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B6db activities: 2.6.1.39

2.6.1.39
Description 2-aminoadipate aminotransferase.
Alternative names kynurenine aminotransferase II;
AADAT;
LysN.
Catalyzed reaction L-2-aminoadipate + 2-oxoglutarate = 2-oxoadipate + L-glutamate.
Cofactor Pyridoxal-phosphate.
In man and rat, the alpha-aminoadipate aminotransferase reaction is also carried out by kynurenine aminotransferase I (2.6.1.7).

The human enzyme listed in family a, too, may be able to transaminate kynurenine and is sometimes annotated as kynurenine aminotransferase II.
The yeast gene listed listed in family a encodes a transaminase with broad substrate specificity; even though it apparently prefers 2-aminoadipate as a substrate, it is annotated as aromatic aminoacid aminotransferase.

Finally, the enzyme from T. thermophilus included in family b is a broad-substrate specificity aminotransferase not closely realted to the subgroup of eukariotic enzymes.

PDB 2ZP7; 2VGZ; 2R2N;
Organisms -Eubacteria -Fungi -Metazoa -Human
 

Family 

 
Links Enzyme (activities) 2.6.1.39
BRENDA (activities) 2.6.1.39
KEGG (pathways) 2.6.1.39
PLPMDB (PLP mutants) 2.6.1.39
 
References
 Karsten WE, Reyes ZL, Bobyk KD, Cook PF, Chooback L. Source (2011) Mechanism of the aromatic aminotransferase encoded by the Aro8 gene from Saccharomyces cerevisiae Arch Biochem Biophys 516 67-74.

 Han, Q.; Robinson, H.; Li, J. (2008) Crystal structure of human kynurenine aminotransferase II J Biol Chem 283 3567-73.

 Rossi F, Garavaglia S, Montalbano V, Walsh MA, Rizzi M. (2008) Crystal structure of human kynurenine aminotransferase II, a drug target for the treatment of schizophrenia J Biol Chem 283 3559-66.

 Miyazaki T, Miyazaki J, Yamane H, Nishiyama M. (2004) alpha-Aminoadipate aminotransferase from an extremely thermophilic bacterium, Thermus thermophilus Microbiology. 2004 150 2327-34.

 Goh, D. L.; Patel, A.; Thomas, G. H.; Salomons, G. S.; Schor, D. S.; Jakobs, C.; Geraghty, M. T. (2002) Characterization of the human gene encoding alpha-aminoadipate aminotransferase (AADAT) Mol Genet Metab 76 172-80.

 Urrestarazu, A.; Vissers, S.; Iraqui, I.; Grenson, M. (1998) Phenylalanine- and tyrosine-auxotrophic mutants of Saccharomyces cerevisiae impaired in transamination Mol Gen Genet 257 230-7.

Articles on 2.6.1.39
 
last changed 2010/03/11 16:17

B6db activities