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B6db activities: 2.6.1.94

2.6.1.94
Description 2'-deamino-2'-hydroxyneamine transaminase
Alternative names 2'-deamino-2'-hydroxyneamine:2-oxoglutarate aminotransferase;
kacL.
Catalyzed reaction 2'-deamino-2'-hydroxyneamine + 2-oxoglutarate = 2'-deamino-2'-hydroxy-6'-dehydroparomamine + L-glutamate
Cofactor Pyridoxal-phosphate.
Comments The reaction occurs in vivo in the opposite direction. Involved in the biosynthetic pathway of kanamycin A and kanamycin D. The enzyme, characterized from the bacterium Streptomyces kanamyceticus, can also catalyse EC 2.6.1.93, neamine transaminase.
Organisms -Eubacteria
 

Family 

2.6.1.94 (3)
 
Links Enzyme (activities) 2.6.1.94
BRENDA (activities) 2.6.1.94
KEGG (pathways) 2.6.1.94
PLPMDB (PLP mutants) 2.6.1.94
 
References
 Park, J.W., Park, S.R., Nepal, K.K., Han, A.R., Ban, Y.H., Yoo, Y.J., Kim, E.J., Kim, E.M., Kim, D., Sohng, J.K. and Yoon, Y.J. (2011) Discovery of parallel pathways of kanamycin biosynthesis allows antibiotic manipulation. Nat Chem Biol. 7 843-52.

Articles on 2.6.1.94
 
last changed 2014/02/24 11:55

B6db activities