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B6db activities:
Description Alanine--glyoxylate aminotransferase
Alternative names L-alanine-glyoxylate transaminase;
L-alanine-glycine transaminase;
serine-glyoxylate aminotransferase (ambiguous);
3-hydroxykynurenine transaminase (ambiguous);
Catalyzed reaction L-alanine + glyoxylate = pyruvate + glycine.
Cofactor Pyridoxal-phosphate.
Comments -!- With one component of the animal enzyme, 2-oxobutanoate can replace glyoxylate. A second component also catalyzes the reaction of EC
The eukariotic sequences included in family a are close homologs of alanine:glyoxylate aminotransferase 1 from rat liver organelles, which in turn is identical to serine-pyruvate aminotransferase ( and asparagine-oxo-acid aminotransferase ([Noguchi & Fujiwara (1988) JBC 263, 182].

The so-called alanine:glyoxylate aminotransferase 2 (AGXT2) from rat liver appears to be identical to (D)-3-amino-2-methylpropanoate aminotransferase ( and aminolevulinate aminotransferase ( Sequences of AGXT2 close homologs (which are very different from those in family a) are listed under

The archaeal sequences included in family b are not closely related to the eukariotic enzymes with alanine-glyoxylate aminotransferase activity.

Diseases Primary hyperoxaluria type 1
Prosite PROSITE; PS00600;
PDB 1H0C; 2YOB; 3ZRR; 2ZC0;
Organisms -Eubacteria -Archea -Plants -Fungi -Metazoa -Human


Links Enzyme (activities)
BRENDA (activities)
KEGG (pathways)
PLPMDB (PLP mutants)
References Articles on
last changed 2019/09/19 12:23

B6db activities