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B6db activities:
Description Adenosylmethionine--8-amino-7-oxononanoate aminotransferase
Alternative names 7,8-diamino-pelargonic acid aminotransferase;
7,8-diaminononanoate aminotransferase,
DAPA aminotransferase;
Diaminopelargonate synthase;
Diaminopelargonic acid synthase.
Catalyzed reaction S-adenosyl-L-methionine + 8-amino-7-oxononanoate = S-adenosyl-4- methylthio-2-oxobutanoate + 7,8-diaminononanoate.
Cofactor Pyridoxal-phosphate.
Comments -!- S-adenosylhomocysteine can also act as donor.
The enzyme from Bacillus subtilis does not use S-adenosyl-L-methionine as the amino group donor; apparently it requires L-lysine, which may grant its inclusion in a different enzyme activity.
Prosite PROSITE; PDOC00519;
PDB 1QJ5; 1QJ3; 1DTY; 3WY7; 6ERK;
Organisms -Eubacteria -Archea -Plants -Fungi

Family (30)
Links Enzyme (activities)
BRENDA (activities)
KEGG (pathways)
PLPMDB (PLP mutants)
 Bezsudnova EY, Stekhanova TN, Popinako AV, Rakitina TV, Nikolaeva AY, Boyko KM, Popov VO (2018) Diaminopelargonic acid transaminase from Psychrobacter cryohalolentis is active towards (S)-(-)-1-phenylethylamine, aldehydes and α-diketones Appl Microbiol Biotechnol 102 71-80.

 Fan S, Li DF, Wang DC, Fleming J, Zhang H, Zhou Y, Zhou L, Zhou J, Chen T, Chen G, Zhang XE, Bi L (2015) Structure and function of Mycobacterium smegmatis 7-keto-8-aminopelargonic acid (KAPA) synthase Int J Biochem Cell Biol 58 71-80.

 Cobessi D, Dumas R, Pautre V, Meinguet C, Ferrer JL, Alban C (2012) Biochemical and structural characterization of the Arabidopsis bifunctional enzyme dethiobiotin synthetase-diaminopelargonic acid aminotransferase: evidence for substrate channeling in biotin synthesis Plant Cell 24 1608-25.

 Bhor, V.M.; Dev, S.; Vasanthakumar, G.R.; Surolia, A. (2006) Spectral and kinetic characterization of 7,8-diaminopelargonic acid synthase from Mycobacterium tuberculosis IUBMB Life 58 225-33.

 Mann S, Ploux O. (2006) 7,8-Diaminoperlargonic acid aminotransferase from Mycobacterium tuberculosis, a potential therapeutic target. Characterization and inhibition studies FEBS J 273 4778-89.

 Eliot, A. C.; Sandmark, J.; Schneider, G.; Kirsch, J. F. (2002) The dual-specific active site of 7,8-diaminopelargonic acid synthase and the effect of the R391A mutation Biochemistry 41 12582-9.

 Kack, H.; Sandmark, J.; Gibson, K.; Schneider, G.; Lindqvist, Y. (1999) Crystal structure of diaminopelargonic acid synthase: evolutionary relationships between pyridoxal-5'-phosphate-dependent enzymes J Mol Biol 291 857-76.

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last changed 2019/10/22 12:22

B6db activities