Activities | Families | Sequences | Fold types | References | Help
B6db activities:
Description Glutamate--prephenate aminotransferase.
Alternative names prephenate transaminase (ambiguous);
PAT (ambiguous);
L-glutamate:prephenate aminotransferase;
L-arogenate:2-oxoglutarate aminotransferase.
Catalyzed reaction L-arogenate + 2-oxoglutarate = prephenate + L-glutamate
Cofactor Pyridoxal-phosphate.
Comments A pyridoxal-phosphate protein. Aspartate can also act as the amino donor, but more slowly (cf. EC, aspartate--prephenate aminotransferase).
The enzyme from higher plants shows a marked preference for prephenate as substrate compared to pyruvate, phenylpyruvate or 4-hydroxyphenylpyruvate.
Organisms -Plants

Family (9)
Links Enzyme (activities)
BRENDA (activities)
KEGG (pathways)
PLPMDB (PLP mutants)
 Graindorge M, Giustini C, Jacomin AC, Kraut A, Curien G, Matringe M. (2010) Identification of a plant gene encoding glutamate/aspartate-prephenate aminotransferase: The last homeless enzyme of aromatic amino acids biosynthesis FEBS Lett 584 4357-60.

 Maeda H, Yoo H, Dudareva N. (2010) Prephenate aminotransferase directs plant phenylalanine biosynthesis via arogenate Nat Chem Biol 7 19-21.

 Bonner, C.; Jensen, R. (1985) Novel features of prephenate aminotransferase from cell cultures of Nicotiana silvestris Arch Biochem Biophys 238 237-46.

Articles on
last changed 2009/07/07 15:41

B6db activities