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B6db activities: 2.6.1.42

2.6.1.42
Description Branched-chain amino acid aminotransferase.
Alternative names Transaminase B.
Catalyzed reaction L-leucine + 2-oxoglutarate = 4-methyl-2-oxopentanoate + L-glutamate.
Cofactor Pyridoxal-phosphate.
Comments -!- Also acts on L-isoleucine and L-valine.
-!- Different from EC 2.6.1.66.
The human cytosolic enzyme is a direct target for c-Myc regulation, and seems somehow involved in apoptosis.
Prosite PROSITE; PDOC00618;
PDB 1I1K; 1EKF; 1EKV;
Organisms -All -Eubacteria -Archea -Plants -Fungi -Metazoa -Human
 

Family 

2.6.1.42 (38) 2.6.1.42 b (5)
 
Links Enzyme (activities) 2.6.1.42
BRENDA (activities) 2.6.1.42
KEGG (pathways) 2.6.1.42
PLPMDB (PLP mutants) 2.6.1.42
 
References
 Uchida Y, Hayashi H, Washio T, Yamasaki R, Kato S, Oikawa T. (2014 ) Cloning and characterization of a novel fold-type I branched-chain amino acid aminotransferase from the hyperthermophilic archaeon Thermococcus sp. CKU-1. Extremophiles. .

 Schuster J, Binder S. (2005) The mitochondrial branched-chain aminotransferase (AtBCAT-1) is capable to initiate degradation of leucine, isoleucine and valine in almost all tissues in Arabidopsis thaliana Plant Mol Biol 57 241-54.

 Venos ES, Knodel MH, Radford CL, Berger BJ. (2004) Branched-chain amino acid aminotransferase and methionine formation in Mycobacterium tuberculosis BMC Microbiol 4 39.

 Berger, B.J.; English, S.; Chan, G.; Knodel, M.H. (2003) Methionine regeneration and aminotransferases in Bacillus subtilis, Bacillus cereus, and Bacillus anthracis J Bacteriol 185 2418-31.

 Madsen, S.M.; Beck, H.C.; Ravn, P.; Vrang, A.; Hansen, A.M.; Israelsen, H. (2002) Cloning and inactivation of a branched-chain-amino-acid aminotransferase gene from Staphylococcus carnosus and characterization of the enzyme Appl Environ Microbiol 68 4007-14.

 Yvon, M.; Chambellon, E.; Bolotin, A.; Roudot-Algaron, F. (2000) Characterization and role of the branched-chain aminotransferase (BcaT) isolated from Lactococcus lactis subsp. cremoris NCDO 763 Appl Environ Microbiol 66 571-7.

 Eden, A.; Benvenisty, N. (1999) Involvement of branched-chain amino acid aminotransferase (Bcat1/Eca39) in apoptosis FEBS Lett 457 255-61.

 Eden, A.; Benvenisty, N. (1998) Characterization of a branched-chain amino-acid aminotransferase from Schizosaccharomyces pombe Yeast 14 189-94.

 Bledsoe, R.K.; Dawson, P.A.; Hutson, S.M. (1997) Cloning of the rat and human mitochondrial branched chain aminotransferases (BCATm) Biochim Biophys Acta 1339 9-13.

 Feild MJ, Nguyen DC, Armstrong FB. (1989 ) Amino acid sequence of Salmonella typhimurium branched-chain amino acid aminotransferase Biochemistry 28 5306-10.

 Inoue, K.; Kuramitsu, S.; Aki, K.; Watanabe, Y.; Takagi, T.; Nishigai, M.; Ikai, A.; Kagamiyama, H. (1988) Branched-chain amino acid aminotransferase of Escherichia coli: overproduction and properties J Biochem (Tokyo) 104 777-84.

Articles on 2.6.1.42
 
last changed 2010/03/11 16:18

B6db activities