CLUSTAL W (1.83) multiple sequence alignment CBS_HUMAN ------MPSETPQAEVGPTGCPHRSGPHSAKGSLEKGSPEDKEAKEPLWIRPDAPSRCTW CBS_RAT ------MPSGTSQCEDGSAGCPQDLEVQPEKGQLEKGASGD---KERVWISPDTPSRCTW AAH44091 ------MPAVPPTTD--SASCPHLKENHVTNG--NNDSVEAELSVDRKWIRPDLPSKCTW AAD13393 MAGFHRISLLSAFSQRGEMSANGKQE--TDKGVQDEAHSEGPESELKDWIRPDRPSRCTW AAN31486 ------------------------------------------------------------ CBS_DICDI ------------------------------------------------MSAPEGPSKCTW AAF71541 ------------------------------------------------------------ AAK16397 ------------------------------------------------------------ AAF50862 ------------------------------------MPQPKPYERPADFIDPGKPSKCKW NP_001035353 ----------------------------------------------MEFKQPNRPSYCTW AAL09565 ------------------------------------------------------------ EAK93698 ------------------------------------------------------------ CBS_YEAST ------------------------------------------------------------ AF422799 ------------------------------------------------------------ EAA30070 ------------------------------------------------------------ EAA78329 ------------------------------------------------------------ AAG48621 ------------------------------------------------------------ CAB89449 ------------------------------------------------------------ ZP_00059346 ------------------------------------------------------------ AAS03341 ------------------------------------------------------------ NP_215593 ------------------------------------------------------------ BAB96806 ------------------------------------------------------------ AAN24961 --------------------------MVNMKNRFTFRIHRTVSGNTRFSNQSHSPFVWER CAE81156 ------------------------------------------------------------ :. . .. . . .. .. . . CBS_HUMAN QLGRPASESPHHHTAPAKSPKILPDILKKIGDTPMVRINKIGKKFGLKCELLAKCEFFNA CBS_RAT QLGRPMADSPHYHTVPTKSPKILPDILRKIGNTPMVRINRISKNAGLKCELLAKCEFFNA AAH44091 ELGKAPTESPHHHVQLCERPQILSSILQKIGDTPLVRINQIGKRFGLKCELLAKCEFFNA AAD13393 ELGAPASKSPHSHQPRIKPPSILPNILGNIGNTPLVRLNKIPKQFGIKCDILVKCEFFSA AAN31486 -MSSPAS---LESSLPPAALEVLPDIMAAIGQTPMVCINSIGKKAHLQCELLAKCEFFNA CBS_DICDI TPN--TTENTPHTTRRTPKKLIMDNILDNIGGTPLVRVNKVSS--DLECELVAKCEFFNA AAF71541 ----MTSATPHDH--------ILANALEAIGNTPCIRLNRVPQKHGIQCEVVAKCEFFNP AAK16397 -MAQNPSAVNNKKEVPDRRTCILDTVLDAIGSTPCIRLNHVPKKHGVCCDVVAKCEFLNP AAF50862 HLGTAEKSPHIHRG-IAHRQQITPNILEVIGCTPLVKLNNIPASDGIECEMYAKCEFLNP NP_001035353 ELN-ATNSPHTCRTKNGDYTKIMPDILTAIGQTPLIKLNNIPKSYGIKCEIYAKCEFLNP