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B6db activities: 2.6.1.13

2.6.1.13
Description Ornithine--oxo-acid aminotransferase.
Alternative names Ornithine aminotransferase;
Ornithine ketoacid aminotransferase;
Ornithine delta-transaminase;
L-ornithine 5-aminotransferase.
Catalyzed reaction L-ornithine + a 2-oxo acid = L-glutamate 5-semialdehyde + an L-amino acid.
Cofactor Pyridoxal-phosphate.
The enzyme controls the L-ornithine level in tissues by catalysing the transfer of the delta-amino group of ornithine to 2-oxoglutarate.

Fungal enzymes also employ L-lysine as a substrate, yielding L-aminoadipate semialdehyde, a metabolic intermediate that can be used in the biosynthesis of antibiotics.

Diseases Ornithinemia with gyrate atrophy of choroid and retina
Prosite PROSITE; PDOC00519;
PDB 1GBN; 2OAT; 1Z7D;
Organisms -Eubacteria -Plants -Fungi -Metazoa -Human
 

Family 

2.6.1.13 (27)
 
Links Enzyme (activities) 2.6.1.13
BRENDA (activities) 2.6.1.13
KEGG (pathways) 2.6.1.13
PLPMDB (PLP mutants) 2.6.1.13
 
References
 Funck D, Stadelhofer B, Koch W. (2008) Ornithine-[delta]-aminotransferase is essential for arginine catabolism but not for proline biosynthesis BMC Plant Biol 8 40.

 Valmaseda, E.M.; Campoy, S.; Naranjo, L.; Casqueiro, J.; Martin, J.F. (2005) Lysine is catabolized to 2-aminoadipic acid in Penicillium chrysogenum by an omega-aminotransferase and to saccharopine by a lysine 2-ketoglutarate reductase. Characterization of the omega-aminotransferase Mol Genet Genomics 274 272-82.

 Gafan, C.; Wilson, J.; Berger, L.C.; Berger, B.J. (2001) Characterization of the ornithine aminotransferase from Plasmodium falciparum. Mol Biochem Parasitol 118 1-10.

 Storici, P.; Capitani, G.; Muller, R.; Schirmer, T.; Jansonius, J. N. (1999) Crystal structure of human ornithine aminotransferase complexed with the highly specific and potent inhibitor 5-fluoromethylornithine J Mol Biol 285 297-309.

 Jhee, K. H.; Yoshimura, T.; Esaki, N.; Yonaha, K.; Soda, K. (1995) Thermostable ornithine aminotransferase from Bacillus sp. YM-2: purification and characterization J Biochem (Tokyo) 118 101-8.

 Delauney, A.J.; Hu, C.A.; Kishor, P.B.; Verma, D.P. (1993) Cloning of ornithine delta-aminotransferase cDNA from Vigna aconitifolia by trans-complementation in Escherichia coli and regulation of proline biosynthesis J Biol Chem 268 18673-8.

 Simmaco, M.; John, R. A.; Barra, D.; Bossa, F. (1986) The primary structure of ornithine aminotransferase. Identification of active-site sequence and site of post-translational proteolysis FEBS Lett 199 39-42.

Articles on 2.6.1.13
 
last changed 2010/02/02 10:24

B6db activities