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B6db activities: 2.6.1.44

2.6.1.44
Description Alanine--glyoxylate aminotransferase.
Alternative names L-alanine-glyoxylate transaminase;
L-alanine-glycine transaminase;
AGT;
AGXT.
Catalyzed reaction L-alanine + glyoxylate = pyruvate + glycine.
Cofactor Pyridoxal-phosphate.
Comments -!- With one component of the animal enzyme, 2-oxobutanoate can replace glyoxylate. A second component also catalyzes the reaction of EC 2.6.1.51.
The isoenzyme alanine:glyoxylate aminotransferase 1 from rat liver organelles is identical to serine-pyruvate aminotransferase (2.6.1.51) and asparagine-oxo-acid aminotransferase (2.6.1.14)[Noguchi & Fujiwara (1988) JBC 263, 182]. Sequences for this enzyme are listed under 2.6.1.51.

The eukariotic sequences included in family a are close homologs of alanine:glyoxylate aminotransferase 2 from rat liver; this enzyme appears to be identical to (D)-3-amino-2-methylpropanoate aminotransferase (2.6.1.40) and aminolevulinate aminotransferase (2.6.1.43).

The archaeal sequences included in family b are not closely related to the eukariotic enzymes with alanine-glyoxylate aminotransferase activity.

Diseases Primary hyperoxaluria type 1 (?) Hyper-beta-aminoisobutyricaciduria (?)
Prosite PROSITE; PS00600;
PDB 2ZC0;
Organisms -Eubacteria -Archea -Plants -Fungi -Metazoa -Human
 

Family 

 
Links Enzyme (activities) 2.6.1.44
BRENDA (activities) 2.6.1.44
KEGG (pathways) 2.6.1.44
PLPMDB (PLP mutants) 2.6.1.44
 
References
 Rodionov RN, Murry DJ, Vaulman SF, Stevens JW, Lentz SR. (2010) Human alanine-glyoxylate aminotransferase 2 lowers asymmetric dimethylarginine and protects from inhibition of nitric oxide production J Biol Chem 285 5385-91.

 Sakuraba H, Yoneda K, Takeuchi K, Tsuge H, Katunuma N, Ohshima T. (2008) Structure of an archaeal alanine:glyoxylate aminotransferase Acta Crystallogr D Biol Crystallogr 64 696-9.

 Sakuraba, H.; Kawakami, R.; Takahashi, H.; Ohshima, T. (2004) Novel archaeal alanine:glyoxylate aminotransferase from Thermococcus litoralis J Bacteriol 186 15292154.

 Lee, I. S.; Muragaki, Y.; Ideguchi, T.; Hase, T.; Tsuji, M.; Ooshima, A.; Okuno, E.; Kido, R. (1995) Molecular cloning and sequencing of a cDNA encoding alanine-glyoxylate aminotransferase 2 from rat kidney J Biochem (Tokyo) 117 856-62.

 Okuno, E.; Minatogawa, Y.; Kido, R. (1982) Co-purification of alanine-glyoxylate aminotransferase with 2- aminobutyrate aminotransferase in rat kidney Biochim Biophys Acta 715 97-104..

Articles on 2.6.1.44
 
last changed 2010/03/11 16:21

B6db activities