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B6db activities:
Description Neomycin C transaminase
Alternative names 2-oxoglutarate:neomycin C aminotransferase;
Catalyzed reaction neomycin C + 2-oxoglutarate = 6′′′-deamino-6′′′-oxoneomycin C + L-glutamate
Cofactor Pyridoxal-phosphate.
Comments The reaction occurs in vivo in the opposite direction. Involved in the biosynthetic pathway of aminoglycoside antibiotics of the neomycin family. Works in combination with EC, 6′′′-hydroxyneomycin C oxidase, to replace the 6′′′-hydroxy group of 6′′′-deamino-6′′′-hydroxyneomycin C with an amino group. The enzyme, characterized from the bacterium Streptomyces fradiae, can also catalyse EC, neamine transaminase.
Organisms -Eubacteria
Links Enzyme (activities)
BRENDA (activities)
KEGG (pathways)
PLPMDB (PLP mutants)
 Clausnitzer D1, Piepersberg W, Wehmeier UF. (2011) The oxidoreductases LivQ and NeoQ are responsible for the different 6'-modifications in the aminoglycosides lividomycin and neomycin J Appl Microbiol 111 642-51.

 Huang F, Spiteller D, Koorbanally NA, Li Y, Llewellyn NM, Spencer JB. (2007) Elaboration of neosamine rings in the biosynthesis of neomycin and butirosin. Chembiochem 8 283-8.

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last changed 2017/06/23 12:03

B6db activities