AAL09565 ------MS-----DNNQPLPPVSNSILEHIGKTPLVKLNRIPKILNLKPQVYAKVELFNS EAK93698 ------MT-----STNKP-PALKEDILELIGNTPLVKLNKIPQSLGIKAKVYAKVELFNA CBS_YEAST ------MT-----KSEQQ-ADSRHNVIDLVGNTPLIALKKLPKALGIKPQIYAKLELYNP AF422799 ------MAANTM--AARGAQSVTESATDLIGNTPLVRLNKIPQSLGIKAQVFGKLELMNT EAA30070 ------MSGDTTNGAVERNPGLTMSATELIGNTPLVRLNRIPQSLGIECEVYGKVELFNA EAA78329 ------MASQVP--HVLPRAATVHSATELIGNTPLVRLNKIPQSLGIECDVYVKPELFSA AAG48621 -------------------MQFHDSMISLVGNTPLVKLNNV--TAGIQATVLAKVEYFNP CAB89449 -------------------MQFHDSMISLVGNTPLVRLNSV--SKGIRATVLAKVEYFNP ZP_00059346 -------------------MRVSNSLIELVGNTPLVRLKKV--TAGLAPTVLAKVEYFNP AAS03341 -------------------MRIAQHISDLIGGTPLVRLNSV--VPDGAGIVAAKVEYLNP NP_215593 -------------------MRIAQHISELIGGTPLVRLNSV--VPDGAGTVAAKVEYLNP BAB96806 -------------------MRIAEHVVDLIGNTPLVKLTSV--TGENFGTVAAKVEYLNP AAN24961 RFTNATQQNPHNPSNEGLHMTIHNSLAELIGNTPLVKLNHIPQAAGVKATIAVKVEYFNP CAE81156 ------------------MSHIYDSILETIGNTPIVRLKNV--TKGSKHQFFAKIEYFNP :* ** : :. : . * * .. CBS_HUMAN GGSVKDRISLRMIEDAERDGTLKPG-DTIIEPTSGNTGIGLALAAAVRGYRCIIVMPEKM CBS_RAT GGSVKDRISLRMIEDAERAGTLKPG-DTIIEPTSGNTGIGLALAAAVKGYRCIIVMPEKM AAH44091 GGSVKDRISLRMVEDAERDGILKPG-DTIIEPTSGNTGIGLALAAAVKGYRCIIVMPEKM AAD13393 GGSIKDRIALRMVEDAERAGLLKPG-DTIIEPTSGNTGIGLALVASVKGYRCVITMPDRM AAN31486 GGSVKDRIGKRMVEDAEAAGRIKPG-DTLIEPTSGNTGIGLALASAIKGYRCIITLPEKM CBS_DICDI GGSVKDRIGHRMIVDAEESGRIKKG-DTLIEPTSGNTGIGLALTAAIKGYKMIITLPEKM AAF71541 GGSVKDRIGKQMVLDAEKNGTLKPG-SVIVEATSGNTGIGLSMAAAIRGYRMVIRMPKKM AAK16397 GGSVKDRIARQMILDAEASGRLRPN-QTIIEATSGNTGIGLSLVAAVKKYPMIITMPKKM AAF50862 GGSVKDRIGYRMVQDAEEQGLLKPG-YTIIEPTSGNTGIGLAMACAVKGYKCIIVMPEKM NP_001035353 GGSVKDRIAYRMIQDAEDKGLLKPG-CTIIEPTSGNTGIGLAMAAAVRGYKCIIVMPEKM AAL09565 GGSIKDRIALRMVEQAEKEGRIKPG-YTLIEPTSGNTGIGLALVGAVKGYRTIITLPEKM EAK93698 GGSIKDRIAKNMVLEAEKQGKIKPG-YTLIEPTSGNTGIGLALVGAVRGYRTIITLPEKM CBS_YEAST GGSIKDRIAKSMVEEAEASGRIHPSRSTLIEPTSGNTGIGLALIGAIKGYRTIITLPEKM AF422799 GGSVKDRIALRMIEEAEKEGRIKPG-DTLIEPTSGNTGIGLALVGAVKGYKTIITLPEKM EAA30070 GGSVKDRIALRMIEEAEKEGRIKPG-DTLIEPTSGNTGIGLALVGAIKGYKTIITLPEKM EAA78329 GGSVKDRIALRMIEEAEKSGRIKPG-DTLIEPTSGNTGIGLALVGAIKGYKTIITLPEKM AAG48621 GGSVKDRIAVRMIEAAEQSGELKPG-GTIVEPTSGNTGVGLAIVAQQKGYKCIFVCPDKV CAB89449 GGSVKDRIALRMIEAAEKSGELQPG-GTIVEPTSGNTGVGLAIVAQQKGYKCIFVCPDKV ZP_00059346 GGSVKDRIALRMVEDAERRGLLKPG-GTIVEPTSGNTGVGLAIVAAEKGYRCVFVCPDKV AAS03341 GGSSKDRIAVRMIDAAEASGALKPG-GTIVEPTSGNTGVGLALVAQQRGYKCVFVCPDKV NP_215593 GGSSKDRIAVKMIEAAEASGQLKPG-GTIVEPTSGNTGVGLALVAQRRGYKCVFVCPDKV BAB96806 GGSSKDRIAVKMIDAAEASGELKPG-GTIVEPTSGNTGIGLALVAQKRGYKCVFVCPDKV AAN24961 GGSSKDRIAERIIDAAEQSGQLKPG-GVIVEPTSGNTGVGLALVAQQRGYRTIFTLPDKV CAE81156 GGSIKDRVAVAMIEEAEKRGDLKAG-GTIVEATSGNTGVGLALAAAVKGYKCIFVMPEKM *** ***:. :: ** * :: . .::*.