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B6db activities: 3.7.1.3

3.7.1.3
Description Kynureninase
Alternative names L-kynurenine hydrolase.
Catalyzed reaction L-kynurenine + H(2)O = anthranilate + L-alanine.
Cofactor Pyridoxal-phosphate.
Comments -!- Also acts on 3'-hydroxykynurenine and some other (3-arylcarbonyl)- alanines.
3'-hydroxykynurenine is the favorite substrate of mammalian rnzymes, whereas bacterial enzymes prefer plain kynurenine.
Diseases Hydroxykynureninuria
PDB 1QZ9; 2HZP;
Organisms -Eubacteria -Fungi -Metazoa -Human
 

Family 

3.7.1.3 (27)
 
Links Enzyme (activities) 3.7.1.3
BRENDA (activities) 3.7.1.3
KEGG (pathways) 3.7.1.3
PLPMDB (PLP mutants) 3.7.1.3
 
References
 Zummo FP, Marineo S, Pace A, Civiletti F, Giardina A, Puglia AM (2012) Tryptophan catabolism via kynurenine production in Streptomyces coelicolor: identification of three genes coding for the enzymes of tryptophan to anthranilate pathway Appl Microbiol Biotechnol 94 719-28.

 Lima S, Khristoforov R, Momany C, Phillips RS. (2007) Crystal structure of Homo sapiens kynureninase Biochemistry 46 2735-44.

 Momany, C.; Levdikov, V.; Blagova, L.; Lima, S.; Phillips, R.S. (2004) Three-dimensional structure of kynureninase from Pseudomonas fluorescens Biochemistry 43 1193-203.

 Walsh, H. A.; Botting, N. P. (2002) Purification and biochemical characterization of some of the properties of recombinant human kynureninase Eur J Biochem 269 2069-74.

 Koushik, S. V.; Sundararaju, B.; McGraw, R. A.; Phillips, R. S. (1997) Cloning, sequence, and expression of kynureninase from Pseudomonas fluorescens Arch Biochem Biophys 344 301-8.

 Toma, S.; Nakamura, M.; Tone, S.; Okuno, E.; Kido, R.; Breton, J.; Avanzi, N.; Cozzi, L.; Speciale, C.; Mostardini, M.; Gatti, S.; Benatti, L. (1997) Cloning and recombinant expression of rat and human kynureninase FEBS Lett 408 5-10.

Articles on 3.7.1.3
 
last changed 2019/01/07 14:43

B6db activities