CLUSTAL W(1.5) multiple sequence alignment AAP34326 maedllseqcksslppgGMTVEEYRKR-------GKEMVDYIADYFLDIR DCHS_DROME ------------------MDFKEYRQR-------GKEMVDYIADYLENIR DCHS_HUMAN -----------------MMEPEEYRER-------GREMVDYICQYLSTVR DCHS_MOUSE -----------------MMEPCEYREYreyyrarGKEMVDYISQYLSTVR DCHS_RAT -----------------MMEPSEYHEYq----arGKEMVDYICQYLSTVR EAA14857 ------------------MDFDEYRVR-------GKEMVDYIADYLQNIR NP_001096063 ------------------MQPQEYMLR-------GKEMVEYIHQYLTGIR XP_001603214 ------------------MNLEEYRQH-------GKEMVDYIADYLENIR XP_392129 ------------------MNLEEYRKH-------GKEMVDYIADYLENIR XP_413833 ------------------MEPEEYRRR-------GKEMVDYICQYLSNVR XP_789367 ------------------MDVEEYRRR-------GKEMVDYVADYLSTIR AAP34326 SRRVFPDVQPGYMQALVPDRAPEEPNKWEDIFADVERVIMPGVTHWQSPR DCHS_DROME ERRVFPDVSPGYMRQLLPESAPIEGEPWPKIFSDVERIVMPGITHWQSPH DCHS_HUMAN ERRVTPDVQPGYLRAQLPESAPEDPDSWDSIFGDIERIIMPGVVHWQSPH DCHS_MOUSE ERQVTPNVQPGYLRAQLPASAPEEPDSWDSIFGDIERVIMPGVVHWQSPH DCHS_RAT ERQVTPNVKPGYLRAQIPSSAPEEPDSWDSIFGDIEQIIMPGVVHWQSPH EAA14857 ERRVLPDVQPGYMRSLIPESAPLEGERWENIFADVERVIMPGITHWQSPH NP_001096063 ERRVLPDVQPGFMRPLLPSSAPYEPEDWSTIMQDVENIIMPGVVHWQSPH XP_001603214 KRRVYPSVSPGYLRNILPQSAPVDGEPWADIFDDIEKCIMPGVTHWQSPH XP_392129 SRRVYPAVSPGYLRNILPSSAPVNGESWEDIFADIERCIMPGVTHWQSPH XP_413833 ERRVTPDVQPGYMRAQLPDSAPMDPDSWDNIFGDIEKIIMPGVVHWQSPH XP_789367 SRRTLPDVQPGYLKQLIPDHAPVNGDKWDDIMEDIERVIMPGITHWQSPH AAP34326 MHAYFPALTSYPSLLGDMLADAVSCLGFTWASSPACTELETIVMDWLGKM DCHS_DROME MHAYFPALNSMPSLLGDMLADAINCLGFTWASSPACTELEIIVMNWLGKM DCHS_HUMAN MHAYYPALTSWPSLLGDMLADAINCLGFTWASSPACTELEMNVMDWLAKM DCHS_MOUSE MHAYYPALTSWPSLLGDMLADAINCLGFTWASSPACTELEMNIMDWLAKM DCHS_RAT MHAYYPALTSWPSLLGDMLADAINCLGFTWASSPACTELEMNIMDWLAKM EAA14857 MHAYFPALNSFPSLLGDMLADAINCLGFTWASSPACTELESIVMNWLGKM NP_001096063 MHAYFPALNSWPSLLGDMLADAINCLGFTWASSPACTELEMCVLDWLCKA XP_001603214 MHAYFPALNSPASLLADMLADAINCLGFTWASSPVCTELETIVMNWLGKM XP_392129 MHAYFPALNSPASLLADMLADAINCLGFTWASSPACTELETIVMNWLGKM XP_413833 MHAYFPALTSWPSLLGDMLADAINCLGFTWASSPACTELEMNVMDWLAKM XP_789367 MHAYFPALTSYPSMLGDMLADGISCLGFTWASSPACTELEKIVMDWLADL AAP34326 LELPESFLHGEKGSrsLGGGCIQTTASDCTFVTLLAARTDAIARYKAI-- DCHS_DROME IGLPDAFLHLSSQS--QGGGVLQTTASEATLVCLLAGRTRAIQRFHER-- DCHS_HUMAN