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2.6.1.76 |
| Description |
Diaminobutyrate-2-oxoglutarate transaminase. |
| Alternative names |
L-2,4-diaminobutyrate:2-ketoglutarate 4-aminotransferase;
2,4-diaminobutyrate 4-aminotransferase;
Diaminobutyrate transaminase;
DABA aminotransferase. |
| Catalyzed reaction |
L-2,4-diaminobutyrate + 2-oxoglutarate = L-glutamate + L-aspartic 4-semialdehyde. |
| Cofactor |
Pyridoxal-phosphate; Potassium. |
| Comments |
-!- Involved in the formation of 1,3-diaminopropane in Haemophilus influenzae and Acinetobacter baumannii.
-!- A product of the ddc gene that also encodes L-2,4-diaminobutyrate decarboxylase in Acinetobacter baumannii.
-!- Differs from EC 2.6.1.46, diaminobutyrate-pyruvate transaminase which has pyruvate as the amino-group acceptor. |
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This is the first enzyme in the ectoine biosynthesis pathway, the other enzymes involved being EC 2.3.1.178 and EC 4.2.1.108. |
| Prosite |
PROSITE; PDOC00519; |
| Organisms |
-Eubacteria |
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Family |
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| Links |
Enzyme (activities) 2.6.1.76
BRENDA (activities) 2.6.1.76
KEGG (pathways) 2.6.1.76
PLPMDB (PLP mutants) 2.6.1.76
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| References |
Vandenende C.S.; Vlasschaert, M.; Seah, S.Y. (2004) Functional characterization of an aminotransferase required for pyoverdine siderophore biosynthesis in Pseudomonas aeruginosa PAO1 J Bacteriol 186 5596-602. Ono, H.; Sawada, K.; Khunajakr, N.; Tao, T.; Yamamoto, M.; Hiramoto, M.; Shinmyo, A.; Takano, M.; Murooka, Y.
(1999) Characterization of biosynthetic enzymes for ectoine as a compatible solute in a moderately halophilic eubacterium, Halomonas elongata J Bacteriol 181 91-9. Ikai, H.; Yamamoto, S. (1998) Two genes involved in the 1,3-diaminopropane production pathway in Haemophilus influenzae Biol Pharm Bull 21 170-3. Ikai, H.; Yamamoto, S. (1997) Identification and analysis of a gene encoding L-2,4-diaminobutyrate:2- ketoglutarate 4-aminotransferase involved in the 1,3-diaminopropane production pathway in Acinetobacter baumannii J Bacteriol 179 5118-25. |
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| last changed |
2010/03/11 16:19 |
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