******:**:: : * :: *.:: CBS_HUMAN SSEKVDVLRALGAEIVRTPTNARFDSPESHVGVAWRLKNEIPNSHILDQYRNASNPLAHY CBS_RAT SMEKVDVLRALGAEIVRTPTNARFDSPESHVGVAWRLKNEIPNSHILDQYRNASNPLAHY AAH44091 SMEKVDVLRALGAEIVRTPTSARFDSPESHVGVAWRLKNEIPNSHILDQYRNASNPLAHY AAD13393 SMEKVDVLKALGAEVVHTPSSAPFDSPESQVGMAWCLKNKIPNSHILDQYRNASNPLAHY AAN31486 SLEKVNVLKALGAEIIRTPTEAAWDSPESHIGIARRLQAELPNAHILDQYANPSNPLAHY CBS_DICDI SQEKVDVLKALGGEIIRTPTEAAFDAPESHIGVAKKLNSEIPNSHILDQYGNPSNPLAHY AAF71541 SHEKETTLQARGAEVIRTETSLPNDHPESLIGVATPLRDEK-GYVLLDQYR-PQQP-DPL AAK16397 SHEKEVTLQALGAEVIRTETALPWDHPDSLIGMARRLEKEK-GYVLLDQYRNPSNPKAHY AAF50862 SNEKVSALRTLGAKIIRTPTEAAYDSPEGLIYVAQQLQRETPNSIVLDQYRNAGNPLAHY NP_001035353 SDEKISTLYALGAKIIRTPTEASWHSPEAHISVAQKLQKEIPNSIILDQYTNPGNPLAHY AAL09565 SNEKVAVLKALGAEIIRTPTEAAWDSPESHIGVARRLEKEIPNAVILDQYGNVNNPDAHF EAK93698 SNEKVSVLKALGAEIIRTPTEAAWDSPESHIGVAKKLEKEIPNSIILDQYGNPANPDAHY CBS_YEAST SNEKVSVLKALGAEIIRTPTAAAWDSPESHIGVAKKLEKEIPGAVILDQYNNMMNPEAHY AF422799 SAEKVSVLKALGATIIRTPTQAAWDAPESHIGVAKRLLKEIPNSHILDQYSNPNNPLAHE EAA30070 SAEKVSVLRALGATIIRTPTQAAWDSPESHIGVARRLLKEIPNSHILDQYTNPNNPLAHE EAA78329 SAEKVSVLRALGATIIRTPTQAAWDAPESHIGVARRLEKELPNAHILDQYSNKDNPNAHE AAG48621 SLDKINVLRAYGAEVVVCPTAVDPEHPDSYYNVSDRLVRETPGAWKPDQYSNPNNPRSHY CAB89449 STDKINVLRAYGAEVVVCPTAVDPEHPDSYYNVSDRLVRETPGAWKPDQYSNPNNPLSHY ZP_00059346 GADKLAVLRAYGAEVVVCPTTVAPDHPESYYSVSDRLAATIPGAWKPDQYSNPNNPESHY AAS03341 GEDKRNVLMAYGAEVVVCPTAVPPEHPDSYYSVSDRLVTEIEGAWKPDQYANPEGPASHY NP_215593 SEDKRNVLIAYGAEVVVCPTAVPPHDPASYYSVSDRLVRDIDGAWKPDQYANPEGPASHY BAB96806 SEDKRNVLRAYGAEVVVCPTAVAPDNPNSYYSVSDRLTREIPGAWKPNQYSNPGGPESHY AAN24961 SESKRAVLRAYGAEVIVTPTDAGPDDPRSYYQVAERLANTIPGGFRPNQYDNPNGPLSHY CAE81156 SEEKRAILRAYGAKVVITP-MVDPEHPLSHYSVSQKIAKETPGAFLTNQYHNPDNPQRHY . .* * : *. :: : . * . :: : . :** . * CBS_HUMAN DTTADEILQQCDG-----KLDMLVASVGTGGTITGIARKLKEKCPG-CRIIGVDPEGSIL CBS_RAT DDTAEEILQQCDG-----KVDMLVASAGTGGTITGIARKLKEKCPG-CKIIGVDPEGSIL AAH44091 DSTAEEILQQCQG-----QLDMLVAGAGTGGTITGLARKLKEKCPN-CKIVGVDPDGSIL AAD13393 DATAEEILEQCDG-----KLDMLVAGIGTGGTLTGVARKLKEKCP---TIVAVDPEGSLL AAN31486 DGTAEEILEQCDG-----KVDMVVMGVGTGGTISGIAKKLKEKCPS-VIVVGVDPEGSIL CBS_DICDI DGTAEELLEQCEG-----KIDMIVCTAGTGGTITGIARKIKERLPN-CIVVGVDPHGSIL AAF71541 