CLUSTAL W (1.83) multiple sequence alignment AAO76260 ------------------------------------------------------------ AAQ66358 ------------------------------------------------------------ BAD52335 ------------------------------------------------------------ SERC_HUMAN ------------------------------------------------------------ SERC_RABIT ------------------------------------------------------------ AAH44467 ------------------------------------------------------------ NP_001040269 ------------------------------------------------------------ SERC_DROME ------------------------------------------------------------ SERC_CAEEL ------------------------------------------------------------ SERC_CHRVO ------------------------------------------------------------ SERC_NEIMA ------------------------------------------------------------ CAD84244 ------------------------------------------------------------ SERC_PSEST ------------------------------------------------------------ ZP_00151949 ------------------------------------------------------------ SERC_ECOLI ------------------------------------------------------------ SERC_SALTY ------------------------------------------------------------ SERC_YEREN ------------------------------------------------------------ SERC_XENNE ------------------------------------------------------------ SERC_VIBVU ------------------------------------------------------------ SERC_HAEIN ------------------------------------------------------------ SERC_PASMU ------------------------------------------------------------ SERC_ARATH --MAATTNSFLVGSNNTQIPALKPKSSSQSFLHLSKPNTVNFVSKTKPVAVRCVASTTQV SERC_SPIOL MAMAATSS---TQTNLFLKAPFNPQQNCQQTHFLP----LNFKIRNPISRITCSATPTAT AAM51827 --MAAAAAAATTPNSLLLRRPAAPKPASAAASPLR--------LPTRAARISCAAVATPA SERC_BACCR ------------------------------------------------------------ SERC_LACLA ------------------------------------------------------------ SERC_BACCI ------------------------------------------------------------ SERC_BACSU ------------------------------------------------------------ CAD74688 -----------------------------------------------------MTASAQG XP_001327551 ------------------------------------------------------------ CAD70964 ------------------------------------------------------------ EAA50300 ------------------------------------------------------------ SERC_YEAST ------------------------------------------------------------ SERC_SCHPO ------------------------------------------------------------ CAC08322 ------------------------------------------------------------ SERC_MYCTU ------------------------------------------------------------ NP_696810 ------------------------------------------------------------ CAE29750 ------------------------------------------------------------ NP_104887 ------------------------------------------------------------ NP_634935 ------------------------------------------------------------ SERC_METBA ------------------------------------------------------------ ZP_00093940 -------------------------------MGRVERALRKHRLTYPAAPLERPAGHAVP AAO76260 --------MKK-----HNFNAGPSILPREVIEDTAKAILDFNGSGLSLMEISHRAKDFQP AAQ66358 --------MKK-----HNFTAGPCILNDLVLKDAASACLNFAGTGLSVLEVSHRDKEFDA BAD52335 --------MERQ--NIHNFGAGPAAMAKEVIEATAKAVNNF-WEGLSILEISHRSKEWIN SERC_HUMAN ---------MDAPRQVVNFGPGPAKLPHSVLLEIQKELLDYKGVGISVLEMSHRSSDFAK SERC_RABIT ---------MDSPRQIVNFGPGPAKLPHSVLLEIQKELLDYKGLGISVLEMSHRSSDFAK