CLUSTAL W (1.83) multiple sequence alignment EAA12069 ----------------------------------------------QQHGPAAAAAVAAE NP_491690 -----------------------------------------------------MRTVQAI AAF48262 MSRMLIKPAAATVSAALQQHQRQQQQYVIRRWKSFLHNNSNNANRRAAKSTATATVTAAA ALAT1_HUMAN ---------------------------------------MQRAAVLVRRGSCPRASGPWG ALAT2_MOUSE ---------------------------------------MQRAAVLVRRGSCPRASGPWG NP_597700 ---------------------------------------MQRAAALVRRGCGPRTPSSWG ALAT_RAT ------------------------------------------------------------ XP_128019 ------------------------------------------------------------ ALAT_DOG ------------------------------------------------------------ AAC62456 ------------------------------------------------------------ ALA2_PANMI ------------------------------------------------------------ ALA2_HORVU ------------------------------------------------------------ AAF82782 ----------------------------MRRFVIGQAKNLIDQSRRRQLHHHKNLSFVSL NP_565040 ------------------------------------------------------------ AET01924 ----------------------------MRKSAADRFRHLFNRS----------LVFVR- BBD74338 ------------------------------------------------------------ XP_001219089 ----------------------MDIYLFSVWFIQNEEKCLDFLNISKKNKAKSSVQHIGG T08064 --------------------------------MRKEATRLVSALLRAGNNGVSTSWAVGG ALAM_YEAST --------------------------------MLSLSAKNHFTVSNSITHVIKSYHIRTL XP_455940 --------------------------------MLSVRVNLKTRISSGMIRVN-------- XP_720174 --------------------------------MLRVNSRLLTTRKS-------------- EAA28376 ------------------------------------------------------------ ALAT_SCHPO --------------------------------MFTDYPNDINCESP-------------- EAA12069 SPINQQQS----------RTFLTMACVQQQ------------------------------ NP_491690 S--GLVTS----------RFFGTSTRIMAS------------------------------ AAF48262 TSQRHGTSGDFIQPLDVRRSFSTSHKMPSS------------------------------ ALAT1_HUMAN RSHSSAAA-------EASAALKVRPERSPR------------------------------ ALAT2_MOUSE RSHSSAAA-------EASAALKVRPERSPR------------------------------ NP_597700 RSQSSAAA-------EASAVLKVRPERSRR------------------------------ ALAT_RAT ------AS-------RVNDQSQASRN-GLK------------------------------ XP_128019 -----MAS-------QRNDRIQASRN-GLK------------------------------ ALAT_DOG -----MAL-------RAGD--QVAMN-GLK------------------------------ AAC62456 ----------------------MAAS---------------------------------- ALA2_PANMI ----------------------MAAT---------------------------------- ALA2_HORVU ----------------------MAAT---------------------------------- AAF82782 IPPFSAPSDSSSRHLSSSSSSDMSASDSSS------------------------------ NP_565040 ----------------------MSASDSTS------------------------------ AET01924 --------NQNQQYHHPSPLRSLSSMASDS------------------------------ BBD74338 ----------------------MSYNKTAS------------------------------ XP_001219089 LARKQNPEPTKSIFVSRYGARSLKTSTMKG------------------------------ T08064 ---------TRLKSAMPQPDEKKDEDLHAK------------------------------ ALAM_YEAST TSSAEKMPHITTPFSTSASSTKLKAFRKVRPVLQRHSSSWIVAQNHRRSLSGQSSLNDLR XP_455940 ------APALKSTMPSVTSLTQLRFSTTVK------------------------------ XP_720174 --------------QFMFTSNSLRFLATFK------------------------------ EAA28376 ----------------MSSSNSRR------------------------------------ ALAT_SCHPO ---------------RMSDLDGFCQN---------------------------------- EAA12069 -------------------QRCVSVDN---------INPAIKSMEYAVRGPLVIRAGVIE NP_491690 -------------------GKTLNTSN---------INPNVIKMEYAVRGPIVIRAVELE AAF48262 -------------------SKALTLDN---------INPNFIAMEYAVRGPLVIRAGEIE ALAT1_HUMAN -------------------DRILTLES---------MNPQVKAVEYAVRGPIVLKAGEIE ALAT2_MOUSE -------------------DRILTLES---------MNPQVKAVEYAVRGPIVLKAGEIE NP_597700 -------------------ERILTLES---------MNPQVKAVEYAVRGPIVLKAGEIE ALAT_RAT -------------------GKVLTLDT---------MNPCVRRVEYAVRGPIVQRALELE XP_128019 -------------------GKVLTLDT---------MNPCVRRVEYAVRGPIVQRALELE ALAT_DOG -------------------EKVLTLDT---------MNPCVRRVEYAVRGPIVLRALELE AAC62456 ----------------------VTVEN---------LNPKVLKCEYAVRGEIVIHAQRRQ ALA2_PANMI ----------------------VAVEN---------LNPKVLKCEYAVRGEIVIHAQHLQ ALA2_HORVU ----------------------VAVDN---------LNPKVLKCEYAVRGEIVIHAQRLQ AAF82782 -------------------SLPVTLDT---------INPKVIKCEYAVRGEIVNIAQKLQ NP_565040 -------------------SLPVTLDS---------INPKVLKCEYAVRGEIVNIAQKLQ AET01924 -------------------PFPVTAQN---------INPQVLKCQYAVRGEIVTLAQNLQ BBD74338 ----------------------ITAET---------INPKVKIFDYEPCGEIARHAERLE XP_001219089 -------------------NQEFFQKGGAHVSKGVHINPRVKKAQYAVRGLVPMRADEIR T08064 -------------------EGKVLHPH--------LLNENVVKTQYAVRGELYLRAEQLR ALAM_YEAST HLNRFPHHTLKTSNNEFYPAEQLTLED---------VNENVLKAKYAVRGAIPMRAEELK XP_455940 ------------------PAPKLSLDD---------VNENVLKAKYAVRGRIPMRAEELR XP_720174 ------------------PADPLTTHD---------INPQTVEAKYAVRGKIPIIADELN EAA28376 ----------------------LNIDN---------INPHVRAAKYAVRGELAVKSEEFR ALAT_SCHPO --------------------AFSDLNS---------LNQQVFKANYAVRGALAILADEIQ :* .