2.8.1.7
Description	Cysteine desulfurase
Alternative names	IscS; NifS; SufS; cysteine desulfurylase.
Catalyzed reaction	L-cysteine + [enzyme]-cysteine = L-alanine + [enzyme]-S-sulfanylcysteine
Cofactor	Pyridoxal-phosphate.
Comments	The reaction shown is the first part of a catalytic process, which is completed by passing on the protein-bound sulfur to other acceptors. In Azotobacter vinelandii, this sulfur provides the inorganic sulfide required for nitrogenous metallocluster formation. The enzyme is involved in the biosynthesis of iron-sulfur clusters, thio-nucleosides in tRNA, thiamine, biotin, lipoate and pyranopterin (molybdopterin) and functions by mobilizing sulfur.
	Cysteine desulfurases are phylogenetically and functionally related to enzymes such as selenocystine lyases (C-DES type). They are also phylogenetically related to selenocysteine lyases (EC 4.4.1.16), and often show some selenocysteine lyase activity.
Diseases	Classical xanthinuria type II
PDB	1ECX; 1P3W; 6M4J;
Organisms	-Eubacteria -Archea -Plants -Metazoa -Human
Links	Enzyme (activities) 2.8.1.7 BRENDA (activities) 2.8.1.7 KEGG (pathways) 2.8.1.7 PLPMDB (PLP mutants) 2.8.1.7
References	Articles on 2.8.1.7
last changed	2020/05/08 01:58