LGLPEHFLHHHPSS--QGGGVLQSTVSESTLIALLAARKNKILEMK--TS DCHS_MOUSE LGLPEYFLHHHPSS--RGGGVLQSTVSESTLIALLAARKNKILAMT--AC DCHS_RAT LGLPDFFLHHHPSS--QGGGVLQRTVSESTLIALLAARKNKILEMKAH-- EAA14857 IGLPDSFLHLPGTS--MGGGVIQTTASEATLVCLLAGRTMAITRFHEH-- NP_001096063 LGLPDHYLHHHPQS--TGGGILQSTVSECTLVALLAARKDRILQMKSEAT XP_001603214 IDLPDDFLHQADGS--GGG-VIQTTASESTLVCLLAARTRAIRDVQEN-- XP_392129 IGLPEEFLHRPGGS--GGGGVIQTTASEATLVCLLAARTRAIRDVQQN-- XP_413833 LGLPDKFLHHHPDS--VGGGVLQSTVSESTLVALLAARKNKILEMK--LS XP_789367 IGLPSTFTHRDTTN--TGGGVLQGTMSEATLVSMFAARRDAIIRLQEKPE AAP34326 HPDKDEAWINGRLIGYCSDQAHSSVEKAGLIGLVKMRFLPSDENLSLRGS DCHS_DROME HPGYQDAEINARLVAYCSDQAHSSVEKAALIGLVRMRYIEADEDLAMRGK DCHS_HUMAN EPDADESCLNARLVAYASDQAHSSVEKAGLISLVKMKFLPVDDNFSLRGE DCHS_MOUSE EPDANESSLNARLVAYTSDQAHSSVEKAGLISLVKIRFLPVDDNFSLRGE DCHS_RAT EPNADESSLNARLVAYASDQAHSSVEKAGLISLVKIKFLPVDDNFSLRGE EAA14857 TPGLQDAEINARLVAYCSDQAHSSVEKAALIGLVRMRFIESDDQLSLRGD NP_001096063 HTDTDESVLNSRLVAYASDQAHSSVEKAGLISLVKIRFLQTDAVFSLRGE XP_001603214 DPDLLPAEINSRLVAYCSDQAHSSVEKAGLIGLVRMRYIDSDDNLSMRGE XP_392129 EPDRLPAEINSRLVAYCSDQAHSSVEKAGLIGLVRMKYIESDDELSMRGE XP_413833 EPDADESSLNSRLIAYASDQAHSSVEKAGLISLVKMKFLPVDENFSLRGE XP_789367 YQGMEEAVICSKLVAYCSDQAHSSLEKNAVIAMVKLRHVPSDKKLSLRGE AAP34326 TLQEAVSKDRERGFIPFYVCATLGTTGACAFDNLAEIGPVCRSEKLWLHL DCHS_DROME LLREAIEDDIKQGLVPFWVCATLGTTGSCSFDNLEEIGIVCAEHHLWLHV DCHS_HUMAN ALQKAIEEDKQRGLVPVFVCATLGTTGVCAFDCLSELGPICAREGLWLHI DCHS_MOUSE ALQKAIEEDKQQGLVPVFVCATLGTTGVCAFDRLSELGPICASEGLWLHV DCHS_RAT ALQKAIEEDKQQGLVPVFVCATLGTTGVCAFDKLSELGPICAREGLWLHV EAA14857 ALREAIEEDIKQGLIPFWVCATLGTTGACAFDHLDEISEVCARYNIWLHV NP_001096063 TLQRAVEEDRRSGLIPVMVCATLGSTGVR--------------EGLWLHV XP_001603214 KLAEALQRDREEGLVPFFVCATLGTTGACSFDNVQEIGPICERNGLWLHV XP_392129 TLLEAITQDRADGLLPFFVCATLGTTGACAFDNLKEVGQVCEQNGLWLHV XP_413833 TLKKAIAEDRKKGLVPIFVCATLGTTGVCAFDSLSELGPICGAEGLWLHI XP_789367 ALHAAIEQDRSRGLVPFFVCATLGTTGACAFDNLAELSEICERDNLWLHV AAP34326 DAAYAGSAFICPEFRSWMAGIEFSDSFAFNPSKWLMVHFDCSAMWVKDAR DCHS_DROME DAAYAGSAFICPEFRTWLRGIERADSIAFNPSKWLMVHFDATALWVRDST DCHS_HUMAN DAAYAGTAFLCPEFRGFLKGIEYADSFTFNPSKWMMVHFDCTGFWVKDKY DCHS_MOUSE DAAYAGTAFLCPELRGFLEGIEYADSFTFNPSKWMMVHFDCTGFWVKDKY DCHS_RAT