* * : : . EAA12069 KELEE----------EVIRANIGDCHAMGQPPITFIRQVLGLVSYPPLFN--------DP NP_491690 KELATGAQK---PFPNVIKANIGDAHAMGQKPITFIRQLLACIVNPEIMKT-------DK AAF48262 KELEKGVKK---PFDQVIRANIGDCHAMGQQPLTFLRQLLALTFETRLLD--------SP ALAT1_HUMAN MELQRGIKK---PFTEVIRANIGDAHAMGQQPITFLRQVMALCTYPNLLN--------SP ALAT2_MOUSE MELQRGIKK---PFTEVIRANIGDAHAMGQQPITFLRQVMALCTYPNLLN--------SP NP_597700 LELQRGIKK---PFTEVIRANIGDAQAMGQQPITFLRQVMALCTYPNLLD--------SP ALAT_RAT QELRQGVKK---PFTEVIRANIGDAQAMGQRPITFFRQVLALCVYPNLLS--------SP XP_128019 QELRQGVKK---PFTEVIRANIGDAQAMGQRPITFFRQVLALCVYPNLLS--------SP ALAT_DOG QELRQGVKK---PFTEVVRANIGDAQAMGQKPITFLRQVLALCVHPDLLN--------SP AAC62456 QQLQTQPGS--LPFDEILYCNIGNPQSLGQQPVTFFREVLALCDHPCLLEKEE----TKS ALA2_PANMI QQLQTQPGS--LPFDEILYCNIGNPQSLGQQPVTFFREVLALCDHPCLLEKEE----TKS ALA2_HORVU EQLKTQPGS--LPFDEILYCNIGNPQSLGQQPVTFFREVLALCDHPDLLQREE----IKT AAF82782 EDLKTNKDA--YPFDEIIYCNIGNPQSLGQQPITFFREVLALCSYTALLDESA----THG NP_565040 EDLKTNKDA--YPFDEIIYCNIGNPQSLGQLPIKFFREVLALCDHASLLDESE----THG AET01924 KALQANPDA--HSFDEIIYCNIGNPQSLGQQPITFFREVLALCDYPALLDKSE----TQG BBD74338 QEMEKSPGS--RPFPEIIYCNLGNPQALGQRPITFFREVISLCDNPALLHRDE----TRM XP_001219089 EEIRSGTGKSKFSFNELVYCNIGNPQALEQKPLTFHRQVMSLIDAPFLLEDNA----VVS T08064 KEGK-----------EIIFTNVGNPHALGAKPLTFTRQVLALCAAPFLLDHPK----VED ALAM_YEAST AQLEKDPQS--LPFDRIINANIGNPQQLQQKPLTYYRQVLSLLQYPELLNQNEQQLVDSK XP_455940 DQLKKDPSS--LPFSKIISANIGNPQQLDQKPLTFYREVLSLLQHPELLEEADEALQT-- XP_720174 ELIQKQPQSHGLPFSKIINANIGNPQQLEQRPLTWYRQVLSLLQYPDLLKNGDPETVKS- EAA28376 AALLRGTSD--IPFSQVISANIGNPQQLDQKPITFFRQVLSLLENPLLLEHED-VLINHL ALAT_SCHPO DDLLENPSS--YPFSEIVYANIGNPQQMGQSPITFVRQVLSLCQYPTLLDHAEEKWFQN- . .:: *:*: : : *:.: *:::. . :: EAA12069 SIPTDAKQRARAILDGCKGGSVGSYSDSAGIEVIRRHAAEYIQRRDGGIPA--DWQNIIL NP_491690 SIPSDVIEHANAFLGSCGGKSAGAYSQSTGVEIVRKHVAEYIKRRDGGIPC--NSEDVCL AAF48262 DYPEDVKKRACAILNGCQGQSVGSYTDSAGLEVVRRQVAQYIEKRDGGIAS--NWQDIYL ALAT1_HUMAN SFPEDAKKRARRILQACGGNSLGSYSASQGVNCIREDVAAFITRRDG-VPA--DPDNIYL ALAT2_MOUSE SFPEDAKKRARRILQACGGNSLGSYSASQGVNCIREDVAAFITRRDG-VPA--DPDNIYL NP_597700 SFPEDAKKRARRILQACGGNSLGSYSASQGVNCIREDVAAYITRRDGGVPA--DPDNIYL ALAT_RAT DFPEDAKRRAERILQACGGHSLGAYSISSGIQPIREDVAQYIERRDGGIPA--DPNNIFL XP_128019 DFPEDAKRRAERILQACGGHSLGAYSISSGIQPIREDVAQYIERRDGGIPA--DPNNIFL ALAT_DOG DFPEDAKRKAERILQACGGHSLGAYSVSSGIQLIREDVAEYIERRDGGIPS--DPNNIYL AAC62456 LFSADAISRAKQILATIPGRATGAYSHSQGIKGLRDAIAAGIMSRDGFPA---NADDIFI ALA2_PANMI