Activities | Families | Sequences | Fold types | References | Help
B6db activities: 2.6.1.4

2.6.1.4
Description Glycine aminotransferase.
Alternative names L-Glutamate:glyoxylate aminotransferase;
Glutamic-glyoxylic transaminase;
Glyoxylate-glutamate aminotransferase;
GGT.
Catalyzed reaction Glycine + 2-oxoglutarate = glyoxylate + L-glutamate.
Cofactor Pyridoxal-phosphate.
Comments The glutamate-glyoxylate transamination in rat liver is carried out mainly by alanine transaminase (EC 2.6.1.2).
Among the human cytosolic aminotransferases, alanine transaminase and also phosphoserine aminotransferase (EC 2.6.1.52) catalyze this reaction with good efficiency.

The validated plant enzymes, carrying out this reaction, are also strict homologs of the eukaryotic alanine transaminase (family 2.6.1.2_b).

Organisms -Eubacteria -Plants -Metazoa -Human
 

Family 

2.6.1.4 (4)
 
Links Enzyme (activities) 2.6.1.4
BRENDA (activities) 2.6.1.4
KEGG (pathways) 2.6.1.4
PLPMDB (PLP mutants) 2.6.1.4
 
References
 Donini S, Ferrari M, Fedeli C, Faini M, Lamberto I, Marletta AS, Mellini L, Panini M, Percudani R, Pollegioni L, Caldinelli L, Petrucco S, Peracchi A. (2009) Recombinant production of eight human cytosolic aminotransferases and assessment of their potential involvement in glyoxylate metabolism Biochem J 422 265-72.

 Liepman, A.H. Olsen, L.J. (2003) Alanine aminotransferase homologs catalyze the glutamate:glyoxylate aminotransferase reaction in peroxisomes of Arabidopsis Plant Physiol 131 215-27.

 Noguchi, T.; Takada, Y.; Kido, R. (1977) Glutamate-glyoxylate aminotransferase in rat liver cytosol. Purification, properties and identity with alanine-2-oxoglutarate aminotransferase Hoppe Seylers Z Physiol Chem 358 1533-42.

Articles on 2.6.1.4
 
last changed 2010/01/27 18:08

B6db activities