AAH44467 ---------MEK-KQTVNFGAGPAKLPQSVLLQAQKELLDYSGTGISILEMSHRSSDFTK NP_001040269 ------------MSKVFNFGAGPAKLPEEVYEIIKNELTNFENSGISLLETSHRSSTYMK SERC_DROME --------------MVINFAAGPAKLPEEVLKEVQENLVNCNGSGISVMEMSHRSSNYAK SERC_CAEEL ---------MAAPGRKINFAAGPAKLPEEVLLKMQEEQLNFNNLGVSVIEMSHRSKEFGA SERC_CHRVO --------MAK----VYNFSAGPAVLPHQVLAEAQSELLDWHGSGMSVMEMSHRGKEFME SERC_NEIMA ------MSLYP----IYNFSAGPAVLPEAVLETARQEMLDYNGTGFPVMAMSHRSEMFLS CAD84244 --------MRK----IYNFSAGPAVLPEEVLEQAREEMLDWHGSGMSVMEMSHRGKEFMS SERC_PSEST -------MSKR----AFNFCAGPAALPEAVLQRAQAELLDWQGRGLSVMEMSHRSDAYVA ZP_00151949 --------MSR----IWNFSAGPAALPEEVLRQAQEELLDWHGAGCSVMEMSHRGKEFMS SERC_ECOLI --------MAQ----IFNFSSGPAMLPAEVLKQAQQELRDWNGLGTSVMEVSHRGKEFIQ SERC_SALTY --------MAQ----VFNFSSGPAMLPAEVLKLAQQELCDWHGLGTSVMEISHRGKEFIQ SERC_YEREN --------MTQ----VYNFSAGPAMLPVEVLRRAEQELRNWHGLGTSVMEISHRSKEFMQ SERC_XENNE --------MNQ----VYNFSAGPAMLPAEVLRRAEQELCNWHGLGTSVMEISHRSKEFIA SERC_VIBVU --------MEQNTDNVFNFSAGPAALPKPVMQQAQQELLNWQGLGTSVMEISHRSKEFIA SERC_HAEIN --------MSQ----VFNFSAGPAMIFPEVLQKAQNELINWLNQGVSVMEVSHRGKYFME SERC_PASMU --------MSK----VFNFSAGPAMMPEAVLAQAQAELLNWQEQQTSVMEVSHRGKLFMA SERC_ARATH QDGVRSGS-VGSQERVFNFAAGPATLPENVLLKAQADLYNWRGSGMSVMEMSHRGKEFLS SERC_SPIOL AVSTTTKIDQRSEERVFNFAAGPAVLPENVLQKAQSELLNWRGSGMSVMEMSHRGKEFTS AAM51827 QSSS-SPAAAAADRGVYNFAAGPATLPLSVLQRAQAELVDYRGSGMSIMEMSHRGKEFDA SERC_BACCR --------MER----VYNFSAGPSILPLPVLEKVQKELLNYNGTGMSIMEMSHRSSYFQS SERC_LACLA ----------M----IYNFGAGPSVLPKEVLKKVQEELLDFEKSGMSVMEISHRSKAFQK SERC_BACCI -------MSKR----AYNFNAGPAALPLEVLERAQAEFVDYQHTGMSIMEMSHRGAVYEA SERC_BACSU --------MER----TTNFNAGPAALPLEVLQKAQKEFIDFNESGMSVMELSHRSKEYEA CAD74688 VQSTSAQSSASHPERVFNFSAGPATMPESVLREVQDEMLCYPGAGASIMEISHRDKLFVD XP_001327551 ------MSAQR----AYNFSAGPAAVPLECLERAAAEMTNWRNSGMSVIEVSHRGKHWME CAD70964 ---------MPARADITYFGAGPAALPTDVLETAAQALLDYQGTGLGIAEHSHRSELAAK EAA50300 ---------MPTRADITYFGAGPAALPTDVLEKAAQALLDYNGTGLGIAEHSHRSEHATT SERC_YEAST --------MSLEREEPQHFGAGPAQMPTPVLQQAAKDLINFNDIGLGIGEISHRSKDATK SERC_SCHPO ---------MSSREEVVNFAAGPAAMITSVVEEFGKDFVNFQGLGMGVAEISHRSKQGSG CAC08322 ------------------MKPADGRFGAGPSKVRVEALDALAATGTSLLGTSHRQAPVKN SERC_MYCTU ----MADQLTPHLEIPTAIKPRDGRFGSGPSKVRLEQLQTLTTTAAALFGTSHRQAPVKN NP_696810 --------MTITLSIPESLKPEDGRFGSGPSKIRPEQIAALDAGATTLLGTSHRQAPVKQ CAE29750 -----------MTVAKPASRPNAPQFSSGPCAKRPG--WTPENLKDAPLGRSHRAKVGKA NP_104887 ----------MTTHTKPGLRPANPNFSSGPCAKRPG--WSVEALKNAALGRSHRAKIGKT NP_634935 --------------MKPTRVPKNPCFSSGPCAKHPG--YSIEDLNDAPFGRSHRSKPGKE SERC_METBA --------------MKPTRVPNNPCFSSGPCAKHPG--YSIEELKDTPFGRSHRSNLGKE ZP_00093940 TPRVLSARRDYMSATIPARKPARPFFSSGPCAKPPG--YSPEKLATESLGRSHRAKIGKT . . *** AAO76260 VVDEAEALFKELLNIPEGY--SVLFLGGGASMEFCMVPFNFLE----------------- AAQ66358 VMLEARNLFKELLDVPEGY--EVLFLGGGASLQFYQVPLNLLK----------------- BAD52335 VMNETKALMKEVMDIPEGY--EILFFGGGASLQFLMVAMNLLN----------------- SERC_HUMAN IINNTENLVRELLAVPDNY--KVIFLQGGGCGQFSAVPLNLIGLKAG------------- SERC_RABIT IVNNTENLVRELLAVPDNY--KVIFLQGGGCGQFSAVPLNLIGLKPG------------- AAH44467 IINTTENLIRELLNVPENY--KILFLQGGGSGQFSAVPLNLIGLKEE------------- NP_001040269 LNVEIQDVVRNLLDVPDNY--KVLFLAGGGLGQFAAVPLNLISRTG-------------- SERC_DROME IHDATISDLRELLNVPSNY--KILLMQGGGTGQFAAVALNLIGKTG-------------- SERC_CAEEL LLNETISLIRELMNVPDNF--EILFMQGGGTGQFAAIPLNLKGDHE-------------- SERC_CHRVO IIHDAEQDLRQLMGIPAGY--KVLFLQGGASLQFAMAPLNLLG-DK-------------- SERC_NEIMA