Activities | Families | Sequences | Fold types | References | Help
B6db activities:
Description 2-amino-4-oxopentanoate thiolase
Alternative names AKPT;
AKP thiolase;
2-amino-4-ketopentanoate thiolase
Catalyzed reaction acetyl-CoA + D-alanine = CoA + (2R)-2-amino-4-oxopentanoate
Cofactor Pyridoxal-phosphate.
Comments A pyridoxal 5'-phosphate enzyme. The enzyme, characterized from the bacterium Clostridium sticklandii, is part of a degradation pathway of ornithine. It is specific for acetyl-CoA and D-alanine
Organisms -Eubacteria

Family (0)
Links Enzyme (activities)
BRENDA (activities)
KEGG (pathways)
PLPMDB (PLP mutants)
 Fonknechten N1, Perret A, Perchat N, Tricot S, Lechaplais C, Vallenet D, Vergne C, Zaparucha A, Le Paslier D, Weissenbach J, Salanoubat M (2009) A conserved gene cluster rules anaerobic oxidative degradation of L-ornithine J Bacteriol 191 3162-7.

 Jeng IM, Somack R, Barker HA. (1974) Ornithine degradation in Clostridium sticklandii; pyridoxal phosphate and coenzyme A dependent thiolytic cleavage of 2-amino-4-ketopentanoate to alanine and acetyl coenzyme A. Biochemistry 13 2898-903.

Articles on
last changed 2018/02/13 18:10

B6db activities