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B6db activities:
Description 4-aminobutyrate—pyruvate transaminase
Alternative names GABA--pyruvate aminotransferase;
4-aminobutyrate--pyruvate aminotransferase;
Catalyzed reaction (1) 4-aminobutanoate + pyruvate = succinate semialdehyde + L-alanine
(2) 4-aminobutanoate + glyoxylate = succinate semialdehyde + glycine.
Cofactor Pyridoxal phosphate.
Comments The enzyme is found in plants that do not have the 2-oxoglutarate dependent enzyme (cf. EC

The reaction with pyruvate is reversible while the reaction with glyoxylate only takes place in the forward direction.

The sequences are similar to (beta-alanine--pyruvate aminotransferase) and indeed this enzyme, too, is an omega-amino acid--pyruvate aminotransferase.
Organisms -Plants

Family (9)
Links Enzyme (activities)
BRENDA (activities)
KEGG (pathways)
PLPMDB (PLP mutants)
 Weber N, Gorwa-Grauslund M, Carlquist M. (2014) Exploiting cell metabolism for biocatalytic whole-cell transamination by recombinant Saccharomyces cerevisiae Appl Microbiol Biotechnol 98 4615-24.

 Trobacher CP, Clark SM, Bozzo GG, Mullen RT, DeEll JR, Shelp BJ (2012) Catabolism of GABA in apple fruit: Subcellular localization and biochemical characterization of two gamma-aminobutyrate transaminases. Postharvest Biol Technol 75 106-113.

 Clark SM, Di Leo R, Dhanoa PK, Van Cauwenberghe OR, Mullen RT, Shelp BJ. (2009) Biochemical characterization, mitochondrial localization, expression, and potential functions for an Arabidopsis gamma-aminobutyrate transaminase that utilizes both pyruvate and glyoxylate J Exp Bot 60 1743-57.

 Palanivelu R, Brass L, Edlund AF, Preuss D. (2003) Pollen tube growth and guidance is regulated by POP2, an Arabidopsis gene that controls GABA levels Cell 114 47-59.

 Van Cauwenberghe, O.R.; Makhmoudova, A.; McLean, M.D.; Clark, S.M.; Shelp, B.J. (2002) Plant pyruvate-dependent gamma-aminobutyrate transaminase:Identification of an Arabidopsis cDNA and its expression in Escherichia coli Can J Bot 80 933-41.

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last changed 2014/02/14 11:33

B6db activities