RVDRSEIYDQCGG-----KVDMVVVSAGTGGTITGAAKKQKELIPE-IIVVGVDPIGSVV AAK16397 EGTAQEIYDQCGG-----KVDMAVFTTGTGGTMAGVAKRLKELLPN-IVIVGVDPYGSIL AAF50862 DGTAAEILWQLDN-----KVDMIVVSAGTAGTISGIGRKIKEQVPS-CQIVGVDPYGSIL NP_001035353 DQTAIEIWKQCEG-----KIDYLVAGAGTGGTISGIGRKLKELSPN-IKIIAVDPKGSIL AAL09565 YTTGAEIWDQTNG-----KVTHGVAGAGTGGTITGIAKFLKSKNPN-IQIIGADPHGSIL EAK93698 YGTGYEIWEQTEG-----KITHLVAGAGTGGTITGISKYLKEKNSK-IHVTGADPKGSIL CBS_YEAST FGTGREIQRQLEDLNLFDNLRAVVAGAGTGGTISGISKYLKEQNDK-IQIVGADPFGSIL AF422799 HGTAEEIWAQTGG-----KITAVVAGAGTGGTISGLARGLRKHSKT-VKVIAADPIGSIL EAA30070 FGTAEEIWKQTNG-----KVTAVVAGAGTGGTITGIARGLRKHNKD-IKVIAADPVGSIL EAA78329 FGTAQEIWEQTGG-----KITALVAGAGTGGTITGIARGLKKHNQD-IKVIAADPHGSIL AAG48621 ETTGPELWEQTDG-----KITHFVAGVGTGGTISGTGNYLKEASGGSVKIIGADPEGSV- CAB89449 HSTGPELWEQTEG-----KITHFVAGVGTGGTISGTGRYLKDASDGAVTVIGADPEGSV- ZP_00059346 YSTGPEIWEQTEG-----RITHFVAGIGTGGTITGTGRYLKEVSNGRVKVIGADPEGSV- AAS03341 ATTGPEIWADTDG-----KVTHFVAGIGTGGTITGAGRYLKEVSGGRVRVIGADPEGSV- NP_215593 VTTGPEIWADTEG-----KVTHFVAGIGTGGTITGAGRYLKEVSGGRVRIVGADPEGSV- BAB96806 ETTGPEIWADTDG-----KITHFVAGVGTGGTITGTGRYLKEVSGGKVKVIGADPEGSV- AAN24961 YTTGPEIWEATDH-----KVTHFVAGIGTGGTISGTGKYLKEASNGAVKVIGSDPEGSI- CAE81156 QTTGPEIWKQMDG-----KVDVVVGGAGTGGTLSGVAKYLKEMNPN-IKAICADPIGSIL *: .: * **.**::* .. :. ** **: CBS_HUMAN AE-PEELNQTEQTT-YEVEGIGYDFIPTVLDRTVVDKWFKSNDEEAFTFARMLIAQEGLL CBS_RAT AE-PEELNQTEQTA-YEVEGIGYDFIPTVLDRAVVDRWFKSNDDDSFAFARMLISQEGLL AAH44091 AE-PEELNQTDKTG-YEVEGIGYDFIPTVLDRTVVDEWYKSNDEESFFMARALIREEGLL AAD13393 IH-S---DDHCKSS-YEVEGIGYDFVPTVLDKSLVDYFYKVNDKETFNMSRRLIRDEGLL AAN31486 AL-PDSLNDKNRLQSYKVEGIGYDFIPDVLDRSLVDQWEKTNDQESFIMSRRLIREEGLL CBS_DICDI AQ-PESLNNTNKSY--KIEGIGYDFIPNVLERKLVDQWIKTDDKESFIMARRLIKEEGLL AAF71541 AD-PEHPCEP-VMYQ-EVEGIGYDFVPAVCERKYVDRWVKTRDQQSFDLARELHRDEGLL AAK16397 AD-PSVPLDP-KPY--LVEGIGYDFVPDVCERKYVDRWVKSADKESFALASEVHREEALL AAF50862 AR-PAELNKTDVQFY-EVEGIGYDFPPTVFDDTVVDVWTKIGDSDCFPMSRRLNAEEGLL NP_001035353 D--PSSDSQNEVGFY-EVEGIGYDFIPTVLDRNVIDKWIKTEDNESLNAARMLIRQEGLL AAL09565 AL-PESLN--TSNEQYKVEGIGYDFIPEVLDREIVDTWYKTDDKDFFKLARQLISEEGIL EAK93698 AE-PESLN--NSTEGYLVEGIGYDFIPDVLNRKYVDDWIKTDDAESFKLARRIIREEGIL CBS_YEAST AQ-PENLNK-TDITDYKVEGIGYDFVPQVLDRKLIDVWYKTDDKPSFKYARQLISNEGVL AF422799 AL-PESLNDNGVNEPYKVEGIGYDFIPDVLDRELVDKWYKTEDRESFMYARRLIAEEGLL EAA30070 AQ-PESLNDPNATAPYKVEGIGYDFIPDVLDREFVDKWYKTEDRESFHLARRLIAEEGLL EAA78329 AL-PELLNQEHINEGYKVEGIGYDFIPDVLDQHIVDKWYKTDDRESFHLARRLISEEGLL AAG48621 ----YSGGSG---RPYLVEGVGEDFWPTAYDRNVTDRIVAVSDKDSFQMTRRLAKEEGLL