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B6db activities: 2.6.1.93

2.6.1.93
Description neamine transaminase
Alternative names glutamate-6'-dehydroparomamine aminotransferase;
neamine:2-oxoglutarate aminotransferase;
btrB;
neoN;
kacL.
Catalyzed reaction neamine + 2-oxoglutarate = 6'-dehydroparomamine + L-glutamate
Cofactor Pyridoxal-phosphate.
Comments The reaction occurs in vivo in the opposite direction. Involved in the biosynthetic pathways of several clinically important aminocyclitol antibiotics, including kanamycin B, butirosin, neomycin and ribostamycin. Works in combination with EC 1.1.3.43, paromamine 6-oxidase, to replace the 6'-hydroxy group of paromamine with an amino group. The enzyme from the bacterium Streptomyces kanamyceticus can also catalyse EC 2.6.1.94, 2'-deamino-2'-hydroxyneamine transaminase, which leads to production of kanamycin A. The enzyme from the bacterium Streptomyces fradiae can also catalyse EC 2.6.1.95, leading to production of neomycin C.
Organisms -Eubacteria
 

Family 

2.6.1.93 (7)
 
Links Enzyme (activities) 2.6.1.93
BRENDA (activities) 2.6.1.93
KEGG (pathways) 2.6.1.93
PLPMDB (PLP mutants) 2.6.1.93
 
References Articles on 2.6.1.93
 
last changed 2014/02/24 11:55

B6db activities