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B6db activities: 2.1.2.7

2.1.2.7
Description D-alanine hydroxymethyltransferase
Alternative names 2-methylserine hydroxymethyltransferase;
alpha-methylserine hydroxymethyltransferase
Catalyzed reaction 5,10-methylenetetrahydrofolate + D-alanine + H(2)O = tetrahydrofolate + 2-methylserine.
Cofactor Pyridoxal-phosphate.
Comments -!- Also acts on 2-hydroxymethylserine.
Organisms -Eubacteria
 

Family 

2.1.2.7_a (8) 2.1.2.7_b (5)
 
Links Enzyme (activities) 2.1.2.7
BRENDA (activities) 2.1.2.7
KEGG (pathways) 2.1.2.7
PLPMDB (PLP mutants) 2.1.2.7
 
References
 Muliandi A, Katsuyama Y, Sone K, Izumikawa M2, Moriya T, Hashimoto J, Kozone I, Takagi M, Shin-ya K, Ohnishi Y. (2014) Biosynthesis of the 4-methyloxazoline-containing nonribosomal peptides, JBIR-34 and -35, in Streptomyces sp. Sp080513GE-23 Chem Biol 21 923-34.

 Nozaki H, Kuroda S, Watanabe K, Yokozeki K. (2009) Screening of microorganisms producing α-methylserine hydroxymethyltransferase, purification of the enzyme, gene cloning, and application to the enzymatic synthesis of α-methyl-l-serine J. Mol. Catal. B: Enzym. 56 221-6.

 Nozaki H, Kuroda S, Watanabe K, Yokozeki K. (2008) Cloning of the gene encoding alpha-methylserine hydroxymethyltransferase from Aminobacter sp. AJ110403 and Ensifer sp. AJ110404 and characterization of the recombinant enzyme Biosci Biotechnol Biochem 72 3002-5.

 Wilson, E.M.; Snell, E.E. (1962) Metabolism of alpha-methylserine. I. alpha-Methylserine hydroxymethyltransferase J Biol Chem 237 3171-9.

Articles on 2.1.2.7
 
last changed 2017/10/10 14:11

B6db activities