Activities | Families | Sequences | Fold types | References | Help
B6db activities: 2.6.1.95

2.6.1.95
Description neomycin C transaminase
Alternative names 2-oxoglutarate:neomycin C aminotransferase;
neoN.
Catalyzed reaction neomycin C + 2-oxoglutarate = 6′′′-deamino-6′′′-oxoneomycin C + L-glutamate
Cofactor Pyridoxal-phosphate.
Comments The reaction occurs in vivo in the opposite direction. Involved in the biosynthetic pathway of aminoglycoside antibiotics of the neomycin family. Works in combination with EC 1.1.3.44, 6′′′-hydroxyneomycin C oxidase, to replace the 6′′′-hydroxy group of 6′′′-deamino-6′′′-hydroxyneomycin C with an amino group. The enzyme, characterized from the bacterium Streptomyces fradiae, can also catalyse EC 2.6.1.93, neamine transaminase.
Organisms -Eubacteria
 
 
Links Enzyme (activities) 2.6.1.95
BRENDA (activities) 2.6.1.95
KEGG (pathways) 2.6.1.95
PLPMDB (PLP mutants) 2.6.1.95
 
References
 Clausnitzer D1, Piepersberg W, Wehmeier UF. (2011) The oxidoreductases LivQ and NeoQ are responsible for the different 6'-modifications in the aminoglycosides lividomycin and neomycin J Appl Microbiol 111 642-51.

 Huang F, Spiteller D, Koorbanally NA, Li Y, Llewellyn NM, Spencer JB. (2007) Elaboration of neosamine rings in the biosynthesis of neomycin and butirosin. Chembiochem 8 283-8.

Articles on 2.6.1.95
 
last changed 2014/02/24 14:35

B6db activities