CLUSTAL W (1.83) multiple sequence alignment BAC84968 ----------------------------------------------------MCAQYCIS SRR_MOUSE ----------------------------------------------------MCAQYCIS SRR_HUMAN ----------------------------------------------------MCAQYCIS XP_603692 ----------------------------------------------------MCDQYCIS JT017883 ------------------------------------------MLSFHRMASVTSGEIRVT CAD41643 ----------------------------------------MGSRGGSGGDGAESHGYAAD XP_015637224 ----------------------------------------MGSRGGSGGDGAESHGYAAD AAT42169 MHVIDCFLVLPRFGSSTATVVVLVLLSPSPWRVVANWRGLMGSRDGTG-DSTGRQGYAAD BAF63026 ----------------------------------------MGSRDDDG-HSTEGQGYAAD BAE72067 ---------------------------------------------MEAN---RE-KYAAD XP_024168930 ----------------MSFKTGKIAEQTNLSAGIFGLLDCTIVLKMEAESQMREIKYAAD XP_027079741 ---------------------------------------------MEADSLTSTKKYAAD XP_021754092 ---------------------------------------------MNTGKDNGTDLYAAD EFA82100 -----------------------------------MECIDNIELTVSQSQTKSDGEFAVT XP_004350026 -----------------------------------MQAITSVNSSSSNLTIYNSKNLGVS Q54HH2 -----------------------------------------MEPMAT-----------VT XP_003291791 -----------------------------------------MDTQIDDV---------VT BAU19443 ----------------------------------------------------MSHMSYSN NP_492318 ------------------------------------------------------MTTKIT .. . .:: : ... BAC84968 FADVEKAHLNIQDSVHLTPVLTSSILNQIAG--RNLFFKCELFQKTGSFKIRGALNAIRG SRR_MOUSE FADVEKAHINIQDSIHLTPVLTSSILNQIAG--RNLFFKCELFQKTGSFKIRGALNAIRG SRR_HUMAN FADVEKAHINIRDSIHLTPVLTSSILNQLTG--RNLFFKCELFQKTGSFKIRGALNAVRS XP_603692 FADVEKAHINIRDFIHLTPVLTSSILNQITG--RNLFFKCELFQKTGSFKIRGALNAIRG JT017883 IEHIQQAAKRIAPYIHQTPVMTCSSLDKMAG--RALHFKCELFQKVGAFKIRGAMNAVLQ CAD41643 IHSIREAQARIAPYVHKTPVLSSTSIDAIVG--KQLFFKCECFQKAGAFKIRGASNSIFA XP_015637224 IHSIREAQARIAPYVHKTPVLSSTSIDAIVG--KQLFFKCECFQKAGAFKIRGASNSIFA AAT42169 IDSIREAQARIAPYVHRTPVLSSASIDAMVG--KQLFFKCECFQKAGAFKIRGASNSIFA BAF63026 INSIREARARIAPYVHKTPILSSTSIDAIAG--KQLFFKCECFQKAGAFKIRGASNSIFA BAE72067 ILSIKEAHDRIKPYIHRTPVLTSESLNSISG--RSLFFKCECLQKGGAFKFRGACNAVLS XP_024168930 ISSIKEAQARIKPFIHETPVLSSETLNLLSG--RQLFFKCECFQKGGAFKFRGACNAVFS XP_027079741 ISSIREAQLRINSYAHKTPVLSSETLNSFCG--RKLYFKCECFQKGGAFKFRGACNAILS XP_021754092 LSSIKEAHERIKPVIHNTPVFSSDTLNVMAG--RKLLFKCECFQKGGAFKFRGASNAVLS EFA82100 