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B6db activities:
Description dTDP-3-amino-3,6-dideoxy-α-D-galactopyranose transaminase
Alternative names dTDP-6-deoxy-D-xylohex-3-uloseaminase;
FdtB (gene name);
WlaRG (gene name);
TDP-3-keto-6-deoxy-D-galactose 3-aminotransferase;
TDP-3-dehydro-6-deoxy-D-galactose 3-aminotransferase;
dTDP-3-amino-3,6-dideoxy-α-D-galactopyranose:2-oxoglutarate aminotransferase
Catalyzed reaction dTDP-3-amino-3,6-dideoxy-α-D-galactopyranose + 2-oxoglutarate = dTDP-3-dehydro-6-deoxy-α-D-galactopyranose + L-glutamate
Cofactor Pyridoxal-phosphate.
Comments A pyridoxal-phosphate protein. The enzyme is involved in the biosynthesis of dTDP-3-acetamido-3,6-dideoxy-α-D-galactose. The reaction occurs in the reverse direction.
The enzyme from C. jejuni (product of the WlarG gene) apparently acts on both dTDP-3-dehydro-6-deoxy-α-D-galactopyranose and on dTDP-3-dehydro-6-deoxy-α-D-glucopyranose.
PDB 5U24;
Organisms -Eubacteria


Links Enzyme (activities)
BRENDA (activities)
KEGG (pathways)
PLPMDB (PLP mutants)
 Dow GT, Gilbert M, Thoden JB, Holden HM (2017) Structural investigation on WlaRG from Campylobacter jejuni: A sugar aminotransferase Protein Sci 26 586-599.

 Li ZZ, Riegert AS, Goneau MF, Cunningham AM, Vinogradov E, Li J, Schoenhofen IC, Thoden JB, Holden HM, Gilbert M (2017) Characterization of the dTDP-Fuc3N and dTDP-Qui3N biosynthetic pathways in Campylobacter jejuni 81116 Glycobiology 27 358-369.

 Kharel MK1, Lian H, Rohr J (2011) Characterization of the TDP-D-ravidosamine biosynthetic pathway: one-pot enzymatic synthesis of TDP-D-ravidosamine from thymidine-5-phosphate and glucose-1-phosphate Org Biomol Chem 9 1799-808.

 Pfoestl A, Hofinger A, Kosma P, Messner P. (2003) Biosynthesis of dTDP-3-acetamido-3,6-dideoxy-alpha-D-galactose in Aneurinibacillus thermoaerophilus L420-91T J Biol Chem 278 26410-7.

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last changed 2019/09/18 10:29

B6db activities