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B6db activities: 2.6.1.51

2.6.1.51
Description Serine--pyruvate aminotransferase.
Alternative names alanine:glyoxylate aminotransferase 1;
serine:pyruvate/alanine:glyoxylate aminotransferase;
SPT;
SPIAT.
Catalyzed reaction L-serine + pyruvate = 3-hydroxypyruvate + L-alanine.
Cofactor Pyridoxal-phosphate.
Comments -!- The liver enzyme may be identical with EC 2.6.1.44. include 2.6.1.44
The sequences included here are close homologs of the enzyme from rat liver organelles, which is identical to isoenzyme 1 of alanine-glyoxylate aminotransferase (2.6.1.44) and also to asparagine-oxo-acid aminotransferase (2.6.1.14) [Noguchi & Fujiwara (1988) JBC 263, 182].

The enzymes from Drosophila and Aedes also show alanine-glyoxylate aminotransferase and 3-hydroxykynurenine aminotransferase activity.

Diseases Primary hyperoxaluria type 1
Prosite PROSITE; PDOC00514;
PDB 1H0C; 2YOB;
Organisms -Eubacteria -Archea -Plants -Metazoa -Human
 

Family 

2.6.1.51 (24)
 
Links Enzyme (activities) 2.6.1.51
BRENDA (activities) 2.6.1.51
KEGG (pathways) 2.6.1.51
PLPMDB (PLP mutants) 2.6.1.51
 
References Articles on 2.6.1.51
 
last changed 2014/03/20 11:11

B6db activities