LFSADAISRAKQILSTIPGRATGAYSHSQGIKGLRDAIAAGIASRDGFPA---NADDIFV ALA2_HORVU LFSADSISRAKQILAMIPGRATGAYSHSQGIKGLRDAIASGIASRDGFPA---NADDIFL AAF82782 LFSSDSIERAWKILDQIPGRATGAYSHSQGIKGLRDAIADGIEARDGFPA---DPNDIFM NP_565040 LFSTDSIDRAWRILDHIPGRATGAYSHSQGIKGLRDVIAAGIEARDGFPA---DPNDIFL AET01924 LFSADSIERAWQIVDQIPGRATGAYSHSQGIQGLRDTIAAGIEERDGFPC---NANDIFL BBD74338 LFSPCAINRARKIIESMPGRNTGAYTNSQGIRSLREAVASGIAARDGFPS---RPEDIFL XP_001219089 RYPSDAVSRARLYLGHIGQR-TGAYTDSAGYAFVRDIVAQYVNERDAYVKPLQEASSIVL T08064 MFPADAIARAKKILASFKGG-VGAYTDSRGNPLVREEVARFIEKRDGVPS---NPDHIFL ALAM_YEAST LFKLDAIKRAKSLME-DIGGSVGAYSSSQGVEGIRKSVAEFITKRDEGEISY--PEDIFL XP_455940 LYKTDSIKRAKRLLS-EVGGSVGAYSQSQGVQGIRETVADFITKRDDGEISY--PEDIYL XP_720174 LYPEDVIERAQSILK-HIG-SIGAYSHSQGASYFRQSIAEFITNRDGGYVSH--ANNIFL EAA28376 GYKTDVIERAKWFLK-NVG-SVGAYSASNGAPAIRQHIAEFLERRD-GFPAN--WQDIYL ALAT_SCHPO LFPTDVVQRSKMLLK-ESG-SLGAYSASQGIPLVRRHVADFIRARD-GFDCE--PSDIYL :: : *:*: * * .* * : ** . : : EAA12069 SAGASGGIKVLMALLRCPIDGKKPGVMIPIPQYPLYSATIAEFDMEQIGYYLDEANKWGL NP_491690 SGGASESIRNVLKLFINHNNAKKVGVMIPIPQYPLYSATIEEFGLGQVGYYLSESSNWSM AAF48262 TGGASPGIKSILSMINAEVGCKAPGVMVPIPQYPLYSATISEYGMTKVDYYLEEETGWSL ALAT1_HUMAN TTGASDGISTILKLLVSGGGKSRTGVMIPIPQYPLYSAVISELDAVQVNYYLDEENCWAL ALAT2_MOUSE TTGASDGISTILKLLVSGGGKSRTGVMIPIPQYPLYSAVISELDAVQVNYYLDEENCWAL NP_597700 TTGASDGISTILKILVSGGGKSRTGVMIPIPQYPLYSAVISELDAIQVNYYLDEENCWAL ALAT_RAT STGASDAIVTMLKLLVSGEGRARTGVLIPIPQYPLYSAALAELDAVQVDYYLDEERAWAL XP_128019 STGASDAIVTMLKLLVAGEGRARTGVLIPIPQYPLYSAALAELDAVQVDYYLDEERAWAL ALAT_DOG STGASDAIVTVLKLLVAGEGPTRTGVLIPIPQYPLYSAALAELNAVQVDYYLDEERTWAL AAC62456 TDGASPGVHMMMQLLIRN---EKDGILCPIPQYPLYSASIALHGGTLVPYYLNEKNGWGL ALA2_PANMI TDGASPGVHMMMQLLIRN---EKDGILCPIPQYPLYSASIALHGGTLVPYYLDEKTGWGL ALA2_HORVU TDGASPGVHLMMQLLIRN---EKDGILVPIPQYPLYSASIALHGGALVPYYLNESTGWGL AAF82782 TDGASPGVHMMMQLLITS---EKDGILCPIPQYPLYSASIALHGGTLVPYYLDEASGWGL NP_565040 TDGASPAVHMMMQLLLSS---EKDGILSPIPQYPLYSASIALHGGSLVPYYLDEATGWGL AET01924 TDGASPAVHMMMQLLIRS---EKDGILCPIPQYPLYSASITLHGGHLVPYYLDEATGWGL BBD74338 TDGASSAINLSMQILIRS---QEDGILCPLPEYPLYSASIILHGGTMVPYNLSEDGDWGL XP_001219089 TDGASTGVRIILQTLVGD---EKDAVMIPIPQYPLYTAQIALLGGTPAMYYLRESEGWAL T08064 TDGASVAVRLCLNAMIRH---DRDSVLVPIPQYPLYSASIRLYGGTLVGYFLDERRGWGL ALAM_YEAST TAGASAAVNYLLSIFCRG---PETGVLIPIPQYPLYTATLALNNSQALPYYLDENSGWST XP_455940 TAGASAAVSYILSILCKG---PNTGVLIPIPQYPLYTASLALNNSRPLPYYLREEQNWST XP_720174 TSGASTAVSYLLQILSVN---ENSGFLIPIPQYPLYTATIALNNAKPIGYYLDESNHWST EAA28376 