FEDIKDAYDRIKPYVHKTPVMTSKAINEIAG--KDLYFKCENLQKVGAFKFRGACNAVFK XP_004350026 FDDIKQAHDRIKPHIHKTPIMTSSVINDMSG--FELYFKCENLQKVGAFKYRGACNSILK Q54HH2 LKDIKEAHKRIEKYIHKTPVLTNSTINELAG--KELYFKCENLQKTGSFKMRGACNAIFS XP_003291791 LKDIKEAHERIKQYIHETPVLTNSTINKLSGD-KEIFFKCENFQKVGAFKFRGACNSVFK BAU19443 LTQINNAVKRINDYIHETPVMQSNVINTLVN--RNVYFKCEHLQKTGSFKLRGALNNILC NP_492318 MEEMRAAYQRTAPFLHKTLVITSENIDEKVGNGTHVLFKCEHLQKTGSFKARGALNSAIL : :. * . * * :: :: . : **** :** *:** *** * BAC84968 LIPDTLEGKPKAVVTHSSGNHGQALTYAAKLEGIPAYIVVPQTAPNCKKLAIQAYG--AS SRR_MOUSE LIPDTPEEKPKAVVTHSSGNHGQALTYAAKLEGIPAYIVVPQTAPNCKKLAIQAYG--AS SRR_HUMAN LVPDALERKPKAVVTHSSGNHGQALTYAAKLEGIPAYIVVPQTAPDCKKLAIQAYG--AS XP_603692 LISAHPEEKPRAVVAHSSGNHGQALSFAARLEGIPAYVIVPETAPNCKKLAIQAYG--AS JT017883 LLDSQQFDHKPVLVTHSSGNHAQALALAAKAMGLQAYIAMPRNAPPVKKEAVREYG--AT CAD41643 LDDDE---ASKGVVTHSSGNHAAAVALAAKLRGIPAYIVIPRNAPACKVDNVKRYG--GH XP_015637224 LDDDE---ASKGVVTHSSGNHAAAVALAAKLRGIPAYIVIPRNAPACKVDNVKRYG--GH AAT42169 LDDEQ---ASKGVVTHSSGNHAAAVALAAKLRGIPAHIVIPRNAPACKVENVKRYG--GH BAF63026 LDDSQ---AAKGVVTHSSGNHAAAVALAAKLRGIPAYIVIPKNAPACKVENVRRYG--GQ BAE72067 LDAEQ---AAKGVVTHSSGNHAAALSLAAKIQGIPAYIVVPKGAPKCKVDNVIRYG--GK XP_024168930 LDDDQ---AAKGVVTHSSGNHAAALSFAAKLRGIPAYIVIPKNAPKCKVENVVRYG--GQ XP_027079741 LDDSQ---AAKGVVTHSSGNHAAALSLAAKIRGIPAYVVMPKNAPKCKVENVRRYG--GQ XP_021754092 LDKEQ---AAKGVVTHSSGNHAAALSLAAQMRGIPAYIVVPSNAPKCKVKNVVRYG--GE EFA82100 LTEED---LKKGVVTHSSGNHGQALALAAKMRGTTAYVVVPNNAPKIKLDAIQGYG--AN XP_004350026 LDEQD---AKKGVVTHSSGNHGQAIAKAAQLRGIPAYIVVPNNAPKVKLDAIRGYAGESN Q54HH2 LDEEE---LSKGVVTHSSGNHGQALSYASKVRCVKCYVVVPEDAPSVKLNAICGYG--AT XP_003291791 LNEED---MKKGVVTHSSGNHGQALSLASKMRGVPCYVVVPENAPIVKLNAIKGYD--AN BAU19443 KLENQ---NINGVVTHSSGNHGQATAYAAKLLNIPAIIVVPKSTPQIKCEAIKFYG--AK NP_492318 AKE-K---NAKGMIAHSSGNHGQALAWAAQKIGLPCTIVVPKNAPISKIEGMREYN--AN :::******. * : *:: . : :* :* * : * . BAC84968 IVYSEPSDESRENVAQRIIQETEG-ILVHPNQEPAVIAGQGTIALEVLNQ-VPLVDALVV SRR_MOUSE IVYCDPSDESREKVTQRIMQETEG-ILVHPNQEPAVIAGQGTIALEVLNQ-VPLVDALVV SRR_HUMAN IVYCEPSDESRENVAKRVTEETEG-IMVHPNQEPAVIAGQGTIALEVLNQ-VPLVDALVV XP_603692 IVYSEQSEESRENITKRIAEETEG-IMVHPNQEPAVIAGQGTIAMEVLNQ-VPLVDALVV JT017883 IVECGVSAEDREITANKILETTANSYLIPPFDHPDIIAGQGTMALELLNQ-VPALDSVVV CAD41643 IIWSDVSIESRESVAKRVQEETGA-ILVHPFNNKNTISGQGTVSLELLEE-VPEIDTIIV XP_015637224 IIWSDVSIESRESVAKRVQEETGA-ILVHPFNNKNTISGQGTVSLELLEE-VPEIDTIIV AAT42169 IIRSDVSIESRESVCKRVQEETGA-VLIHPFNDKYTISGQGTVSLELLEQ-VPEIDTIIV