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B6db activities: 2.6.1.30

2.6.1.30
Description Pyridoxamine--pyruvate transaminase
Alternative names pyridoxamine-pyruvate aminotransferase;
Pyridoxamine-pyruvic transaminase;
PM-pyruvate transaminase
Catalyzed reaction pyridoxamine + pyruvate = pyridoxal + L-alanine
Cofactor None.
This activity is not, strictly speaking, B6-dependent enzyme, but it is included in the database because:
1) the enzymes with this activity bind pyridoxamine and pyridoxal (two B6 vitamers) as substrates/products;
2) the known enzymes with this activity possess a Fold-type I structure, similar to those of many PLP-dependent transaminases.
The known sequences also retain an active-site lysine residue.
PDB 2Z9X;
Organisms -Eubacteria -Plants
 

Family 

2.6.1.30 (0)
 
Links Enzyme (activities) 2.6.1.30
BRENDA (activities) 2.6.1.30
KEGG (pathways) 2.6.1.30
PLPMDB (PLP mutants) 2.6.1.30
 
References
 Yoshikane Y, Yokochi N, Yamasaki M, Mizutani K, Ohnishi K, Mikami B, Hayashi H, Yagi T (2008) Crystal structure of pyridoxamine-pyruvate aminotransferase from Mesorhizobium loti MAFF303099 J Biol Chem 283 1120-7.

 Yoshikane Y, Yokochi N, Ohnishi K, Hayashi H, Yagi T (2006) Molecular cloning, expression and characterization of pyridoxamine-pyruvate aminotransferase Biochem J 396 499-507.

Articles on 2.6.1.30
 
last changed 2017/12/13 13:08

B6db activities