SAGASSGVNTLLHIICAD---EKSGILVPIPQYPLYTASLSILNATCVPYLLDESKNWGT ALAT_SCHPO TSGASHAARLIMTLIIAR---PTDGVMVPAPQYPLYGAQIDLMSGSMVSYSLSEENNWDI : *** . : : ..: * *:**** * : . * * * * EAA12069 DIAELERSLKEARKTS--APRILVVINPGNPTGQVLSRSNIEDIIKFAQRERLVLFADEV NP_491690 DEAELERSFNDHCKEY--DIRVLCIINPGNPTGQALSRENIETIIKFAQKKNLFLMADEV AAF48262 DRKELQRSYDEAKKVC--NPRALVVINPGNPTGQVLTRENIEEIIKFAHDNKVLVLADEV ALAT1_HUMAN NVDELRRALRQAKDHC--DPKVLCIINPGNPTGQVQSRKCIEDVIHFAWEEKLFLLADEV ALAT2_MOUSE NVDELRRALRQAKDHC--DPKVLCIINPGNPTGQVQSRKCIEDVIHFAWEEKLFLLADEV NP_597700 NVNELRRAVQEAKDHC--DPKVLCIINPGNPTGQVQSRKCIEDVIHFAWEEKLFLLADEV ALAT_RAT DIAELRRALCQARDRC--CPRVLCVINPGNPTGQVQTRECIEAVIRFAFKEGLFLMADEV XP_128019 DIAELRRALCQARDRC--CPRVLCVINPGNPTGQVQTRECIEAVIRFAFEEGLFLMADEV ALAT_DOG DVAELRRALCQARAHC--RPRALCVINPGNPTGQVQARECIEAVIRFAFEERLFLMADEV AAC62456 EISDFKTRLEDVRSKG-IDVRALVVINPGNPTGQVLAEDNQYDIVKFCKNEGLVLLADEV ALA2_PANMI EISDLKKQLEDARSKG-IDVRALVVINPGNPTGQVLAEDNQCDIVRFCKNEGLVLLADEV ALA2_HORVU ETSDVKKQLEDARSRG-INVRALVVINPGNPTGQVLAEENQYDIVKFCKNEGLVLLADEV AAF82782 EISELKKQLEDARSKG-ITVRALAVINPGNPTGQVLSEENQRDVVNFCKQEGLVLLADEV NP_565040 EISDLKKQLEEARSKG-ISVRALVVINPGNPTGQVLAEENQRDIVNFCKQEGLVLLADEV AET01924 EISELKKQLEDAKSKG-ISVRALAVINPGNPTGQVLAEDNQRAIVEFCKQEGLVLLADEV BBD74338 EIFEVKRCLEEARIAG-LTVRAMVIINPGNPTGQVLSVTNQEEIVEFCRKEGLVILADEV XP_001219089 NVGELEAVYKDCVANGNATPRVLVVINPGNPTGGVLERTVMEEVAKFCCDHGVVLMADEV T08064 SVEELQRALQESREEG-KLVRGLVFINPGNPTGQCLSKENLQELIKLAYQEKIVLMADEV ALAM_YEAST NPEEIETVVKEAIQNE-IKPTVLVVINPGNPTGAVLSPESIAQIFEVAAKYGTVVIADEV XP_455940 DPEEIEQVVLDAIQKG-IKPTCLVVINPGNPTGAILSEQSIQKIFEVAAKYGIVVIADEV XP_720174 NPQEIRELIETNQSQG-INIKALVVINPGNPTGAILSSQDIIELIDIAAEYGIVLIADEV EAA28376 DINTIKESYQKAKDAG-VDTRAIVIINPGNPTGASLSEEDIRAVLEFARQERLVVLADEV ALAT_SCHPO DFDQFKKSFDEASKKG-INVRLCVVINPGNPTGACISENSMEKVLRFAKAKGIVLLADEV . .. .******** : .. .::**** EAA12069 YQDNVYESGSQFHSFKKVMMEMGEPYS-----KMELCSFMSCSKGYMGECGIRGGYAEIV NP_491690 YQDNVYAQGSQFHSFKKVLVEMGEPYN-----KMELASFHSVSKGYMGECGMRGGYVEFL AAF48262 YQDNVYDKNSKFWSFKKVAYEMGDPYR-----NLEMVSFLSTSKGYLGECGIRGGYMEVL ALAT1_HUMAN YQDNVYSPDCRFHSFKKVLYQMGHEYS----SNVELASFHSTSKGYMGECGYRGGYMEVI ALAT2_MOUSE YQDNVYSPDCRFHSFKKVLYQMGHEYS----SNVELASFHSTSKGYMGECGYRGGYMEVI NP_597700 YQDNVYSPDCRFHSFKKVLYEMGPEYS----SNVELASFHSTSKGYMGECGYRGGYMEVI ALAT_RAT YQDNVYAEGSQFHSFKKVLMEMGPPYS----TQQELASFHSVSKGYMGECGFRGGYVEVV XP_128019 YQDNVYAEGSQFHSFKKVLTEMGPPYA----TQQELASFHSVSKGYMGECGFRGGYVEVV ALAT_DOG YQDNVYAEGSQFHSFKKVLTEMGPPYA----THQELASFHSVSKGYMGECGFRGGYVEVV AAC62456 