CLUSTAL W (1.83) multiple sequence alignment 3HLM ----------------------------------------------------SSWWTHVE AATM_RAT -----------------------MALLHSGRVLSGMAAAFHPGLAAAASARASSWWTHVE AATM_HUMAN -----------------------MALLHSGRVLPGIAAAFHPGLAAAASARASSWWTHVE AATM_HORSE ----------------------------------------------------SSWWAHVE AATM_PIG -----------------------MALLHSGRVLSGVASAFHPGLAAAASARASSWWAHVE AATM_CHICK -----------------------MALLQSRLLLS-------APRRAAATARASSWWSHVE AAH56110 -----------------------MALLKSRLLVG---VARCQPCLAVVQGRASSWWSHVE NP_956283 -----------------------MALLKTTKFIS--SVGSLTPSLASLPIRASSWWTEVQ AAD47121 ------------------------MLAFFRRFMS---------TTTVTAQPVLPWFRNVP EAA56559 ----------------------MLSTMRIASRQVAGRRMAVRP---LAALRPASTWANVQ XP_329457 ----------------------MLSSVRLVTRRAAVRSAFASPGRSLLAVRAASFWANVP EAA63894 ----------------------MLSTLKVASRQAASRNASVRS--VFAGARCASTWSNVP EAK81244 ---------------------MMLTAATIRTAVRASQAPLLGAMSLPAVRQFKSTWAHVK AAT1_ARATH -----------------------MALAMMIRNAASKRGMTPISGHFGGLRSMSSWWKSVE JC5125 -----------------------MAMSRAAAAAAGTPVARRRLMGAVAARSMASWFGHVE AAC50014 MRPPVILKTTTSLLDSSSSSPPCDRRLNTLARHFLPQMASHDSISASPTSASDSVFNHLV AAT1_MEDSA -------------------------------------MASQN-ITPSPTASSDSVFAHLV AAT2_ARATH ---------------------------------------------------MDSVFSNVA AAT3_ARATH -------MKTTHFSSSSSSDRRIGALLRHLNSGSDSDNLSSLYASPTSGGTGGSVFSHLV AATC_ORYSA ------------MASSS-------------------------------------VFAGLA AATC_DAUCA ---------------------------------------------------MSSVFANVV AAT5_ARATH MASLMLSLGSTSLLP---REINKDNVKLGTSASNPFLKAKSFSRVTMTVAVKPSRFEGIT AATM_LUPAN --SSLLSIPSLSLQYNDKLKVGGNSLRFSKEQSNTFSNAKSSCRISMVAAVNVSRFEGIP AATC_YEAST --------------------------------------------------MSATLFNNIE NP_593264 --------------------------------------------------MSDYGFANIE AATC_CAEEL ----------------------------------------------------MSFFDGIP CAE69898 ----------------------------------------------------MSFFDGIP AAL06335 ---------------------------------------------------MASFFGNIE NP_725534 -------------------------------MFIILKRLNYPGLLQNFQLSTMSIYADVP AATC_PIG --------------------------------------------------APPSVFAEVP BAH05022 -------------------------------------------------MAPPSIFAEVP AATC_HORSE --------------------------------------------------TSPSIFVEVP NP_002070 -------------------------------------------------MAPPSVFAEVP AATC_RAT --------------------------------------------------APPSFFAQVP AATC_CHICK ---------------------------------------------------AASIFAAVP CAF94552 ----------------------------------------------------MSVFCEVP XP_001709849 ----------------------------------------------------MSVFSGFP AAK73814 -------------------------------------------MSG----SPTDNFDGLS AF416601 -------------------------------------------MSTQAAMTTTERWQKIQ AAK73815 -------------------------------------------MSR--------PFKDLA : . 