B6db activities : 2_6_1

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	2.6.1.72
Description	D-4-hydroxyphenylglycine aminotransferase
Alternative names	D-phenylglycine aminotransferase
Catalyzed reaction	D-4-hydroxyphenylglycine + 2-oxoglutarate = 4-hydroxyphenylglyoxylate + L-glutamate.
Cofactor	Pyridoxal-phosphate.
	The enzyme from Pseudomonas strutzeri accepts as amino group donor only D-4-hydroxyphenylglycine or D-phenylglycine, whereas 2-oxoglutarate is the exclusive amino group acceptor and is converted into L-glutamate.
PDB	2CY8;
Organisms	-Eubacteria
Family	2.6.1.72 (0)

Links	Enzyme (activities) 2.6.1.72 BRENDA (activities) 2.6.1.72 KEGG (pathways) 2.6.1.72 PLPMDB (PLP mutants) 2.6.1.72

References	Walton CJ, Thiebaut F, Brunzelle JS, Couture JF, Chica RA (2018) Structural determinants of the stereo-inverting activity of Pseudomonas stutzeri D-phenylglycine aminotransferase Biochemistry 57 5437-5446. Chantarasiri A, Meevootisom V, Isarangkul D, Wiyakrutta S. (2012) Effective improvement of D-phenylglycine aminotransferase solubility by protein crystal contact engineering J Mol Microbiol Biotechnol 22 147-55. Müller U, van Assema F, Gunsior M, Orf S, Kremer S, Schipper D, Wagemans A, Townsend CA, Sonke T, Bovenberg R, Wubbolts M. (2006) Metabolic engineering of the E. coli L-phenylalanine pathway for the production of D-phenylglycine (D-Phg) Metab Eng 8 196-208. Wiyakrutta S, Meevootisom V. (1997) A stereo-inverting D-phenylglycine aminotransferase from Pseudomonas stutzeri ST-201: purification, characterization and application for D-phenylglycine synthesis J Biotechnol 55 193-203. Van den Tweel, W.J.J.; Smits, J.P.; Ogg, R.L.H.P.; de Bont, J.A.M. (1988) The involvement of an enantioselctive transaminase in the metabolism of D-3- and D-4-hydroxyphenylglycine in Pseudomonas putida LW-4 Appl Microbiol Biotechnol 29 224-230. Articles on 2.6.1.72

last changed	2019/06/20 11:22

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