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B6db activities:
Description Serine--pyruvate aminotransferase.
Alternative names alanine:glyoxylate aminotransferase 1;
serine:pyruvate/alanine:glyoxylate aminotransferase;
Catalyzed reaction L-serine + pyruvate = 3-hydroxypyruvate + L-alanine.
Cofactor Pyridoxal-phosphate.
Comments -!- The liver enzyme may be identical with EC include
The sequences included here are close homologs of the enzyme from rat liver organelles, which is identical to isoenzyme 1 of alanine-glyoxylate aminotransferase ( and also to asparagine-oxo-acid aminotransferase ( [Noguchi & Fujiwara (1988) JBC 263, 182].

The enzymes from Drosophila and Aedes also show alanine-glyoxylate aminotransferase and 3-hydroxykynurenine aminotransferase activity.

Diseases Primary hyperoxaluria type 1
Prosite PROSITE; PDOC00514;
Organisms -Eubacteria -Archea -Plants -Metazoa -Human

Family (24)
Links Enzyme (activities)
BRENDA (activities)
KEGG (pathways)
PLPMDB (PLP mutants)
References Articles on
last changed 2014/03/20 11:11

B6db activities