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2.6.1.94 |
Description |
2'-deamino-2'-hydroxyneamine transaminase |
Alternative names |
2'-deamino-2'-hydroxyneamine:2-oxoglutarate aminotransferase;
kacL. |
Catalyzed reaction |
2'-deamino-2'-hydroxyneamine + 2-oxoglutarate = 2'-deamino-2'-hydroxy-6'-dehydroparomamine + L-glutamate |
Cofactor |
Pyridoxal-phosphate. |
Comments |
The reaction occurs in vivo in the opposite direction. Involved in the biosynthetic pathway of kanamycin A and kanamycin D. The enzyme, characterized from the bacterium Streptomyces kanamyceticus, can also catalyse EC 2.6.1.93, neamine transaminase. |
Organisms |
-Eubacteria |
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Family |
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Links |
Enzyme (activities) 2.6.1.94
BRENDA (activities) 2.6.1.94
KEGG (pathways) 2.6.1.94
PLPMDB (PLP mutants) 2.6.1.94
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References |
Park, J.W., Park, S.R., Nepal, K.K., Han, A.R., Ban, Y.H., Yoo, Y.J., Kim, E.J., Kim, E.M., Kim, D., Sohng, J.K. and Yoon, Y.J. (2011) Discovery of parallel pathways of kanamycin biosynthesis allows antibiotic manipulation. Nat Chem Biol. 7 843-52. Articles on 2.6.1.94 |
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last changed |
2014/02/24 11:55 |
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