DAAYAGTAFLRPELRGFLKGIEYADSFTFNPSKWMMVHFDCTGFWVKDKY EAA14857 DAAYAGSAFICPEFRVWLKGIEKADSIAFNPSKWLMVHFDCTAMWLKNSG NP_001096063 DAAYAGSALLCPELRYFLDGIQFADSFVFNPSKWMLVHFDCTAFWVKNKM XP_001603214 DAAYAGSAFVCPEFRSWMKGIEYADSFAFNPSKWLMVHFDCTAMWVRNSQ XP_392129 DAAYAGSAFVCPEFRGWLKGIEYADSIAFNPSKWLMVHFDCTAMWVKSSQ XP_413833 DAAYAGTAFLCPEFRLFLDGIEYADSFAFNPSKWMMVHFDCTGFWVKDKY XP_789367 DAAYAGTAFLCPEFRGHLHGVETVQSFAFNPSKWLMVHFDCTAMWIRDSK AAP34326 ALHRTFNVEPLYLQHENSGAAIDYMHWQIALSRRFRALKLWFVLRSFGVS DCHS_DROME AVHRTFNVEPLYLQHENSGVAVDFMHWQIPLSRRFRALKVWFVLRSYGIK DCHS_HUMAN KLQQTFSVNPIYLRHANSGVATDFMHWQIPLSRRFRSVKLWFVIRSFGVK DCHS_MOUSE KLQQTFSVNPIYLRHANSGAATDFMHWQIPLSRRFRSIKLWFVIRSFGVK DCHS_RAT KLQQTFSVNPIYLRHANSGVATDFMHWQIPLSRRFRSIKLWFVIRSFGVK EAA14857 ALHRTFNVAPLYLQHENSGLSIDYMHWQIPLSKRFRALKLWFVLRSFGTR NP_001096063 KLQQTFTVDPLYLRHDNS-NATDFMHWQIPLSRRFRSLKLWFVIRSFGLK XP_001603214 SLHRTFNVEPIYLQHENSGLAIDYMHWQIPLSKKFRALKLWFVIRNYGIT XP_392129 ALHRTFNVDPLYLKHENSGLAIDYMHWQIPLSKRFRALKLWFVIRNYGIT XP_413833 KLHQTFSVNPVYLRHPNSGAAVDFMHWQIPLSRRFRSLKLWFVIRSFGVK XP_789367 TLEKAFCVKPLYLRHDKQGSAVDFMHWQIPLSRRFRSLKLWFVLRSFGVK AAP34326 GLQRHIRRGVELAQMFENLVQADLRFEVTAPRWLGMVVFRLVGPNELTEA DCHS_DROME GLQRHIREGVRLAQKFEALVLADHRFELPAKRHLGLVVFRIRGDNEITEK DCHS_HUMAN NLQAHVRHGTEMAKYFESLVRNDPSFEIPAKRHLGLVVFRLKGPNCLTEN DCHS_MOUSE NLQAHVRHGTEMAKYFESLVRSDPSFEIPAKRHLGLVVFRLKGPNCLTES DCHS_RAT NLQAHVRHGTDMAKYFESLVRSDPVFEIPAERHLGLVVFRLKGPNCLTES EAA14857 GLQKHIREGVRLAQKFEALILADHRFEIPATRHLGMVVFRIKGENELTEK NP_001096063 KLQEHIRHGVEMAKLFESLVRKDTHFQIPAQRHLGLVVFCLRAGNAATQE XP_001603214 GLQKHIREGVRLAQKFEALVLADSRFEIPAARHLGMVVFRLRGENSLTER XP_392129 GLQKHIREGVRLAQKFEALVLADARFEIPATRHLGLVVFRLRGENSLTER XP_413833 KLQAHVRHGTETAKFFESLVRSDPLFEIPAKRHLGLVVFRLKGPNWLTEK XP_789367 KLQEHVRRGVRLGHYFEKLVLNDAAFEIPAERILGLIVFRLKGPNGLTQE AAP34326 LLKRLNKEGKVHMVPASLKGKYVIRFTVTSQFTLESDIEKDWITITDMAS DCHS_DROME LLKRLNHRGNLHCIPSSLKGQYVIRFTITSTHTTLDDIVKDWMEIRQVAS DCHS_HUMAN VLKEIAKAGRLFLIPATIQDKLIIRFTVTSQFTTRDDILRDWNLIRDAAT DCHS_MOUSE VLKEIAKAGQLFLIPATIQDKLIIRFTVTSQFTTKEDILRDWHLIQEAAN DCHS_RAT VLKEIAKTGQVFLIPATIQDKLIIRFTVTSQFTTKDDILRDWNLIREAAN EAA14857 LLKRLNQRGHMHAVPASLKGRYVIRFTVTSTYTTNDDILSDWNEIRTVTT NP_001096063 LLRKLTRSGRMFLIPAAVGNQLILRFSVTSQLTTEQDIRRDWSLIQQAAR