CAB89449 ----YSGGSG---RPYLVEGVGEDFWPTAYDREVADEIVAVSDKDSFQMTRRLAKEEGLL ZP_00059346 ----YSGGTG---RPYLVEGVGEDIWPATYDTKICDEIIAVSDKDSFLMTRRLAKEEALL AAS03341 ----YSGGTG---RPYLVEGVGEDFWPQAYDRTVPDEIIAVSDSDSFNMTRRLAREEAML NP_215593 ----YSGGAG---RPYLVEGVGEDFWPAAYDPSVPDEIIAVSDSDSFDMTRRLAREEAML BAB96806 ----YSGGTG---RPYLVEGVGEDFWPSAYDPSIPDEIIAVSDADSFEMTRRLAREEGLL AAN24961 ----YSASSRDEVHQYDIEGVGEDFYPKAFDRNITDDIVRVSDAEAFEMTRRLAGEEALL CAE81156 YDLYYHKKIVDPPGSYKVEGVGEDMLPDNVHLNIYDGFERVSDPEAFTMTRRLVAEEGLL :**:* *: * . * * : : : :*.:* CBS_HUMAN CGGSAGSTVAVAVKAAQE---LQEGQRCVVILPDSVRNYMTKFLSDRWMLQKGFLKEEDL CBS_RAT CGGSSGSAMAVAVKAAQE---LKEGQRCVVILPDSVRNYMSKFLSDKWMLQKGFMK-EEL AAH44091 CGGSSGSAMSAAMKAAKE---LGEGQRCVVILPDSVRNYMSKFLSDKWMTQKQFLKVEEL AAD13393 CGGSSGSAMAAAVKVAQH---LKEGQRCVVILADSVRNYMSKFLSDKWMSEKGFLVPEAP AAN31486 CGGSSGSAMAAAVRAASV---LKPGQRCVVVLPDSTRNYMSKFLNDAWMYENKYVENTVH CBS_DICDI CAGSSGSAMVGALLAAKQ---LKKGQRCVVLLADSIRNYMTKHLNDDWLVDNGFVDPEYK AAF71541 VGGSSGAAMAGVLEAAKD---LRADQRCVVLMADGIRNYMGKFADTNWMIEHGFRQGE-- AAK16397 VGGSSGAAMWGVLQAAKD---LRPDQRCVVVFPDGIRNYMTKFPDKNWLVENGLEEGE-- AAF50862 CGGSSGGAMHAALEHARK---LKKGQRCVVILPDGIRNYMTKFVSDNWMEARNFKEPV-- NP_001035353 CGGSSGAALIAALKIAKD---IPEEKRMVIILPDGIRNYLTKFVSEYWMETRGFLQPVCQ AAL09565 VGGSSGSALSAAVKIINDA-KLDESAVVVVVCPDSIRSYLTKFADDDWMKLNGFTED--- EAK93698 VGGSSGSALQAALQVAKD---LTEDDTVVVVFPDSIRSYLSKFADDEWLISNGFEVE--- CBS_YEAST VGGSSGSAFTAVVKYCEDHPELTEDDVIVAIFPDSIRSYLTKFVDDEWLKKNNLWDDDVL AF422799 VGGSSGSAMAAMVRAVKDL-NLGEDDVVVVVLPDSIRSYLSKFADDDWLAANDLLLPTPD EAA30070 VGGSSGSAMAAMIRAVKDY-NLGKDDVVVVVLPDSIRSYLSKFADDDWLAANGLLVTDDE EAA78329 VGGSSGSAMAAMLLAVKEY-GFKKGDVVVVVLPDSIRSYLSKFADDDWLAANNLLPVNGV AAG48621 VGGSCGMAVVAALEVAREL-GPDD--VVVVLLPDSGRGYMSKIFSDEWMAGHGFL----E CAB89449 VGGSCGMAVVAALEVAARL-GEDD--VVVVLLPDSGRGYLSKIFNDEWMADYGFL----E ZP_00059346 VGGSCGLAVVAALKVAAQA-GPDD--VIVVLLPDGGRGYLGKIFNDEWMADYGFL----E AAS03341 VGGSCGMAVVAALRVAEQA-GPDA--LVVVLLPDGGRGYMAKIFNDAWMSSYGFLRTRLD NP_215593 VGGSCGMAVVAALKVAEEA-GPDA--LIVVLLPDGGRGYMSKIFNDAWMSSYGFLRSRLD BAB96806 VGGSCGMAVVAALEVAKRE-GPDA--LIVVLLPDGGRGYLSKIFNDQWMASYGFLRTPLD AAN24961 VGGSSGMAVASAIKYALAN-DLDENQIVVVLAPDSGRSYLEKIFNDDWMRANGYG----- CAE81156 VGPSSALALVGAMKAAEKI-EKPS--NIVVVFPDSGRAYLSKAFNDTWMIENALLK---- . *.. :. : * : .