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B6db activities: 2.6.1.101

2.6.1.101
Description L-glutamine:3-amino-2,3-dideoxy-scyllo-inosose aminotransferase
Alternative names L-glutamine:5-amino-2,3,4-trihydroxycyclohexanone aminotransferase
Catalyzed reaction L-glutamine + 3-amino-2,3-dideoxy-scyllo-inosose = 2-oxoglutaramate + 2-deoxystreptamine
Cofactor Pyridoxal-phosphate.
Comments Involved in the biosynthetic pathways of several clinically important aminocyclitol antibiotics, including kanamycin, butirosin, neomycin and ribostamycin. Also catalyses EC 2.6.1.100, L-glutamine:2-deoxy-scyllo-inosose aminotransferase.

Enzymes with this activity have been included in family 2.6.1.101.

PDB 2C7T; 2C81;
Organisms -Eubacteria
 
 
Links Enzyme (activities) 2.6.1.101
BRENDA (activities) 2.6.1.101
KEGG (pathways) 2.6.1.101
PLPMDB (PLP mutants) 2.6.1.101
 
References
 Huang F, Haydock SF, Mironenko T, Spiteller D, Li Y, Spencer JB. (2005) The neomycin biosynthetic gene cluster of Streptomyces fradiae NCIMB 8233: characterisation of an aminotransferase involved in the formation of 2-deoxystreptamine Org Biomol Chem 3 1410-8.

 Kudo F, Yamamoto Y, Yokoyama K, Eguchi T, Kakinuma K. (2005) Biosynthesis of 2-deoxystreptamine by three crucial enzymes in Streptomyces fradiae NBRC 12773 J Antibiot (Tokyo) 58 766-74.

 Tamegai, H.; Nango, E.; Kuwahara, M.; Yamamoto, H.; Ota, Y.; Kuriki, H.; Eguchi, T.; Kakinuma, K. (2002) Identification of L-glutamine: 2-deoxy-scyllo-inosose aminotransferase required for the biosynthesis of butirosin in Bacillus circulans J Antibiot (Tokyo) 55 707-714.

Articles on 2.6.1.101
 
last changed 2017/11/03 18:18

B6db activities