XP_001603214 LLKKMNSRGRVHCVPAALHGKYVIRFTVTSTNTTNEDILRDWAEIKSTAT XP_392129 LLKKMNSRGRVHCVPAALHGKYVIRFTVTSTNTTNEDILRDWAEIRNTAN XP_413833 LLKELSSSGRLFLIPATIHDKFIIRFTVTSQFTTREDILQDWNIIQRTAA XP_789367 LLRRLNYSGKIYVVPASIKGLYVIRFTVTSTETTEDDILEDWRLIQSLAR AAP34326 KILIEAgeqadesieendeedDDTSEAETTQMSTNSNKEepptlqrvprk DCHS_DROME TVLEEM----------------NITISN--RVYLKETKE----------- DCHS_HUMAN LILSQH---------------CTSQPSPRVGNLISQIRG----------- DCHS_MOUSE LVLSQH---------------CTSQPSPRAKNVIPPPPG----------- DCHS_RAT LVLSQH---------------CTSQPSPRAKNLIPPPVTr---------- EAA14857 ELLSDL----------------NIQQVDKQRVSLKDTRE----------- NP_001096063 EVLQSG-------------------VVTRQPSVTSDPES----------- XP_001603214 EILGSG----------------TSSPSR-ARVSLAETRE----------- XP_392129 EILDDD----------------TISPVR-AKVPLADTRE----------- XP_413833 QIISQHne----------lhrVSSGDEAKIPNMISEPSS----------- XP_789367 EIFVST-----------------------EFVANVPT------------- AAP34326 naarsngltngeahlcrprplphplphAKTASLRRKEFGISLLLSNVPMS DCHS_DROME ---------------------------------KNEAFGSSLLLSNSPLS DCHS_HUMAN ---------------------------ARAWACGTSLQSVSGAGDDPVQA DCHS_MOUSE -------------------------------TRGLSLESVSEGGDDPAQA DCHS_RAT --------------------------dSKDLTNGLSLESVNEGGDDPVQV EAA14857 ---------------------------------KNEAFGSSLLLANSPMS NP_001096063 -----------------------------------EPEPLTIH-TEPMLD XP_001603214 ---------------------------------KNENFGSSLLLANSPMS XP_392129 ---------------------------------KNENFGTSLLLANSPMS XP_413833 -------------------------------SVISHASQLYLEGKYKIPS XP_789367 ---------------------------------RMASWPGALNLTGAPGA AAP34326 PKVVNGSFAALYDDNDVG---LEQLAGQLSVGGEFIRLSPRKRGKLSEkD DCHS_DROME PKVVNGSFAAIFDADEFL---AKTYAGVRIAHQESPSMRRRVRGILMS-G DCHS_HUMAN RKIIKQPQRVGAGPMKRENGLHLETLLDPVDDCFSEEAPDATKHKLSS-- DCHS_MOUSE RKIIKQP---GASLARREGGSDLETMPDPFDDCFSEEAPNTTKHKLSS-- DCHS_RAT RKIFRLP------------GDSLETTMDPFDDCFSEEASDTTKHKLSS-- EAA14857 PKIVNGSFAAIFDADEFL---AKVYAGIRISNQDSPAMRRRVRGILMS-G NP_001096063 QRLVRQG--------------QRRAVRSYSCSAELPPAPGRTQTHRDA-- XP_001603214 PKIVNGSFAAIYDAADVFNECMKTFGQLRMEARDSPAMRRRIRGILMS-G XP_392129 PKIVNGSFAAIYDTADVFEECTKAFGQLRLEARDSPAMRRRIRGILMS-G XP_413833 