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B6db activities: 2.6.1.21

2.6.1.21
Description D-alanine aminotransferase.
Alternative names D-aspartate aminotransferase;
D-amino acid aminotransferase;
D-amino acid transaminase.
Catalyzed reaction D-alanine + 2-oxoglutarate = pyruvate + D-glutamate.
Cofactor Pyridoxal-phosphate.
Comments -!- Acts on the D-isomers of leucine, aspartate, glutamate, aminobutyrate, norvaline and asparagine.
-!- Formerly EC 2.6.1.10.
Prosite PROSITE; PDOC00618;
PDB 3DAA; 2DAA; 1G2W;
Organisms -Eubacteria -Plants
 

Family 

2.6.1.21 (25)
 
Links Enzyme (activities) 2.6.1.21
BRENDA (activities) 2.6.1.21
KEGG (pathways) 2.6.1.21
PLPMDB (PLP mutants) 2.6.1.21
 
References
 Kobayashi J.; Shimizu, Y.; Mutaguchi, Y.; Doi, K. (2013) Characterization of d-amino acid aminotransferase from Lactobacillus salivarius J. Mol. Catal. B: Enzymatic 94 1522.

 Funakoshi M, Sekine M, Katane M, Furuchi T, Yohda M, Yoshikawa T, Homma H. (2008) Cloning and functional characterization of Arabidopsis thaliana D-amino acid aminotransferase--D-aspartate behavior during germination. FEBS J 275 1188-200.

 Lee, S.G.; Hong, S.P.; Song, J.J.; Kim, S.J.; Kwak, M.S.; Sung, M.H. (2006) Functional and Structural Characterization of Thermostable D-Amino Acid Aminotransferases from Geobacillus spp Appl. Envir. Microbiol. 72 1588-94.

 Berger, B.J.; English, S.; Chan, G.; Knodel, M.H. (2003) Methionine regeneration and aminotransferases in Bacillus subtilis, Bacillus cereus, and Bacillus anthracis J Bacteriol 185 2418-31.

 Pucci, M.J.; Thanassi, J.A.; Ho, H.T.; Falk, P.J.; Dougherty, T.J. (1995) Staphylococcus haemolyticus contains two D-glutamic acid biosynthetic activities, a glutamate racemase and a D-amino acid transaminase J Bacteriol 177 336-42.

 Sugio, S.; Petsko, G. A.; Manning, J. M.; Soda, K.; Ringe, D. (1995) Crystal structure of a D-amino acid aminotransferase: how the protein controls stereoselectivity Biochemistry 34 9661-9661.

 Tanizawa K, Asano S, Masu Y, Kuramitsu S, Kagamiyama H, Tanaka H, Soda K. (1989) The primary structure of thermostable D-amino acid aminotransferase from a thermophilic Bacillus species and its correlation with L-amino acid aminotransferases J Biol Chem 264 2450-4.

Articles on 2.6.1.21
 
last changed 2010/03/11 16:12

B6db activities