAMFKAAGLPVMDSVSHIVPVLVGDPVHCKMISDMLLADFGV ZP_00303686 AS--SAERDGQQAAAAYLKKAFADAGLPVMPSTTHIVPLMVGDPVKAKKISDILLAEYGV SGX80493 SDLTL--RNKFRQVVQKTKESLERRGIHIMKNNSHIVVALINCAEKCKQICDDLLAEHNI XP_001350846 NDMSL--RKKLTQVVNKTKQKLQERGIQVLHNNSHIVVLMINSAEKCKQICDDLLKEYNI : : . :**: . :: . AAR83718 YIQPINYPTVAKGKE-RLRITPSPYHDDDLMDRLAEALVDVWETLELPLGA--KPLAAE- HEM1_BRAJA YIQPINYPTVAKGSE-RLRITPSPYHDDGLIDQLAEALLQVWDRLGLPLKQ--KSLAAE- AF3452 YIQPINYPTVPRGTE-RLRITPSPLHDDKLIDGLKDALLEVWNELGIPFAEPSAPQAANS AAD20808 YVQAINYPTVARGEE-KLRVAATPHHTKEMMDHFVDCVVKVWLEHGLTLNP--------- CAA74915 YLQSINYPTVARGQE-KLRLAPTPFHTFEMMNALVTDLKKVWEMVDLSTNVPLSPNACMF AD20807 YVQPINYPTVPRGQE-LLRVAPTPHHTKEMMDSFVNATLSVFLNNNIELKSTCGINCLYC HEM0_BRARE YVQAINYPTVPRGEE-LLRLAPSPFHNPIMMNYFAEKLLDVWQEVGLPLNGPAQASCTFC HEM0_OPSTA YVQAINYPTVPRGQE-LLRLAPSPHHHPAMMEYFVDKLVEVWQEAGLLLNGPATVSCTFC HEM0_MOUSE YVQAINYPTVPRGEE-LLRLAPSPHHSPQMMENFVEKLLLAWTEVGLPLQDVSVAACNFC HEM0_RAT YVQAINYPTVPRGEE-LLRLAPSPHHSPQMMENFVEKLLLAWTEVGLPLQDVSVAACNFC HEM0_HUMAN YVQAINYPTVPRGEE-LLRLAPSPHHSPQMMEDFVEKLLLAWTAVGLPLQDVSVAACNFC HEM1_HUMAN YVQAINYPTVPRGEE-LLRIAPTPHHTPQMMNYFLENLLVTWKQVGLELKPHSSAECNFC HEM1_RAT YVQAINYPTVPRGEE-LLRIAPTPHHTPQMMNYFLEKLLLTWKRVGLELKPHSSAECNFC HEM1_CHICK YVQAINYPTVPRGEE-LLRIAPTPHHTPQMMSYFLEKLLATWKDVGLELKPHSSAECNFC HEM1_OPSTA YVQAINYPTVARGDE-LLRIAPTPHHTPEMMKYFVDRLVQTWKEVGLELKPHSSAECTFC HEM0_CHICK YVQAINHPTVPRGQELLLRIAPTPHHSPPMLENLADKLSECWGAVGLPREDPPGPSCSSC AAO62615 YVQPINAPSVRAGEE-ILRVAPSATHTTGDVEKFAEAVEGIWRDLGIPRAQERAGR---- AAX98209 YVQSINAPSVPLGQE-ILRIAPSTVHGREDVENFAEALRGIWKELNIPTATDRNWLS--- KDN87766 YVQAINAPSVRAGQE-ILRSAPGAVHQPAQVEAFVAALDGIWRELGAPRGRGPRQSG--- SKA31381 YVQPINAPSVPVGTE-RLRVTPTPLHSDREVLAFADALDSAWENAGLPRALAQAAL---- HEM0_RHOSH YVQPINYPTVARGQE-RFRLTPTPFHTTSHMEALVEALLAVGRDLGWAMSRRAA------ AAD38391 YVQAINYPTVPRGEE-RLRITPTPGHIKEHRDHLVQAVQTVWNELGIKRTSDWEAQGGFV HEM1_EMENI YVQAINYPTVPRGEE-RLRITPTPGHTQELRDHLVEAVNTVWNDLGIKRASDWKAMGGFV HEM1_KLULA YVQAINFPTVARGTE-RLRITPSPGHTNDLSDILMDALEDVWSTLQLPRVRDWEAQGGLL HEM1_YEAST YVQAINFPTVARGTE-RLRITPTPGHTNDLSDILINAVDDVFNELQLPRVRDWESQGGLL HEM1_CANAL YVQAINFPTVPIGEE-RLRITPTPGHGPELSKQLVEAVDSVFTELNLNRINDWKKLGGLV HEM1_AGABI YVQAINYPTVARGEE-RLRITVTPRHTMEQMEGLIRSLNQVFEELNINRLSDWKLAGGRA ABD39319 YVQPINYPTVPRKTE-RLRITPTPLHTDADIEQLVGALHQLWSHCALARAVA-------- HEM1_RHIME YVQPINYPTVPKKTE-RLRITPTPMHSDADIDHLVSALHSLWSRCALARAVA-------- AFU07636 YVQPINYPTVPRGTE-RLRITPSPQHTDADIEHLVQALSEIWTRVGLAKAA--------- HEM1_PARDE YVQPINFPTVPRGTE-RLRFTASPVHDPKQIDHLVKAMDSLWSQCKLNRSTSAA------ HEM1_RHOCA YVQPINFPTVPRGTE-RLRFTPSPVHDLKQIDGLVHAMDLLWARCA-------------- HEM1_RHOSH YVQPINFPTVPRGTE-RLRFTPSPVHDSGMIDHLVKAMDVLWQHCALNRAEVVA------ CEM21130 YIQPINYPTVPKGTE-RLRATPGPLHSATDLLHLVDSLDKIWNELGLKRVEKEELSELPE D87417 YVQPINYPTVPRGTE-RLRFTPTPFHTDDMMRKLVAAMEKLWAHCNVARMGGYAA----- ZP_00303686 YVQPINFPTVPRGTE-RLRFTPGPSHTEAMMDELTGALVEIWQRMEMELQKAA------- SGX80493 YLQPINYPTVSRGSE-RIRITPSPYHTDEHIEKLARSLYLLFKKYQVNMFDGKNSQVQMK XP_001350846 YIQPINYPTVPMGME-RIRITPSPFHTDEQIFKLVNSLYTLFKKYQVNMFDKKNKHTLMK *:*.** *:* * :* : . * : AAR83718 ------------------------------------------------------------ HEM1_BRAJA ------------------------------------------------------------ AF3452 DRIIPLMVSKAGG----------------------------------------------- AAD20808 ---------DSTRPAEFNVK-FKKFSI--------------------------------- CAA74915 CNSESCWHQDTSPDLECGIPNCPRLEISLAA----------------------------- AD20807 HQPMKCEAFTNRERAPCDGVHCDDYLLRAAASC--------------------------- HEM0_BRARE DRPLHFDLMSEWEKSYFGNMEPRYITVAAQ------------------------------ HEM0_OPSTA DRPLHFDLMSEWEKSYFGNMEPQYITMSA------------------------------- HEM0_MOUSE HRPVHFELMSEWERSYFGNMGPQYVTTYA------------------------------- HEM0_RAT RRPVHFELMSEWERSYFGNMGPQYVTTYA------------------------------- HEM0_HUMAN