B6db activities : 2_6_1

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	2.6.1.39
Description	2-aminoadipate aminotransferase
Alternative names	kynurenine aminotransferase II; KATII; AADAT; LysN.
Catalyzed reaction	L-2-aminoadipate + 2-oxoglutarate = 2-oxoadipate + L-glutamate.
Cofactor	Pyridoxal-phosphate.
	In man and rat, the alpha-aminoadipate aminotransferase reaction is also carried out by kynurenine aminotransferase I (2.6.1.7). The human enzyme listed in family a, too, is apparently able to transaminate kynurenine and hydroxykynurenine and is often annotated as kynurenine aminotransferase II. The yeast gene listed listed in family a encodes a transaminase with broad substrate specificity; even though it apparently prefers 2-aminoadipate as a substrate, it is annotated as aromatic aminoacid aminotransferase. The enzyme from T. thermophilus included in family b is a broad-substrate specificity aminotransferase not closely related to the subgroup of eukariotic enzymes. The enzyme from Pseudomonas putida, upo which family c is based, is yet another type of enzyme, related to GABA aminotransferases (2.6.1.18_b).
PDB	2ZP7; 2VGZ; 2R2N;
Organisms	-Eubacteria -Fungi -Metazoa -Human
Family	2.6.1.39_a (17) 2.6.1.39_b (5) 2.6.1.39_c (8)

Links	Enzyme (activities) 2.6.1.39 BRENDA (activities) 2.6.1.39 KEGG (pathways) 2.6.1.39 PLPMDB (PLP mutants) 2.6.1.39

References	Thompson MG, Blake-Hedges JM, Cruz-Morales P, Barajas JF, Curran SC, Eiben CB, Harris NC, Benites VT, Gin JW, Sharpless WA, Twigg FF, Skyrud W, Krishna RN, Henrique Pereira J, Baidoo EEK, Petzold CJ, Adams PD, Arkin AP, Deutschbauer AM, Keasling JD (2019) Massively parallel fitness profiling reveals multiple novel enzymes in Pseudomonas putida lysine metabolism MBio 10 pii: e02577-18. Dindo M, Costanzi E, Pieroni M, Costantini C, Annunziato G, Bruno A, Keller NP, Romani L, Zelante T, Cellini B (2018) Biochemical Characterization of Aspergillus fumigatus AroH, a Putative Aromatic Amino Acid Aminotransferase Front Mol Biosci 5 Art. 104. Rząd K, Milewski S, Gabriel I (2018) Versatility of putative aromatic aminotransferases from Candida albicans Fungal Genet Biol 110 26-37. Sathyasaikumar KV, Tararina M, Wu HQ, Neale SA, Weisz F, Salt TE, Schwarcz R (2017) Xanthurenic acid formation from 3-hydroxykynurenine in the mammalian Brain: Neurochemical characterization and physiological effects Neuroscience 367 85-97. Rząd K, Gabriel I (2015) Characterization of two aminotransferases from Candida albicans Acta Biochim Pol. 62 903-12. Karsten WE, Reyes ZL, Bobyk KD, Cook PF, Chooback L. (2011) Mechanism of the aromatic aminotransferase encoded by the Aro8 gene from Saccharomyces cerevisiae Arch Biochem Biophys 516 67-74. Han Q, Cai T, Tagle DA, Robinson H, Li J. (2008) Substrate specificity and structure of human aminoadipate aminotransferase/kynurenine aminotransferase II Biosci Rep 28 205-15. Han, Q.; Robinson, H.; Li, J. (2008) Crystal structure of human kynurenine aminotransferase II J Biol Chem 283 3567-73. Rossi F, Garavaglia S, Montalbano V, Walsh MA, Rizzi M. (2008) Crystal structure of human kynurenine aminotransferase II, a drug target for the treatment of schizophrenia J Biol Chem 283 3559-66. Miyazaki T, Miyazaki J, Yamane H, Nishiyama M. (2004) alpha-Aminoadipate aminotransferase from an extremely thermophilic bacterium, Thermus thermophilus Microbiology. 2004 150 2327-34. Goh, D. L.; Patel, A.; Thomas, G. H.; Salomons, G. S.; Schor, D. S.; Jakobs, C.; Geraghty, M. T. (2002) Characterization of the human gene encoding alpha-aminoadipate aminotransferase (AADAT) Mol Genet Metab 76 172-80. Urrestarazu, A.; Vissers, S.; Iraqui, I.; Grenson, M. (1998) Phenylalanine- and tyrosine-auxotrophic mutants of Saccharomyces cerevisiae impaired in transamination Mol Gen Genet 257 230-7. Articles on 2.6.1.39

last changed	2019/05/14 10:31

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