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B6db activities: 2.6.1.11

2.6.1.11
Description Acetylornithine aminotransferase.
Alternative names Acetylornithine 5-aminotransferase;
N-acetylornithine-delta-transaminase.
Catalyzed reaction N2-acetyl-L-ornithine + 2-oxoglutarate = N-acetyl-L-glutamate 5-semialdehyde + L-glutamate.
Cofactor Pyridoxal-phosphate.
In E. coli, this enzyme exhibits also succinyldiaminopimelate aminotransferase activity (2.6.1.17), and shows similar specificity constants for N-acetylornithine and N-succinyldiaminopimelate.
Prosite PROSITE; PDOC00519;
PDB 1VEF; 2PB0;
Organisms -Eubacteria -Archea -Plants -Fungi
 

Family 

2.6.1.11 (24)
 
Links Enzyme (activities) 2.6.1.11
BRENDA (activities) 2.6.1.11
KEGG (pathways) 2.6.1.11
PLPMDB (PLP mutants) 2.6.1.11
 
References
 Remacle C, Cline S, Boutaffala L, Gabilly S, Larosa V, Barbieri MR, Coosemans N, Hamel PP. (2009) The ARG9 gene encodes the plastid-resident N-acetyl ornithine aminotransferase in the green alga Chlamydomonas reinhardtii Eukaryot Cell 8 1460-3.

 Rajaram V, Ratna Prasuna P, Savithri HS, Murthy MR. (2008) Structure of biosynthetic N-acetylornithine aminotransferase from Salmonella typhimurium: studies on substrate specificity and inhibitor binding Proteins 70 429-41.

 Hirotsu K, Goto M, Okamoto A, Miyahara I. (2005) Dual substrate recognition of aminotransferases Chem Rec 5 160-72.

 Ledwidge, R.; Blanchard, J.S. (1999) The dual biosynthetic capability of N-acetylornithine aminotransferase in arginine and lysine biosynthesis. Biochemistry 38 3019-24.

 Heimberg, H.; Boyen, A.; Crabeel, M.; Glansdorff, N. (1990) Escherichia coli and Saccharomyces cerevisiae acetylornithine aminotransferase: evolutionary relationship with ornithine aminotransferase Gene 90 69-78.

Articles on 2.6.1.11
 
last changed 2010/02/02 10:24

B6db activities