*. * *: * . *: CBS_HUMAN TEK------------------------KPWWWHLRVQELGL-SAP-LTVLPTITCGHTIE CBS_RAT SVK------------------------RPWWWHLRVQELSL-SAP-LTVLPTVTCEHTIA AAH44091 EER------------------------KPWWWNLKVSSLSL-SAP-LTVLPTVSCGQTIQ AAD13393 VEP------------------------KPWWWGTTVNCLHL-SPP-FSTLPSVSCQEAIE AAN31486 TRENYSKYRKE---------------TATWWSQQRVSVLEL-PHP-STVSPQLSCAAAIE CBS_DICDI TKD------QQ---------------EEEKYHGATVKDLTL-PKP-ITISATTTCAAAVQ AAF71541 -----------------------------------------------------VTRPTYD AAK16397 -----------------------------------------------------VTRPTYG AAF50862 NEH------------------------GHWWWSLAIAELEL-PAPPVILKSDATVGEAIA NP_001035353 NEM------------------------NKWWWNMKISNLSF-DKQSLLKENTVTCQEAMH AAL09565 ---EPAPLKRK------------SSFSKDTLSSYTIKDLAL--KPVVSVTIDDSIESTIN EAK93698 ---DSPGANKA------------DEF----LNGKTIKDLVAGKAPVVTVTLSDTVAKTFD CBS_YEAST ARFDSSKLEAS------------TTKYADVFGNATVKDLHL--KPVVSVKETAKVTDVIK AF422799 SSVNGDTLDSPAVAEAQALHKSRARRASNPYGGATVRSLRL--KPVTSVLADSKCSEAIE EAA30070 IKTADEAKGTATVKKQQETEQ---KKTDDGYAGATVRALRL--KPVTSVLADSPCSEAIE EAA78329 ESTVNGNGD---------------KKNSDPYEGATIAALRL--KPVTSVGATSTCSEAIE AAG48621 DT------------------------SSATVADVLRHKEGGTMPSLVHMHPDETVGQAIE CAB89449 DTG-----------------------PSARVAEVLNHKEGGHIPSLVHMHPDETVGQAIE ZP_00059346 PET-----------------------EEATAGQVLAAKDD-SLPEFVHTHPHETVGTAIA AAS03341 GST-----------------------DQSRVGDVLRRKSG-ELPDLVHTHPSETVRDAIG NP_215593 GST-----------------------EQSTVGDVLRRKSG-ALPALVHTHPSETVRDAIG BAB96806 GKT-----------------------NVPTVGDVLRGKSG-ELPDLVHTHPSETLRDAIE AAN24961 ----------------------------DIVERTSK------------------------ CAE81156 ---------------------------PEEAKNVFN------------------------ CBS_HUMAN ILREKGFDQAPVVDE--------AGVILGMVTLGNMLSSLLAGKVQPSDQVGKVIY---- CBS_RAT ILREKGFDQAPVVNE--------SGAILGMVTLGNMLSSLLAGKVRPSDEVCKVLY---- AAH44091 LLRDKGFDQVPIVSE--------TGLVLGMVTLGNMLSSVLAGKVKPSDLVTKVIY---- AAD13393 ILKERAIDHLPVVDD--------SGLAQSVVTTDTILSSVSSGRVKLSDPISKVVC---- AAN31486 TMERHGYDQLPVVKE--------DGTVQGVVTIGNLLSRLSSGRVMRTDPVATVTF---- CBS_DICDI LLQQYGFDQLPVVSE--------SKKVLVNSLLVTSLT-YASKKAVPTDAVSKVMFRFT- AAF71541 ALKKELEGVKAKLAQY-------ESAAK-------------------------------- AAK16397 SLEAQLEEAKKKLSEY-------EAKCGGSVEEGKRCCEKAK------------------ AAF50862 LMKKHRVDQLPVVDQD-------DGSVLGVVGQETLITQIVSMNRQQSDPAIKALN---- NP_001035353 MLKN-ADSQLLVISDD-------NIHIKGVISLNKLTSYVISGIVKCTDFVDKAMV---- AAL09565 ILQTKGFDQLPVLKND---------KLAGIVTLSQLLRLLSNKKIHLTSKVESAYFDFSK EAK93698 LLQSNGFDQLPVLNNS-------G-RLVGLITLSKILKSLSTKKIQTTNSISSIIIDFRK CBS_YEAST ILKDNGFDQLPVLTED-------G-KLSGLVTLSELLRKLSINNSNNDNTIKGKYLDFKK AF422799 TMRDKGFDQLPVVRDN---------KLVGLVTLGNMLSYVSRGRVKTNSPVSDVMFDFGR