ILHHAEQDLRQLLKVPDNY--KILFLQGGATTQFNMAAMNLAH-GF-------------- CAD84244 IADETESALRELAGIPDHY--KVLFLQGGASSQFAMVPMNLLG-KK-------------- SERC_PSEST IAEKAEQDLRDLMAIPSDY--KVLFLQGGASQQFAEIPLNLLP-EG-------------- ZP_00151949 ILEQAEADLRELMGIPEQY--KVLFLQGGATQQFAQIPMNLLA-G--------------- SERC_ECOLI VAEEAEKDFRDLLNVPSNY--KVLFCHGGGRGQFAAVPLNILG-DK-------------- SERC_SALTY VAEEAEQDFRDLLNIPSNY--KVLFCHGGGRGQFAGVPLNLLG-DK-------------- SERC_YEREN VAEEAEKDLRDLMQIPANY--KVLFCHGGRRAQFAAVPLNLLG-DS-------------- SERC_XENNE VAAEAEKDLRDLLAIPENY--NVLFCHGGARGQFSALPQNLLG-DK-------------- SERC_VIBVU VAEQSEQDLRDLLNIPDNY--KVLFCQGGARAQFAAVPLNLLG-DA-------------- SERC_HAEIN LVTQAEKDLREVYNIPDNY--RTLFLQGGARGQFATIPMNLIG-KK-------------- SERC_PASMU LASQSELDLRQLYQIPDNY--RILFLQGGARGQFAAIPMNLLK-EK-------------- SERC_ARATH IIQKAESDLRQLLEIPQEY--SVLFLQGGATTQFAALPLNLCK-SD-------------- SERC_SPIOL IIDKAEADLRTLLNIPSDY--TVLFLQGGASTQFSAIPLNLCT-PD-------------- AAM51827 AIKKAEADLRALLAVPDTH--EVLFLQGGATSQFAAAPLNLCASPS-------------- SERC_BACCR IIEEASNLLRELMSIPDEY--EVLFLQGGASLQFSMIPLNLMNTY--------------- SERC_LACLA VIDEAENDLRDLMSIPQNY--KILFLQGGASSQFSMVPMNLAIG---------------- SERC_BACCI VHNEAQARMLALMGNPTGY--KVLFIQGGASTQFAMIPMNFLK-EG-------------- SERC_BACSU VHQKAKSLLIELMGIPEDY--DILFLQGGASLQFSMLPMNFLT-PE-------------- CAD74688 VLHDAESTIRELLNVSDDY--SVMFMQGGATLQFSAIPANLLRGSG-------------- XP_001327551 EQKEATERLRTLLQVPENF--NILFVAGGASLQFSAIPFNFIG--EH------------- CAD70964 IINEAKADLATYLDFSPEQ-YEVLFMQGGGTGEFAASMYNLVGAWVSRQHAAVQKELGEG EAA50300 IINEAKADLLAYLDVPEAADYDVLFMQGGGSGEFAATVYNLVGAWVARQVKAAGLE-GE- SERC_YEAST VIEDSKKHLIELLNIPDTH--EVFYLQGGGTTGFSSVATNLAAAYVGKHGKIAPAG---- SERC_SCHPO IVTSAESNFRKLYNIPENF--HILFMQGGGTEQFAACLYNVYAHHALKNGNAKSLVAN-- CAC08322 LVGKVREGIRELFRLPDGY--EVILGNGGSTAFWDVATHGLIENK--------------- SERC_MYCTU LVGRVRSGLAELFSLPDGY--EVILGNGGATAFWDAAAFGLIDKR--------------- NP_696810 LVASIREGLREFFHLPEGY--EVALGNGGASAFWEIACASLITRR--------------- CAE29750 KLKLAIDLTRDVLEVPADY--KIGIVPASDTGAVEMALWSLLGPRP-------------- NP_104887 KLEQAIELTREILQVPADH--RIGIVPASDTGAVEMALWSLLGERG-------------- NP_634935 KLAEAIKRTRDMLGLPSDY--LVGIVPASDTGAFEMCLWSMLGCRG-------------- SERC_METBA KLAEAIKKTRDMLGLPDDY--LVGIVPASDTGAFEMCLWSMLGCRG-------------- ZP_00093940 RLQYCIDLMREVLQLPDTH--RIGIVPGSDTGAFEMAMWTMLGARP-------------- . .. . AAO76260 -------------------KKAAYLNTGVWAKKAMKEAKGF-----GEVVEVASSA---E AAQ66358 -------------------KKAAFINTGTWATNAIKQAKIMTQVYGGEVEVLASSE---D BAD52335 -------------------KKACYLDTGVWASKAIKEAENI-----GEVKIIGTSK---D SERC_HUMAN -------------------RCADYVVTGAWSAKAAEEAKKFG-----TINIVHPKL---- SERC_RABIT -------------------RCADYVVTGAWSAKAAEEAKKFG-----TVNIVHPKL---- AAH44467 -------------------RCADYLVTGTWSARAAKEAEKYG-----KVNVIHPKL---- NP_001040269 --------------------TADYVVTGAWSAKAAKEAKKYG-----KVNLVLPPT---- SERC_DROME --------------------TADYVITGSWSAKAAKEAAQYG-----TVNAVLPKL---- SERC_CAEEL --------------------HADYIVTGAWSSKAADEAGKYI-----NVKKVFQPS---- SERC_CHRVO -------------------DSIDIVNTGHWSKLAIKEAKRYA-----KVNVVASS---ED SERC_NEIMA -------------------RTADAVVTGNWSRIAYEQMSRLT-----DTEIRLAAHGGEQ CAD84244 -------------------GKADYVNTGQWSAKAISEAKNYG-----SVQIAASS---ES SERC_PSEST -------------------GVADYVDTGIWSRKSIEEARRFG-----NVNLAASA---KP ZP_00151949 -------------------RSADYIVTGSWSKKAFKEAQRFG-----NVRCAATT---ES SERC_ECOLI -------------------TTADYVDAGYWAASAIKEAKKYC-----TPNVFDAKV--TV