RKIVGQPKKLAASPSTCVISQQVQGQGD-LDDCFPEDVQDVTKHKLTS-- XP_789367 THVLKNRKEIYIENNNED---------KKEEDEENESLAKKMEG------ AAP34326 RQRSLDCsflayrrdnpiKMKMMGSLdskiddile--------mgskvag DCHS_DROME KQFSLDS-----------HMDVVVQTtldagngatrtsttnsyghttsaa DCHS_HUMAN ------------------FLFSYLSV------------------------ DCHS_MOUSE ------------------FLFSYLSV------------------------ DCHS_RAT ------------------FLFSYLSV------------------------ EAA14857 KQFSLDS-----------RMDLVVHG------------------------ NP_001096063 ------------------PLQLIPEQ------------------------ XP_001603214 KQFSLDS-----------RMDLVQGY------------------------ XP_392129 KQFSLDS-----------RMDLVQGY------------------------ XP_413833 ------------------FLFSYLSV------------------------ XP_789367 -------------------MNVEEKA------------------------ AAP34326 ggDDSDGETAEGRKEKDKEEDDRREGKGKVDEEGKEVDQAEEAESNEKSF DCHS_DROME qaNSERQASIQEDNEESPEETELLSLCRTSNVPSPEHAHSLSTPSRSCSS DCHS_HUMAN ---QTKKKTVRSLSCNSVPVS---AQKPLPTEASVKNGGSSRVRIFSRFP DCHS_MOUSE ---QNRRKTTRSLSCNSVPMS---AQKSLPADASLKNGGSFRARIFSGFP DCHS_RAT ---QNKKKTMRSLSCNSMPMS---AQKSPPPDASVKHGGFFRARIFSGFP EAA14857 ------------------------------------IGP---GEVRNGIE NP_001096063 ---PERPQHRRLLKFXSVPSL-------------------AQVWAQCGMQ XP_001603214 ---ASCARPLSEPCANLLQVKEDEDYVG-KSDSTLSIDK--SESTIGSQD XP_392129 ---ACCRPAIEMATELPLQEDEDVGIAETRSDANQSSNDDLDERSTGQQE XP_413833 ---QGKKKTARSLSCNSVPMTDLLEQCNPKTTDSDQKEPHANGRILSRLP XP_789367 -----NGPPIFKPGKLEAVLA----------------------------- AAP34326 SEKNVVGAKKGRVIEVPAVTKVkvkmsngglvkgegtslegrvleQERWD DCHS_DROME SSHSLTHSLTQSSARSSPVNQFrhitlcavpsqshlsmplamplpNRNVT DCHS_HUMAN EDMMMLK------------------------------------------- DCHS_MOUSE EQMMMMK------------------------------------------- DCHS_RAT EEMMMMK------------------------------------------- EAA14857 SKAITED------------------------------------------- NP_001096063 QLHHPFR------------------------------------------- XP_001603214 SDGKIVNGSTYDKFQRFKESEE-----------------------DEEVE XP_392129 SEDITEKALKRQTSKSRSNYTV-----------------------NGSVK XP_413833 EEVMMLK------------------------------------------- XP_789367 -------------------------------------------------- AAP34326 TGHRGQKGkksqtgqekdtgvknneiakvasa-------gknspqkrdqk