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B6db activities: 2.5.1.48

2.5.1.48
Description Cystathionine gamma-synthase
Alternative names O-succinylhomoserine (thiol)-lyase;
Homoserine transsuccinylase.;
Cystathionine synthase;
MetB.
Catalyzed reaction O-succinyl-L-homoserine + L-cysteine = cystathionine + succinate.
Cofactor Pyridoxal-phosphate.
Comments -!- Can also use hydrogen sulfide and methanethiol as substrates producing homocysteine and methionine respectively.
-!- In the absence of thiol, can also catalyse beta,gamma-elimination to form 2-oxobutanoate, succinate and ammonia.

The plant enzyme can also use O-phosphohomoserine as a substrate.

Formerly EC 4.2.99.9.

Subfamily 2.5.1.48a includes enzymes from gram-negative bacteria; subfamily b encompasses enzymes from plants (plastidial proteins) and cyanobacteria.
Prosite PROSITE; PDOC00677;
PDB 1I48; 1I43; 1I41; 1CS1; 1QGN;
Organisms -Eubacteria -Archea -Plants -Fungi
 
 
Links Enzyme (activities) 2.5.1.48
BRENDA (activities) 2.5.1.48
KEGG (pathways) 2.5.1.48
PLPMDB (PLP mutants) 2.5.1.48
 
References Articles on 2.5.1.48
 
last changed 2010/01/27 18:06

B6db activities