Activities | Families | Sequences | Fold types | References | Help
B6db activities: 2.6.1.39

2.6.1.39
Description 2-aminoadipate aminotransferase.
Alternative names kynurenine aminotransferase II;
AADAT;
LysN;
Catalyzed reaction L-2-aminoadipate + 2-oxoglutarate = 2-oxoadipate + L-glutamate.
Cofactor Pyridoxal-phosphate.
In man and rat, the alpha-aminoadipate aminotransferase reaction is also carried out by kynurenine aminotransferase I (2.6.1.7).

The human enzyme listed in family a, too, may be able to transaminate kynurenine and is sometimes annotated as kynurenine aminotransferase II.
The yeast gene listed listed in family a encodes a transaminase with broad substrate specificity; even though it apparently prefers 2-aminoadipate as a substrate, it is annotated as aromatic aminoacid aminotransferase.

Finally, the enzyme from T. thermophilus included in family b is a broad-substrate specificity aminotransferase not closely realted to the subgroup of eukariotic enzymes.

PDB 2DTV; 2VGZ; 2R2N;
Organisms -Bacteria -Fungi -Metazoa -Human
 

Family 

 
Links Enzyme (activities) 2.6.1.39
BRENDA (activities) 2.6.1.39
KEGG (pathways) 2.6.1.39
PLPMDB (PLP mutants) 2.6.1.39
 
References
 Han, Q.; Robinson, H.; Li, J. (2008) Crystal structure of human kynurenine aminotransferase II J Biol Chem 283 3567-73.

 Rossi F, Garavaglia S, Montalbano V, Walsh MA, Rizzi M. (2008) Crystal structure of human kynurenine aminotransferase II, a drug target for the treatment of schizophrenia J Biol Chem 283 3559-66.

 Miyazaki T, Miyazaki J, Yamane H, Nishiyama M. (2004) alpha-Aminoadipate aminotransferase from an extremely thermophilic bacterium, Thermus thermophilus Microbiology. 2004 150 2327-34. .

 Goh, D. L.; Patel, A.; Thomas, G. H.; Salomons, G. S.; Schor, D. S.; Jakobs, C.; Geraghty, M. T. (2002) Characterization of the human gene encoding alpha-aminoadipate aminotransferase (AADAT) Mol Genet Metab 76 172-80..

 Urrestarazu, A.; Vissers, S.; Iraqui, I.; Grenson, M. (1998) Phenylalanine- and tyrosine-auxotrophic mutants of Saccharomyces cerevisiae impaired in transamination Mol Gen Genet 257 230-7.

Articles on 2.6.1.39
 
last changed 2007/12/27 12:06

B6db activities