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B6db activities:
Description beta-methylphenylalanine transaminase
Alternative names (2S,3S)-3-methylphenylalanine:2-oxoglutarate aminotransferase;
Catalyzed reaction (2S,3S)-3-methylphenylalanine + 2-oxoglutarate = (3S)-2-oxo-3-phenylbutanoate + L-glutamate
Cofactor Pyridoxal-phosphate.
Comments Requires pyridoxal phosphate. Isolated from the bacterium Streptomyces hygroscopicus NRRL3085. It is involved in the biosynthesis of the glycopeptide antibiotic mannopeptimycin.
The only functionally validated enzyme with this activity, is TyrB from E. coli, an aromatic-aminoacid-transferase included in family
Organisms -Eubacteria
Links Enzyme (activities)
BRENDA (activities)
KEGG (pathways)
PLPMDB (PLP mutants)
 Huang YT, Lyu SY, Chuang PH, Hsu NS, Li YS, Chan HC, Huang CJ, Liu YC, Wu CJ, Yang WB, Li TL (2009) In vitro characterization of enzymes involved in the synthesis of nonproteinogenic residue (2S,3S)-beta-methylphenylalanine in glycopeptide antibiotic mannopeptimycin Chembiochem 10 2480-7.

Articles on
last changed 2019/03/25 11:14

B6db activities