Activities | Families | Sequences | Fold types | References | Help
B6db activities: 2.6.1.96

2.6.1.96
Description 4-aminobutyrate—pyruvate transaminase
Alternative names GABA--pyruvate aminotransferase;
4-aminobutyrate--pyruvate aminotransferase;
GABA-T.
Catalyzed reaction (1) 4-aminobutanoate + pyruvate = succinate semialdehyde + L-alanine
(2) 4-aminobutanoate + glyoxylate = succinate semialdehyde + glycine.
Cofactor Pyridoxal phosphate.
Comments The enzyme is found in plants that do not have the 2-oxoglutarate dependent enzyme (cf. EC 2.6.1.19).

The reaction with pyruvate is reversible while the reaction with glyoxylate only takes place in the forward direction.

The sequences are similar to 2.6.1.18 (beta-alanine--pyruvate aminotransferase) and indeed this enzyme, too, is an omega-amino acid--pyruvate aminotransferase.
Organisms -Plants
 

Family 

2.6.1.96 (9)
 
Links Enzyme (activities) 2.6.1.96
BRENDA (activities) 2.6.1.96
KEGG (pathways) 2.6.1.96
PLPMDB (PLP mutants) 2.6.1.96
 
References
 Nora Weber, Marie Gorwa-Grauslund and Magnus Carlquist (2014) Exploiting cell metabolism for biocatalytic whole-cell transamination by recombinant Saccharomyces cerevisiae Applied microbial and cell physiology .

 Christopher P. Trobacher, Shawn M. Clark, Gale G. Bozzo, Robert T. Mullen, Jennifer R. DeEll, Barry J. Shelp (2012) Catabolism of GABA in apple fruit: Subcellular localization and biochemical characterization of two gamma-aminobutyrate transaminases. Postharvest Biology and Technology 75 106-113.

Articles on 2.6.1.96
 
last changed 2014/02/14 11:33

B6db activities