3HLM MGPPDPILGVTEAFKRDTNSKKMNLGVGAYRDDNGKPYVLPSVRKAEA-QIAAKN-LDKE AATM_RAT MGPPDPILGVTEAFKRDTNSKKMNLGVGAYRDDNGKPYVLPSVRKAEA-QIAGKN-LDKE AATM_HUMAN MGPPDPILGVTEAFKRDTNSKKMNLGVGAYRDDNGKPYVLPSVRKAEA-QIAAKN-LDKE AATM_HORSE MGPPDPILGVTEAYKRDTNSKKMNLGVGAYRDDNGKPYVLPSVRKAEA-QIAAKN-LDKE AATM_PIG MGPPDPILGVTEAFKRDTNSKKMNLGVGAYRDDNGKPYVLPSVRKAEA-QIAAKN-LDKE AATM_CHICK MGPPDPILGVTEAFKRDTNSKKMNLGVGAYRDDNGKSYVLNCVRKAEA-MIAAKK-MDKE AAH56110 MGPPDPILGVTEAFKRDTNPKKMNLGVGAYRDDNGKPYVLSSVRKAEA-QLASKN-LDKE NP_956283 MGPPDPILGVTEAFKRDTNSKKMNLGVGAYRDDNGKPYVLNCVRKAES-LIASKA-LDKE AAD47121 LAPADPILGVTEAFKKDTNPNKINLGVGAYRDDQGKPFVLRAVREAEQ-QIIDAK-MDKE EAA56559 MGPPDAILGITEAFKADSNNKKINLGVGAYRDDAGKPYVLPSVRQAEE-KVIAAR-MNKE XP_329457 QGPPDAILGITEAFKADTFDKKINLGVGAYRDDKGKPYVLPSVRKAED-KVIHSR-MNKE EAA63894 QGPPDAILGITEAYKADSFKEKINLGVGAYRDDQGKPYVLPSVRAAED-KVVASR-FDKE EAK81244 AGPPDPILGVTEAFKRDQDPRKINLGVGAYRDENGKPYVLPSVRQAEE-LVITAK-GDKE AAT1_ARATH PAPKDPILGVTEAFLADPSPEKVNVGVGAYRDDNGKPVVLECVREAEK-RLAGS--TFME JC5125 PAAKDPILGVTEAFLADPSPDKVNVGVGAYRDDSGKPVVLECVREAGR-RIAGS--MNME AAC50014 RAPEDPILGVTVAYNKDPSPVKLNLGVGAYRTEEGKPLVLNVVRRVEQQLINDVS-RNKE AAT1_MEDSA RAPEDPILGVTVAYNKDPSPIKLNLGVGAYRTEEGKPLVLDVVRRVERQLLNDMS-RNKE AAT2_ARATH RAPEDPILGVTVAYNNDPSPVKINLGVGAYRTEEGKPLVLDVVRKAEQQLVNDPS-RVKE AAT3_ARATH QAPEDPILGVTVAYNKDPSPVKLNLGVGAYRTEEGKPLVLNVVRKAEQQLINDRT-RIKE AATC_ORYSA QAPEDPILGVTVAYNKDPSPVKVNLGVGAYRTEEGKPLVLNVVRRAEQMLINNPS-RVKE AATC_DAUCA RAPEDPILGVTVAYHKDQSPNKLNLGVGAYRTEEGKPLVLNVVKKAEQMLVNDQS-RVKE AAT5_ARATH MAPPDPILGVSEAFKADTNGMKLNLGVGAYRTEELQPYVLNVVKKAENLMLE-RG-DNKE AATM_LUPAN MAPPDPILGVSEAFRADTSDAKLNLGVGAYRTEELQPYVLKVVNKAENLMLE-RG-QNKE AATC_YEAST LLPPDALFGIKQRYGQDQRATKVDLGIGAYRDDNGKPWVLPSVKAAEKLIHNDSS-YNHE NP_593264 EAKADAIFKLNAQYHQDEDPKKVNMSVGAYRDDTGKPWILPAVKKASKIVEEQAS-FNHE AATC_CAEEL VAPPIEVFHKNKMYLDETAPVKVNLTIGAYRTEEGQPWVLPVVHETEVEIANDTS-LNHE CAE69898 VAPPIEVFHKNKLYLEETAPVKVNLTIGAYRTEEGLPWVLPVVHDTEVEIANDTT-LNHE AAL06335 IASPIEVFYMNKMYHEEPAEYKVNLTVGAYRTEEGQPWVLPVVREAEKRLADD---ISHE NP_725534 KGPAIEVFALTQAFKDDSNPNKVNLSVGAYRTDAGVPWVLPVVRKTEISIASDEQ-VNHE AATC_PIG QAQPVLVFKLIADFREDPDPRKVNLGVGAYRTDDCQPWVLPVVRKVEQRIANDSS-LNHE BAH05022 QAQPVLVFKLTADFREDPDPRKVNLGVGAYRTDDSQPWVLPVVRKVEQRIANDSS-INHE AATC_HORSE QAQPVLVFKLTADFREDPDPRKVNLGVGAYRTDDCQPWVLPVVRKVEQKIANNSS-LNHE NP_002070 QAQPVLVFKLTADFREDPDPRKVNLGVGAYRTDDCHPWVLPVVKKVEQKIANDNS-LNHE AATC_RAT QAPPVLVFKLIADFRDDPDPRKVNLGVGAYRTDDSQPWVLPVVTKVEQKIANDHS-LNHE AATC_CHICK RAPPVAVFKLTADFREDGDSRKVNLGVGAYRTDEGQPWVLPVVRKVEQLIAGDGS-LNHE CAF94552 QATPVAVFKLTQDFNNDQSPQKVNLGVGAYRTDESKPWVLPVVKKVEKLIVQDDK-LNHE XP_001709849 ASPPDAILNLTVLYNADTNPKKVNLGVGAYRDESGKPWILPAVKEAEAIISSDLSKYNKE AAK73814 ALPPDSIFFTSQKAKAAQGP-KADLIIGAYRDEHGCPYPLKTVRKAER-ILLDMN-LDYE AF416601 GRAPDPIFELAKRAAAAKGP-KANLVIGAYRDEQGLPYPLRVVRKAEQ-LLLDMN-LNYE AAK73815 PVPLDPVFGLARAAKAAPEP-KADLVIGAYRDQNGLPYPLKVVRKAER-RIVDMG-LDKE :: * :: :**** : . * * . * 3HLM YLPIGGLAEFCKASAELALGENNEVLKSGRFVTVQTISGTGALRVGASFLQRFFKF---- AATM_RAT YLPIGGLADFCKASAELALGENSEVLKSGRFVTVQTISGTGALRVGASFLQRFFKF---- AATM_HUMAN YLPIGGLAEFCKASAELALGENSEVLKSGRFVTVQTISGTGALRIGASFLQRFFKF---- AATM_HORSE