B6db activities : 2_6_1

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	2.6.1.40
Description	(R)-3-amino-2-methylpropionate--pyruvate aminotransferase
Alternative names	D-3-aminoisobutyrate--pyruvate aminotransferase; Beta-aminoisobutyrate--pyruvate transaminase; D-AIB AT; AGXT2; alanine-glyoxylate aminotransferase 2;
Catalyzed reaction	(R)-3-amino-2-methylpropanoate + pyruvate = 2-methyl-3-oxopropanoate + L-alanine.
Cofactor	Pyridoxal-phosphate.
	The enzyme from rat liver appears to be identical to Alanine--glyoxylate aminotransferase (2.6.1.44), isoenzyme 2.
Diseases	Hyper-beta-aminoisobutyricaciduria
Organisms	-Plants -Metazoa -Human
Family	2.6.1.40 (0)

Links	Enzyme (activities) 2.6.1.40 BRENDA (activities) 2.6.1.40 KEGG (pathways) 2.6.1.40 PLPMDB (PLP mutants) 2.6.1.40

References	Parthasarathy A, Adams LE, Savka FC, Hudson AO (2019) The Arabidopsis thaliana gene annotated by the locus tag At3g08860 encodes alanine aminotransferase Plant direct 3 e00171. Rodionov RN, Murry DJ, Vaulman SF, Stevens JW, Lentz SR. (2010) Human alanine-glyoxylate aminotransferase 2 lowers asymmetric dimethylarginine and protects from inhibition of nitric oxide production J Biol Chem 285 5385-91. Lee, I. S.; Muragaki, Y.; Ideguchi, T.; Hase, T.; Tsuji, M.; Ooshima, A.; Okuno, E.; Kido, R. (1995) Molecular cloning and sequencing of a cDNA encoding alanine-glyoxylate aminotransferase 2 from rat kidney J Biochem (Tokyo) 117 856-62. Kontani, Y.; Kaneko, M.; Kikugawa, M.; Fujimoto, S.; Tamaki, N. (1993) Identity of D-3-aminoisobutyrate-pyruvate aminotransferase with alanine- glyoxylate aminotransferase 2 Biochim Biophys Acta 1156 161-6. Okuno, E.; Minatogawa, Y.; Kido, R. (1982) Co-purification of alanine-glyoxylate aminotransferase with 2- aminobutyrate aminotransferase in rat kidney Biochim Biophys Acta 715 97-104.. Articles on 2.6.1.40

last changed	2019/09/19 12:21

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