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B6db activities:
Description S-sulfo-L-cysteine synthase (3-phospho-L-serine-dependent)
Alternative names cysK2 (gene name)
Catalyzed reaction O-phospho-L-serine + thiosulfate = S-sulfo-L-cysteine + phosphate
Cofactor Pyridoxal phosphate
Comments The enzyme, which has been characterized from the bacterium Mycobacterium tuberculosis, has no activity with O-acetyl-L-serine. Requires pyridoxal 5'-phosphate. cf. EC, S-sulfo-L-cysteine synthase (O-acetyl-L-serine-dependent).
Mycobacterial CysK2 provides an alternative metabolic rout to cysteine, either directly using sulfide as donor or indirectly via S-sulfocysteine.
Mycobacterium tubercolosis infects macrophages evading the bacterial action of immune cells. S-sulfocysteine could also acts as a signaling molecule triggering additional responses in redox defense upon exposure to reactive oxygen species.
Organisms -Eubacteria

Family (0)
Links Enzyme (activities)
BRENDA (activities)
KEGG (pathways)
PLPMDB (PLP mutants)
 Steiner EM, Böth D, Lössl P, Vilaplana F, Schnell R, Schneider G. (2014) CysK2 from Mycobacterium tuberculosis is an O-phospho-L-serine-dependent S-sulfocysteine synthase. J Bacteriol 196 3410-20.

Articles on
last changed 2018/06/04 11:54

B6db activities