YLPIGGLAEFCKASAELALGENSEALKSGRYVTVQSISGTGALRIGANFLQRFFKF---- AATM_PIG YLPIGGLAEFCKASAELALGENNEVLKSGRYVTVQTISGTGALRIGANFLQRFFKF---- AATM_CHICK YLPIAGLADFTRASAELALGENSEAFKSGRYVTVQGISGTGSLRVGANFLQRFFKF---- AAH56110 YLPIGGLAEFARASAQLALGENCEAVKNGQFITVQTISGTGSLRIGANFLQRFYKY---- NP_956283 YLGIVGLGDFNKACAELALGQDSDVLKSKRSITVQTISGTGSLRVGANFLSRFHTV---- AAD47121 YSTITGVPEFAPLAAKLAFGDNSEVIRDGRVFTTQSISGTGALRIGGQFVEKFIP----- EAA56559 YAGITGVPEFTSGALTLAYGKDSTAL--DRTAITQSISGTGALRIGAEFLSKFYPG---- XP_329457 YAGITGVPEFTKAAAVLAYGKDSSAL--DRLVITQSISGTGALRIGGEFLNRFFPG---- EAA63894 YAGITGIPSFTKAAAQLAYGADSPVLKEDRLVITQSISGTGALRIGGAFLQRFYPG---- EAK81244 YLPITGLADFTKNAAVLAYGKDSAPIKENRIAITQSISGTGALRIGGAFLQRHYPE---- AAT1_ARATH YLPMGGSAKMVDLTLKLAYGDNSEFIKDKRIAAVQTLSGTGACRLFADFQKRFSP----- JC5125 YLPMGGSIKMIEESLKLAYGENCEFIKDKRIAAVQALSGTGACRLFADFQKRFLP----- AAC50014 YIPIVGLADFNKLSAKLIFGADSPAIQDNRVTTVQCLSGTGSLRVGGEFLAKHYH----- AAT1_MEDSA YIPIVGLADFNKLSAKLIFGADSPAIQENRVTTVQGLSGTGSLRVGGEFLAKHYH----- AAT2_ARATH YIPIVGISDFNKLSAKLILGADSPAITESRVTTVQCLSGTGSLRVGAEFLKTHYH----- AAT3_ARATH YLPIVGLVEFNKLSAKLILGADSPAIRENRITTVECLSGTGSLRVGGEFLAKHYH----- AATC_ORYSA YLPITGLADFNKLSAKLIFGADSPAIQENRVATVQCLSGTGSLRVGGEFLARHYH----- AATC_DAUCA YLPIVGLADFNKLSAKLIFGADSPAIQENRVATVQCLSGTGSLRVGGEFLARHYH----- AAT5_ARATH YLPIEGLAAFNKATAELLFGAGHPVIKEQRVATIQGLSGTGSLRLAAALIERYFP----- AATM_LUPAN YLAIEGLAAFNKATAELLLGADNPAIKQQRVATVQGLSGTGSLRLGAALIERYFP----- AATC_YEAST YLGITGLPSLTSNAAKIIFGTQSDAFQEDRVISVQSLSGTGALHISAKFFSKFFPDKL-- NP_593264 YLPIAGLPRFTKAAAEVLFRPNPHLLSEDRVASMQSVSGTGANFLAASFIETFYVKHTG- AATC_CAEEL YLPVLGHEGFRKAATELVLGAESPAIKEERSFGVQCLSGTGALRAGAEFLASVCN----- CAE69898 YLPVLGHEGFRKAATELVLGEDSPAIKEGRSFGVQCLSGTGALRAGAEFLAHVCN----- AAL06335 YLPVLGYEPFCSAAVELVLGKNSSTIRAGKAIGVQCLSGTGSLKAGADFLSFVMK----- NP_725534 YLPVTGLETFTNAATELVLGADSPAIKENRAFGVQTISGTGALRVAADFLHTQLN----- AATC_PIG YLPILGLAEFRTCASRLALGDDSPALQEKRVGGVQSLGGTGALRIGAEFLARWYNGTNNK BAH05022 YLPILGLAEFRTCASRLALGDDSPALQEKRVGGVQCLGGTGALRIGAEFLARWYNGTNNK AATC_HORSE YLPILGLAEFRSCASRLALGDDSPALQEKRVGGVQSLGGTGALRIGAEFLSRWYNGTNNK NP_002070 YLPILGLAEFRSCASRLALGDDSPALKEKRVGGVQSLGGTGALRIGADFLARWYNGTNNK AATC_RAT YLPILGLAEFRSCASQLVLGDNSPALRENGVGGVQSLGATGALRIGADFLARWYNGTDNK AATC_CHICK YLPILGLPEFRANASRIALGDDSPAIAQKRVGSVQGLGGTGALRIGAEFLRRWYNGNNNT CAF94552 YLPILGLPEFRCSASKIVLGDDSAAIGEDRVGAVQCLGGTGALKMGAEFLRRFYNGNNNS XP_001709849 YPPVAGFPLFLEAAQFLMFGKDSKAAQEGRIASCQSLSGTGSLHIGFEFLHLWMP----- AAK73814 YLPMTGYKPFVDEATKIIYAD---SVAPDHLVAVQTLSGTGAVYLGAAFLAEVYDP---K AF416601 YLPISGYQPFIDEAVKMTYGD---TVELENLVAVQTLSGTGALSLGAKLLTHVFDA---E AAK73815 YPPMTGLLNFVEEAVKLAYGN---TVPLERIAASQGLSGTGSLSLGATLLRQVVP----E * : * : : : :..