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2.6.1.95 |
Description |
Neomycin C transaminase |
Alternative names |
2-oxoglutarate:neomycin C aminotransferase;
neoB. |
Catalyzed reaction |
neomycin C + 2-oxoglutarate = 6′′′-deamino-6′′′-oxoneomycin C + L-glutamate
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Cofactor |
Pyridoxal-phosphate. |
Comments |
The reaction occurs in vivo in the opposite direction. Involved in the biosynthetic pathway of aminoglycoside antibiotics of the neomycin family. Works in combination with EC 1.1.3.44, 6′′′-hydroxyneomycin C oxidase, to replace the 6′′′-hydroxy group of 6′′′-deamino-6′′′-hydroxyneomycin C with an amino group. The enzyme, characterized from the bacterium Streptomyces fradiae, can also catalyse EC 2.6.1.93, neamine transaminase. |
Organisms |
-Eubacteria |
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Links |
Enzyme (activities) 2.6.1.95
BRENDA (activities) 2.6.1.95
KEGG (pathways) 2.6.1.95
PLPMDB (PLP mutants) 2.6.1.95
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References |
Articles on 2.6.1.95 |
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last changed |
2017/06/23 12:03 |
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