Activities | Families | Sequences | Fold types | References | Help
B6db activities: 2.6.1.72

2.6.1.72
Description D-4-hydroxyphenylglycine aminotransferase.
Alternative names D-phenylglycine aminotransferase
Catalyzed reaction D-4-hydroxyphenylglycine + 2-oxoglutarate = 4-hydroxyphenylglyoxylate + L-glutamate.
Cofactor Pyridoxal-phosphate.
The enzyme from Pseudomonas strutzeri accepts as amino group donor only D-4-hydroxyphenylglycine or D-phenylglycine, whereas 2-oxoglutarate is the exclusive amino group acceptor and is converted into L-glutamate.
PDB 2CY8;
Organisms -Eubacteria
 

Family 

2.6.1.72 (4)
 
Links Enzyme (activities) 2.6.1.72
BRENDA (activities) 2.6.1.72
KEGG (pathways) 2.6.1.72
PLPMDB (PLP mutants) 2.6.1.72
 
References
 Kongsaeree P, Samanchart C, Laowanapiban P, Wiyakrutta S, Meevootisom V. (2003) Crystallization and preliminary X-ray crystallographic analysis of d-phenylglycine aminotransferase from Pseudomonas stutzeri ST201 Acta Crystallogr D Biol Crystallogr 59 953-4.

 Wiyakrutta S, Meevootisom V. (1997) A stereo-inverting D-phenylglycine aminotransferase from Pseudomonas stutzeri ST-201: purification, characterization and application for D-phenylglycine synthesis J Biotechnol 55 193-203.

 Van den Tweel, W.J.J.; Smits, J.P.; Ogg, R.L.H.P.; de Bont, J.A.M. (1988) The involvement of an enantioselctive transaminase in the metabolism of D-3- and D-4-hydroxyphenylglycine in Pseudomonas putida LW-4 Appl Microbiol Biotechnol 29 224-230.

Articles on 2.6.1.72
 
last changed 2010/03/11 16:29

B6db activities