BAF63026 VIWSDVTMESRESIAKKVQEETGA-ILIHPFNDKYTISGQGTVCLELLEQ-VPEIDTIIV BAE72067 VIWSEATMSSREEIASKVLQETGS-VLIHPYNDGRIISGQGTIALELLEQ-IQEIDAIVV XP_024168930 VIWSEPTMQSRESTAAKVLQETGA-VLLHPYNDRRIISGQGTISLELLEQQVPHLDAIVV XP_027079741 IIWSEAAIESREETATKVLQETGA-VMIHPYNDGRIISGQGTISLELLEQ-VLEIDTIIV XP_021754092 VIWCEPTFESRQVTADKVQQDTGA-VLIHPYNDSRIISGQGTISLELLEQ-FPEIDTLIV EFA82100 VTLCEPTLVARESGVEKLIQEHGA-TLIHPFDNREVIAGQGTVAIELLSQ-VENLDAIIV XP_004350026 VVLCQPNLQSRESTCNDLITKTGC-TLIHPFDNADVIAGQGTVAIELLSQ-VDNLDVIIC Q54HH2 VTKCKATLEARESNTKQLIEQHSC-KLIHPFDNLQVIAGQGTASLELMEQ-VENLDAIIT XP_003291791 VTLCKATLEARETNTNALIEKHGC-KLIHPFNNLDVIAGQGTAALELLEQ-VKDLDAVIT BAU19443 IFFSEDTPQSREELCYKLAKENGY-TIIHPYDDYDTINGQGTLGVEFLKQVPN-LDAVLI NP_492318 IVFCEPTVTSRESVCADLTEKLEY-YCVEPYNCVSMINGHSSVAFEILEQVGNEIDSIFL : . *: : : * : * *:.: .*.:.: :* :. BAC84968 PVGGGGMVAGIAITIKTLKPSVKVYAAEPSNADDCYQSKLKGELTPNLH-PPETIADGVK SRR_MOUSE PVGGGGMVAGIAITIKALKPSVKVYAAEPSNADDCYQSKLKGELTPNLH-PPETIADGVK SRR_HUMAN PVGGGGMLAGIAITVKALKPSVKVYAAEPSNADDCYQSKLKGKLMPNLY-PPETIADGVK XP_603692 PVGGGGMLAGIAVTVKALRPSVKVYAAEPLNADDCYQSKLKGELTPNPY-PPETIADGIK JT017883 PVSGGGMLSGICIAVKAIKPDIKIYAAEPLNADDCAKSFAAGRRIPLQG-PPNTIADGLR CAD41643 PISGGGLISGVALAAKAINPSIRILAAEPKGADDSAQSKAAGKIITLP--STNTIADGLR XP_015637224 PISGGGLISGVALAAKAINPSIRILAAEPKGADDSAQSKAAGKIITLP--STNTIADGLR AAT42169 PISGGGLISGVTLAAKAINPSIRILAAEPKGADDSAQSKAAGKIITLP--STNTIADGLR BAF63026 PISGGGLISGVTLAAKAINPSIRILAAEPKGADDSAQSKAAGRIIKLP--ATSTIADGLR BAE72067 PISGGGLISGVALAAKSIKPSIRIIAAEPKGADDAAQSKVAGKIITLP--VTNTIADGLR XP_024168930 PISGGGLISGVALAAKSINPAIRVFAAEPEGANDAAQSKEAGRIITLS--ETNTVADGLR XP_027079741 PVSGGGLISGVAIAAKSLKPSIRILAAEPKGADDAAQSKAAGEIVKLP--ETKTIADGLR XP_021754092 PISGGGLISGVALAAKSINPSIRVLAAEPVGANDAALSKEKGKLITLP--QTNTIADGLR EFA82100 PIGGGGVCSGISIAAKRMNPEIKIIGVEPTGADDACRSFKKGERLPHLEGYPNTIADGLL XP_004350026 PIGGGGVLSGVCIAAKTLNPDIKIIGVEPLGADDAARSLEAGEALPHLPGKPNTIADGLL Q54HH2 PVGGGGLLSGTCITAKSLNPNIKVFAAEPLGADDTYRSLLSGEIQKHTPGKPNTIADGLL XP_003291791 PVGGGGLLSGTLISVKSINPNIKVFAAEPEGADDAFRSLKEGSIQSHTEGKPNTIADGLL BAU19443 SVSGGGLAAGCSVALKNLNPKIRVYCVEPFGKELEESLRAGRRLWKGEQKCLDTVAEGLK NP_492318 SVGGGGLASSVAFLIGNLRPDIEVYLVQPAQKELSNFLENG---IKCPVDTLDTIADGVR .:.***: :. . :.* :.: .:* : .