**: : 3HLM SRDVFLPKPSWGNHTPIFRDAGMQ-LQGYRYYDPKTC----GFDFSGALEDISKIPEQSV AATM_RAT SRDVFLPKPSWGNHTPIFRDAGMQ-LQGYRYYDPKTC----GFDFSGALEDISKIPEQSV AATM_HUMAN SRDVFLPKPTWGNHTPIFRDAGMQ-LQGYRYYDPKTC----GFDFTGAVEDISKIPEQSV AATM_HORSE SRDVFLPKPSWGNHTPIFRDAGLQ-LHAYRYYDPKTC----GFDVTGALEDISKIPQQSI AATM_PIG SRDVFLPKPSWGNHTPIFRDAGMQ-LHSYRYYDPKTC----GFDFTGALEDISKIPAQSV AATM_CHICK SRDVYLPKPSWGNHTPIFRDAGLQ-LQAYRYYDPKTC----SLDFTGAMEDISKIPEKSI AAH56110 SRDVYLPKPSWGNHTPIFRDAGLE-VKGYRYYDPKTC----GFDFAGALDDLSKIPEQSI NP_956283 ARDVYLPKPSWGNHTPIFRDAGMQ-LKAYRYYDPATC----GFDFTGALDDISKIPQNSV AAD47121 SKTLFYPTPTWANHLPVFRNSGLS-IQPYRYYNQETL----GFDVEGALEDISKMPEGSV EAA56559 AKNIYIPTPSWANHGAVFTQAGLK-VEKYRYYNKDTI----GLDFEGLVADVKAAPKGSI XP_329457 AKKIYIPTPSWANHGAVFRDSGLE-VAQYAYYDKNTI----GLDFEGLIRDLKAAPNSSI EAA63894 AKKIYLPTPSWANHNAVFKDSGLE-VEKYRYYNKDTI----GLDFEGLVEDLKAAPNNSI EAK81244 AKTIYLPTPSWGNHTPIFRDSGLE-VKQYRYYDKKTV----GLDFKGMIEDIKAAPAGSI AAT1_ARATH GSQIYIPVPTWSNHHNIWKDAQVP-QKTYHYYHPETK----GLDFSALMDDVKNAPEGSF JC5125 DSQIYIPTPTWANHHNIWRDAQVP-QKTFTYYHPESR----GLDFAGLMDDIKNAPDGSF AAC50014 QRTIYLPTPTWGNHPKVFNLAGLS-VKTYRYYAPATR----GLDFQGLLEDLGSAPSGSI AAT1_MEDSA QRIIYLPTPTWGNHTKVFNLAGLT-VKTYRYYAPATR----GLDFQGLLEDLGSAPSGSV AAT2_ARATH QSVIYIPKPTWGNHPKVFNLAGLS-VEYFRYYDPATR----GLDFKGLLEDLGAAPSGAI AAT3_ARATH QKTIYITQPTWGNHPKIFTLAGLT-VKTYRYYDPATR----GLNFQGLLEDLGAAAPGSI AATC_ORYSA ERTIYIPQPTWGNHPKVFTLAGLT-VRSYRYYDPATR----GLDFQGLLEDLGSAPSGAI AATC_DAUCA EHTVYIPQPTWGNHPKIFTLAGLS-VKTYRYYNPETR----GLDFEGMLEDLGSAPLGAI AAT5_ARATH GAKVVISSPTWGNHKNIFNDAKVP-WSEYRYYDPKTI----GLDFEGMIADIKEAPEGSF AATM_LUPAN GAKVLISAPTWGNHKNIFNDARVP-WSEYRYYDPKTV----GLDFEGMIEDIKAAPEGTF AATC_YEAST ---VYLSKPTWANHMAIFENQGLK-TATYPYWANETK----SLDLNGFLNAIQKAPEGSI NP_593264 -AHVYISNPTWPVHRTLWEKLGVT-VDTYPYWDAKNR----SFDYEGMLSTIKSAPEGSI AATC_CAEEL MKTVYVSNPTWGNHKLVFKKAGFTTVADYTFWDYDNK----RVHIEKFLSDLESAPEKSV CAE69898 MKTVYVSNPTWGNHKLVFKKAGFSEVRDYTFWDYDNK----RVHIEKLLSDLENAPEKSV AAL06335 METVYVSKPTWGNHKLIFARAGFTDIREYYYWDSTNR----CINMKNMLADLETAPENAV NP_725534 RNVVYYSNPTWENHHKIFCDAGFTTVKSYRYWDQNKR----ELDFKNMLADLNDAPPGAV AATC_PIG DTPVYVSSPTWENHNGVFTTAGFKDIRSYRYWDTEKR----GLDLQGFLSDLENAPEFSI BAH05022 DTPVYVSSPTWENHNGVFIAAGFKDIRSYHYWDAAKR----GLDLQGFLNDLEKAPEFSI AATC_HORSE NTPVYVSSPTWENHNGVFSGAGFKDIRSYHYWDATKR----GLDLQGFLNDLENAPEFSI NP_002070 NTPVYVSSPTWENHNAVFSAAGFKDIRSYRYWDAEKR----GLDLQGFLNDLENAPEFSI AATC_RAT NTPVYVSSPTWENHNGVFSAAGFKDIRSYRYWDAEKR----GLDLQGFLNDLENAPEFSI AATC_CHICK ATPVYVSSPTWENHNSVFMDAGFKDIRTYRYWDAAKR----GLDLQGLLDDMEKAPEFSI CAF94552 KTPVYVSAPTWENHNAVFTSAGFEDVRPYRYWDAERR----GLDLAGFLGDLEGCPERSI XP_001709849 KAEFYMPSTTWPNHYGIYDKVFNKLKVPYKEYTYLRKDGELEIDFSNTKKDIQSAPEKSI AAK73814 TTPIYLPNPTWPNHPSILKLTGWKDIRTYNYYDPKTV----ALDFEGIKKDIQEAPECSV AF416601 KTPIYLADPTWPNHYSIVKAAGWKDIRTYAYYDHKTL----GLDFEGMKKDILAAPDGSV AAK73815 DTPVYVSNPTWSNHVSIFGIVGHKNIREYRYYSPSTH----ELDFVGLIEDLNVAPQGSI . . .:* * : : : .. : . :. 3HLM LLLHACAHNPTGVDPRPEQWKEIASVVKKKNLFAFFDMAYQGFASGDGDKDAWAVR---H AATM_RAT LLLHACAHNPTGVDPRPEQWKEMAAVVKKKNLFAFFDMAYQGFASGDGDKDAWAVR---H AATM_HUMAN LLLHACAHNPTGVDPRPEQWKEIATVVKKRNLFAFFDMAYQGFASGDGDKDAWAVR---H AATM_HORSE ILLHACAHNPTGVDPRPEQWKEIATLVKKNNLFAFFDMAYQGFASGDGNKDAWAVR---Y AATM_PIG ILLHACAHNPTGVDPRPEQWKEMATLVKKNNLFAFFDMAYQGFASGDGNKDAWAVR---H AATM_CHICK ILLHACAHNPTGVDPRQEQWKELASVVKKRNLLAYFDMAYQGFASGDINRDAWALR---H AAH56110 ILFHACAHNPTGVDPKQEQWKELAALCKSRRLFPFFDMAYQGFASGDTDRDAWAVR---H NP_956283 