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B6db activities: 2.6.1.84

2.6.1.84
Description Arginine--pyruvate transaminase.
Alternative names arginine:pyruvate aminotransferase;
AruH.
Catalyzed reaction L-arginine + pyruvate = 5-guanidino-2-oxopentanoate + L-alanine.
Cofactor Pyridoxal-phosphate.
Comments A pyridoxal-phosphate protein.

While L-arginine is the best substrate, the enzyme exhibits broad substrate specificity, with L-lysine, L-methionine, L-leucine, L-ornithine and L-glutamine also able to act as substrates, but more slowly.
Pyruvate cannot be replaced by 2-oxoglutarate as amino-group acceptor.
This is the first catalytic enzyme of the arginine transaminase pathway for L-arginine utilization in Pseudomonas aeruginosa. This pathway is only used when the major route of arginine catabolism, i.e. the arginine succinyltransferase pathway, is blocked.

Organisms -Eubacteria
 

Family 

2.6.1.84 (3)
 
Links Enzyme (activities) 2.6.1.84
BRENDA (activities) 2.6.1.84
KEGG (pathways) 2.6.1.84
PLPMDB (PLP mutants) 2.6.1.84
 
References Articles on 2.6.1.84
 
last changed 2010/02/02 10:27

B6db activities