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B6db activities: 2.6.1.17

2.6.1.17
Description Succinyldiaminopimelate aminotransferase.
Alternative names Succinyldiaminopimelate transaminase;
N-succinyl-L,L-diaminopimelate aminotransferase;
N-succinyl-L,L-DAP aminotransferase;
Catalyzed reaction N-succinyl-L-2,6-diaminoheptanedioate + 2-oxoglutarate = N-succinyl- L-2-amino-6-oxoheptanedioate + L-glutamate.
Cofactor Pyridoxal-phosphate.
Comments In E. coli, this activity is carried out also by the enzyme that catalyzes the acetylornitine transaminase reaction (2.6.1.11)
The gene coding for succinyldiaminopimelate aminotransferase in bacteria is termed DapC. However in the literature confusion still exists regarding the gene acronym-enzyme relationships of the dapC and dapD genes, and in several database annotations dapD genes are still incorrectly reported to encode the N-succinyl-L,L-diaminopimelate aminotransferase.

An enzyme from M. tuberculosis, whose structure has been solved (PDB 2O0R) and which is assumed to possess N-succinyl-L,L-diaminopimelate aminotransferase activity, does not show a high similarity to the only functionally-validated DapC gene (from Bordetella) but rather to enzymes with kynurenine aminotransferase activity (EC 2.6.1.7).

Prosite PROSITE; PDOC00094;
PDB 2O0R;
Organisms -Eubacteria
 

Family 

2.6.1.17 (14)
 
Links Enzyme (activities) 2.6.1.17
BRENDA (activities) 2.6.1.17
KEGG (pathways) 2.6.1.17
PLPMDB (PLP mutants) 2.6.1.17
 
References Articles on 2.6.1.17
 
last changed 2010/02/02 10:26

B6db activities