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2.6.1.39 |
Description |
2-aminoadipate aminotransferase. |
Alternative names |
kynurenine aminotransferase II; AADAT; LysN. |
Catalyzed reaction |
L-2-aminoadipate + 2-oxoglutarate = 2-oxoadipate + L-glutamate. |
Cofactor |
Pyridoxal-phosphate. |
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In man and rat, the alpha-aminoadipate aminotransferase reaction is also carried out by kynurenine aminotransferase I (2.6.1.7).
The human enzyme listed in family a, too, may be able to transaminate kynurenine and is sometimes annotated as kynurenine aminotransferase II.
The yeast gene listed listed in family a encodes a transaminase with broad substrate specificity; even though it apparently prefers 2-aminoadipate as a substrate, it is annotated as aromatic aminoacid aminotransferase.
Finally, the enzyme from T. thermophilus included in family b is a broad-substrate specificity aminotransferase not closely realted to the subgroup of eukariotic enzymes. |
PDB |
2ZP7; 2VGZ; 2R2N; |
Organisms |
-Eubacteria -Fungi -Metazoa -Human |
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Family |
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Links |
Enzyme (activities) 2.6.1.39
BRENDA (activities) 2.6.1.39
KEGG (pathways) 2.6.1.39
PLPMDB (PLP mutants) 2.6.1.39
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References |
Karsten WE, Reyes ZL, Bobyk KD, Cook PF, Chooback L.
Source (2011) Mechanism of the aromatic aminotransferase encoded by the Aro8 gene from Saccharomyces cerevisiae Arch Biochem Biophys 516 67-74. Han, Q.; Robinson, H.; Li, J. (2008) Crystal structure of human kynurenine aminotransferase II J Biol Chem 283 3567-73. Rossi F, Garavaglia S, Montalbano V, Walsh MA, Rizzi M. (2008) Crystal structure of human kynurenine aminotransferase II, a drug target for the treatment of schizophrenia J Biol Chem 283 3559-66. Miyazaki T, Miyazaki J, Yamane H, Nishiyama M. (2004) alpha-Aminoadipate aminotransferase from an extremely thermophilic bacterium, Thermus thermophilus Microbiology. 2004 150 2327-34. Goh, D. L.; Patel, A.; Thomas, G. H.; Salomons, G. S.; Schor, D. S.; Jakobs, C.; Geraghty, M. T. (2002) Characterization of the human gene encoding alpha-aminoadipate aminotransferase (AADAT) Mol Genet Metab 76 172-80. Urrestarazu, A.; Vissers, S.; Iraqui, I.; Grenson, M. (1998) Phenylalanine- and tyrosine-auxotrophic mutants of Saccharomyces cerevisiae impaired in transamination Mol Gen Genet 257 230-7. Articles on 2.6.1.39 |
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last changed |
2010/03/11 16:17 |
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