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B6db activities: 2.6.1.2

2.6.1.2
Description Alanine aminotransferase.
Alternative names Glutamic--alanine transaminase;
Glutamic--pyruvic transaminase;
GPT;
ALT.
Catalyzed reaction L-alanine + 2-oxoglutarate = pyruvate + L-glutamate.
Cofactor Pyridoxal-phosphate.
Comments -!- 2-aminobutanoate acts slowly instead of alanine.
Family 2.6.1.2a includes only archaeal enzymes similar to the prototypical alanine aminotransferase from Pyrococcus furiosus.

Family 2.6.1.2b is composed by eukaryotic enzymes.

PDB 1XI9; 3TCM;
Organisms -Archea -Plants -Fungi -Metazoa -Human
 

Family 

2.6.1.2_a (7) 2.6.1.2_b (19)
 
Links Enzyme (activities) 2.6.1.2
BRENDA (activities) 2.6.1.2
KEGG (pathways) 2.6.1.2
PLPMDB (PLP mutants) 2.6.1.2
 
References
 Rajamohan, F.; Nelms, L.; Joslin, D.L.; Lu, B.; Reagan, W.J.; Lawton, M. (2006) cDNA cloning, expression, purification, distribution, and characterization of biologically active canine alanine aminotransferase-1 Protein Expr Purif 48 81-9.

 Jadhao SB, Yang RZ, Lin Q, Hu H, Anania FA, Shuldiner AR, Gong DW. (2004) Murine alanine aminotransferase: cDNA cloning, functional expression, and differential gene regulation in mouse fatty liver Hepatology 39 1297-302.

 Yang, R.Z. Blaileanu, G. Hansen, B.C. Shuldiner, A.R. Gong, D.W. (2002) cDNA cloning, genomic structure, chromosomal mapping, and functional expression of a novel human alanine aminotransferase Genomics 79 445-50.

 Ward, D.E.; Kengen, S.W.; van Der Oost, J.; de Vos, W.M. (2000) Purification and characterization of the alanine aminotransferase from the hyperthermophilic Archaeon pyrococcus furiosus and its role in alanine production J Bacteriol 182 2559-2566.

 Chen, Z.Y.; Burow, M.D.; Mason, C.B.; Moroney, J.V. (1996) A low-CO2-inducible gene encoding an alanine: alpha-ketoglutarate aminotransferase in Chlamydomonas reinhardtii Plant Physiol 112 677-84.

 Muench, D.G.; Good, A.G. (1994) Hypoxically inducible barley alanine aminotransferase: cDNA cloning and expression analysis Plant Mol Biol 24 417-27.

 Umemura, I.; Yanagiya, K.; Komatsubara, S.; Sato, T.; Tosa, T. (1994) Purification and some properties of alanine aminotransferase from Candida maltosa Biosci Biotechnol Biochem 58 283-7.

 Ishiguro, M.; Takio, K.; Suzuki, M.; Oyama, R.; Matsuzawa, T.; Titani, K. (1991) Complete amino acid sequence of human liver cytosolic alanine aminotransferase (GPT) determined by a combination of conventional and mass spectral methods Biochemistry 30 10451-7.

Articles on 2.6.1.2
 
last changed 2014/03/20 11:39

B6db activities