ILLHACAHNPTGVDPRPEQWKELSAVIKERKLLPFFDMAYQGFASGDIDRDAWAVR---Y AAD47121 ILLHACAHNPTGVDPTKEQWKKLSQVLKERKILPFFDMAYQGFASGDVDDDAFALR---H EAA56559 FLFHACAHNPTGVDPTPEQWREIETVVKSAGHYAFFDMAYQGFASGDIHKDAFALR---H XP_329457 FLFHACAHNPTGVDPTPEQWKEIEAVVKDKGHYSFFDMAYQGFASGDIHKDAFAVR---Y EAA63894 ILLHACAHNPTGVDPTQDQWRQISNVMKEKGHFAFFDMAYQGFASGNADTDAFAPR---H EAK81244 VLLHACAHNPTGVDPTVEQWKEISNVVKEKGHFPFFDMAYQGFASGDTDKDAFAVR---H AAT1_ARATH FLLHACAHNPTGVDPTEEQWREISQLFKAKKHFAFFDMAYQGFASGDPARDAKSIR---I JC5125 FLLHACAHNPTGVDPSEEQWREISHQFKVKKHFPFFDMAYQGFASGDPERDAKAIR---I AAC50014 VLLHACAHNPTGVDPTLEQWEQIRQLIRSKALLPFFDSAYQGFASGSLDADAQPVR---L AAT1_MEDSA VLLHACAHNPTGVDPTLEQWEQIRQLIRSKSLLPFFDSAYQGFASGSLDADAQPVR---L AAT2_ARATH VLLHACAHNPTGVDPTSEQWEQIRQLMRSKSLLPFFDSAYQGFASGSLDTDAQSVR---T AAT3_ARATH VLLHACAHNPTGVDPTIQQWEQIRKLMRSKGLMPFFDSAYQGFASGSLDTDAKPIR---M AATC_ORYSA VLLHACAHNPTGVDPTLDQWEQIRQLMRSKALLPFFDSAYQGFASGSLDQDAQSVR---M AATC_DAUCA VLLHACAHNPTGVDPTIEQWEQIRQLMRSKSLLPFFDSAYQGFASGSLDADAQSVR---I AAT5_ARATH ILLHGCAHNPTGIDPTPEQWVKIADVIQEKNHIPFFDVAYQGFASGSLDEDAASVR---L AATM_LUPAN VLLHGCAHNPTGIDPTPEQWEKIADVIQEKNHIPFFDVAYQGFASGSLDEDAASVR---L AATC_YEAST FVLHSCAHNPTGLDPTSEQWVQIVDAIASKNHIALFDTAYQGFATGDLDKDAYAVRLGVE NP_593264 FLLHACAHNPTGIDPTREQWLSIFESLLSRKHLVVFDIAYQGFASGDLNRDSWALN---E AATC_CAEEL IILHGCAHNPTGMDPTQEQWKLVAEVIKRKNLFTFFDIAYQGFASGDPAADAWAIR---Y CAE69898 IILHGCAHNPTGMDPTQDQWKLIAEVIKRKNLFTFFDIAYQGFASGDPAADAWAIR---Y AAL06335 VVLHGCAHNPTGMDPTRDQWKQIAEVFKRRHLFPFFDLAYQGFASGDLDADAWAVR---Y NP_725534 IILHACAHNPTGIDPTQEQWTELADLMEKKKLFPLFDSAYQGFASGDPDRDAWAAR---Y AATC_PIG FVLHACAHNPTGTDPTPEQWKQIASVMKRRFLFPFFDSAYQGFASGNLEKDAWAIR---Y BAH05022 FVLHACAHNPTGTDPTPEQWKQIASVMKRRFLFPFFDSAYQGFASGNLEKDAWAIR---Y AATC_HORSE FVLHACAHNPTGTDPTPEQWKQIASVMKRRFLFPFFDSAYQGFASGNLDRDAWAVR---Y NP_002070 VVLHACAHNPTGIDPTPEQWKQIASVMKHRFLFPFFDSAYQGFASGNLERDAWAIR---Y AATC_RAT FVLHACAHNPTGTDPTEEEWKQIAAVMKRRFLFPFFDSAYQGFASGDLEKDAWAIR---Y AATC_CHICK FILHACAHNPTGTDPTPDEWKQIAAVMKRRCLFPFFDSAYQGFASGSLDKDAWAVR---Y CAF94552 FVLHACAHNPTGTDPTPEQWKQIAEAMMRRKLFVFFDSAYQGFASGSLDKDAWAVR---Y XP_001709849 FLFHACAHNPSGIDFTEAQWKELLPIMKEKKHIAFFDSAYQGFATGSFEADAFAVR---M AAK73814 FLLHQCAHNPTGVDPSHAQWEEIADLMLAKKHQVFFDSAYQGYASGSLDEDAFAAR---L AF416601 FLLHQCAHNPTGVDPSQEQWNEIASLMLAKHHQVFFDSAYQGYASGSLDTDAYAAR---L AAK73815 IVLHACAHNPTGVDPSKDQWATIADVFVERKLIPFFDSAYQGFASGSLDEDAYAIR---H .::* *****:* * :* : ** ****:*:*. *: . . 3HLM FIEQGINVCLCQSYAXNMGLYGERVGAFTV--------VCKDAEEAKRVESQLKILIRPL AATM_RAT FIEQGINVCLCQSYAKNMGLYGERVGAFTV--------VCKDAEEAKRVESQLKILIRPL AATM_HUMAN FIEQGINVCLCQSYAKNMGLYGERVGAFTM--------VCKDADEAKRVESQLKILIRPM AATM_HORSE FIEQGINVCLCQSYAKNMGLYGERVGAFTM--------VCKDADEAKRVESQLKILIRPL AATM_PIG FIEQGINVCLCQSYAKNMGLYGERVGAFTV--------VCKDAEEAKRVESQLKILIRPM AATM_CHICK FIEQGIDVVLSQSYAKNMGLYGERAGAFTV--------ICRDAEEAKRVESQLKILIRPM AAH56110 FIQEGINLVLSQSYAKNMGLYGERVGAFTV--------VCSDAEEAKRVESQIKILIRPM NP_956283 FIEQGHNILLSQSFAKNMGLYGERVGGFTV--------VCGDAEEAKRVESQLKILIRPI AAD47121 FIEQGHNVLVAQSFAKNMGLYGERVGAFSI--------VCDSAEEAIRVGSQMRIIIRPM