RRPVHFELMSEWERSYFGNMGPQYVTTYA------------------------------- HEM1_HUMAN RRPLHFEVMSEREKSYFSGLS-KLVSAQA------------------------------- HEM1_RAT RRPLHFEVMSEREKAYFSGMS-KMVSAQA------------------------------- HEM1_CHICK RRPLHFEVMSERERSYFSGMS-KLLSVSA------------------------------- HEM1_OPSTA QQPLHFEVMNEREKSYFSGLS-HLVSVCA------------------------------- HEM0_CHICK HRPLHLSLLSPLERDQFGVRG----AAAG------------------------------- AAO62615 ------------------------------------------------------------ AAX98209 ------------------------------------------------------------ KDN87766 ------------------------------------------------------------ SKA31381 ------------------------------------------------------------ HEM0_RHOSH ------------------------------------------------------------ AAD38391 GVGVDGAEAENQPIWNDVQLGLKENEAIE--AAVEREFAEAP--MRT------------- HEM1_EMENI GVGVEAAELENQPIWTDAQLNMRPDETLE--AAVEREFQAAVPGMKAGG----------- HEM1_KLULA GVGDPNHVPQPN-LWTKDQLTLT-NNDLH--PNVKQPIIEQL------------------ HEM1_YEAST GVGESGFVEESN-LWTSSQLSLT-NDDLN--PNVRDPIVKQL------------------ HEM1_CANAL GVGVEGAAKVEH-IWTEEQLALT-DADLN--PNVVNPAISPL------------------ HEM1_AGABI GVGIPGAADDVQPIWTDEQIGLLNGTAPRSLRNAEKSVVDMRAVTIARSRFDVLLGPVYG ABD39319 ------------------------------------------------------------ HEM1_RHIME ------------------------------------------------------------ AFU07636 ------------------------------------------------------------ HEM1_PARDE ------------------------------------------------------------ HEM1_RHOCA ------------------------------------------------------------ HEM1_RHOSH ------------------------------------------------------------ CEM21130 LTEQFYFASLPVEHLRNTPHLAQTAVVQM------------------------------- D87417 ------------------------------------------------------------ ZP_00303686 ------------------------------------------------------------ SGX80493 L----------------------------------------------------------- XP_001350846 L----------------------------------------------------------- AAR83718 ---------------------------------- HEM1_BRAJA ---------------------------------- AF3452 ---------------------------------- AAD20808 ---------------------------------- CAA74915 ---------------------------------- AD20807 ---------------------------------- HEM0_BRARE ---------------------------------- HEM0_OPSTA ---------------------------------- HEM0_MOUSE ---------------------------------- HEM0_RAT ---------------------------------- HEM0_HUMAN ---------------------------------- HEM1_HUMAN ---------------------------------- HEM1_RAT ---------------------------------- HEM1_CHICK ---------------------------------- HEM1_OPSTA ---------------------------------- HEM0_CHICK ---------------------------------- AAO62615 ---------------------------------- AAX98209 ---------------------------------- KDN87766 ---------------------------------- SKA31381 ---------------------------------- HEM0_RHOSH ---------------------------------- AAD38391 ---------ATRPAAAAAS-----SIPVGVAA-- HEM1_EMENI --------AKAKPVGSIAANPIGASIPVAAAA-- HEM1_KLULA ------------------------EVSSGIRY-- HEM1_YEAST ------------------------EVSSGIKQ-- HEM1_CANAL ------------------------DVSSGIST-- HEM1_AGABI ELQPTEDFDTPAVGATFKAPLVDREVAHDITVSA ABD39319 ---------------------------------- HEM1_RHIME ---------------------------------- AFU07636 ---------------------------------- HEM1_PARDE ---------------------------------- HEM1_RHOCA ---------------------------------- HEM1_RHOSH ---------------------------------- CEM21130 ---------------------------------- D87417 ---------------------------------- ZP_00303686 ---------------------------------- SGX80493 ---------------------------------- XP_001350846 ----------------------------------