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B6db activities:
Description Pyridoxamine--pyruvate transaminase
Alternative names pyridoxamine-pyruvate aminotransferase;
Pyridoxamine-pyruvic transaminase;
PM-pyruvate transaminase
Catalyzed reaction pyridoxamine + pyruvate = pyridoxal + L-alanine
Cofactor None.
This activity is not, strictly speaking, B6-dependent enzyme, but it is included in the database because:
1) the enzymes with this activity bind pyridoxamine and pyridoxal (two B6 vitamers) as substrates/products;
2) the known enzymes with this activity possess a Fold-type I structure, similar to those of many PLP-dependent transaminases.
The known sequences also retain an active-site lysine residue.
Organisms -Eubacteria -Plants

Family (0)
Links Enzyme (activities)
BRENDA (activities)
KEGG (pathways)
PLPMDB (PLP mutants)
 Yoshikane Y, Yokochi N, Yamasaki M, Mizutani K, Ohnishi K, Mikami B, Hayashi H, Yagi T (2008) Crystal structure of pyridoxamine-pyruvate aminotransferase from Mesorhizobium loti MAFF303099 J Biol Chem 283 1120-7.

 Yoshikane Y, Yokochi N, Ohnishi K, Hayashi H, Yagi T (2006) Molecular cloning, expression and characterization of pyridoxamine-pyruvate aminotransferase Biochem J 396 499-507.

Articles on
last changed 2017/12/13 13:08

B6db activities