SERC_SALTY -------------------TTADYVDAGYWAASAIKEAKKYC-----APQIIDAKI--TV SERC_YEREN -------------------RSADYIDGGYWAHSAVKEAQKYC-----TPNVIDVTT--HD SERC_XENNE -------------------STADYIVSGYWSECAAKEAEKYC-----TPNIIDIRS--NT SERC_VIBVU -------------------TTATYIDAGYWAESAVEEAKKYC-----QPDVFVAKA--EK SERC_HAEIN -------------------GKALYLNSGHWSATAAKEARNFA-----EIDEITIVE--NG SERC_PASMU -------------------GKALYLTSGHWSATAAKEARLFG-----DIDEVNILE--EG SERC_ARATH -------------------DTVDFVVTGSWGDKAVKEAKKYC-----KTNVIWSGK---S SERC_SPIOL -------------------SAVDYIVTGSWGDKAAKEAAKYA-----AVSSIWSGK---S AAM51827 -------------------DPADFVVSGSWSDKAFKEAKKFS-----AASVAWSGK---D SERC_BACCR -------------------KKAGYVLTGSWSKKALQEAEKVG-----EVQVIASSE---Q SERC_LACLA -------------------KKAYYNISGAFGEKAYDEAVKLSHFLDLMAISLGSTK---K SERC_BACCI -------------------QTANYVMTGSWASKALKEAKLIG-----DTHVAASSE---A SERC_BACSU -------------------KTAHFVMTGAWSEKALAETKLFG-----NTSITATSE---T CAD74688 -------------------KRAQYVLTGSWGKKAVKEAKKEG-----DVDVLFDAA---E XP_001327551 -------------------KAVDYLCTGTWSKKAFDECKRLAFPG-VTVNSVAGNP---P CAD70964 AAADEAQVLAALRQRVESGLKVDYIVTGSWSLKAYQEAVRLLGP--EYVNLVCDARTIND EAA50300 --KDDAKVAEALRPKLQY-LKLDYIVTGGWSLKAYQEAQRLVGP--EHVNLVADSRPANG SERC_YEAST -----------------------YLVTGSWSQKSFEEAKRLHVP--AEV--IFNAKDYNN SERC_SCHPO -----------------------YIITGAWSKKAYAEAERLGFP--CHV--AVDMKELAG CAC08322 ---------------------SQHLSFGEFSSKFAKAAKLAP-----WLAEPTVVA---- SERC_MYCTU ---------------------SLHLTYGEFSAKFASAVSKNP-----FVGEPIIIT---- NP_696810 ---------------------AAFGTYGSFSAKFAASAANAP-----FLEDPVLFP---- CAE29750 ---------------------VTTLAWESFGDGWVGDITKEL-----KLPNVTKLK---- NP_104887 ---------------------VDMVAWESFGSGWVTDVVKQL-----KLPDVRKLE---- NP_634935 ---------------------VDVLVWESFSKEWATDITKQL-----KLKDTRVFE---- SERC_METBA ---------------------VDVLVWESFSKGWATDITKQL-----KLKDVRVFE---- ZP_00093940 ---------------------VTTLAWESFGEGWVTDAAKQL-----KL-DPTVLR---- :. AAO76260 ATYTYIPK----DYT---IPADADYFHITTNNTIYGTELK----EDLNS-------PVPM AAQ66358 KNFSYIPK----DFV---IPEDVDYFHFTTNNTIYGTEIR----KDFDT-------KTRL BAD52335 KNYTYIP-----EYQ---IPSDYDYFHITTNNTIYGTEIR----KDIES-------PIPL SERC_HUMAN GSYTKIPDPS--TWN---LNPDASYVYYCANETVHGVEFD--FIPDV--------KGAVL SERC_RABIT GSYTKIPDPS--TWN---LNPDASYVYYCANETVHGVEFD--FVPDV--------KGAIL AAH44467 DSYTKIPDSS--TWS---LNPSASYVYYCCNETVHGVEFN--FIPDT--------KGVIL NP_001040269 DKYEDIPDQT--KWN---LDPNASYVHICTNETIHGVEFD--FIPDT--------KGVPL SERC_DROME AKYTTVPRQE--TWK---LDPNASYVYYCDNETVEGVEFD--FVPEVP-------AGVPL SERC_CAEEL KPYVTVPDQE--NWV---HDEKAAYLYYCANETVHGIEFT--PTAPES-------HNVPL SERC_CHRVO RNFCYVPEEA--AWQ---RDPNAAYLHYTSNETIGGLQFP--YIPAEQ------HGVP-L SERC_NEIMA FDYLDLPPVE--TWD---VAPDSAFVHFAVNETVNGLQYR--EVPRLS------EGMPPL CAD84244 DGFNSVPPLA--QWH---ISPDAAYVHYASNETIGGVEFQ--WTPDLSAVAGDNKNIP-L SERC_PSEST YDYFAISGQN--DWQ---LSDNAAYLHYASNETIGGLQFD--WVPELG-------DTP-L ZP_00151949 SGFTRLPAAD--EIR---LDPFAAYLHVCTNETIHGVEIP--AERIAD------TGVP-L SERC_ECOLI DGLRAVKPMR--EWQ---LSDNAAYMHYCPNETIDGIAID--ETPDFGA-------DVVV SERC_SALTY DGKRAVKPMR--EWQ---LSDNAAYLHYCPNETIDGIAID--ETPDFGP-------EVVV SERC_YEREN NGVTGIAPMK--QWK---LSDNAAYVHYCPNETIDGLAIN--EEPDFG--------NKVV SERC_XENNE DGITSVKPMN--EWA---LSSDAAYVHYCPNETIEGTAIF--EEPDFGD-------DKIV SERC_VIBVU EGKQAVLPAS--EWQ---IHPDAAYVHFCPNETIDGIEIN--DLP--VT-------DKPI SERC_HAEIN E-QTRITDLD--FSH---IADQYDYVHYCPNETISGVEIF--DVPNVG--------NAVL