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B6db activities: 2.6.1.90

2.6.1.90
Description dTDP-3-amino-3,6-dideoxy-α-D-galactopyranose transaminase
Alternative names dTDP-6-deoxy-D-xylohex-3-uloseaminase;
FdtB (gene name);
WlaRG (gene name);
TDP-3-keto-6-deoxy-D-galactose-3-aminotransferase;
RavAMT;
TDP-3-keto-6-deoxy-D-galactose 3-aminotransferase;
TDP-3-dehydro-6-deoxy-D-galactose 3-aminotransferase;
dTDP-3-amino-3,6-dideoxy-α-D-galactopyranose:2-oxoglutarate aminotransferase
Catalyzed reaction dTDP-3-amino-3,6-dideoxy-α-D-galactopyranose + 2-oxoglutarate = dTDP-3-dehydro-6-deoxy-α-D-galactopyranose + L-glutamate
Cofactor Pyridoxal-phosphate.
Comments A pyridoxal-phosphate protein. The enzyme is involved in the biosynthesis of dTDP-3-acetamido-3,6-dideoxy-α-D-galactose. The reaction occurs in the reverse direction.
The enzyme from C. jejuni (product of the WlarG gene) apparently acts on both dTDP-3-dehydro-6-deoxy-α-D-galactopyranose and on dTDP-3-dehydro-6-deoxy-α-D-glucopyranose.
PDB 5U24;
Organisms -Eubacteria
 

Family 

 
Links Enzyme (activities) 2.6.1.90
BRENDA (activities) 2.6.1.90
KEGG (pathways) 2.6.1.90
PLPMDB (PLP mutants) 2.6.1.90
 
References
 Dow GT, Gilbert M, Thoden JB, Holden HM (2017) Structural investigation on WlaRG from Campylobacter jejuni: A sugar aminotransferase Protein Sci 26 586-599.

 Li ZZ, Riegert AS, Goneau MF, Cunningham AM, Vinogradov E, Li J, Schoenhofen IC, Thoden JB, Holden HM, Gilbert M (2017) Characterization of the dTDP-Fuc3N and dTDP-Qui3N biosynthetic pathways in Campylobacter jejuni 81116 Glycobiology 27 358-369.

 Kharel MK1, Lian H, Rohr J (2011) Characterization of the TDP-D-ravidosamine biosynthetic pathway: one-pot enzymatic synthesis of TDP-D-ravidosamine from thymidine-5-phosphate and glucose-1-phosphate Org Biomol Chem 9 1799-808.

 Pfoestl A, Hofinger A, Kosma P, Messner P. (2003) Biosynthesis of dTDP-3-acetamido-3,6-dideoxy-alpha-D-galactose in Aneurinibacillus thermoaerophilus L420-91T J Biol Chem 278 26410-7.

Articles on 2.6.1.90
 
last changed 2019/09/18 10:29

B6db activities