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B6db activities: 2.6.1.92

2.6.1.92
Description UDP-4-amino-4,6-dideoxy-N-acetyl-beta-L-altrosamine transaminase
Alternative names UDP-4-keto-6-deoxy-GlcNAc aminotransferase;
Cj1294.
PseC;
UDP-4-amino-4,6-dideoxy-N-acetyl-beta-L-altrosamine transaminase
UDP-4-amino-4,6-dideoxy-N-acetyl-β-L-altrosamine:2-oxoglutarate aminotransferase;
UDP-β-L-threo-pentapyranos-4-ulose transaminase;
UDP-4-dehydro-6-deoxy-D-glucose transaminase
Catalyzed reaction UDP-4-amino-4,6-dideoxy-N-acetyl-β-L-altrosamine + 2-oxoglutarate = UDP-2-acetamido-2,6-dideoxy-β-L-arabino-hex-4-ulose + L-glutamate
Cofactor Pyridoxal-phosphate.
Comments A pyridoxal 5'-phosphate protein. The enzyme transfers the primary amino group of L-glutamate to C-4'' of UDP-4-dehydro sugars, forming a C-N bond in a stereo configuration opposite to that of UDP. The enzyme from the bacterium Bacillus cereus has been shown to act on UDP-2-acetamido-2,6-dideoxy-β-L-arabino-hex-4-ulose, UDP-β-L-threo-pentapyranos-4-ulose, UDP-4-dehydro-6-deoxy-D-glucose, and UDP-2-acetamido-2,6-dideoxy-α-D-xylo-hex-4-ulose. cf. EC 2.6.1.34, UDP-N-acetylbacillosamine transaminase, which catalyses a similar reaction, but forms the C-N bond in the same stereo configuration as that of UDP.
The enzyme is involved in the biosynthesis of diacetamidofucosamine, a presumed component of proteoglycans.
PDB 2FN6;
Organisms -Eubacteria
 

Family 

2.6.1.92 (12)
 
Links Enzyme (activities) 2.6.1.92
BRENDA (activities) 2.6.1.92
KEGG (pathways) 2.6.1.92
PLPMDB (PLP mutants) 2.6.1.92
 
References
 Schoenhofen IC, Lunin VV, Julien JP, Li Y, Ajamian E, Matte A, Cygler M, Brisson JR, Aubry A, Logan SM, Bhatia S, Wakarchuk WW, Young NM. (2006) Structural and functional characterization of PseC, an aminotransferase involved in the biosynthesis of Pseudaminic acid, an essential flagellar modification in helicobacter pylori. J Biol Chem. 281 8907-16.

 Schoenhofen IC, McNally DJ, Vinogradov E, Whitfield D, Young NM, Dick S, Wakarchuk WW, Brisson JR, Logan SM. (2006) Functional characterization of dehydratase/aminotransferase pairs from Helicobacter and Campylobacter: enzymes distinguishing the pseudaminic acid and bacillosamine biosynthetic pathways J Biol Chem 281 723-32.

 Obhi, R.K.; Creuzenet, C. (2005) Biochemical characterization of the Campylobacter jejuni Cj1294, a novel UDP-4-keto-6-deoxy-GlcNAc aminotransferase that generates UDP-4-amino-4,6-dideoxy-GalNAc J Biol Chem 280 20902-8.

Articles on 2.6.1.92
 
last changed 2018/07/18 11:21

B6db activities