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B6db activities: 2.6.1.107

2.6.1.107
Description beta-methylphenylalanine transaminase
Alternative names (2S,3S)-3-methylphenylalanine:2-oxoglutarate aminotransferase;
TyrB;
Catalyzed reaction (2S,3S)-3-methylphenylalanine + 2-oxoglutarate = (3S)-2-oxo-3-phenylbutanoate + L-glutamate
Cofactor Pyridoxal-phosphate.
Comments Requires pyridoxal phosphate. Isolated from the bacterium Streptomyces hygroscopicus NRRL3085. It is involved in the biosynthesis of the glycopeptide antibiotic mannopeptimycin.
The only functionally validated enzyme with this activity, is TyrB from E. coli, an aromatic-aminoacid-transferase included in family 2.7.1.57_a.
Organisms -Eubacteria
 
 
Links Enzyme (activities) 2.6.1.107
BRENDA (activities) 2.6.1.107
KEGG (pathways) 2.6.1.107
PLPMDB (PLP mutants) 2.6.1.107
 
References
 Huang YT, Lyu SY, Chuang PH, Hsu NS, Li YS, Chan HC, Huang CJ, Liu YC, Wu CJ, Yang WB, Li TL (2009) In vitro characterization of enzymes involved in the synthesis of nonproteinogenic residue (2S,3S)-beta-methylphenylalanine in glycopeptide antibiotic mannopeptimycin Chembiochem 10 2480-7.

Articles on 2.6.1.107
 
last changed 2019/03/25 11:14

B6db activities