SERC_PASMU N-ELKIGQLD--FSH---IADQYDYVHYCPNETISGVEIF--DLPKVG--------NAVL SERC_ARATH EKYTKVPSFE--ELE---QTPDAKYLHICANETIHGVEFK--DYPVPKN--------GFL SERC_SPIOL DNYVRIPNFDGSEFV---QNSQARYLHICANETIYGVEFK--KYPVPANP------DGFL AAM51827 GKYTSLPPFD--AIE---QNPEARFLHICSNETIHGVEFK--DYPEPKNK------SGIL SERC_BACCR EKFTTIPKLDG-LLS---DEK-LDYVHITTNNTIEGTKYV--DIPHVEK--------VPL SERC_LACLA DNYNHLLKIDK-SKI---DEKNGAYLHLTTNNTIEGTSIFPENLPEFAS--------LPL SERC_BACCI SNYMTMPKLQ--EIQ---LQDNAAYLHLTSNETIEGAQFK--AFPDTG--------SVPL SERC_BACSU DNYSYIPEVD--LTD---VKD-GAYLHITSNNTIFGTQWQ--EFPNS---------PIPL CAD74688 SNYDHIPSAS--DLA---CPDDAAYMYYCSNETIQGVQFP--TEPNCPD-------SVPL XP_001327551 ANPVEVPARD--TWK---LSEDAAYFYYCDNETIQGIEFQ--QFPDVP---------APL CAD70964 GKFGKIPDES--TWK---LSKDAAYVYFCDNETVDGVEFP--NFPKILEPKE-DGTGPIV EAA50300 GKFGTIPPES--EWK---LSKDAAMVYYCDNETVDGVEFP--KFPDILATS--GGEGPLV SERC_YEAST GKFGKIPDES--LWEDKIKGKAFSYVYLCENETVHGVEWP--ELPKCLVND----PNIEI SERC_SCHPO -KYGSLPEDK--DLKFT-PDGETSLVYYCDNETVHGVEFN--EPPTNIPKG------AIR CAC08322 ADPGTHPEAR--------AEAGVDVYGLTHNETSTGVAMPIRRVAGADEG-------ALV SERC_MYCTU SDPGSAPEPQ--------TDPSVDVIAWAHNETSTGVAVAVRRPEGSDD--------ALV NP_696810 GEPGTYRLPE--------LTEGVDTYCWAHNETSTGVAAPIRRVAGSREAG------ALT CAE29750 AGYGEIPDLS--------KVDCNTDVVFTWNGTTSGVRVPNADWIKADRE-------GLT NP_104887 AGYGELPDLA--------KIDFDRDVVFTWNGTTSGVRVPNGDFIPADRK-------GLT NP_634935 AEYGKLPDLE--------NVDFKNDVVFVWNGTTSGVKVPNGDWIPDSRE-------GLT SERC_METBA AEYGKLPDLK--------KVDFKNDVVFVWNGTTSGVKVPNGDWIPENRE-------GLT ZP_00093940 ADYGQIPDLN--------AIDWSNDVLFTWNGTTSGVRVPNADFIPADRE-------GLA * * * AAO76260 VADMSSDIFSRPID-VSKYICIYGGAQKNLAPAG-VTFVIVKNDAVG------------- AAQ66358 VADMSSDIFSRPID-VSKYDLIYGGAQKNIGPAG-ATFVLVKTDVLG------------- BAD52335 VADMSSDILSKPID-ISKYSLIYAGAQKNCGAAG-VTIVIIKKEILG------------- SERC_HUMAN VCDMSSNFLSKPVD-VSKFGVIFAGAQKNVGSAG-VTVVIVRDDLLG------------- SERC_RABIT VCDMSSNFLSRPVD-VSKFGVIFAGAQKNVGAAG-VTVVIVRDDLLG------------- AAH44467 VSDMSSNFLSRPVD-VSKFGLIFAGAQKNVGCAG-VTVVIVREDLIG------------- NP_001040269 IADMSSNIMSKKVD-VSKFGVIYAGAQKNIGTSG-VALVIVREDLLN------------- SERC_DROME VADMSSNFLSRPFD-VSKFGVIYAGAQKNIGPAG-TTVIIVRDDLIG------------- SERC_CAEEL VADVSSNFMARPFD-FKDHGVVFGGAQKNLGAAG-LTIVIVRKDLIG------------- SERC_CHRVO VCDMSSDFLSREVD-VSRFGMIYAGAQKNIGPSG-LTVLLIREDLLG------------- SERC_NEIMA VCDMSSEILSREFD-VADYGLIYAGAQKNIGPAG-VTVVIVREDLLE------------- CAD84244 VADMSSNFLSRPFD-VSKFGLIYAGAQKNVGPAG-LVVVIVREDLLD------------- SERC_PSEST VVDMSSDILSRAID-VSKFGLIYAGAQKNIGPSG-LVVVIVRDDLLG------------- ZP_00151949 VADMSSHILSRPVN-VEKFGLIYAGAQKNIGPSG-LTLVIVHRDLLG------------- SERC_ECOLI AADFSSTILSRPID-VSRYGVIYAGAQKNIGPAG-LTIVIVREDLLG------------- SERC_SALTY TADFSSTILSAPLD-VSRYGVIYAGAQKNIGPAG-LTLVIVREDLLG------------- SERC_YEREN VADYSSSILSRPID-VSRYGVIYAGAQKNIGPAG-LTVVIVREDLLG------------- SERC_XENNE IADYSSTILSAPID-VSRYGVIYAGAQKNIGPAG-ITVVIIREDLLG------------- SERC_VIBVU VADMSSTILSREID-VSKYGVIYAGAQKNIGPSG-IAIAIVRDDLLG------------- SERC_HAEIN VADMSSNILSRQID-ISKFGVIYAGAQKNLGPAG-ITLVIIRDDLIG------------- SERC_PASMU VADMSSNILSRKID-ISQFGLIYAGAQKNLGPAG-ITLVIVREDLIG------------- SERC_ARATH VADMSSNFCSKPVD-VSKFGVIYGGAQKNVGPSG-VTIVIIRKDLIG------------- SERC_SPIOL VADMSSNFCSKPVD-VTKFGLIYAGAQKNVGPSG-VTIVIVRNDLIG------------- AAM51827 VADMSSNFCSKPVD-VSRFGLIYAGAQKNVGPSG-VTIAIVRKDLVG------------- SERC_BACCR VADMSSNILSERYD-VSKFGLIYAGAQKNLGPAG-LTIAIIKRDLI-------------- SERC_LACLA