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B6db activities:
Description Tryptophan aminotransferase
Catalyzed reaction L-tryptophan + 2-oxoglutarate = indole-3-pyruvate + L-glutamate.
Cofactor Pyridoxal-phosphate.
Comments -!- Also acts on 5-hydroxytryptophan and, to a lesser extent on the phenyl amino acids.
The activity overlaps substantially with that of aromatic amino acid aminotransferase (
The tryptophan aminotransferases from plants produce indole-3-pyruvate used for the auxin biosynthetic pathway.
Organisms -Eubacteria -Plants -Fungi -Metazoa

Family (11)
Links Enzyme (activities)
BRENDA (activities)
KEGG (pathways)
PLPMDB (PLP mutants)
 Guo T, Chen K, Dong NQ, Ye WW, Shan JX, Lin HX (2019) TILLERING AND SMALL GRAIN 1 dominates the tryptophan aminotransferase family required for local auxin biosynthesis in rice J Integr Plant Biol in press.

 Kakei Y, Nakamura A, Yamamoto M, Ishida Y, Yamazaki C, Sato A, Narukawa-Nara M, Soeno K, Shimada Y. (2017) Biochemical and chemical biology study of rice OsTAR1 revealed that tryptophan aminotransferase is involved in auxin biosynthesis; identification of a potent OsTAR1 inhibitor, pyruvamine2031 Plant Cell Physiol 58 598–606.

 Phillips KA, Skirpan AL, Liu X, Christensen A, Slewinski TL, Hudson C, Barazesh S, Cohen JD, Malcomber S, McSteen P. (2008) vanishing tassel2 encodes a grass-specific tryptophan aminotransferase required for vegetative and reproductive development in maize. Plant Cell 23 550-66.

 Stepanova AN, Robertson-Hoyt J, Yun J, Benavente LM, Xie DY, Dolezal K, Schlereth A, Jürgens G, Alonso JM. (2008) TAA1-mediated auxin biosynthesis is essential for hormone crosstalk and plant development Cell 133 177-91.

 Tao Y, Ferrer JL, Ljung K, Pojer F, Hong F, Long JA, Li L, Moreno JE, Bowman ME, Ivans LJ, Cheng Y, Lim J, Zhao Y, Ballaré CL, Sandberg G, Noel JP, Chory J. (2008) Rapid synthesis of auxin via a new tryptophan-dependent pathway is required for shade avoidance in plants Cell 133 164-7.

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last changed 2018/12/20 11:14

B6db activities