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B6db activities: 1.17.1.1

1.17.1.1
Description CDP-4-dehydro-6-deoxyglucose reductase.
Alternative names CDP-4-keto-6-deoxy-D-glucose-3-dehydrase;
CDP-6-deoxy-L-threo-D-glycero-4-hexulose 3-dehydrase;
CDP-4-keto-6-deoxy-D-glucose-3-dehydrogenase system.
Catalyzed reaction CDP-4-dehydro-3,6-dideoxy-D-glucose + NAD(P)+ + H2O = CDP-4-dehydro-6-deoxy-D-glucose + NAD(P)H + H+
Cofactor Pyridoxamine-phosphate and iron-sulfur cluster.
Comments The enzyme consists of two proteins. One forms an enzyme-bound adduct of the CDP-4-dehydro-6-deoxyglucose with pyridoxamine phosphate, in which the 3-hydroxy group has been removed. The second catalyses the reduction of this adduct by NAD(P)H and release of the CDP-4-dehydro-3,6-dideoxy-D-glucose and pyridoxamine phosphate.
The first protein, termed E1, is CDP-6-deoxy-L-threo-D-glycero-4-hexulose-3-dehydrase, which is a pyridoxamine 5'-phosphate dependent iron-sulfur protein. The second protein, CDP-6-deoxy-L-threo-D-glycero-4-hexulose-3-dehydrase reductase, formally called CDP-6-deoxy-delta(3,4)-glucoseen reductase (E3), is an NADH dependent [2Fe-2S]-containing flavoenzyme.
PDB 3BCX;
Organisms -Eubacteria
 

Family 

1.17.1.1 (6)
 
Links Enzyme (activities) 1.17.1.1
BRENDA (activities) 1.17.1.1
KEGG (pathways) 1.17.1.1
PLPMDB (PLP mutants) 1.17.1.1
 
References Articles on 1.17.1.1
 
last changed 2010/01/27 18:03

B6db activities