EAA30070 TMRDKGFDQLPVLAPT-------GGKLVGLVTLGNILSFIQRGRATPATPVAKVMFDFSR EAA78329 TMRDKGFDQLPVLSAS-------GTKLVGLVTLGNLLSYISSGRATGQSSVSDVMFDFAR AAG48621 VLREYGVSQMPIVKPGAGHPDVMAAEVVGSVVERDVLDALFTQRASLEDSLESHMS---- CAB89449 VLREYGVSQMPIVKPGAGHPDVMAAEVVGSVVERELLDALFAKRASLEDPLEKHMS---- ZP_00059346 IMREYGVSQLPVMKE---EPPVMAAEVVGAIAERDLLDALFNGRAQLGDPVEQHMR---- AAS03341 ILREYGVSQMPVVGA---EPPVMAGEVAGSVSERELLSAVFEGRAKLADAVSLHMS---- NP_215593 ILREYGVSQMPVVGA---EPPVMAGEVAGSVSERELLSAVFEGRAKLADAVSAHMS---- BAB96806 ILREYGVSQMPVVGA---EPPVMAGEVAGSVSERDLLSAVFEGRAHLADSVEKHMS---- AAN24961 -------------------PSLAEQYLNGAPSDE-------------------------- CAE81156 -------------------RVVNAADFLAELNK--------------------------- CBS_HUMAN --------------------------KQFKQIRLTDTLGRLSHILEMDHFALVVHEQIQY CBS_RAT --------------------------KQFKPIHLTDTLGMLSHILEMDHFALVVHEQIQS AAH44091 --------------------------KQFTQVNLADSLGKLSRILETDHFALVLHGQIQY AAD13393 --------------------------KPFKEVRMSDSLGLLSQILETDRFALVVQEPQQN AAN31486 --------------------------GNFSRVTHESSLAELAAIFDKDYFAVVT------ CBS_DICDI ------------------------KNEKYIPITQSTSLATLSKFFENHSSAIVT------ AAF71541 ------------------------------------------------------------ AAK16397 ------------------------------------------------------------ AAF50862 --------------------------KRVIRLNESEILGKLARVLEVDPSVLILGKN--- NP_001035353 --------------------------KQYVKVKHSATLGYISRVLEKEPYVIILDDE--- AAL09565 LENFEKSYN--------INKESTNKRREYQKITTSTTLAKLNKFFETSSAAIVENDK--- EAK93698 LADFEKSFT--------ITKKSGFTKRSYEPIKLDTPLAALNKFFETNSNAIITDDE--- CBS_YEAST LNNFNDVSS--------YNENKSGKKK-FIKFDENSKLSDLNRFFEKNSSAVITDG---- AF422799 LDEVITDPRDVEGAAKMSTAHG-RKKRNFVEITMNTPLDVLSKFLEWNSAAIVTEKSGEV EAA30070 LDEVVTDPR------KFDNNLK-DKQRKFVDITMDTPLAALSKFLEWNSAAIVTEKTDNG EAA78329 LDEIVTDPR------EFASPINPGKRRQFVEITKDTPLTTLSKFFEWNSAAVVTEKSGDS AAG48621 --------------------------APLPQVGSGEPVAALMSVLGDAADAAIVLVE--- CAB89449 --------------------------APLPQVGSGEPVADLMSVLG-GADAAIVLVE--- ZP_00059346 --------------------------PPLPVVGSGEPVSRCVELLQ-SSGAVVVLED--- AAS03341 --------------------------PPLPMIGAGESVSAAGKALR-DWDALMVVEE--- NP_215593 --------------------------PPLRMIGAGELVSAAGKALR-DWDALMVVEE--- BAB96806 --------------------------KPFPLIGSGEPVSAATKALG-DTDALMVVDD--- AAN24961 --------------------------------GAGDGLHN-------------------- CAE81156 ------------------------------------------------------------ . CBS_HUMAN HS--------------TGKSSQRQMVFGVVTAIDLLNFVAAQERDQK------------- CBS_RAT