B6db activities : 2_5_1

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	2.5.1.49
Description	O-acetylhomoserine (thiol)-lyase.
Alternative names	Methionine synthase. O-acetylhomoserine sulfhydrylase. OAH sulfhydrylase.
Catalyzed reaction	O-acetyl-L-homoserine + methanethiol = L-methionine + acetate.
Cofactor	Pyridoxal-phosphate
Comments	-!- Also reacts with other thiols or H(2)S, producing homocysteine or thioethers. -!- The name methionine synthase is more commonly applied to EC 2.1.1.13. -!- An enzyme from baker's yeast also catalyzes the reaction of EC 2.5.1.47, more slowly.
	Formerly 4.2.99.10
Prosite	PROSITE; PDOC00677;
Organisms	-Bacteria -Archea -Fungi
Family	2.5.1.49 (23)

Links	Enzyme (activities) 2.5.1.49 BRENDA (activities) 2.5.1.49 KEGG (pathways) 2.5.1.49 PLPMDB (PLP mutants) 2.5.1.49

References	Yamagata, S.; Ichioka, K.; Goto, K.; Mizuno, Y; Iwama, T. (2001) Occurrence of transsulfuration in synthesis of L-homocysteine in an extremely thermophilic bacterium, Thermus thermophilus HB8 J Bacteriol 183 2086-92. Bourhy, P.; Martel, A.; Margarita, D.; Saint Girons, I.; Belfaiza, J. (1997) Homoserine O-acetyltransferase, involved in the Leptospira meyeri methionine biosynthetic pathway, is not feedback inhibited J Bacteriol 179 4396-4398. Yamagata, S.; Isaji, M.; Nakamura, K.; Fujisaki, S.; Doi, K.; Bawden, S.; D'Andrea, R. (1994) Overexpression of the Saccharomyces cerevisiae MET17/MET25 gene in Escherichia coli and comparative characterization of the product with O-acetylserine.O-acetylhomoserine sulfhydrylase of the yeast Appl Microbiol Biotechnol 42 92-99.. Brzywczy, J.; Yamagata, S.; Paszewski, A. (1993) Comparative studies on O-acetylhomoserine sulfhydrylase: physiological role and characterization of the Aspergillus nidulans enzyme Acta Biochim Pol 40 421-8. Articles on 2.5.1.49

last changed	2007/10/19 19:08

Family