*:*:*: BAC84968 SS-IGLNTWPIIRDLVDD-VFTVTEDEIKYATQLVWERMKLLIEPTAGVGLAAVLSQHFQ SRR_MOUSE SS-IGLNTWPIIRDLVDD-VFTVTEDEIKYATQLVWGRMKLLIEPTAGVALAAVLSQHFQ SRR_HUMAN SS-IGLNTWPIIRDLVDD-IFTVTEDEIKCATQLVWERMKLLIEPTAGVGVAAVLSQHFQ XP_603692 SS-IGLNTWPIIRDLVDD-VFTVTEDEIKYATQLVWERMKLLIEPTAGVGVAVVLSQHFR JT017883 TS-VGHLCWPIIQDCVTD-VITVTEDEIISAMRLVWERMKLLIEPSAAVGVAAVLSDKFK CAD41643 AF-LGDLTWPVVRDLVDD-IIVVDDNAIVDAMKMCYEMLKVAVEPSGAIGLAAALSDEFK XP_015637224 AF-LGDLTWPVVRDLVDD-IIVVDDNAIVDAMKMCYEMLKVAVEPSGAIGLAAALSDEFK AAT42169 AF-LGDLTWPVVRDLVDD-VIVVDDTAIVDAMKMCYEILKVAVEPSGAIGLAAALSDEFK BAF63026 AF-LGDLTWPVVRDLVDD-VIVVDDNAIVDAMKMCYETLKVAVEPSGAIGLAAALSDEFK BAE72067 AS-LGDLTWPVVRDLVDD-VVTLEECEIIEAMKMCYEILKVSVEPSGAIGLAAVLSNSFR XP_024168930 AF-LGDLTWPIVRDLVDG-IVTVEDKEIINAMKLCYEILKVAVEPSGAIGLAAVLSDSFK XP_027079741 AF-LGEFTWPVVRDLVDD-IIVVEDGEIVEAMRHCYEILKVAVEPSGAIGLAAVLSDSFR XP_021754092 AF-LGDLTWPIVRDLVDA-VITVEEKEIVEAVKLCYEILKVAVEPSGAIGLAAVLSDSFQ EFA82100 TT-VGDLTWPVIKSHLHN-VLTVDDNEIKAAMKLVWDRMKLIIEPSSATVLAAVLSKEFK XP_004350026 TC-VGKLNFPIVQSLCDG-IITVDDEEIKYALKTIWERMKIIVEPSSATVLAAWCQKDWT Q54HH2 TT-VGSLTFPIIKENCDG-VILVTEDEIKYAMKLVWERMKIIIEPSSATTLAAILKQEFK XP_003291791 TT-LGPLNFPIIQKYIDG-IITVSDDEIKSSMKLVWERMKIIIEPSSATVLAAIIKQNSL BAU19443 VHQPGQLTFPILCDLAEQNIFSVTNPEMIDGVKKSMKYLKQVIEHAAGAAVAALFKYNKV NP_492318 VARVGPLCEPILKQYCAQKVISVKEDEIKEGLKLIWTRMKQRIEPTAALAFAGVLYHK-- * *:: . :. : : : . : :* :* :.. .* BAC84968 TVSPE-----VKNICIVLSGGNVDLTS-LSWVK-QAERPAP------ SRR_MOUSE TVSPE-----VKNVCIVLSGGNVDLTS-LNWVG-QAERPAPYQTVSV SRR_HUMAN TVSPE-----VKNICIVLSGGNVDLTSSITWVK-QAERPASYQSVSV XP_603692 TVPAE-----VKNICIVLSGGNVDLTS-LTWVKKQDEKAAP------ JT017883 AIPVQG----LSNVGVILCGGNVDLDN-IPWSK-------------- CAD41643 QSSAWH---ESSKIGIIVSGGNVDLGV--LWESLYKR---------- XP_015637224 QSSAWH---ESSKIGIIVSGGNVDLGV--LWESLYKR---------- AAT42169 QSSAWH---ESSKIGIIVSGGNVDLGT--LWESLYKQ---------- BAF63026 QSSAWH---ESSKIGIIVSGGNVDLRV--LWDSLYK----------- BAE72067 NNPSCR---DCKNIGIVLSGGNVDLGS--LWDSFKSSK--------- XP_024168930 NNPAWK---DCTNIGIILSGGNVDLGI--IWDSYTK----------- XP_027079741 NNPAWK---DSEHIGIIVSGGNLDLGI--LWDSLCKAEL-------- XP_021754092 QNPLWA---NCKNVAIIVSGGNVDLDV--LWEALSK----------- EFA82100 ELYGQ--DGTIKRIGLIVTGGNVDLAKVLTFFS-------------- XP_004350026 HCHWR------------------------------------------ Q54HH2 D------KKDIKKVGIIISGGNVDLSSISKILN-------------- XP_003291791 DEENKQIKSNIKRIGVIISGGNVDLSNISKILNI------------- BAU19443 IPVECE------NIGIILCGGNINVDSLL------------------ NP_492318 -PAHIK------RPLVILCGGNVDTNYVIN----------------- ... .