VADMSSNILAVDYD-VSKFGLIYAGAQKNLGIAG-LTIVIIREDLL-------------- SERC_BACCI IGDMSSDIMSRPFD-LNQFGLVYAGAQKNLGPSG-VTVVIVREDLVA------------- SERC_BACSU VADMSSDILSRKID-VSKFDVIYGGAQKNLGPSG-VTVVIMKKSWLQ------------- CAD74688 VSDASSDFLCRPLP-IEKYGLLYACAQKNAGPAG-VSVVIMRKDLLD------------- XP_001327551 IIDMSSNFLSRPITQWEKVGCIFACAQKNFGLAG-MSVVIIRKDMLE------------- CAD70964 VSDMSSNILSRRIP-VNNYSLLFFGAQKNLGCPG-VAVAILKKTFLPPTLSQPSPALL-- EAA50300 VADMSSNILSRRIP-VKNYGVLFFGAQKNLGSTG-VTVAVVKKSLLPPTTPQPSATLL-- SERC_YEAST VADLSSDILSRKID-VSQYGVIMAGAQKNIGLAG-LTLYIIKKSILK-NISGASDETL-- SERC_SCHPO VCDVSSNFISRKID-FTKHDIIFAGAQKNAGPAG-ITVVFVRDSVLA----RPTPAEL-- CAC08322 LVDATSGAGGLPVD-ISETDVYYFAPQKSFASDGGLWIGVFSPAAIERAERVHASG---- SERC_MYCTU VIDATSGAGGLPVD-IAETDAYYFAPQKNFASDGGLWLAIMSPAALSRIEAIAATG---- NP_696810 VIDGTSAAGALPVD-ISQTDVYYFSPQKAFGADGGLWVAILSPEAIDRAAGVESSAHLEG CAE29750 ICDATSAAFAQPLD-WAKLDVVTFSWQKALGGEAAHGMLILSPRAVARLESYTPTWP--- NP_104887 ICDATSAAFAQRLD-FEKLDVVTFSWQKVLGGEGAHGMLILSPRAVARLESYKPAWP--- NP_634935 LCDATSAVFAMDIP-YHKLDVLTFSWQKVLGGEGAHGMLILSPRAVQRLESYTPAWP--- SERC_METBA LCDATSAIFAMDIP-YHKLDVITFSWQKVLGGEGAHGMLILSPRAVQRLESYTPAWP--- ZP_00093940 FADATSAVFAYDID-WSKIDVATFSWQKVLGGEGGHGVLILGPRAVERLETYTPAWP--- * :* ** . . . .. : AAO76260 ----KVS-RYIPSMLNYQTHIDNGSMFNTPPVVPIYAALLNLRWIKA---QGGVKEMERR AAQ66358 ----QVD-RPLPDMLNYQIHIKKDSMFNTPPVFPVYVALQTMKWYKE---LGGVKVLEKM BAD52335 ----KVQ-RKIPIILDYQVHILNNSMYNTPPVISIFTVNQTLKYIKK---IGGLKKIQEL SERC_HUMAN ----FAL-RECPSVLEYKVQAGNSSLYNTPPCFSIYVMGLVLEWIKN---NGGAAAMEKL SERC_RABIT ----FAL-RECPSVLEYKVQATSSSLYNTPPCFSIYVMGLVLEWIKN---NGGAAAMKKL AAH44467 ----KAL-KECPIILDYQVQAGNNSLYNTPPCFSIYIMGLVLEWIRN---NGGADAMERL NP_001040269 ----QAL-PTCPSLLDWTANYKQNSILNTPPMFAIYIMGRVLQWIQR---NGGLEGMSQL SERC_DROME ----KHL-KITPSILNFEQMDKNNSLLNTPPTFGIYVMGLVFKWIKR---NGGVAGMAKL SERC_CAEEL ----KQQ-AITPSVFSYKEMIANNSLYNTPPTGGIYTTNLVLKWIKS---KGGLQAIYEL SERC_CHRVO ----KAR-ADIPTMLNYQVHADADSMYNTPGTYPIYIAGLVFKWLKE---QGGVKGIATR SERC_NEIMA ----RCP-NDIPDVFNYRSHINRDGMYNTPSTYAIYMSGLVFRWLQA---QGGVKKIEAV CAD84244 ----IPPLAGTPAMFRYKTHADNASMYNTPPTYAIYIMGLVMEWLKK---QGGLTAIEQR SERC_PSEST ----KAR-SSCPTMLDYKIAADNGSMYNTPATFSWYLSGLVFEWLKE---QGGVEVMEQR ZP_00151949 ----MAP-LTIPTVMDYAVMAENGSMLNTPPTYGIYIAGLVFQWLKR---QGGLPGIAAV SERC_ECOLI ----KAN-IACPSILDYSILNDNGSMFNTPPTFAWYLSGLVFKWLKA---NGGVAEMDKI SERC_SALTY ----KAH-ESCPSILDYTVLNDNDSMFNTPPTFAWYLSGLVFKWLKA---QGGVAAMHKI SERC_YEREN ----KAR-TELPSILDYKVLAENDSMFNTPPTFAWYLSGLVFKWLKE---QGGLGEMGKR SERC_XENNE ----KAH-KHIPSILDYTVQVKADSMYNTPPTFAWYLSGMVFKWLKE---QGGLQEISKR SERC_VIBVU ----LAK-EVLPSILNYKVLAEQDSMFNTPPTFAWYLSGLVFKWLKA---QGGVKAIEQV SERC_HAEIN ----NAR-KETPSIWNYATQRDADSMINTPPTFAWYLCSLVFKHLKE---IGGLEIIEKR SERC_PASMU ----HAR-QTTPTIWNYEIQSKADSMINTPPTFAWYLCALVFKHLLS---LGGIEEIEKR SERC_ARATH ----NAQ-DITPVMLDYKIHDENSSLYNTPPCFGIYMCGLVFEDLLE---QGGLKEVEKK SERC_SPIOL ----NAQ-KMTPVMLDYKIHADNKSLYNTPPCYGIYMCGLVFEDLLN---QGGLVEVEKK AAM51827 ----SAQ-PITPVMLDYKTHADNASLYNTPPCFAIYICGLVFEDLLA---QGGLAEVEKK SERC_BACCR ----GEADRSCPTMLNYETYSKNNSLYNTPPSFSIYVTKLVLEWLKE---QGGVSAIEEQ SERC_LACLA ----NEAE-SLSSMMDYQILVENGSMYNTPPTFAIYVAGLVFKWVKA---QGGVKKLEEM SERC_BACCI ----ESP-KHLPTMLRYDTYVKNNSMYNTPPSFGIYMVNEVLKWIEE---RGGLEGVQQA SERC_BACSU ----NEN-ANVPKILKYSTHVKADSLYNTPPTFAIYMLSLVLEWLKE---NGGVEAVEQR CAD74688 ----KAD-PNIPGYLHFKNHHDNDSEWNTPPTFAIYVLGKVARWLRDD--MGGLEKMESI XP_001327551 ----RPVKPFCPITMDYRIQVKNNCMYNTPPTFAIYFANHIFKWIEE---KGGLAAMDAL CAD70964 ---RKLALPIPPIVLQYEIIAKNNSLYNTLSIFDVYIAGQVLKKLLATFPNG-VDGQQAL EAA50300 ---RKLGLPVGPIILSYETIAKNNSLYNTLSIFDVYIAGLVLKKLLATYPADKVDGQQAV SERC_YEAST ---HELGVPITPIAFDYPTVVKNNSAYNTIPIFTLHVMDLVFQHILK---KGGVEAQQAE SERC_SCHPO ---HKLNIPVSPTVSDYKIMADNHSLYNTLPVATLHAINLGLEYMLE---HGGLVALEAS CAC08322 --RHVPEFFSLP---TAIDNSRKNQTYNTPALATLFLLGEQLDWMNG---QGGLDFTTAR SERC_MYCTU --RWVPDFLSLP---IAVENSLKNQTYNTPAIATLALLAEQIDWLVG---NGGLDWAVKR NP_696810 AHRWVPPFLSLT---TALNNSRKDQTLNTPAVATLIMMENQIRWLNN---NGGLAWATTR CAE29750 ----MPKIFRLTKGGKLMEGIFQGETINTPSMLCVEDYIDALQWAKS---VGGLKGLIAR NP_104887 ----LPKIFRLTSGGKLIEGIFKGETINTPSMLCVEDYLDALHWAKS---IGGLDVLVAR NP_634935 ----LPKIFRLTKGGKLNKEIFEGSTINTPSMLANEDWLATLKWAES---VGGLKQLIQR SERC_METBA ----LPKIFRLTKGGKLNKKIFEGSTINTPSMLANEDWLATLKWAES---VGGLKPLIQR ZP_00093940 ----LPKVFRLVSKGKLAEGVFKGETINTPSMLAVEDAIFALEWAKG---LGGLEGLQAR ** . AAO76260 AIEKADMLYAEIDRNK-LFVGTAAK-EDRSRMNICFVMAPEYK----------DLEADFM AAQ66358 NLDKAALIYDAIDSSK-IFRGTVNP-EDRSIMNACFVMKDEYK----------ELEKEFA BAD52335 NEEKARLLYAEIDRNK-IFRGTVRK-KDRSIMNVCFVMEEQYK----------QLENEFS SERC_HUMAN SSIKSQTIYEIIDNSQGFYVCPVEP-QNRSKMNIPFRIGNAKGD------D--ALEKRFL SERC_RABIT STIKSQMIYEIIDNSQGFYVCPVEP-RNRSMMNIPFRIGNAKGD------E--ALEKRFL AAH44467 NKQKSALVYDIINRSNGFYSCPVDA-ACRSRMNIPFRIGKKEGD------E--SLEKSFL NP_001040269 ATKKASLIYNTIEQSNGFYYAPVAK-NVRSKMNVPFRIG-CPGD------D--ALEKEFL SERC_DROME AAAKSKLIYDTINQSNGFYYCPVDV-NVRSRMNVPFRIGSASGD------D--ALEKEFL SERC_CAEEL NLQKSGMIYDIIDNSNGFYHCAVDK-RYRSIMNVCFRIGGPSGN------D--ELEEKFL SERC_CHRVO NEEKAGLLYHVIDSSGGFYSTHIEQ-PFRSKMNVVFKLRDE------------ALDEIFL SERC_NEIMA NRLKAQTLYETIDGSGGFYINRIRP-NARSKMNVVFQTGDE------------ELDRRFV CAD84244 NIAKAKLIYDLIDVSS-FYHCPVNQ-ADRSRMNVPFTLSDP------------GLDDAFL SERC_PSEST NRAKKELLYGFIDASE-FYTNPIAE-NARSWMNVPFRLADE------------RLDKAFL ZP_00151949 NAEKARILYAAIDDSEGFYTNPVDP-DCRSAMNVPFVLANP------------ELDAAFL SERC_ECOLI NQQKAELLYGVIDNSD-FYRNDVAK-ANRSRMNVPFQLADS------------ALDKLFL SERC_SALTY NQQKAELLYGVIDNSD-FYRNDVAQ-ANRSRMNVPFQLADN------------TLDKVFL SERC_YEREN NQAKAELLYGAIDRTD-FYRNQVAT-ANRSWMNVPFQMIDP------------SLDKLFL SERC_XENNE NLAKAELLYRAIDNSN-LYINRVAL-QNRSIMNVPFQLVNP------------ALDGKFL SERC_VIBVU NREKAAILYNYIDESD-FYINNVHP-DNRSLMNVPFQMVKP------------ELDAKFL SERC_HAEIN NALKAQTLYDYIDSSK-LYRNVVAK-ENRSTMNVTFITGNP------------ELDAKFV SERC_PASMU NQAKAQLLYDYLESTP-FYRNPVAK-VNRSRMNVTFTTDND------------ELNAKFV SERC_ARATH NQRKADLLYNAIEESNGFFRCPVEK-SVRSLMNVPFTLEKS------------ELEAEFI SERC_SPIOL NKAKAQVLYDAIDESNGFYKCPVEK-SVRSLMNVPFTLEKS------------ELEGDFI AAM51827 NAHKAGILYDAIDASGGYYICPVEK-SVRSLMNVPFTLAKGG-----------DFEKQFI SERC_BACCR NRMKSSLLYNFLDESK-LFTSPVDP-TYRSLMNIPFTTPSE------------ELNSEFL SERC_LACLA NQRKAQLLYDLIDQSD-FYQNPIKNKDERSICNVVFTSPSQ------------ELDELFT SERC_BACCI NRKKASLIYDAIDQSGGFYRGCVDV-DSRSDMNITFRLASE------------ELEKEFV SERC_BACSU NEQKAQVLYSCIDESNGFYKGHARK-DSRSRMNVTFTLRDD------------ELTKTFV CAD74688 NHEKSQQLYSVIDSSNGFYRGHAQT-DCRSLMNVTFNLPSD------------ELTAKFI XP_001327551 NKEKAKKVYEAIDSNP-NFVNRIKP-EWRSRMNMPFFRPDGYEN------KDLDADAKFV CAD70964 AEKKAELIYSALEAHPEAYKIVPDK-SARSKMNICFRVIKGG--------NVDEAEKAFL EAA50300 ADKKAKLIYAALDAHPEVFRVVPAK-SARSRMNICFRVTKGGEA------NTDAAEKEFL SERC_YEAST NEEKAKILYEALDANSDFYNVPVDP-KCRSKMNVVFTLKKDG------------LDDQFL SERC_SCHPO SIEKSKLLYDTLDKH-DLYISVVEP-AARSRMNVTFRIEPQE------------LESEFL CAC08322 TKDSSSRLYTWADESKYATPFVSDP-TKRSQVIGTIDFSDD------------IDAAAVA SERC_MYCTU