EAA56559 FVAQGHNVCLAQSFAKNMGLYGERVGAFSI--------VCDSAEEKKRVDSQLKILVRPM XP_329457 FVEQGHNICLAQSFAKNMGLYGERVGAFSI--------VCADADEKKRVDSQVKILVRPL EAA63894 FVEQGHNIALCQSFAKNMGLYGERVGAFSL--------VCESAEEKKRVDSQIKILIRPF EAK81244 FVAEGHQICLSQSFAKNMGLYGERVGAFSI--------VCADPDERARVDSQIKIIVRPM AAT1_ARATH FLEDGHHIGISQSYAKNMGLYGQRVGCLSV--------LCEDPKQAVAVKSQLQQLARPM JC5125 FLEDGHQIGCAQSYAKNMGLYGQRAGCLSI--------LCDDEMQAVAVKSQLQQIARPL AAC50014 FVADGGELLVAQSYAKNLGLYGERVGALSI--------VCKSADVASRVESQLKLVIRPM AAT1_MEDSA FVADGGELLVAQSYAKNMGLYGERVGALSI--------VSKSADVSSRVESQLKLVIRPM AAT2_ARATH FVADGGECLIAQSYTKNMGLYGERVGALSI--------VCKSADVASKVESQVKLVVRPM AAT3_ARATH FVADGGECLVAQSYAKNMGLYGERVGALSI--------VCKSADVAGRVESQLKLVIRPM AATC_ORYSA FVADGGELLMAQSYAKNMGLYGERVGALSI--------VCGSADVAVRVESQLKLVIRPM AATC_DAUCA FVADGGECLAAQSYAKNMGLYGERVGALSI--------VCKTADVASKVESQLKLVIRPM AAT5_ARATH FAERGMEFFVAQSYSKNLGLYAERIGAINV--------VCSSADAATRVKSQLKRIARPM AATM_LUPAN FVARGLEVLVAQSYSKNLGLYAERIGAINV--------ISSSPESAARVKSQLKRIARPM AATC_YEAST KLSTVSPVFVCQSFAKNAGMYGERVGCFHLALT----KQAQNKTIKPAVTSQLAKIIRSE NP_593264 FVKYNKDFFVCQSFAKNMGLYGERTGCMHY--------VAKDASTKNKVLSQLCIVQRNT AATC_CAEEL FVDQGMEMVVSQSFAKNFGLYNERVGNLTV--------VVNNPAVIAGFQSQMSLVIRAN CAE69898 FVEQGMEMVVSQSFAKNFGLYNERVGNLTV--------VVNNPAVIAGFQSQMSLVIRAN AAL06335 FVEQGLEMFCAQSFAKNFGLYNERVGNLTV--------VASDPLVLASIKSQMSLVIRSN NP_725534 FVQRGFELFICQSFAKNFGLYCERTGNLAV--------VQKNGATKAAVHSQLTLLIRGQ AATC_PIG FVSEGFELFCAQSFSKNFGLYNERVGNLTV--------VAKEPDSILRVLSQMEKIVRVT BAH05022 FVSEGFELFCAQSFSKNFGLYNERVGNLTV--------VAKEPDSILRVLSQMEKIVRIT AATC_HORSE FVSEGFELFCAQSFSKNFGLYNERVGNLTV--------VAKEPDSILRVLSQMQKIVRIT NP_002070 FVSEGFEFFCAQSFSKNFGLYNERVGNLTV--------VGKEPESILQVLSQMEKIVRIT AATC_RAT FVSEGFELFCPQSFSKNFGLYNERVGNLTV--------VGKEHDSVLRVLSQMEKIVRIT AATC_CHICK FVSEGFELFCAQSFSKNFGLYNERVGNLSV--------VGKDEDNVQRVLSQMEKIVRTT CAF94552 FVSKGFELFCAQSFSKNFGLYNERVGNLTI--------VTRDADNLKRILSQMEKIVRTT XP_001709849 FVDAGVEVLVAQSFSKNFGLYGERIGCLHVVHAGVEGSVEKNKALSAAMVSGMTLQIRKT AAK73814 FVKKGVQFILAQSFSKNMGLYNERTGTLSV--------VLRNPERAAAVKTHLDLLIRAN AF416601 FARRGIEVLLAQSFSKNMGLYSERAGTLSL--------LLKDKTKRADVKSVMDSLIRAE AAK73815 FAKRGMEMLLAQSFSKNMGLYAERVGVISA--------VVSDASRKEAVRSRLEVIARSY **:: * *:* :* * : . : : * 3HLM YSNPPLNGARIAATILTSPDLRKQWLQEVKGMADRIISMRTQLVSN-LKKEGSSH----N AATM_RAT YSNPPLNGARIAATILTSPDLRKQWLQEVKGMADRIISMRTQLVSN-LKKEGSSH----N AATM_HUMAN YSNPPLNGARIAAAILNTPDLRKQWLQEVKGMADRIIGMRTQLVSN-LKKEGSTH----N AATM_HORSE YSNPPLNGARIASTILTSPDLRKQWLQEVKGMADRIISMRTQLVSN-LKKEGSSH----S AATM_PIG YSNPPVNGARIASTILTSPDLRQQWLQEVKGMADRIISMRTQLVSN-LKKEGSSH----N AATM_CHICK YSNPPMNGARIASLILNTPELRKEWLVEVKGMADRIISMRTQLVSN-LKKEGSSH----N AAH56110 YSNPPLNGARIAASILTQPDLRKEWLQEVKGMANRIISMREQLVSN-LKKEGSIH----N NP_956283 YSNPPMNGARIASTILTTPELRSTWLEEVKGMADRIIRMREMLVTN-LKKEGSTH----N AAD47121 ISMPPLHGARIASRILSNPELKKSWLEDVKLMADRIKSMRTALKDG-LKAEGSTL----N EAA56559 YSNPPIHGARIAAQILNTPALYDQWLAEVKGMADRIITMRALLKEN-LEKLGSKH----D XP_329457 YSNPPIHGARIAAEILNTPELYEQWLTEVKEMADRIIKMRALLKEN-LEKLGSKH----D