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B6db activities:
Description 3,4-dihydroxyphenylacetaldehyde synthase
Alternative names DHPAA synthase.
Catalyzed reaction 3,4-dihydroxyphenylalanine + O(2) = 3,4-dihydroxyphenylacetaldehyde + H(2)O(2) + NH(3) + CO(2).
Cofactor Pyridoxal-phosphate.
Comments A pyridoxal 5'-phosphate protein. The enzyme, isolated from the mosquito Aedes aegypti, catalyses the production of 3,4-dihydroxylphenylacetaldehyde directly from L-dopa. Dopamine is not formed as an intermediate (cf. EC, aromatic-L-amino-acid decarboxylase). The enzyme is specific for L-dopa and does not react with other aromatic amino acids with the exception of a low activity with α-methyl-L-dopa.
Specialized enzymes from insects, strictly related to aromatic amino acid aminotransferases. The highly toxic product, 3,4-dihydroxyphenylacetaldehyde, is involved in cuticle formation.
Organisms -Metazoa

Family (0)
Links Enzyme (activities)
BRENDA (activities)
KEGG (pathways)
PLPMDB (PLP mutants)
References Articles on
last changed 2018/05/09 15:40

B6db activities