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B6db activities:
Description Arginine--pyruvate transaminase
Alternative names arginine:pyruvate aminotransferase;
Catalyzed reaction L-arginine + pyruvate = 5-guanidino-2-oxopentanoate + L-alanine.
Cofactor Pyridoxal-phosphate.
Comments A pyridoxal-phosphate protein.

While L-arginine is the best substrate, the enzyme exhibits broad substrate specificity, with L-lysine, L-methionine, L-leucine, L-ornithine and L-glutamine also able to act as substrates, but more slowly.
Pyruvate cannot be replaced by 2-oxoglutarate as amino-group acceptor.
This is the first catalytic enzyme of the arginine transaminase pathway for L-arginine utilization in Pseudomonas aeruginosa. This pathway is only used when the major route of arginine catabolism, i.e. the arginine succinyltransferase pathway, is blocked.

Organisms -Eubacteria

Family (0)
Links Enzyme (activities)
BRENDA (activities)
KEGG (pathways)
PLPMDB (PLP mutants)
References Articles on
last changed 2017/10/10 14:10

B6db activities