YQENIYVDNKKFNSFKKIVRSMG-YGE----DDLPLVSLQSVSKGYYGECGKRGGYMEIT ALA2_PANMI YQENIYVDDKKFNSFKKIARSVG-YGE----DDLPLVSFQSVSKGYYGECGKRGGYMEIT ALA2_HORVU YQENIYVDNKKFHSFKKIVRSLG-YGE----EDLPLVSYQSVSKGYYGECGKRGGYFEIT AAF82782 YQENVYVPDKKFHSFKKVARSMG-YGE----KDLALVSFQSVSKGYYGECGKRGGYMEVT NP_565040 YQENVYVPDKKFHSFKKVARSLG-YGE----KDISLVSFQSVSKGYYGECGKRGGYMEVT AET01924 YQENVYVPEKKFHSFKKVSRSMG-YGD----NDICLVSFQSVSKGYHGECGKRGGYMEVT BBD74338 YQDNVYVEDRKFNSFKKVARSLG-YDE----NDISIVSFHSVSMGYSGECGRRGGYMEIC XP_001219089 YQENIYTATKRFESFRKIVLELPPPYN----TDTVLVSLHSVSKGIIGECGRRGGYFTLT T08064 YQENVYQDERPFVSAKKVMWEMGEPYR----SHVELLSFHTVSKGTAGECGLRGGYVEMT ALAM_YEAST YQENIFPGT-KFHSMKKILRHLQREHP-GKFDNVQLASLHSTSKGVSGECGQRGGYMELT XP_455940 YQENVFKGS-KFYSMKKVLRNLQKTYH-GQYDNIQLASLHSTSKGVSGECGQRGGYMELV XP_720174 YQENIFKG--KFVSFKKILSELIEQDP-QTYKHVQLASLHSTSKGVSGECGQRGGYMELV EAA28376 YQTNVFIG--EFISFKRVLRQLQKENPDGKYDCVELASLHSISKGMVGECGHRGGYFELV ALAT_SCHPO YQNNIYQN--KFHSFRRKLGELREKEPDNHWDQVSLISVNSVSKGQFGECGQRGGYLDVV ** *:: * * :: : : * : * * **** **** . EAA12069 NLCPDVRTMLLKCISAQLCPTTAGQAVLDCVVNPPRKGEPSYEQFEKEKASVLESLRERA NP_491690 NLDPEVYVLFKKMISAKLCSTVLGQAVIDAVVNPPKEGDASYALWKQEKDAVLASLKERA AAF48262 NLDPKVKAMLTKSITAALCSTTAGQVAVSALVNPPQPGEPSYDLYKKERDGILAALKERA ALAT1_HUMAN NLHPEIKGQLVKLLSVRLCPPVSGQAAMDIVVNPPEPGEESFEQFSREKEFVLGNLAKKA ALAT2_MOUSE NLHPEIKGQLVKLLSVRLCPPVSGQAAMDIVVNPPEPGEESFEQFSREKEFVLGNLAKKA NP_597700 NLHPEIKGQLVKLLSVRLCPPVSGQAAMDIVVNPPVAGEESFEQFSREKESVLGNLAKKA ALAT_RAT NMDAEVQKQMGKLMSVRLCPPVPGQALMDMVVSPPTPSEPSFKQFQAERQEVLAELAAKA XP_128019 NMDAEVQKQMAKLMSVRLCPPVPGQALMGMVVSPPTPSEPSFKQFQAERQEVLAELAAKA ALAT_DOG NMDPAVQRQMQKLMSVRLCPPVPGQVLLSIVVSPPAPSDPSFVQFQAERQAVLAELAAKA AAC62456 GFSAPVREQIYKIASVNLCSNITGQILASLVMNPPKAGDESYASYKAEKDGILESLARRA ALA2_PANMI GFSAPVREQIYKIASVNLCSNITGQILASLVMNPPKVGDESYAAYKAEKDGILQSLARRA ALA2_HORVU GFSAPVREQIYKIASVNLCSNITGQILASLVMNPPKASDESYASYKAEKDGILASLARRA AAF82782 GFTSDVREQIYKMASVNLCSNISGQILASLIMSPPKPGDDSYESYIAEKDGILSSLARRA NP_565040 GFTSDVREQIYKMASVNLCSNISGQILASLVMSPPKPGDDSYDSYMAERDGILSSMAKRA AET01924 GFSPDVREQIYKVASVNLCSNITGQILASLIMSPPKVGDESYESFMAERGAILSSLTTRA BBD74338 GFGDDVMGEIRKVASVTLCPNTNGQILTSLAMDPPKLGDGCFEAFMAEKEEISTSLAKRA XP_001219089 NAPPELVEQVMKLCSINLCSNVNGQLMTALMCSPPKPGDASFDHYTAEYSGIFESLKRRA T08064 NIHPGAIEEVYKCASINLSPNTMGQIALSVLVNPPKPGDPSYDQYTKEKASELVSLRRRR ALAM_YEAST GFSHEMRQVILKLASISLCPVVTGQALVDLMVRPPVEGEESFESDQAERNSIHEKLITRA XP_455940 GFNHDIRQVFLKLASISLCPVVTGQALVDLMVSPPQPGDESYEQDQQEREDIHDALDERA XP_720174 