Activities | Families | Sequences | Fold types | References | Help
B6db activities:
Description 5-hydroxydodecatetraenal 1-aminotransferase
Alternative names cpkG (gene name)
Catalyzed reaction (2E,5S,6E,8E,10E)-1-aminododeca-2,6,8,10-tetraen-5-ol + pyruvate = (2E,5S,6E,8E,10E)-5-hydroxydodeca-2,6,8,10-tetraenal + L-alanine
Cofactor Pyridoxal phosphate
Comments The enzyme, characterized from the bacterium Streptomyces coelicolor A3(2), participates in the biosynthesis of coelimycin P1, where it catalyses the amination of (2E,5S,6E,8E,10E)-5-hydroxydodeca-2,6,8,10-tetraenal. L-glutamate can also serve as the amino group donor with lower efficiency.
The product of the gene ArpN, in Streptomyces argillaceus, could catalyze a similar but distinct reaction in the biosynthesis of Argimycins P alkaloids.
Organisms -Eubacteria

Family (0)
Links Enzyme (activities)
BRENDA (activities)
KEGG (pathways)
PLPMDB (PLP mutants)
 Awodi UR, Ronan JL, Masschelein J, de Los Santos ELC, Challis GL (2017) Thioester reduction and aldehyde transamination are universal steps in actinobacterial polyketide alkaloid biosynthesis Chem Sci 8 411-415.

Articles on
last changed 2019/03/25 14:06

B6db activities