EAA63894 YSNPPVHGARVASTIMNDPALNKQWLGEVKGMADRIIEMRALLKKN-LEELGSKH----D EAK81244 YSNPPMHGAKIAGTILADQQLYQQWLGEVKGMADRINGMRSTLKDLLVQDFNSKL----N AAT1_ARATH YSNPPLHGAQLVSTILEDPELKSLWLKEVKVMADRIIGMRTTLRES-LEKLGSPL----S JC5125 YSNPPVHGALIVSTILGDPELKSLWLKEVKGMADRIIGMRTALKEN-LEKLGSPM----S AAC50014 YSSPPIHGASIVAAILKDRNLFNDWTIELKAMADRIISMRQELFDALCSRGTPG-----D AAT1_MEDSA YSSPPIHGASIVAAILKDRDLYNDWTIELKAMADRIINMRQQLFDALRARGTPG-----D AAT2_ARATH YSSPPIHGASIVATILKSSDMYNNWTIELKEMADRIKSMRQQLFEAIQARGTPG-----D AAT3_ARATH YSSPPIHGASIVAVILRDKNLFNEWTLELKAMADRIISMRKQLFEALRTRGTPG-----D AATC_ORYSA YSNPPIHGASIVATILKDSAMFNEWTVELKGMADRIISMRQQLFDALKTRETPG-----D AATC_DAUCA YSSPPLHGASIVAAILKDGDLYNEWTLELKAMADRIISMRQELFNALQAKGTPG-----D AAT5_ARATH YSNPPVHGARIVANVVGDVTMFSEWKAEMEMMAGRIKTVRQELYDSLVSKDKSGK----D AATM_LUPAN YSNPPVHGARIVADIVGNPALFDEWKVEMEMMAGRIKNVRQQLYDSISSKDKSGK----D AATC_YEAST VSNPPAYGAKIVAKLLETPELTEQWHKDMVTMSSRITKMRHALRDHLVKLGTPG-----N NP_593264 ISNPPAYGARIAAEILNSPQLFAEWEQDLKTMSSRIIEMRKRLRDSLVALKTPG-----S AATC_CAEEL WSNPPAHGARIVHKVLTTPARREQWNQSIQAMSSRIKQMRAALLRHLMDLGTPG-----T CAE69898 WSNPPAHGARIVHKVLTTPARREHWHQAIQTMSSRIKEMRAALLGHLKQLSTPG-----T AAL06335 WSNPPSHGARIVHMILTSPSMCAQWHDAIKTMSSRIKDMRYALRNNLEKLGTPG-----T NP_725534 YSNPPAYGARIVSKVLNTPELRKEWMASIQAMSSRIREMRTALRDKLVALGTPG-----T AATC_PIG WSNPPAQGARIVARTLSDPELFHEWTGNVKTMADRILSMRSELRARLEALKTPG-----T BAH05022 WSNPPAQGARIVARTLSDPELFNEWTGNVKTMADRILTMRSELRARLEALKTPG-----T AATC_HORSE WSNPPAQGARIVAFTLSDPGLFKEWTGNVKTMADRILSMRSELRARLEALKTPG-----T NP_002070 WSNPPAQGARIVASTLSNPELFEEWTGNVKTMADRILTMRSELRARLEALKTPG-----T AATC_RAT WSNPPAQGARIVATTLSNPELFKEWKGNVKTMADRILTMRSELRARLEALKTPG-----T AATC_CHICK WSNPPSQGARIVATTLTSPQLFAEWKDNVKTMADRVLLMRSELRSRLESLGTPG-----T CAF94552 WSNPPSQGARVVAVTLNSPELFAEWKENVKTMADRVLLMRAQLKEKLQRLGTPG-----T XP_001709849 WSMSAIHGAYIVQVIVHDKRLLQMFYDNVKEMSARIHRMRSLLHASLAKRKTPGPGSKGT AAK73814 YSNPPAHGARLVHLVLSDKELRKEWEAELAEMANRIRTMRHTVYDELKRLGTPG-----T AF416601 YTCPPAHGARLAHLILSNNELRKEWEAELSAMAERIRTMRRTVYDELLRLQTPG-----R AAK73815 YSTPPVHGARIAHLVMSDKELRAEWEQELKEMVNRVRSMRQGVYEGLMKLGTPG-----T : .. ** :. : : : * *: :* : . 3HLM WQHITDQIGMFCFTGLKPEQVERLTKEFSVYMTKDG-RISVAGVTSGNVGYLAHAIHQVT AATM_RAT WQHITDQIGMFCFTGLKPEQVERLTKEFSVYMTKDG-RISVAGVTSGNVGYLAHAIHQVT AATM_HUMAN WQHITDQIGMFCFTGLKPEQVERLIKEFSIYMTKDG-RISVAGVTSSNVGYLAHAIHQVT AATM_HORSE WQHIADQIGMFCFTGLKPEQVERLTKEFSIYMTKDG-RISVAGVTSGNVGYLAHAIHQVT AATM_PIG WQHIVDQIGMFCFTGIKPEQVERLTKEFSIYMTKDG-RISVAGVTSGNVGYLAHAIHQVT AATM_CHICK WQHITDQIGMFCFTGLKPEQVERLTKEFSIYMTKDG-RISVAGVASSNVGYLAHAIHQVT AAH56110 WQHISDQIGMFCFTGLRPEQVERLIKEFSIYMTKDG-RISVAGVTSANNGYLAHAIHQVT NP_956283 WQHVTDQIGMFCFTGLKPEQVERLTKDFSVYMTKDG-RISVAGVTSGNVEYLAHAIHQVT AAD47121 WDHITNQIGMFCFTGINEKQVQKLIKEHSVYLTNDG-RISISGINTGNVAYLAKALHDVT EAA56559 WSHITSQIGMFAYTGLTPEQMEQLAKSHSVYATKDG-RIRSLVSPARTLAVLLRLSSRSR XP_329457 WSHITSQIGMFAYTGLTPEQMEKLAKEHSVYATKDG-RISVAGITSENVGRLAEAIFKVK EAA63894 WTHITSQIGMFAYTGLKPEQMEALAKEHSVYATKDG-RISVAGITTGNVKRLAESIYKVT EAK81244 WDHITNQIGMFAFLGISPEQVAKLVNEHHVYLTGDG-RISVAGITDHNVKHLAESLHKVT