B6db activities : 2_6_1

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	2.6.1.94
Description	2'-deamino-2'-hydroxyneamine transaminase
Alternative names	2'-deamino-2'-hydroxyneamine:2-oxoglutarate aminotransferase; kacL.
Catalyzed reaction	2'-deamino-2'-hydroxyneamine + 2-oxoglutarate = 2'-deamino-2'-hydroxy-6'-dehydroparomamine + L-glutamate
Cofactor	Pyridoxal-phosphate.
Comments	The reaction occurs in vivo in the opposite direction. Involved in the biosynthetic pathway of kanamycin A and kanamycin D. The enzyme, characterized from the bacterium Streptomyces kanamyceticus, can also catalyse EC 2.6.1.93, neamine transaminase.
Organisms	-Eubacteria
Family	2.6.1.94 (0)

Links	Enzyme (activities) 2.6.1.94 BRENDA (activities) 2.6.1.94 KEGG (pathways) 2.6.1.94 PLPMDB (PLP mutants) 2.6.1.94

References	Park, J.W., Park, S.R., Nepal, K.K., Han, A.R., Ban, Y.H., Yoo, Y.J., Kim, E.J., Kim, E.M., Kim, D., Sohng, J.K. and Yoon, Y.J. (2011) Discovery of parallel pathways of kanamycin biosynthesis allows antibiotic manipulation. Nat Chem Biol. 7 843-52. Articles on 2.6.1.94

last changed	2014/02/24 11:55

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