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B6db activities: 2.6.1.40
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2.6.1.40
Description (R)-3-amino-2-methylpropionate--pyruvate aminotransferase.
Alternative names D-3-aminoisobutyrate--pyruvate aminotransferase. Beta-aminoisobutyrate--pyruvate transaminase.
Catalyzed reaction (R)-3-amino-2-methylpropanoate + pyruvate = 2-methyl-3-oxopropanoate + L-alanine.
Cofactor Pyridoxal-phosphate.
The enzyme from rat liver appears to be identical to Alanine--glyoxylate aminotransferase (2.6.1.44), isoenzyme 2.
Diseases Hyper-beta-aminoisobutyricaciduria
Organisms -Metazoa -Human
 
 
Links Enzyme (activities) 2.6.1.40
BRENDA (activities) 2.6.1.40
KEGG (pathways) 2.6.1.40
PLPMDB (PLP mutants) 2.6.1.40
 
References
 Kontani, Y.; Kaneko, M.; Kikugawa, M.; Fujimoto, S.; Tamaki, N. (1993) Identity of D-3-aminoisobutyrate-pyruvate aminotransferase with alanine- glyoxylate aminotransferase 2 Biochim Biophys Acta 1156 161-6..

Articles on 2.6.1.40
 
last changed 2007/11/19 17:46

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