AAT1_ARATH WEHVTKQIGMFCYSGLTPEQVDRLTSEYHIYMTRNG-RISMAGVTTGNVGYLANAIHEVT JC5125 WEHITNQIGMFCYSGMTPEQVDRLTKEFHIYMTRNG-RISMAGVTTGNVAYLANAIHEVT AAC50014 WSHIIKQIGMFTFTGLNAEQVSFMTKEFHIYMTSDG-RISMAGLSSKTVPLLADAIHAAV AAT1_MEDSA WSHIIKQIGMFTFTGLNPEQVSILTKEYHIYLTSDG-RISMAGLSSKTVPHLAHAIHAVV AAT2_ARATH WSHIIKQIGMFTFTGLNKEQVEFMTKEFHIYMTSDG-RISMAGLSSKTVPHLADAMHAAV AAT3_ARATH WSHIIKQIGMFTFTGLNPAQVSFMTKEYHIYMTSDG-RISMAGLSSKTVPHLADAIHAVV AATC_ORYSA WSHIIKQIGMFTFTGLNSDQVAFMRQEYHIYMTSDG-RISMAGLSGRTIPHLADAIHAAV AATC_DAUCA WSHIVKQIGMFTFTGLNSEQVTFMTNEYHIYLTSDG-RISMAGLSSRTVPHLADAIHAAV AAT5_ARATH WSFILKQIGMFSFTGLNKAQSDNMTDKWHVYMTKDG-RISLAGLSLAKCEYLADAIIDSY AATM_LUPAN WSFILKQIGMFSYTGLNKNQSDNMTNKWHVYMTKDG-RISLAGLSLAKCEYLADAIIDSF AATC_YEAST WDHIVNQCGMFSFTGLTPQMVKRLEETHAVYLVASG-RASIAGLNQGNVEYVAKAIDEVV NP_593264 WDHITQQIGMFSFTGLTPAQVQFCQERYHLYFSANG-RISMAGLNNSNVEHVAQAFNHAV AATC_CAEEL WDHIIQQIGMFSYTGLTSAQVDHLIANHKVFLLRDG-RINICGLNTKNVEYVAKAIDETV CAE69898 WDHITQQIGMFSYTGLTSAQVDHLIAHHKVFLLSDG-RINICGLNTKNVEYVAKAIDETV AAL06335 WEHITQQIGMFSFIGLNTEQVDHLIKKYKVFLLKNG-RINVCGLNPENVEYVAKAINETI NP_725534 WDHIVNQIGMFSYTGLNESHVRVLIDQYHIYLLKTG-RISMSGLNKGNVEYVAKAIHAAV AATC_PIG WNHITDQIGMFSFTGLNPKQVEYLINEKHIYLLPSG-RINMCGLTTKNLDYVATSIHEAV BAH05022 WNHITEQIGMFSFTGLNPKQVEYLVNEKHIYLLPSG-RINMCGLTTKNLEYVATSIHEAV AATC_HORSE WNHITEQIGMFSFTGLNPKQVEYLVNQKHIYLLPSG-RINMCGLTTKNLDYVATSIHEAV NP_002070 WNHITDQIGMFSFTGLNPKQVEYLVNEKHIYLLPSG-RINVSGLTTKNLDYVATSIHEAV AATC_RAT WSHITEQIGMFSFTGLNPKQVEYLVNEKHIYLMPSG-RINMCGLTTKNLDYVATSINEAV AATC_CHICK WNHITDQIGMFSFTGLNPKQVEYMIKEKHIYLMASG-RINMCGLTTKNLDYVAKSIHEAV CAF94552 WDHITDQIGMFSFTGLNPKQVEFMVKEKHIYLMASG-RINMCGLTTKNIDYVAASIHEAV XP_001709849 WDHILTAIGMFTFTGLTPEHVDYLKEKWSIYLVKAGGRMSMCGLTESNCDYVAEAIHDAV AAK73814 WEHIINQIGMFSFLGLSKEQCQYCQDHN-VFILLSG-RANMAGLTHDTALMLARTIDEAV AF416601 WEHVINQIGMFSFLGLSKEQCEYCQNHN-IFITLSG-RANIAGLTHETALMLAQTINDAV AAK73815 WEHIINQKGMFSYMGLSRPQCERLCEKR-VFVLPVG-RANLAALTPSTMDFLVKSIDDVV * .: *** : *: :: * * . : 3HLM K-------------- AATM_RAT K-------------- AATM_HUMAN K-------------- AATM_HORSE K-------------- AATM_PIG K-------------- AATM_CHICK K-------------- AAH56110 K-------------- NP_956283 K-------------- AAD47121 K-------------- EAA56559 VRW------------ XP_329457 G-------------- EAA63894 G-------------- EAK81244 S-------------- AAT1_ARATH KSS------------ JC5125 KTK------------ AAC50014 TRVV----------- AAT1_MEDSA TRVA----------- AAT2_ARATH TRLG----------- AAT3_ARATH TKAV----------- AATC_ORYSA TKLK----------- AATC_DAUCA TGKA----------- AAT5_ARATH HNVS----------- AATM_LUPAN HYVS----------- AATC_YEAST RFYTIEAKL------ NP_593264 RELP----------- AATC_CAEEL RAVKSNI-------- CAE69898 RAVKSNI-------- AAL06335 NNIK----------- NP_725534 TGSGESASCPCENKL AATC_PIG TKIQ----------- BAH05022 TKIQ----------- AATC_HORSE TKFQ----------- NP_002070 TKIQ----------- AATC_RAT TKFQ----------- AATC_CHICK TKIQ----------- CAF94552 TTVQ----------- XP_001709849 TKLPFKK-------- AAK73814 RTV------------ AF416601 RNVNRE--------- AAK73815 RHVRNK---------