GFKPEVKDVVFKLASINLCSVVSGQALMELMINPPQEGDPSYPLYKSETESIHNDLESRA EAA28376 NFDPEVQAEIYKFVSIMLCAPVIGQCLVELMVNPPKPGEPSYELYEKEYRGIYEGMRERA ALAT_SCHPO NIPEPAKDQILKLATIDICPPVAGQLLVDMLVNPPKPGDPSYDLFIKEVDEIHEALRLQC . . * : :.. ** ** .: .: * : : EAA12069 ELVARTFNSIEGFSCNPVQGAMYAFPQIRLP------AKALEAAKKDGKPADTFYAFQLL NP_491690 TLVEKAYSSIDGISCNPVQGAMYAFPQITIP------QRAVEKAQSLNQQPDFFYAMQLL AAF48262 ELVHKALNSFEGYKVNPVQGAMYVFPQIEIP------PKAIEAAKAKGMAPDVFYAFELL ALAT1_HUMAN KLTEDLFNQVPGIQCNPLQGAMYAFPRILIP------AKAVEAAQSHKMAPDMFYCMKLL ALAT2_MOUSE KLTEDLFNQVPGIQCNPLQGAMYAFPRILIP------AKAVEAAQSHKMAPDMFYCMKLL NP_597700 KLTEDLFNQVPGIHCNPLQGAMYAFPRIFIP------AKAVEAAQAHQMAPDMFYCMKLL ALAT_RAT KLTEQVFNEAPGIRCNPVQGAMYSFPQVQLP------LKAVQRAQELGLAPDMFFCLCLL XP_128019 KLTEQVFNEAPGIRCNPVQGAMYSFPQIQLP------LKAVQRAQDLGLAPDMFFCLCLL ALAT_DOG KLTEQVFNESPGIRCNPVQGAMYSFPRVQLP------PRAVQRAQELSLAPDMFFCMRLL AAC62456 KALEDAFNKLEGFSCNKAEGAMYLFPQIHLP------QKAIEAAKAAKKAPDAFYALRLL ALA2_PANMI KALEDAFNNLEGISCNKAEGAMYLFPQIHLP------KKAIEAAKAANKAPDAFYALRLL ALA2_HORVU KALEHAFNKLEGITCNEAEGAMYVFPQICLP------QKAIEAAKAANKAPDAFYALRLL AAF82782 KTLEEALNKLEGVTCNRAEGAMYLFPCLHLP------QKAIAAAEAEKTAPDNFYCKRLL NP_565040 KTLEDALNSLEGVTCNRAEGAMYLFPRINLP------QKAIEAAEAEKTAPDAFYCKRLL AET01924 KALEEALNKLEGVTCNKAEGAMYLFPRIRLP------EKAIKAAEAEKSAPDAFYCKRLL BBD74338 KTLVNAFSSLEGMTCNKVEGAIYAFPRIHLP------AAAIKAAKAEDMSPDTFYACRLL XP_001219089 DLLAKELNNIRGFKSQSVEGAMYAFPTIELPPKYVKHNDEMNSKEGRQLAPDARWALELL T08064 HMVTDGFNALDGVTCNFTEGAMYSFPQIKLP------AKALEAAKAAGKAGDVFYCLKLL ALAM_YEAST MTLYETFNSLEGIECQKPQGAMYLFPKIDLP------FKAVQEARHLELTPDEFYCKKLL XP_455940 SKLFETFSRLEGIECRKPQGAMYLYPKLDLP------YKVIQEAQHLEMEPDEFYCKALL XP_720174 ESLYQAFLQMEDIKCNKPMGAMYIFPTLDFDPA--RYHKLYSRAKNSNLQIDDIYCIELL EAA28376 NALHKAFEQMEGVECGAPQGAMYLFPTINLP------PKAAEAAAKEGRTPDEFYCMKLL ALAT_SCHPO RQLYEGTKRMKRVSCLEPHGAMYLHPSVSLP------EKLITTAKAQKIQPDEFYAIELL **:* .* : : * :. ** EAA12069 EETGICIVPGSGFGQRPG------TYHFRTTILPQPEKLKEMLGLFKSFHEKFLQKYK-- NP_491690 ETTGICIVPGSGFGQKDG------TYHFRTTILPQPELFKDMLSRFTDFHQKFLAEYKRL AAF48262 ETSGICIVPGSGFGQKPG------TWHFRSTILPQTDKLKLMMEKFRVFHAEFMKKYK-- ALAT1_HUMAN EETGICVVPGSGFGQREG------TYHFRMTILPPVDKLKTVLHKVKDFHLKFLEQYS-- ALAT2_MOUSE EETGICVVPGSGFGQREG------TYHFRMTILPPVDKLKTVLHKVKDFHLKFLEQYS-- NP_597700 EETGICVVPGSGFGQREG------TYHFRMTILPPVEKLKTVLQKVKDFHINFLEKYA-- ALAT_RAT EETGICVVPGSGFGQQEG------TYHFRMTILPPMEKLRLLLEKLSHFHAKFTHEYS-- XP_128019 EETGICVVPGSGFGQQEG------TYHFRMTILPPMEKLRVLLEKLRHFHAKFTHEYS-- ALAT_DOG