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B6db activities: 2.6.1.64

2.6.1.64
Description Glutamine--phenylpyruvate aminotransferase.
Alternative names Glutamine transaminase K.
Catalyzed reaction L-glutamine + phenylpyruvate = 2-oxoglutaramate + L-phenylalanine.
Cofactor Pyridoxal-phosphate.
Comments -!- L-methionine, L-histidine and L-tyrosine can act as donors.
-!- Has little activity on pyruvate and glyoxylate (cf. EC 2.6.1.15).
Documented enzymes with this function also show kynurenine aminotransferase (EC 2.6.1.7) and cysteine-conjugate beta-lyase (EC 4.4.1.13) activities. These sequences have been included in the 2.6.1.7 family.

In E. coli, the transamination of glutamine is apparently carried out by aspartate aminotransferase (2.6.1.1).

Organisms -Eubacteria -Metazoa
 
 
Links Enzyme (activities) 2.6.1.64
BRENDA (activities) 2.6.1.64
KEGG (pathways) 2.6.1.64
PLPMDB (PLP mutants) 2.6.1.64
 
References
 Cooper AJ, Pinto JT, Krasnikov BF, Niatsetskaya ZV, Han Q, Li J, Vauzour D, Spencer JP. (2008) Substrate specificity of human glutamine transaminase K as an aminotransferase and as a cysteine S-conjugate beta-lyase Arch Biochem Biophys 474 72-81.

 Han, Q.; Fang, J.; Li, J. (2001) Kynurenine aminotransferase and glutamine transaminase K of Escherichia coli: identity with aspartate aminotransferase Biochem J 360 617-23.

Articles on 2.6.1.64
 
last changed 2010/03/11 16:27

B6db activities