RDQAWSGVVGGPTDRNNGVSSKQLMVFGVVTAIDLLNFVAAREQTRK------------- AAH44091 HS--------------DGSSSKKQMVFGVVTAIDLLNFITRERERRVSESGERDLVERVR AAD13393 KS--------------KGSAHQEKMLS-VVTAMELLSYITAKREQVVLPASTSQTQLHHP AAN31486 --------------------STDGKIAGLATRIDLLNYITSAREE--------------- CBS_DICDI ---------------------ENDEIISIVTKIDLLTYLMKSQQKN-------------- AAF71541 ------------------------------------------------------------ AAK16397 ------------------------------------------------------------ AAF50862 -------------------PAGKVELKALATKLDVTTFIAAGKQKPKANGTTNGGSH--- NP_001035353 -------------------HDD--AFIGIVNQFHILQFITK-------NGTSNNYLIN-- AAL09565 -----------------------GQPIHIVSKVDLLSFLASKGEFN-------------- EAK93698 -----------------------LKPVQIVTKVDLLSYLTKNASF--------------- CBS_YEAST -----------------------LKPIHIVTKMDLLSYLA-------------------- AF422799 -----------------------SKPVAVVTKVDLLTWMMKELKA--------------- EAA30070 -----------------------SKPVAVVTKVDLLTYMLHQQSL--------------- EAA78329 KS--------------------LSKPIAVVTKVDLLTWMINKKL---------------- AAG48621 -----------------------GKPTGVVSRQDLLAFLANGGAK--------------- CAB89449 -----------------------GKPTGVVSRQDLLSFLAK--VK--------------- ZP_00059346 -----------------------GKPSGILTRQDLLAHLAS------------------- AAS03341 -----------------------GKPVGVITRYDLLGFLSEGPRGSGGRR---------- NP_215593 -----------------------GKPVGVITRYDLLGFLSEG----AGRR---------- BAB96806 -----------------------GKPVGVITRHDLLGFLSSDS----------------- AAN24961 ------------------------------------------------------------ CAE81156 ------------------------------------------------------------ . . . CBS_HUMAN ----------------------- CBS_RAT ----------------------- AAH44091 HFSAS------------------ AAD13393 PFRGLRMLQGDLLKKPTAFYLTV AAN31486 ----------------------- CBS_DICDI ----------------------- AAF71541 ----------------------- AAK16397 ----------------------- AAF50862 ----------------------- NP_001035353 ----------------------- AAL09565 ----------------------- EAK93698 ----------------------- CBS_YEAST ----------------------- AF422799 ----------------------- EAA30070 ----------------------- EAA78329 ----------------------- AAG48621 ----------------------- CAB89449 ----------------------- ZP_00059346 ----------------------- AAS03341 ----------------------- NP_215593 ----------------------- BAB96806 ----------------------- AAN24961 ----------------------- CAE81156 ----------------------- . ... ...:: :