EETGICVVPGSGFGQREG------TYHFRMTILPPMEKLRPLLEKLSQFHAKFTREYS-- AAC62456 ESTGIVVVPGSGFGQVPG------TWHIRCTILPQEDKIPAVISRFRAFHEAFLAEYRD- ALA2_PANMI ESTGIVVVPGSGFGQVPG------TWHIRCTILPQEDKIPAVITRFKAFHEAFMAEYRD- ALA2_HORVU ESTGIVVVPGSGFGQVPG------TWHFRCTILPQEDKIPAVISRFTVFHEAFMSEYRD- AAF82782 KATGIVVVPGSGFRQVPG------TWHFRCTILPQEDKIPAIVDRLTAFHQSFMDEFRD- NP_565040 NATGVVVVPGSGFGQVPG------TWHFRCTILPQEDKIPAIVNRLTEFHKSFMDEFRN- AET01924 NATGIVVVPGSGFGQVPG------TWHFRCTILPQEDRIPAIVTRLTEFHQKFMDEFRD- BBD74338 DATGIAVVPGSGFHQISGRNTATGTWHIRCTILVAEDKIEAMIARLKAFHESFMNEFRDR XP_001219089 ESTGIVVVPGSGFGQQPG------TLHFRTTILPPEAHMERVVKALRQFQEGIWAKYA-- T08064 EATGISTVPGSGFGQEEG------TFHLRTTILPREEVMTTFVEKFDKFHKDFMKQYS-- ALAM_YEAST ESTGICTVPGSGFGQEPG------TYHLRTTFLAPG---LEWIKKWESFHKEFFDQYRD- XP_455940 ENTGICTVPGSGFGQVPG------TYHLRTTFLPPG---TEWVETWEKFHKAFFDKYRD- XP_720174 EGTGICCVPGNGFGQKPD------TYHLRTTFLPPG---KEWIDKWINFHKSFIKKYKDE EAA28376 EATGVCVVPGSGFGQKEG------SLHFRTTFLAPG---TEWVGSIVKFHKEFMDQYR-- ALAT_SCHPO KRSGICVVPGSGFGQPEG------DYHIRITFLAKG---TEYIERFVKAHNEIMDLYE-- . :*: ***.** * . *:* *:* : : : : EAA12069 ------------------------------------------------ NP_491690 YCHFHLTNNRTSDSFWHTLIDGFPKYKVFVQNRRSTQCAFHSIQLSRF AAF48262 ------------------------------------------------ ALAT1_HUMAN ------------------------------------------------ ALAT2_MOUSE ------------------------------------------------ NP_597700 ------------------------------------------------ ALAT_RAT ------------------------------------------------ XP_128019 ------------------------------------------------ ALAT_DOG ------------------------------------------------ AAC62456 ------------------------------------------------ ALA2_PANMI ------------------------------------------------ ALA2_HORVU ------------------------------------------------ AAF82782 ------------------------------------------------ NP_565040 ------------------------------------------------ AET01924 ------------------------------------------------ BBD74338 S----------------------------------------------- XP_001219089 ------------------------------------------------ T08064 ------------------------------------------------ ALAM_YEAST ------------------------------------------------ XP_455940 ------------------------------------------------ XP_720174 ------------------------------------------------ EAA28376 ------------------------------------------------ ALAT_SCHPO ------------------------------------------------