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2.1.2.7 |
Description |
D-alanine hydroxymethyltransferase |
Alternative names |
2-methylserine hydroxymethyltransferase; alpha-methylserine hydroxymethyltransferase |
Catalyzed reaction |
5,10-methylenetetrahydrofolate + D-alanine + H(2)O = tetrahydrofolate + 2-methylserine. |
Cofactor |
Pyridoxal-phosphate. |
Comments |
-!- Also acts on 2-hydroxymethylserine. |
Organisms |
-Eubacteria |
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Family |
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Links |
Enzyme (activities) 2.1.2.7
BRENDA (activities) 2.1.2.7
KEGG (pathways) 2.1.2.7
PLPMDB (PLP mutants) 2.1.2.7
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References |
Muliandi A, Katsuyama Y, Sone K, Izumikawa M2, Moriya T, Hashimoto J, Kozone I, Takagi M, Shin-ya K, Ohnishi Y. (2014) Biosynthesis of the 4-methyloxazoline-containing nonribosomal peptides, JBIR-34 and -35, in Streptomyces sp. Sp080513GE-23 Chem Biol 21 923-34. Nozaki H, Kuroda S, Watanabe K, Yokozeki K. (2009) Screening of microorganisms producing α-methylserine hydroxymethyltransferase, purification of the enzyme, gene cloning, and application to the enzymatic synthesis of α-methyl-l-serine J. Mol. Catal. B: Enzym. 56 221-6. Nozaki H, Kuroda S, Watanabe K, Yokozeki K. (2008) Cloning of the gene encoding alpha-methylserine hydroxymethyltransferase from Aminobacter sp. AJ110403 and Ensifer sp. AJ110404 and characterization of the recombinant enzyme Biosci Biotechnol Biochem 72 3002-5. Wilson, E.M.; Snell, E.E. (1962) Metabolism of alpha-methylserine. I. alpha-Methylserine hydroxymethyltransferase J Biol Chem 237 3171-9. Articles on 2.1.2.7 |
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last changed |
2017/10/10 14:11 |
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