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2.6.1.58 |
Description |
Phenylalanine(histidine) aminotransferase |
Catalyzed reaction |
L-phenylalanine + pyruvate = phenylpyruvate + L-alanine. |
Cofactor |
Pyridoxal-phosphate. |
Comments |
-!- L-histidine and L-tyrosine can act instead of L-phenylalanine, in the reverse reaction, L-methionine, l-serine and L-glutamine can replace L-alanine. |
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A phenylalanine transaminase from Pseudomonas (Paracoccus) denitrificans has been later classified as an aromatic amino acid aminotransferase (EC 2.6.1.57) and is included in family 2.6.1.57_a. |
Organisms |
-Metazoa -Human |
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Family |
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Links |
Enzyme (activities) 2.6.1.58
BRENDA (activities) 2.6.1.58
KEGG (pathways) 2.6.1.58
PLPMDB (PLP mutants) 2.6.1.58
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References |
Wackler B, Schneider P, Jacobs JM, Pauly J, Allen C, Nett M, Hoffmeister D (2011) Ralfuranone biosynthesis in Ralstonia solanacearum suggests functional divergence in the quinone synthetase family of enzymes Chem Biol 18 354-60. Takagi, T.; Taniguchi, T.; Yamamoto, Y.; Shibatani, T. (1991) Molecular cloning of the L-phenylalanine transaminase gene from Paracoccus denitrificans in Escherichia coli K-12 Biotechnol Appl Biochem. 13 112-9. Noguchi, T.; Okuno, E.; Kido, R. (1977) Identity of rat kidney histidine-pyruvate aminotransferase with glutamine-oxo acid aminotransferase Biochem J 161 177-9. Articles on 2.6.1.58 |
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last changed |
2019/04/18 12:44 |
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