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B6db activities: 2.6.1.105

2.6.1.105
Description Lysine--8-amino-7-oxononanoate transaminase
Alternative names DAPA aminotransferase (ambiguous);
bioA (gene name) (ambiguous);
bioK (gene name)
Catalyzed reaction L-lysine + 8-amino-7-oxononanoate = (S)-2-amino-6-oxohexanoate + 7,8-diaminononanoate.
Cofactor Pyridoxal-phosphate.
Comments Participates in the pathway for biotin biosynthesis. The enzyme from the bacterium Bacillus subtilis cannot use S-adenosyl-L-methionine as amino donor and catalyses an alternative reaction for the conversion of 8-amino-7-oxononanoate to 7,8-diaminononanoate (cf. EC 2.6.1.62, adenosylmethionineŚ8-amino-7-oxononanoate transaminase).
The second product of the reaction, (S)-2-amino-6-oxohexanoate, is also called L-2-aminoadipate 6-semialdehyde or allysine.
PDB 3DOD;
Organisms -Eubacteria -Fungi
 

Family 

2.6.1.105 (0)
 
Links Enzyme (activities) 2.6.1.105
BRENDA (activities) 2.6.1.105
KEGG (pathways) 2.6.1.105
PLPMDB (PLP mutants) 2.6.1.105
 
References
 Dey, S.; Lane, J.M.; Lee, R.E.; Rubin, E.J.; Sacchettini, J.C. (2010) Structural characterization of the Mycobacterium tuberculosis biotin biosynthesis enzymes 7,8-diaminopelargonic acid synthase and dethiobiotin synthetase Biochemistry 49 6746-60.

 Van Arsdell, SW.; Perkins, J.B.; Yocum, R.R.; Luan, L.; Howitt, C.L.; Prasad Chatterjee, N.; Pero, J.G. (2005) Removing a bottleneck in the Bacillus subtilis biotin pathway: bioA utilizes lysine rather than S-adenosylmethionine as the amino donor in the KAPA-to-DAPA reaction Biotechnol Bioeng 91 75-83.

Articles on 2.6.1.105
 
last changed 2018/10/23 13:02

B6db activities