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B6db activities: 2.6.1.79

2.6.1.79
Description Glutamate--prephenate aminotransferase.
Alternative names prephenate transaminase (ambiguous);
PAT (ambiguous);
L-glutamate:prephenate aminotransferase;
L-arogenate:2-oxoglutarate aminotransferase.
Catalyzed reaction L-arogenate + 2-oxoglutarate = prephenate + L-glutamate
Cofactor Pyridoxal-phosphate.
Comments A pyridoxal-phosphate protein. Aspartate can also act as the amino donor, but more slowly (cf. EC 2.6.1.78, aspartate--prephenate aminotransferase).
The enzyme from higher plants shows a marked preference for prephenate as substrate compared to pyruvate, phenylpyruvate or 4-hydroxyphenylpyruvate.
Organisms -Plants
 

Family 

2.6.1.79 (9)
 
Links Enzyme (activities) 2.6.1.79
BRENDA (activities) 2.6.1.79
KEGG (pathways) 2.6.1.79
PLPMDB (PLP mutants) 2.6.1.79
 
References
 Graindorge M, Giustini C, Jacomin AC, Kraut A, Curien G, Matringe M. (2010) Identification of a plant gene encoding glutamate/aspartate-prephenate aminotransferase: The last homeless enzyme of aromatic amino acids biosynthesis FEBS Lett 584 4357-60.

 Maeda H, Yoo H, Dudareva N. (2010) Prephenate aminotransferase directs plant phenylalanine biosynthesis via arogenate Nat Chem Biol 7 19-21.

 Bonner, C.; Jensen, R. (1985) Novel features of prephenate aminotransferase from cell cultures of Nicotiana silvestris Arch Biochem Biophys 238 237-46.

Articles on 2.6.1.79
 
last changed 2009/07/07 15:41

B6db activities