TADSSQRLYSWAQERPYTTPFVTDP-GLRSQVVGTIDFVDD------------VDAGTVA NP_696810 CAKSASILYSWAERSEYAAPFVVDA-DARSNAVVTIDLDER------------VQASQVL CAE29750 ADANTKVLTDWQAKTPWVDFLAKDP-AIRSNTSVCLKVVDPAITALSPEAQADFAKKLVA NP_104887 ADANAAVLDGFVDKSSWLGHLAVQP-ATRSNTSVCLSFTDPDVAALDADGQATFAKGLVS NP_634935 TNENLAVFEAFVAKNNWIHFLAETK-EIRSSTSVCFKVD------LSEEK----LKELIK SERC_METBA TNDNLAVFEAFVAKNNWIHFLAETK-EIRSSTSVCFKVD------LSDEK----LKELIK ZP_00093940 SDANAAALNKIVEERSWLSHLAADE-ATRSKTSVCLSVEG---------ADADFIKKFAG . . ** : . AAO76260 KFATEKGMVGIKGHR--SVGGFRASCYNALPKESVQALIDCMQEFEKLH-------- AAQ66358 TFAASRGMVGIKGHR--SVGGFRASLYNALPIESVQSLVSVMKEFEAKH-------- BAD52335 EYALQKGIIGIKGHR--SVGGFRASIYNAVTIESVQALIKCMHDFEQLHTH------ SERC_HUMAN DKALELNMLSLKGHR--SVGGIRASLYNAVTIEDVQKLAAFMKKFLEMHQL------ SERC_RABIT DKALELHMISLKGHR--SVGGVRVSLYNAVTIEDVQKLASFMKNFLEMHQL------ AAH44467 DGASKLGMISLKGHR--SVGGIRASLYNAVTVEDVKILAAYMEDFLRNHQ------- NP_001040269 KGAETLGLIQLKGHR--DVGGIRASIYNAVTLEEVQALVQYMEEFYKKHSK------ SERC_DROME SKAEAEGMIQLKGHR--SVGGIRASLYNAVTLAETQQLANLMLAFYKNNKNKLHNTN SERC_CAEEL KGSIERNMISLKGHR--SVGGIRASLYNAISVEETQVLATWMNEFQKLHNTN----- SERC_CHRVO LEARKNGLAQLKGHR--AVGGMRASIYNAMPIEGVKSLVNFMQDFARQYG------- SERC_NEIMA LEAELQGLCLLKGYK--TVGGMRASIYNAMPLEGVRALADFMRDFQRRYG------- CAD84244 KQAQAHGLIQLKGHR--SVGGMRASIYNAMPLEGVQTLVTFMREFEKNHA------- SERC_PSEST AGADARGLLNLKGHR--SVGGMRASIYNAVGLDAVEALVAYMAEFEKEHG------- ZP_00151949 AESKAAGLVSLKGHK--SVGGMRASIYNAVSLAGVQSLVDFMNDFAQRKA------- SERC_ECOLI EESFAAGLHALKGHR--VVGGMRASIYNAMPLEGVKALTDFMVEFERRHG------- SERC_SALTY EESFAAGLHALKGHR--VVGGMRASIYNAMPIEGVKALTDFMIDFERRHG------- SERC_YEREN SEAEAQGLQALKGHR--VAGGMRASIYNAMPIEGVKALTDFMAEFERRHG------- SERC_XENNE EEAYAHGLHALKGHK--VAGGARASIYNAMSYEGVKALVEFMADFERRNG------- SERC_VIBVU KEAEALGLKSLKGHR--VVGGMRASIYNAMPIEGVKALVDFMRQFEQENA------- SERC_HAEIN AESTAAGLQALKGHK--VLGGMRASIYNAMSQNGVEALISFMKKFETENLPQ----- SERC_PASMU AEATAAGLHALKGHK--VLGGMRASIYNAMPMEGVQALIAFMKQFEAENR------- SERC_ARATH KEAAKEKMVQLKGHR--SVGGMRASIYNAMPLAGVEKLVAFMKDFQAKHA------- SERC_SPIOL KEAAKEKMVALKGHR--SVGGMRASIYNAMPLAGVEKLVAFMKEFQAKHA------- AAM51827 AEAAKEGMVQLKGHR--SVGGVRASIYNAMPLAGVEKLVAFMKDFQARNP------- SERC_BACCR QKAKERGLVTLKGHR--SVGGMRASIYNAMPVQGVQQLVNYMKEFELENR------- SERC_LACLA QKAEEKGFKSLKGHR--SVGGMRASIYNAFPLEGVVELVKFMKEFEEGYK------- SERC_BACCI KASEQEGFVGLKGHR--SVGGLRASIYNAVPYESCEALVQFMEHFKRSRG------- SERC_BACSU QKAKDAKMIGLGGHR--SVGGCRASIYNAVSLEDCEKLAAFMKKFQQENE------- CAD74688 AEAAEHKLAALKGHR--SVGGIRASIYNAMPREGVNALASFMNNFASKNS------- XP_001327551 NFCTQRKLLTLKGHV--SVGGFRASCYNACPMEAVDALVQAMKEWPGF--------- CAD70964 KESTAINLTGLKGHR--SVGGIRASNYNSIPLEGAEKLANFIHEFAKA--------- EAA50300 KQATALNLTGLKGHR--SVGGIRASNYNSIPLEGAEKLARFIEDFAKA--------- SERC_YEAST KEAAARHLTGLKGHR--SVGGFRASIYNALSVKAVQNLVDFIKEFAEKNA------- SERC_SCHPO AEAEKHHLVQLKGYR--SVGGIRASLYNAISVEQTRRLIDLLESFAKAHSN------ CAC08322 KVLRANGIVDTEPYRKLGRNQLRVAMFPAIDPADVEALTKCVDHVIEKL-------- SERC_MYCTU KILRANGIVDTEPYRKLGRNQLRVAMFPAVEPDDVSALTECVDWVVERL-------- NP_696810 SILRENGIVDAAGYRKLGRNQLRVGVFPSVEPADVMAFTKCVDYVVEHL-------- CAE29750 AVEKEGAGFDLGAYRDAPPG-LRIWCGATVEAADVAALTQWLDWAFETTKASLTQAA NP_104887 ALDKEGVAYDIGSYRDAPPG-LRIWCGATVETSDLETLLPWLDWAFAAQKASLKAAA NP_634935 MLENEKVAYDIGSYRDAPSG-LRIWCGATIEKEDLECLCEWIEWAYDLVK------- SERC_METBA TLEKEKVAYDIGSYRDAPSG-LRIWCGATVEKEDLQCLCEWIEWAYNLVK------- ZP_00093940 LLEKQGAAYDIAGYRDAPAG-LRIWCGATVNAEDIADLGPWLDWAYETTRAELAAA- : . * : : :