DCHS_DROME VSVDSLLNpvttcnvyhgkrfleplenlaqtsasfsssifrlptpmatpt DCHS_HUMAN -------------------------------------------------- DCHS_MOUSE -------------------------------------------------- DCHS_RAT -------------------------------------------------- EAA14857 -------------------------------------------------- NP_001096063 -------------------------------------------------- XP_001603214 NSLVDIGN------------------------------------------ XP_392129 IGSQDCSNt----------------------------------------- XP_413833 -------------------------------------------------- XP_789367 -------------------------------------------------- AAP34326 sntasenqnsvgdhKMVLKASKSSELPTKSKNSVGGSNPDAGGTGGRYMM DCHS_DROME respedpdwpaktfSQLLLERYSSQSQSLGNNSSTESSSLSGGA---TPT DCHS_HUMAN ------------------------KSAFKKLIKFYSVPSFPECSSQC-GL DCHS_MOUSE ------------------------KGAFKKLIKFYSVPSFPECSSQC-AR DCHS_RAT ------------------------KGGFKKLIKFYSVPSFPECSSQCGTL EAA14857 -------------------------------------------------- NP_001096063 ------------------------RGLITSRASCFTCPPLPEGT------ XP_001603214 --------------SVIKTG--ISKSETIGAINSCFSNVIADGG---TLT XP_392129 ------------ltSMLSTEGNLPRSETIAAIG--HRSYTDDLS---MMQ XP_413833 ------------------------KSAFKKLIKFYSVPSFSECSIQC-GL XP_789367 -------------------------------------------------- AAP34326 ELSKAVCSKVKealltlpgsgggnstpaamagdgdgdeccpccgrelpss DCHS_DROME PTPMSSLDELVtplllsfaspsqpmlsahgigegqrergsdsdatvcstt DCHS_HUMAN QLPCCPLQAMV--------------------------------------- DCHS_MOUSE QLPCCPLEAMV--------------------------------------- DCHS_RAT QLPCCPLQAMV--------------------------------------- EAA14857 ------LEEVWe-------------------------------------- NP_001096063 -----PLPTK---------------------------------------- XP_001603214 MTRLN-SENLMesaelcrkcghyvkqq----------------------- XP_392129 SENICKGDNNVedvtvcrkcghcmknke---------------------- XP_413833 QLPCCPLQAIV--------------------------------------- XP_789367 -------------------------------------------------- AAP34326 lls--- DCHS_DROME ssmesl DCHS_HUMAN ------ DCHS_MOUSE ------ DCHS_RAT ------ EAA14857 ------ NP_001096063 ------ XP_001603214 ------ XP_392129 ------ XP_413833 ------ XP_789367 ------