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Description Acetylornithine aminotransferase
Alternative names Acetylornithine 5-aminotransferase;
Catalyzed reaction N2-acetyl-L-ornithine + 2-oxoglutarate = N-acetyl-L-glutamate 5-semialdehyde + L-glutamate.
Cofactor Pyridoxal-phosphate.
In E. coli, this enzyme exhibits also succinyldiaminopimelate aminotransferase activity (, and shows similar specificity constants for N-acetylornithine and N-succinyldiaminopimelate.
Prosite PROSITE; PDOC00519;
Organisms -Eubacteria -Archea -Plants -Fungi

Family (0)
Links Enzyme (activities)
BRENDA (activities)
KEGG (pathways)
PLPMDB (PLP mutants)
 Frémont N.; Riefler, M.; Stolz A.; Schmülling, T. (2013) The Arabidopsis TUMOR PRONE5 gene encodes an acetylornithine aminotransferase required for arginine biosynthesis and root meristem maintenance in blue light Plant Physiol 161 1127-40.

 Xu M1, Zhang X, Rao Z, Yang J, Dou W, Jin J, Xu Z. (2011) Cloning, expression and characterization of N-acetylornithine aminotransferase from Corynebacterium crenatum and its effects on L-arginine fermentation. [Article in Chinese] Sheng Wu Gong Cheng Xue Bao 27 1013-23.

 Remacle C, Cline S, Boutaffala L, Gabilly S, Larosa V, Barbieri MR, Coosemans N, Hamel PP. (2009) The ARG9 gene encodes the plastid-resident N-acetyl ornithine aminotransferase in the green alga Chlamydomonas reinhardtii Eukaryot Cell 8 1460-3.

 Rajaram V, Ratna Prasuna P, Savithri HS, Murthy MR. (2008) Structure of biosynthetic N-acetylornithine aminotransferase from Salmonella typhimurium: studies on substrate specificity and inhibitor binding Proteins 70 429-41.

 Hirotsu K, Goto M, Okamoto A, Miyahara I. (2005) Dual substrate recognition of aminotransferases Chem Rec 5 160-72.

 Ledwidge, R.; Blanchard, J.S. (1999) The dual biosynthetic capability of N-acetylornithine aminotransferase in arginine and lysine biosynthesis. Biochemistry 38 3019-24.

 Heimberg, H.; Boyen, A.; Crabeel, M.; Glansdorff, N. (1990) Escherichia coli and Saccharomyces cerevisiae acetylornithine aminotransferase: evolutionary relationship with ornithine aminotransferase Gene 90 69-78.

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last changed 2018/10/23 13:01

B6db activities