B6db activities : 2_6_1

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	2.6.1.28
Description	Tryptophan--phenylpyruvate aminotransferase.
Alternative names	TdiD
Catalyzed reaction	L-tryptophan + phenylpyruvate = indole-3-pyruvate + L-phenylalanine.
Cofactor	Pyridoxal-phosphate.
Comments	-!- Valine, leucine and isoleucine can replace tryptophan as amino donor.
	Activity originally reported in bacteria, but an enzyme with this specificity has recently been cloned from Aspergillus nidulans, where it catalyzes the first step in the synthesis of bioactive alkaloids belonging to the bis-indolylquinone family.
Organisms	-Bacteria -Fungi
Family	2.6.1.28 (3)

Links	Enzyme (activities) 2.6.1.28 BRENDA (activities) 2.6.1.28 KEGG (pathways) 2.6.1.28 PLPMDB (PLP mutants) 2.6.1.28

References	Schneider P, Weber M, Rosenberger K, Hoffmeister D. (2007) A one-pot chemoenzymatic synthesis for the universal precursor of antidiabetes and antiviral bis-indolylquinones Chem Biol 14 635-44.. Articles on 2.6.1.28

last changed	2007/11/15 11:35

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