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4.1.1.107 |
Description |
3,4-dihydroxyphenylacetaldehyde synthase |
Alternative names |
DHPAA synthase. |
Catalyzed reaction |
3,4-dihydroxyphenylalanine + O(2) = 3,4-dihydroxyphenylacetaldehyde + H(2)O(2) + NH(3) + CO(2). |
Cofactor |
Pyridoxal-phosphate. |
Comments |
A pyridoxal 5'-phosphate protein. The enzyme, isolated from the mosquito Aedes aegypti, catalyses the production of 3,4-dihydroxylphenylacetaldehyde directly from L-dopa. Dopamine is not formed as an intermediate (cf. EC 4.1.1.28, aromatic-L-amino-acid decarboxylase). The enzyme is specific for L-dopa and does not react with other aromatic amino acids with the exception of a low activity with α-methyl-L-dopa. |
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Specialized enzymes from insects, strictly related to aromatic amino acid aminotransferases. The highly toxic product, 3,4-dihydroxyphenylacetaldehyde, is involved in cuticle formation. |
Organisms |
-Metazoa |
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Family |
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Links |
Enzyme (activities) 4.1.1.107
BRENDA (activities) 4.1.1.107
KEGG (pathways) 4.1.1.107
PLPMDB (PLP mutants) 4.1.1.107
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References |
Liang J, Han Q, Ding H, Li J (2017) Biochemical identification of residues that discriminate between 3,4-dihydroxyphenylalanine decarboxylase and 3,4-dihydroxyphenylacetaldehyde synthase-mediated reactions Insect Biochem Mol Biol 91 34-43. Vavricka C, Han Q, Huang Y, Erickson SM, Harich K, Christensen BM, Li J. (2011) From L-dopa to dihydroxyphenylacetaldehyde: a toxic biochemical pathway plays a vital physiological function in insects IPLoS One 6 e16124. Articles on 4.1.1.107 |
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last changed |
2018/05/09 15:40 |
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